{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:06:43Z","timestamp":1792796803154,"version":"4.5.0"},"reference-count":83,"publisher":"Springer Science and Business Media LLC","issue":"7-8","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P35262-B"],"award-info":[{"award-number":["P35262-B"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005788","name":"Medical University of Vienna","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005788","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Wien Klin Wochenschr"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Primary hyperparathyroidism is a\u00a0frequent endocrine disorder that affects various organ systems. In this review we present and discuss alterations of bone metabolism in primary hyperparathyroidism. Excessive secretion of parathyroid hormone results in increased bone remodelling with an excess of bone resorption. Consequently, bone mineral density declines, bone quality is compromised and fracture risk increases.<\/jats:p>\n                  <jats:p>Successful surgery for hyperparathyroidism results in a\u00a0normalization of bone turnover and a\u00a0decrease of fracture risk. Osteitis fibrosa cystica, a\u00a0severe bone manifestation of hyperparathyroidism, is observed rarely today.<\/jats:p>","DOI":"10.1007\/s00508-025-02670-z","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:32:39Z","timestamp":1764689559000},"page":"217-224","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Bone metabolism in primary hyperparathyroidism"],"prefix":"10.1007","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1128-7532","authenticated-orcid":false,"given":"Katharina","family":"Kerschan-Schindl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Gelles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Butylina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Crevenna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Pietschmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,2]]},"reference":[{"issue":"1","key":"2670_CR1","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1002\/jcb.20388","volume":"95","author":"DW Dempster","year":"2005","unstructured":"Dempster\u00a0DW, Hughes-Begos\u00a0CE, Plavetic-Chee\u00a0K, Brandao-Burch\u00a0A, Cosman\u00a0F, Nieves\u00a0J, Neubort\u00a0S, Lu\u00a0SS, Iida-Klein\u00a0A, Arnett\u00a0T, Lindsay\u00a0R. Normal human osteoclasts formed from peripheral blood monocytes express PTH type\u00a01 receptors and are stimulated by PTH in the absence of osteoblasts. J\u00a0Cell Biochem. 2005;95(1):139\u201348. https:\/\/doi.org\/10.1002\/jcb.20388.","journal-title":"J Cell Biochem"},{"issue":"2","key":"2670_CR2","doi-asserted-by":"publisher","first-page":"284","DOI":"10.3892\/ijmm.2015.2423","volume":"37","author":"S Liu","year":"2016","unstructured":"Liu\u00a0S, Zhu\u00a0W, Li\u00a0S, Ma\u00a0J, Zhang\u00a0H, Li\u00a0Z, Zhang\u00a0L, Zhang\u00a0B, Li\u00a0Z, Liang\u00a0X, Shi\u00a0W. Bovine parathyroid hormone enhances osteoclast bone resorption by modulating V\u2011ATPase through PTH1R. Int J Mol Med. 2016;37(2):284\u201392. https:\/\/doi.org\/10.3892\/ijmm.2015.2423.","journal-title":"Int J Mol Med"},{"issue":"21","key":"2670_CR3","doi-asserted-by":"publisher","first-page":"11639","DOI":"10.3390\/ijms252111639","volume":"25","author":"M Iwanowska","year":"2024","unstructured":"Iwanowska\u00a0M, Kochman\u00a0M, Szatko\u00a0A, Zgliczy\u0144ski\u00a0W, Glinicki\u00a0P. Bone Disease in Primary Hyperparathyroidism-Changes Occurring in Bone Metabolism and New Potential Treatment. Strategies Int J Mol Sci. 2024;25(21):11639. https:\/\/doi.org\/10.3390\/ijms252111639.","journal-title":"Strategies Int J Mol Sci"},{"issue":"3","key":"2670_CR4","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1210\/jc.2007-1645","volume":"93","author":"IA Nakchbandi","year":"2008","unstructured":"Nakchbandi\u00a0IA, Lang\u00a0R, Kinder\u00a0B, Insogna\u00a0KL. The role of the receptor activator of nuclear factor-kappaB ligand\/osteoprotegerin cytokine system in primary hyperparathyroidism. J\u00a0Clin Endocrinol Metab. 