{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:48:40Z","timestamp":1756309720598,"version":"3.37.3"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"21-22","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["W1241"],"award-info":[{"award-number":["W1241"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010109","name":"Medical University of Graz","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010109","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Wien Klin Wochenschr"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Vaccination against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) was one crucial element to overcome the coronavirus disease 2019 (COVID-19) pandemic. Even though anaphylaxis to vaccines is rare, 47\u00a0patients came to the Allergy Unit at the University Hospital Graz, Austria, reporting immediate anaphylactoid symptoms after administration of COVID-19 vaccines. In addition, 29\u00a0patients with known drug-induced anaphylaxis wanted to be tested for a\u00a0possible sensitization against COVID-19 vaccines or excipients, such as polyethylene glycol (PEG) or polysorbate\u00a080 (PS80) before the first COVID-19 vaccination. Skin prick tests and intradermal tests were performed in all 76\u00a0patients, mostly using PEG 2000, and\/or PS80. Skin prick tests with COVID-19 vaccines were performed depending on availability.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>Our aim was to characterize this patient cohort in terms of patients\u2019 anaphylactoid responses, their willingness to future vaccinations against SARS-Cov\u20112, and reasons for their decision.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We developed a\u00a0questionnaire and analyzed 34\u00a0completed copies.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Of the 47\u00a0patients with anaphylactoid reactions to COVID-19 vaccination, most were female (40\u00a0female\/7\u00a0male). The skin tests, even when performed with the respective COVID-19 vaccine, were negative in all but one patient. Most patients who experienced anaphylactoid reactions after a\u00a0COVID-19 vaccination, did not want another COVID-19 vaccination at the time of answering the questionnaire because of anxiety for another anaphylactoid response at the next shot. Premedication with antihistamines significantly lowered (<jats:italic>n<\/jats:italic>\u202f=\u200974\u00a0vaccinations) the severity of anaphylactoid responses after COVID-19\u00a0vaccinations.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Anxiety about another anaphylactoid episode hinders patients to be vaccinated against SARS-CoV\u20112 again. Premedication with antihistamines and collaboration of allergologists with psychologists might lower the risk of an anaphylactic\/anaphylactoid response as well anxiety in drug-induced anaphylactic patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00508-024-02435-0","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T14:03:20Z","timestamp":1726063400000},"page":"590-597","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["COVID-19 vaccines: anaphylaxis and anxiety"],"prefix":"10.1007","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1142-949X","authenticated-orcid":false,"given":"Andrea R.","family":"Teufelberger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrada-Renata","family":"Dan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Irmler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birger","family":"Kr\u00e4nke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"issue":"9","key":"2435_CR1","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.1016\/j.jaip.2022.04.035","volume":"10","author":"KB Corey","year":"2022","unstructured":"Corey\u00a0KB, Koo\u00a0G, Phillips\u00a0EJ. 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P.\u00a0Wolf was supported by FWF Austrian Science Fund number W1241.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}