{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T20:59:40Z","timestamp":1778965180612,"version":"3.51.4"},"reference-count":4,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005788","name":"Medical University of Vienna","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005788","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Wien Klin Wochenschr"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Musculocontractural Ehlers-Danlos syndrome (mcEDS) is a\u00a0rare autosomal recessive connective tissue disorder characterized by fragility of skin, vasculature and musculoskeletal structures. We report a\u00a0case of a\u00a0young male with CHST14(Carbohydrate sulfotransferase 14)-related mcEDS who developed a\u00a0massive subcutaneous hematoma following minor trauma, necessitating surgical evacuation. This case highlights the potential for life-threatening bleeding complications in mcEDS and underscores the importance of early recognition and multidisciplinary management.<\/jats:p>","DOI":"10.1007\/s00508-025-02577-9","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T17:46:59Z","timestamp":1754329619000},"page":"55-58","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hypovolemic shock due to massive subcutaneous hemorrhage in a\u00a0patient with musculocontractural Ehlers-Danlos syndrome (mcEDS)"],"prefix":"10.1007","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7822-7529","authenticated-orcid":false,"given":"R.","family":"Laggner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Payr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Adam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Baron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Zak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"issue":"1","key":"2577_CR1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1002\/ajmg.c.31552","volume":"175","author":"F Malfait","year":"2017","unstructured":"Malfait\u00a0F, Francomano\u00a0C, Byers\u00a0P, Belmont\u00a0J, Berglund\u00a0B, Black\u00a0J, et\u00a0al. The 2017 international classification of the Ehlers-Danlos syndromes. Am J Med Genet C Semin Med Genet. 2017;175(1):8\u201326.","journal-title":"Am J Med Genet C Semin Med Genet"},{"issue":"1","key":"2577_CR2","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/s41572-020-0194-9","volume":"6","author":"F Malfait","year":"2020","unstructured":"Malfait\u00a0F, Castori\u00a0M, Francomano\u00a0CA, Giunta\u00a0C, Kosho\u00a0T, Byers\u00a0PH. The Ehlers-Danlos syndromes. Nat Rev Dis Primers. 2020;6(1):64.","journal-title":"Nat Rev Dis Primers"},{"issue":"8","key":"2577_CR3","first-page":"e66774","volume":"16","author":"Y Uemura","year":"2024","unstructured":"Uemura\u00a0Y, Tsuboi\u00a0N, Nakagawa\u00a0S. Musculocontractural Ehlers-Danlos Syndrome Leading to Hemorrhagic Shock From Giant Subcutaneous Hematoma: A\u00a0Case Report. Cureus. 2024;16(8):e66774.","journal-title":"Cureus"},{"key":"2577_CR4","doi-asserted-by":"crossref","unstructured":"Kosho T, Mizumoto S, Watanabe T, Yoshizawa T, Miyake N, Yamada S. Recent Advances in the Pathophysiology of Musculocontractural Ehlers-Danlos Syndrome. Genes (basel). 2019;11(1).","DOI":"10.3390\/genes11010043"}],"container-title":["Wiener klinische Wochenschrift"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00508-025-02577-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00508-025-02577-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00508-025-02577-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T11:23:00Z","timestamp":1769167380000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00508-025-02577-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,4]]},"references-count":4,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["2577"],"URL":"https:\/\/doi.org\/10.1007\/s00508-025-02577-9","relation":{},"ISSN":["0043-5325","1613-7671"],"issn-type":[{"value":"0043-5325","type":"print"},{"value":"1613-7671","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,4]]},"assertion":[{"value":"26 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"R.\u00a0Laggner, S.\u00a0Payr, L.\u00a0Adam, D.\u00a0Baron and L.\u00a0Zak declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The patient provided written informed consent for the publication of all clinical details and images presented in this report.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}