2008;93(3):967\u201373. https:\/\/doi.org\/10.1210\/jc.2007-1645.","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"2670_CR5","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1055\/s-0033-1349842","volume":"45","author":"J Szymczak","year":"2013","unstructured":"Szymczak\u00a0J, Bohdanowicz-Pawlak\u00a0A. Osteoprotegerin, RANKL, and bone turnover in primary hyperparathyroidism: the effect of parathyroidectomy and treatment with alendronate. Horm Metab Res. 2013;45(10):759\u201364. https:\/\/doi.org\/10.1055\/s-0033-1349842.","journal-title":"Horm Metab Res"},{"issue":"50","key":"2670_CR6","doi-asserted-by":"publisher","first-page":"48868","DOI":"10.1074\/jbc.M208494200","volume":"277","author":"Q Fu","year":"2002","unstructured":"Fu\u00a0Q, Jilka\u00a0RL, Manolagas\u00a0SC, O\u2019Brien\u00a0CA. Parathyroid Hormone Stimulates Receptor Activator of NF\u03baB Ligand and Inhibits Osteoprotegerin Expression via Protein Kinase A Activation of cAMP-response Element-binding Protein. J\u00a0Biol Chem. 2002;277(50):48868\u201375. https:\/\/doi.org\/10.1074\/jbc.M208494200.","journal-title":"J Biol Chem"},{"issue":"9","key":"2670_CR7","doi-asserted-by":"publisher","first-page":"4047","DOI":"10.1210\/endo.142.9.8356","volume":"142","author":"YL Ma","year":"2001","unstructured":"Ma\u00a0YL, Cain\u00a0RL, Halladay\u00a0DL, Yang\u00a0X, Zeng\u00a0Q, Miles\u00a0RR, Chandrasekhar\u00a0S, Martin\u00a0TJ, Onyia\u00a0JE. Catabolic effects of continuous human PTH (1\u201338) in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation. Endocrinology. 2001;142(9):4047\u201354. https:\/\/doi.org\/10.1210\/endo.142.9.8356.","journal-title":"Endocrinology"},{"issue":"1","key":"2670_CR8","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1002\/jbm4.10021","volume":"2","author":"MN Wein","year":"2017","unstructured":"Wein\u00a0MN. Parathyroid Hormone Signaling in Osteocytes. Jbmr Plus. 2017;2(1):22\u201330. https:\/\/doi.org\/10.1002\/jbm4.10021.","journal-title":"Jbmr Plus"},{"issue":"5","key":"2670_CR9","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1530\/EJE-10-0699","volume":"163","author":"AH van Lierop","year":"2010","unstructured":"van Lierop\u00a0AH, Witteveen\u00a0JE, Hamdy\u00a0NA, Papapoulos\u00a0SE. Patients with primary hyperparathyroidism have lower circulating sclerostin levels than euparathyroid controls. Eur J Endocrinol. 2010;163(5):833\u20137. https:\/\/doi.org\/10.1530\/EJE-10-0699.","journal-title":"Eur J Endocrinol"},{"issue":"7","key":"2670_CR10","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1055\/s-0031-1275661","volume":"119","author":"H Kaji","year":"2011","unstructured":"Kaji\u00a0H, Imanishi\u00a0Y, Sugimoto\u00a0T, Seino\u00a0S. Comparisons of serum sclerostin levels among patients with postmenopausal osteoporosis, primary hyperparathyroidism and osteomalacia. Exp Clin Endocrinol Diabetes. 2011;119(7):440\u20134. https:\/\/doi.org\/10.1055\/s-0031-1275661.","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"6","key":"2670_CR11","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1007\/s00198-011-1806-8","volume":"23","author":"MS Ardawi","year":"2012","unstructured":"Ardawi\u00a0MS, Al-Sibiany\u00a0AM, Bakhsh\u00a0TM, Rouzi\u00a0AA, Qari\u00a0MH. Decreased serum sclerostin levels in patients with primary hyperparathyroidism: a\u00a0cross-sectional and a\u00a0longitudinal study. Osteoporos Int. 2012;23(6):1789\u201397. https:\/\/doi.org\/10.1007\/s00198-011-1806-8.","journal-title":"Osteoporos Int"},{"issue":"4","key":"2670_CR12","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1007\/s00223-012-9665-7","volume":"92","author":"O Viapiana","year":"2013","unstructured":"Viapiana\u00a0O, Fracassi\u00a0E, Troplini\u00a0S, Idolazzi\u00a0L, Rossini\u00a0M, Adami\u00a0S, Gatti\u00a0D. Sclerostin and DKK1 in primary hyperparathyroidism. Calcif Tissue Int. 2013;92(4):324\u20139. https:\/\/doi.org\/10.1007\/s00223-012-9665-7.","journal-title":"Calcif Tissue Int"},{"key":"2670_CR13","doi-asserted-by":"publisher","first-page":"709024","DOI":"10.1155\/2014\/709024","volume":"2014","author":"SP Cheng","year":"2014","unstructured":"Cheng\u00a0SP, Liu\u00a0CL, Liu\u00a0TP, Hsu\u00a0YC, Lee\u00a0JJ. Association between parathyroid hormone levels and inflammatory markers among US adults. Mediators Inflamm. 2014;2014:709024. https:\/\/doi.org\/10.1155\/2014\/709024.","journal-title":"Mediators Inflamm"},{"issue":"8","key":"2670_CR14","doi-asserted-by":"publisher","first-page":"e12290","DOI":"10.1371\/journal.pone.0012290","volume":"5","author":"H Tawfeek","year":"2010","unstructured":"Tawfeek\u00a0H, Bedi\u00a0B, Li\u00a0JY, Adams\u00a0J, Kobayashi\u00a0T, Weitzmann\u00a0MN, Kronenberg\u00a0HM, Pacifici\u00a0R. Disruption of PTH receptor\u00a01 in T\u00a0cells protects against PTH-induced bone loss. Plos One. 2010;5(8):e12290. https:\/\/doi.org\/10.1371\/journal.pone.0012290.","journal-title":"Plos One"},{"issue":"5","key":"2670_CR15","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/j.cmet.2015.09.012","volume":"22","author":"JY Li","year":"2015","unstructured":"Li\u00a0JY, D\u2019Amelio\u00a0P, Robinson\u00a0J, Walker\u00a0LD, Vaccaro\u00a0C, Luo\u00a0T, Tyagi\u00a0AM, Yu\u00a0M, Reott\u00a0M, Sassi\u00a0F, Buondonno\u00a0I, Adams\u00a0J, Weitzmann\u00a0MN, Isaia\u00a0GC, Pacifici\u00a0R. IL-17A Is Increased in Humans with Primary Hyperparathyroidism and Mediates PTH-Induced Bone Loss in Mice. Cell Metab. 