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This feasibility study aimed to establish proof-of-concept for a\u00a0novel, multimodal treatment regimen and to explore potential diagnostic tools for PRMDs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Musicians from the Orchestra Academy of the Vienna Philharmonic Orchestra participated in different interventions from a\u00a0therapeutic and diagnostic protocol. The therapeutic part encompassed self-administered transcranial direct current stimulation (tDCS) sessions targeting the primary motor cortex with tailored physiotherapeutic exercises and psychological coaching. Separate diagnostic interventions included comprehensive physiotherapeutic and psychological assessments, pain questionnaires, and the acquisition of magnetic resonance imaging and 3D motion capture data. The feasibility of these methods was thoroughly evaluated through safety questionnaires, completion checklists, direct observation by the investigators, and detailed participant feedback.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The therapeutic tDCS sessions with concurrent physiotherapeutic exercises were completed by 2 participants across all 10 scheduled sessions. Mild to moderate tingling\/burning sensations during tDCS sessions were reported in 3\u00a0of 10\u00a0sessions (30%), and electrode connectivity issues occurred in 3\u00a0of 10\u00a0sessions (30%), which participants could resolve independently. All seven participants engaged in various diagnostic assessments. The novel pain assessment questionnaire was completed by four participants in under 5\u202fmin, with reported pain intensities ranging from 0\u20135 on a\u00a00\u201310 scale, most frequently in the neck, wrist\/hand, and upper and lower back. Functional magnetic resonance imaging during simulated instrument playing revealed discernible activation patterns, including bilateral primary motor cortex activation, and 3D motion capture provided detailed kinematic data from a\u00a0violinist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This study provides initial evidence for the feasibility and safety of a\u00a0combined treatment approach (tDCS, physiotherapy, psychological support) for musicians suffering from PRMDs. Furthermore, the results encourage further exploration of advanced imaging and motion capture techniques as potential diagnostic and monitoring tools. These findings support conducting a\u00a0larger scale, randomized clinical trial to investigate the efficacy of these approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00508-025-02566-y","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T15:53:59Z","timestamp":1753718039000},"page":"38-47","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Safety and feasibility of a\u00a0multimodal approach for orchestra musicians with playing-related musculoskeletal disorders (PRMDs)"],"prefix":"10.1007","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4473-3818","authenticated-orcid":false,"given":"Paul Emmerich","family":"Krumpoeck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerold","family":"Ebenbichler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Knosp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricarda-Samantha","family":"Roiger-Simek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Margreiter-Neuwirth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Neuwirth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Kasprian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Heinz","family":"Nenning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Schmidbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emir","family":"Benca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fritz","family":"Sterz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"key":"2566_CR1","unstructured":"Orchestras at a glance https:\/\/americanorchestras.org\/orchestras-at-a-glance\/. 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