2015;22(5):799\u2013810. https:\/\/doi.org\/10.1016\/j.cmet.2015.09.012.","journal-title":"Cell Metab"},{"issue":"11","key":"2670_CR16","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.1007\/s00198-021-06018-x","volume":"32","author":"J Pepe","year":"2021","unstructured":"Pepe\u00a0J, Bonnet\u00a0N, Cipriani\u00a0C, Ferrara\u00a0C, Rossi\u00a0M, De Martino\u00a0V, Colangelo\u00a0L, Sonato\u00a0C, Cecchetti\u00a0V, Ferrari\u00a0S, Minisola\u00a0S. Higher serum levels of a\u00a0cathepsin K\u2013generated periostin fragment are associated with fractures in postmenopausal women with primary hyperparathyroidism: a\u00a0pilot study. Osteoporos Int. 2021;32(11):2365\u20139. https:\/\/doi.org\/10.1007\/s00198-021-06018-x.","journal-title":"Osteoporos Int"},{"issue":"9","key":"2670_CR17","doi-asserted-by":"publisher","first-page":"4489","DOI":"10.1210\/jc.2004-0724","volume":"89","author":"A Gupta","year":"2004","unstructured":"Gupta\u00a0A, Winer\u00a0K, Econs\u00a0MJ, Marx\u00a0SJ, Collins\u00a0MT. FGF-23 is elevated by chronic hyperphosphatemia. J\u00a0Clin Endocrinol Metab. 2004;89(9):4489\u201392. https:\/\/doi.org\/10.1210\/jc.2004-0724.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2670_CR18","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1530\/eje.0.1510055","volume":"151","author":"H Yamashita","year":"2004","unstructured":"Yamashita\u00a0H, Yamashita\u00a0T, Miyamoto\u00a0M, Shigematsu\u00a0T, Kazama\u00a0JJ, Shimada\u00a0T, Yamazaki\u00a0Y, Fukumoto\u00a0S, Fukagaw\u00a0M, Noguchi\u00a0S. Fibroblast growth factor (FGF)-23 in patients with primary hyperparathyroidism. Eur J Endocrinol. 2004;151(1):55\u201360. https:\/\/doi.org\/10.1530\/eje.0.1510055.","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"2670_CR19","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1530\/eje.1.02053","volume":"154","author":"K Kobayashi","year":"2006","unstructured":"Kobayashi\u00a0K, Imanishi\u00a0Y, Miyauchi\u00a0A, Onoda\u00a0N, Kawata\u00a0T, Tahara\u00a0H, Goto\u00a0H, Miki\u00a0T, Ishimura\u00a0E, Sugimoto\u00a0T, Ishikawa\u00a0T, Inaba\u00a0M, Nishizawa\u00a0Y. Regulation of plasma fibroblast growth factor\u00a023 by calcium in primary hyperparathyroidism. Eur J Endocrinol. 2006;154(1):93\u20139. https:\/\/doi.org\/10.1530\/eje.1.02053.","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"2670_CR20","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/s12020-025-04173-3","volume":"88","author":"C Columbu","year":"2025","unstructured":"Columbu\u00a0C, Rendina\u00a0D, Gennari\u00a0L, Pugliese\u00a0F, Carnevale\u00a0V, Salcuni\u00a0AS, Chiodini\u00a0I, Battista\u00a0C, Tabacco\u00a0P, Guarnieri\u00a0V, Guglielmi\u00a0G, Eller-Vainicher\u00a0C, Cipriani\u00a0C, Cuttitta\u00a0A, De Filippo\u00a0G, Velluzzi\u00a0F, Falchetti\u00a0A, Minisola\u00a0S, Scillitani\u00a0A, Vescini\u00a0F. Phosphate metabolism in primary hyperparathyroidism: a\u00a0real-life long-term study. Endocrine. 2025;88(2):571\u201380. https:\/\/doi.org\/10.1007\/s12020-025-04173-3.","journal-title":"Endocrine"},{"issue":"2","key":"2670_CR21","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1046\/j.1365-2796.1998.00241.x","volume":"243","author":"S Valdemarsson","year":"1998","unstructured":"Valdemarsson\u00a0S, Linderg\u00e5rd\u00a0B, Tibblin\u00a0S, Bergenfelz\u00a0A. Increased biochemical markers of bone formation and resorption in primary hyperparathyroidism with special reference to patients with mild disease. J\u00a0Intern Med. 1998;243(2):115\u201322. https:\/\/doi.org\/10.1046\/j.1365-2796.1998.00241.x.","journal-title":"J Intern Med"},{"issue":"2","key":"2670_CR22","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/s8756-3282(99)00150-7","volume":"25","author":"P Christiansen","year":"1999","unstructured":"Christiansen\u00a0P, Steiniche\u00a0T, Brixen\u00a0K, Hessov\u00a0I, Melsen\u00a0F, Heickendorff\u00a0L, Mosekilde\u00a0L. Primary hyperparathyroidism: short-term changes in bone remodeling and bone mineral density following parathyroidectomy. Bone. 1999;25(2):237\u201344. https:\/\/doi.org\/10.1016\/s8756-3282(99)00150-7.","journal-title":"Bone"},{"issue":"1","key":"2670_CR23","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1007\/s00223-001-1142-7","volume":"73","author":"F Lumachi","year":"2003","unstructured":"Lumachi\u00a0F, Ermani\u00a0M, Basso\u00a0SM, Camozzi\u00a0V, Nardi\u00a0A, Favia\u00a0G, Luisetto\u00a0G. Short- and long-term changes in bone mineral density of the lumbar spine after parathyroidectomy in patients with primary hyperparathyroidism. Calcif Tissue Int. 2003;73(1):44\u20138. https:\/\/doi.org\/10.1007\/s00223-001-1142-7.","journal-title":"Calcif Tissue Int"},{"issue":"3","key":"2670_CR24","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1210\/jcem.74.3.1740480","volume":"74","author":"MJ Seibel","year":"1992","unstructured":"Seibel\u00a0MJ, Gartenberg\u00a0F, Silverberg\u00a0SJ, Ratcliffe\u00a0A, Robins\u00a0SP, Bilezikian\u00a0JP. Urinary hydroxypyridinium cross-links of collagen in primary hyperparathyroidism. J\u00a0Clin Endocrinol Metab. 1992;74(3):481\u20136. https:\/\/doi.org\/10.1210\/jcem.74.3.1740480.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2670_CR25","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/8756-3282(92)90360-9","volume":"13","author":"P Christiansen","year":"1992","unstructured":"Christiansen\u00a0P, Steiniche\u00a0T, Vesterby\u00a0A, Mosekilde\u00a0L, Hessov\u00a0I, Melsen\u00a0F. Primary hyperparathyroidism: iliac crest trabecular bone volume, structure, remodeling, and balance evaluated by histomorphometric methods. Bone. 1992;13(1):41\u20139. https:\/\/doi.org\/10.1016\/8756-3282(92)90360-9.","journal-title":"Bone"},{"issue":"10","key":"2670_CR26","doi-asserted-by":"publisher","first-page":"3487","DOI":"10.1210\/jcem.81.10.8855790","volume":"81","author":"CY Guo","year":"1996","unstructured":"Guo\u00a0CY, Thomas\u00a0WE, al-Dehaimi\u00a0AW, Assiri\u00a0AM, Eastell\u00a0R. Longitudinal changes in bone mineral density and bone turnover in postmenopausal women with primary hyperparathyroidism. J\u00a0Clin Endocrinol Metab. 1996;81(10):3487\u201391. https:\/\/doi.org\/10.1210\/jcem.81.10.8855790.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2670_CR27","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/s8756-3282(97)00078-1","volume":"21","author":"P Christiansen","year":"1997","unstructured":"Christiansen\u00a0P, Steiniche\u00a0T, Brixen\u00a0K, Hessov\u00a0I, Melsen\u00a0F, Charles\u00a0P, Mosekilde\u00a0L. Primary hyperparathyroidism: biochemical markers and bone mineral density at multiple skeletal sites in Danish patients. Bone. 1997;21(1):93\u20139. https:\/\/doi.org\/10.1016\/s8756-3282(97)00078-1.","journal-title":"Bone"},{"issue":"2","key":"2670_CR28","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1046\/j.1365-2265.2000.00900.x","volume":"52","author":"Y Abe","year":"2000","unstructured":"Abe\u00a0Y, Ejima\u00a0E, Fujiyama\u00a0K, Kiriyama\u00a0T, Ide\u00a0A, Sera\u00a0N, Tominaga\u00a0T, Ashizawa\u00a0K, Yokoyama\u00a0N, Eguchi\u00a0K. Parathyroidectomy for primary hyperparathyroidism induces positive uncoupling and increases bone mineral density in cancellous bones. Clin Endocrinol (oxf). 2000;52(2):203\u20139. https:\/\/doi.org\/10.1046\/j.1365-2265.2000.00900.x.","journal-title":"Clin Endocrinol (oxf)"},{"issue":"5","key":"2670_CR29","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1530\/eje.0.1420451","volume":"142","author":"CY Guo","year":"2000","unstructured":"Guo\u00a0CY, Holland\u00a0PA, Jackson\u00a0BF, Hannon\u00a0RA, Rogers\u00a0A, Harrison\u00a0BJ, Eastell\u00a0R. Immediate changes in biochemical markers of bone turnover and circulating interleukin\u20116 after parathyroidectomy for primary hyperparathyroidism. Eur J Endocrinol. 2000;142(5):451\u20139. https:\/\/doi.org\/10.1530\/eje.0.1420451.","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"2670_CR30","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1007\/s00223-002-2100-8","volume":"73","author":"LS Stilgren","year":"2003","unstructured":"Stilgren\u00a0LS, Heged\u00fcs\u00a0LM, Beck-Nielsen\u00a0H, Abrahamsen\u00a0B. Osteoprotegerin levels in primary hyperparathyroidism: effect of parathyroidectomy and association with bone metabolism. Calcif Tissue Int. 2003;73(3):210\u20136. https:\/\/doi.org\/10.1007\/s00223-002-2100-8.","journal-title":"Calcif Tissue Int"},{"issue":"1","key":"2670_CR31","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.bone.2004.03.012","volume":"35","author":"LS Stilgren","year":"2004","unstructured":"Stilgren\u00a0LS, Rettmer\u00a0E, Eriksen\u00a0EF, Heged\u00fcs\u00a0L, Beck-Nielsen\u00a0H, Abrahamsen\u00a0B. Skeletal changes in osteoprotegerin and receptor activator of nuclear factor-kappab ligand mRNA levels in primary hyperparathyroidism: effect of parathyroidectomy and association with bone metabolism. Bone. 2004;35(1):256\u201365. https:\/\/doi.org\/10.1016\/j.bone.2004.03.012.","journal-title":"Bone"},{"issue":"6","key":"2670_CR32","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1055\/s-0032-1308998","volume":"44","author":"K Kerschan-Schindl","year":"2012","unstructured":"Kerschan-Schindl\u00a0K, Riss\u00a0P, Krestan\u00a0C, Rauner\u00a0M, Bieglmayer\u00a0C, Gleiss\u00a0A, Fialka-Moser\u00a0V, Niederle\u00a0B, Pietschmann\u00a0P. Bone metabolism in patients with primary hyperparathyroidism before and after surgery. Horm Metab Res. 2012;44(6):476\u201381. https:\/\/doi.org\/10.1055\/s-0032-1308998.","journal-title":"Horm Metab Res"},{"issue":"5","key":"2670_CR33","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/s0039-6060(97)90328-7","volume":"122","author":"K Thorsen","year":"1997","unstructured":"Thorsen\u00a0K, Kristoffersson\u00a0AO, Lorentzon\u00a0RP. Changes in bone mass and serum markers of bone metabolism after parathyroidectomy. Surgery. 1997;122(5):882\u20137. https:\/\/doi.org\/10.1016\/s0039-6060(97)90328-7.","journal-title":"Surgery"},{"issue":"8","key":"2670_CR34","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/BF02115782","volume":"69","author":"P Pietschmann","year":"1991","unstructured":"Pietschmann\u00a0P, Niederle\u00a0B, Anvari\u00a0A, Woloszczuk\u00a0W. Serum osteocalcin levels in primary hyperparathyroidism. Klin Wochenschr. 1991;69(8):351\u20133. https:\/\/doi.org\/10.1007\/BF02115782.","journal-title":"Klin Wochenschr"},{"issue":"1","key":"2670_CR35","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s002230050004","volume":"66","author":"B Cortet","year":"2000","unstructured":"Cortet\u00a0B, Cortet\u00a0C, Blanckaert\u00a0F, Racadot\u00a0A, d\u2019Herbomez\u00a0M, Marchandise\u00a0X, Dewailly\u00a0D. Bone ultrasonometry and turnover markers in primary hyperparathyroidism. Calcif Tissue Int. 2000;66(1):11\u20135. https:\/\/doi.org\/10.1007\/s002230050004.","journal-title":"Calcif Tissue Int"},{"issue":"Suppl 1","key":"2670_CR36","doi-asserted-by":"publisher","first-page":"90s","DOI":"10.1016\/s0753-3322(00)80021-9","volume":"54","author":"S Suzuki","year":"2000","unstructured":"Suzuki\u00a0S, Fukushima\u00a0T, Ami\u00a0H, Asahi\u00a0S, Onogi\u00a0H, Nakamura\u00a0I, Tsuchiya\u00a0A, Takenoshita\u00a0S. Pre- and postoperative bone metabolism of primary hyperparathyroidism. Biomed Pharmacother. 2000;54(Suppl 1):90s\u20136s. https:\/\/doi.org\/10.1016\/s0753-3322(00)80021-9.","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"2670_CR37","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1507\/endocrj.47.231","volume":"47","author":"D Nakaoka","year":"2000","unstructured":"Nakaoka\u00a0D, Sugimoto\u00a0T, Kobayashi\u00a0T, Yamaguchi\u00a0T, Kobayashi\u00a0A, Chihara\u00a0K. Evaluation of changes in bone density and biochemical parameters after parathyroidectomy in primary hyperparathyroidism. Endocr\u00a0J. 2000;47(3):231\u20137. https:\/\/doi.org\/10.1507\/endocrj.47.231.","journal-title":"Endocr J"},{"issue":"5","key":"2670_CR38","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/S8756-3282(00)00260-X","volume":"26","author":"T Steiniche","year":"2000","unstructured":"Steiniche\u00a0T, Christiansen\u00a0P, Vesterby\u00a0A, Ullerup\u00a0R, Hessov\u00a0I, Mosekilde\u00a0LE, Melsen\u00a0F. Primary hyperparathyroidism: bone structure, balance, and remodeling before and 3\u00a0years after surgical treatment. Bone. 2000;26(5):535\u201343. https:\/\/doi.org\/10.1016\/S8756-3282(00)00260-X.","journal-title":"Bone"},{"issue":"1","key":"2670_CR39","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.jocd.2012.11.004","volume":"16","author":"AG Costa","year":"2013","unstructured":"Costa\u00a0AG, Bilezikian\u00a0JP. Bone turnover markers in primary hyperparathyroidism. J\u00a0Clin Densitom. 2013;16(1):22\u20137. https:\/\/doi.org\/10.1016\/j.jocd.2012.11.004.","journal-title":"J Clin Densitom"},{"issue":"11","key":"2670_CR40","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1002\/jbmr.4677","volume":"37","author":"JP Bilezikian","year":"2022","unstructured":"Bilezikian\u00a0JP, Khan\u00a0AA, Silverberg\u00a0SJ, Fuleihan\u00a0GE, Marcocci\u00a0C, Minisola\u00a0S, Perrier\u00a0N, Sitges-Serra\u00a0A, Thakker\u00a0RV, Guyatt\u00a0G, Mannstadt\u00a0M, Potts\u00a0JT, Clarke\u00a0BL, Brandi\u00a0ML. International Workshop on Primary Hyperparathyroidism. Evaluation and Management of Primary Hyperparathyroidism: Summary Statement and Guidelines from the Fifth International Workshop. J\u00a0Bone Miner Res. 2022;37(11):2293\u2013314. https:\/\/doi.org\/10.1002\/jbmr.4677.","journal-title":"J Bone Miner Res"},{"issue":"4","key":"2670_CR41","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1210\/jc.2014-3708","volume":"100","author":"C Cipriani","year":"2015","unstructured":"Cipriani\u00a0C, Biamonte\u00a0F, Costa\u00a0AG, Zhang\u00a0C, Biondi\u00a0P, Diacinti\u00a0D, Pepe\u00a0J, Piemonte\u00a0S, Scillitani\u00a0A, Minisola\u00a0S, Bilezikian\u00a0JP. Prevalence of kidney stones and vertebral fractures in Primary hyperparathyroidism using imaging technology. J\u00a0Clin Endocrinol Metab. 2015;100(4):1309\u201315. https:\/\/doi.org\/10.1210\/jc.2014-3708.","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"2670_CR42","doi-asserted-by":"publisher","first-page":"4148","DOI":"10.1210\/jc.2017-01080","volume":"102","author":"E Castellano","year":"2017","unstructured":"Castellano\u00a0E, Attanasio\u00a0R, Boriano\u00a0A, Pellegrino\u00a0M, Garino\u00a0F, Gianotti\u00a0L, Borretta\u00a0G. Sex Difference in the Clinical Presentation of Primary Hyperparathyroidism: Influence of Menopausal Status. J\u00a0Clin Endocrinol Metab. 2017;102(11):4148\u201352. https:\/\/doi.org\/10.1210\/jc.2017-01080.","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"2670_CR43","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1210\/js.2019-00316","volume":"3","author":"E Castellano","year":"2019","unstructured":"Castellano\u00a0E, Attanasio\u00a0R, Boriano\u00a0A, Borretta\u00a0G. Clinical Presentation of Primary Hyperparathyroidism in Older. Adults J Endocr Soc. 2019;3(12):2305\u201312. https:\/\/doi.org\/10.1210\/js.2019-00316.","journal-title":"Adults J Endocr Soc"},{"issue":"9","key":"2670_CR44","doi-asserted-by":"publisher","first-page":"3462","DOI":"10.1210\/jc.2007-1215","volume":"93","author":"MR Rubin","year":"2008","unstructured":"Rubin\u00a0MR, Bilezikian\u00a0JP, McMahon\u00a0DJ, Jacobs\u00a0T, Shane\u00a0E, Siris\u00a0E, Udesky\u00a0J, Silverberg\u00a0SJ. The Natural History of Primary Hyperparathyroidism with or without Parathyroid Surgery after 15 Years. J\u00a0Clin Endocrinol Metab. 2008;93(9):3462\u201370. https:\/\/doi.org\/10.1210\/jc.2007-1215.","journal-title":"J Clin Endocrinol Metab"},{"key":"2670_CR45","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/j.1365-2796.2004.01422.x","volume":"257","author":"JP Bilezikian","year":"2005","unstructured":"Bilezikian\u00a0JP, Brandi\u00a0ML, Rubin\u00a0M, Silverberg\u00a0SJ. Primary hyperparathyroidism: New concepts in clinical, densitometric and biochemical features. J\u00a0Intern Med. 2005;257:6\u201317. https:\/\/doi.org\/10.1111\/j.1365-2796.2004.01422.x.","journal-title":"J Intern Med"},{"issue":"1","key":"2670_CR46","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.bone.2012.11.041","volume":"53","author":"E Romagnoli","year":"2013","unstructured":"Romagnoli\u00a0E, Cipriani\u00a0C, Nofroni\u00a0I, Castro\u00a0C, Angelozzi\u00a0M, Scarpiello\u00a0A, Pepe\u00a0J, Diacinti\u00a0D, Piemonte\u00a0S, Carnevale\u00a0V, Minisola\u00a0S. \u201cTrabecular Bone Score\u201d (TBS): an indirect measure of bone micro-architecture in postmenopausal patients with primary hyperparathyroidism. Bone. 2013;53(1):154\u20139. https:\/\/doi.org\/10.1016\/j.bone.2012.11.041.","journal-title":"Bone"},{"issue":"5","key":"2670_CR47","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.1210\/jc.2012-4255","volume":"98","author":"BC Silva","year":"2013","unstructured":"Silva\u00a0BC, Boutroy\u00a0S, Zhang\u00a0C, McMahon\u00a0DJ, Zhou\u00a0B, Wang\u00a0J, Udesky\u00a0J, Cremers\u00a0S, Sarquis\u00a0M, Guo\u00a0XD, Hans\u00a0D, Bilezikian\u00a0JP. Trabecular bone score (TBS)\u2014a novel method to evaluate bone microarchitectural texture in patients with primary hyperparathyroidism. J\u00a0Clin Endocrinol Metab. 2013;98(5):1963\u201370. https:\/\/doi.org\/10.1210\/jc.2012-4255.","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2670_CR48","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1530\/EJE-13-0305","volume":"169","author":"C Eller-Vainicher","year":"2013","unstructured":"Eller-Vainicher\u00a0C, Filopanti\u00a0M, Palmieri\u00a0S, Ulivieri\u00a0FM, Morelli\u00a0V, Zhukouskaya\u00a0VV, Cairoli\u00a0E, Pino\u00a0R, Naccarato\u00a0A, Verga\u00a0U, Scillitani\u00a0A, Beck-Peccoz\u00a0P, Chiodini\u00a0I. Bone quality, as measured by trabecular bone score, in patients with primary hyperparathyroidism. Eur J Endocrinol. 2013;169(2):155\u201362. https:\/\/doi.org\/10.1530\/EJE-13-0305.","journal-title":"Eur J Endocrinol"},{"issue":"4","key":"2670_CR49","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1007\/s00223-019-00517-0","volume":"104","author":"AR Hong","year":"2019","unstructured":"Hong\u00a0AR, Lee\u00a0JH, Kim\u00a0JH, Kim\u00a0SW, Shin\u00a0CS. Effect of Endogenous Parathyroid Hormone on Bone Geometry and Skeletal Microarchitecture. Calcif Tissue Int. 2019;104(4):382\u20139. https:\/\/doi.org\/10.1007\/s00223-019-00517-0.","journal-title":"Calcif Tissue Int"},{"issue":"9","key":"2670_CR50","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1002\/jbmr.98","volume":"25","author":"S Hansen","year":"2010","unstructured":"Hansen\u00a0S, Beck Jensen\u00a0JE, Rasmussen\u00a0L, Hauge\u00a0EM, Brixen\u00a0K. Effects on bone geometry, density, and microarchitecture in the distal radius but not the tibia in women with primary hyperparathyroidism: A\u00a0case-control study using HR-pQCT. J\u00a0Bone Miner Res. 2010;25(9):1941\u20137. https:\/\/doi.org\/10.1002\/jbmr.98.","journal-title":"J Bone Miner Res"},{"issue":"5","key":"2670_CR51","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1002\/jbmr.1841","volume":"28","author":"EM Stein","year":"2013","unstructured":"Stein\u00a0EM, Silva\u00a0BC, Boutroy\u00a0S, Zhou\u00a0B, Wang\u00a0J, Udesky\u00a0J, Zhang\u00a0C, McMahon\u00a0DJ, Romano\u00a0M, Dworakowski\u00a0E, Costa\u00a0AG, Cusano\u00a0N, Irani\u00a0D, Cremers\u00a0S, Shane\u00a0E, Guo\u00a0XE, Bilezikian\u00a0JP. Primary hyperparathyroidism is associated with abnormal cortical and trabecular microstructure and reduced bone stiffness in postmenopausal women. J\u00a0Bone Miner Res. 2013;28(5):1029\u201340. https:\/\/doi.org\/10.1002\/jbmr.1841.","journal-title":"J Bone Miner Res"},{"issue":"1","key":"2670_CR52","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s00198-019-05186-1","volume":"31","author":"W Wang","year":"2020","unstructured":"Wang\u00a0W, Nie\u00a0M, Jiang\u00a0Y, Li\u00a0M, Meng\u00a0X, Xing\u00a0X, Wang\u00a0O, Xia\u00a0W. Impaired geometry, volumetric density, and microstructure of cortical and trabecular bone assessed by HR-pQCT in both sporadic and MEN1-related primary hyperparathyroidism. Osteoporos Int. 2020;31(1):165\u201373. https:\/\/doi.org\/10.1007\/s00198-019-05186-1.","journal-title":"Osteoporos Int"},{"issue":"3","key":"2670_CR53","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1172\/JCI112400","volume":"77","author":"PD Delmas","year":"1986","unstructured":"Delmas\u00a0PD, Demiaux\u00a0B, Malaval\u00a0L, Chapuy\u00a0MC, Edouard\u00a0C, Meunier\u00a0PJ. Serum bone gamma carboxyglutamic acid-containing protein in primary hyperparathyroidism and in malignant hypercalcemia. Comparison with bone histomorphometry. J\u00a0Clin Invest. 1986;77(3):985\u201391. https:\/\/doi.org\/10.1172\/JCI112400.","journal-title":"J Clin Invest"},{"issue":"5","key":"2670_CR54","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1359\/jbmr.070120","volume":"22","author":"P Roschger","year":"2007","unstructured":"Roschger\u00a0P, Dempster\u00a0DW, Zhou\u00a0H, Paschalis\u00a0EP, Silverberg\u00a0SJ, Shane\u00a0E, Bilezikian\u00a0JP, Klaushofer\u00a0K. New observations on bone quality in mild primary hyperparathyroidism as determined by quantitative backscattered electron imaging. J\u00a0Bone Miner Res. 2007;22(5):717\u201323. https:\/\/doi.org\/10.1359\/jbmr.070120.","journal-title":"J Bone Miner Res"},{"issue":"6","key":"2670_CR55","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1007\/s00198-021-05822-9","volume":"32","author":"H Ejlsmark-Svensson","year":"2021","unstructured":"Ejlsmark-Svensson\u00a0H, Rolighed\u00a0L, Rejnmark\u00a0L. Risk of fractures in primary hyperparathyroidism: a\u00a0systematic review and meta-analysis. Osteoporos Int. 2021;32(6):1053\u201360. https:\/\/doi.org\/10.1007\/s00198-021-05822-9.","journal-title":"Osteoporos Int"},{"issue":"4","key":"2670_CR56","doi-asserted-by":"publisher","first-page":"e10482","DOI":"10.1002\/jbm4.10482","volume":"5","author":"N Narayanan","year":"2021","unstructured":"Narayanan\u00a0N, Palui\u00a0R, Merugu\u00a0C, Kar\u00a0SS, Kamalanathan\u00a0S, Sahoo\u00a0J, Selvarajan\u00a0S, Naik\u00a0D. The Risk of Fractures in Primary Hyperparathyroidism: A\u00a0Meta-Analysis. Jbmr Plus. 2021;5(4):e10482. https:\/\/doi.org\/10.1002\/jbm4.10482.","journal-title":"Jbmr Plus"},{"issue":"3","key":"2670_CR57","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1111\/cen.14703","volume":"97","author":"M Nilsson","year":"2022","unstructured":"Nilsson\u00a0M, St\u00e5hl\u00a0E, \u00c5kesson\u00a0KE, Thier\u00a0M, Nordenstr\u00f6m\u00a0E, Almquist\u00a0M, Bergenfelz\u00a0A. Reduced fracture incidence in patients having surgery for primary hyperparathyroidism. Clin Endocrinol (oxf). 2022;97(3):276\u201383. https:\/\/doi.org\/10.1111\/cen.14703.","journal-title":"Clin Endocrinol (oxf)"},{"issue":"12","key":"2670_CR58","doi-asserted-by":"publisher","first-page":"5353","DOI":"10.1210\/jc.2002-021370","volume":"87","author":"JP Bilezikian","year":"2002","unstructured":"Bilezikian\u00a0JP, Potts\u00a0JT Jr, Fuleihan Gel\u2011H, Kleerekoper\u00a0M, Neer\u00a0R, Peacock\u00a0M, Rastad\u00a0J, Silverberg\u00a0SJ, Udelsman\u00a0R, Wells\u00a0SA. Summary statement from a\u00a0workshop on asymptomatic primary hyperparathyroidism: a\u00a0perspective for the 21st\u00a0century. J\u00a0Clin Endocrinol Metab. 2002;87(12):5353\u201361. https:\/\/doi.org\/10.1210\/jc.2002-021370.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2670_CR59","doi-asserted-by":"publisher","first-page":"140","DOI":"10.24875\/CIRU.20001307","volume":"90","author":"C Ortiz-Hidalgo","year":"2022","unstructured":"Ortiz-Hidalgo\u00a0C. The latest anatomical discovery: the parathyroid glands or Glandulae parathyreoideae of Owen-Sandstr\u00f6m-Gley. Cir Cir. 2022;90(1):140\u20139. https:\/\/doi.org\/10.24875\/CIRU.20001307.","journal-title":"Cir Cir"},{"issue":"7","key":"2670_CR60","doi-asserted-by":"publisher","first-page":"2927","DOI":"10.1007\/s00402-024-05372-9","volume":"144","author":"MO Karaca","year":"2024","unstructured":"Karaca\u00a0MO, \u00d6zy\u0131ld\u0131ran\u00a0M, Savran\u00a0MD, Ba\u015far\u0131r\u00a0K, Y\u0131ld\u0131z\u00a0HY. Brown tumors: Retrospective analysis of 26\u00a0cases. Arch Orthop Trauma Surg. 2024;144(7):2927\u201334. https:\/\/doi.org\/10.1007\/s00402-024-05372-9.","journal-title":"Arch Orthop Trauma Surg"},{"key":"2670_CR61","doi-asserted-by":"publisher","DOI":"10.1007\/s42000-025-00693-9","author":"AD Anastasilakis","year":"2025","unstructured":"Anastasilakis\u00a0AD, Yavropoulou\u00a0MP, Kassi\u00a0E, Adamidou\u00a0F, Vryonidou\u00a0A, Tournis\u00a0S, Makras\u00a0P. Diagnosis and management of primary hyperparathyroidism: recommendations from the Bone Section of the Hellenic Endocrine Society. Horm (athens). 2025; https:\/\/doi.org\/10.1007\/s42000-025-00693-9. Online ahead of print.","journal-title":"Horm (athens)"},{"issue":"2","key":"2670_CR62","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1007\/s12020-017-1414-2","volume":"58","author":"W Misiorowski","year":"2017","unstructured":"Misiorowski\u00a0W, Czajka-Oraniec\u00a0I, Kochman\u00a0M, Zgliczy\u0144ski\u00a0W, Bilezikian\u00a0JP. Osteitis fibrosa cystica\u2014a forgotten radiological feature of primary hyperparathyroidism. Endocrine. 2017;58(2):380\u20135. https:\/\/doi.org\/10.1007\/s12020-017-1414-2.","journal-title":"Endocrine"},{"issue":"9","key":"2670_CR63","doi-asserted-by":"publisher","first-page":"e10403","DOI":"10.1002\/jbm4.10403","volume":"4","author":"W Misiorowski","year":"2020","unstructured":"Misiorowski\u00a0W, Bilezikian\u00a0JP. Osteitis Fibrosa Cystica. Jbmr Plus. 2020;4(9):e10403. https:\/\/doi.org\/10.1002\/jbm4.10403.","journal-title":"Jbmr Plus"},{"issue":"7","key":"2670_CR64","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1016\/j.eprac.2020.12.012","volume":"27","author":"AK Arya","year":"2021","unstructured":"Arya\u00a0AK, Bhadada\u00a0SK, Kumari\u00a0P, Agrawal\u00a0K, Mukhopadhyay\u00a0S, Sarma\u00a0D, Rao\u00a0SD. Differences in Primary Hyperparathyroidism Between Pre- and Postmenopausal Women in India. Endocr Pract. 2021;27(7):710\u20135. https:\/\/doi.org\/10.1016\/j.eprac.2020.12.012.","journal-title":"Endocr Pract"},{"key":"2670_CR65","doi-asserted-by":"publisher","first-page":"69","DOI":"10.4137\/CMED.S13147","volume":"6","author":"C Eufrazino","year":"2013","unstructured":"Eufrazino\u00a0C, Veras\u00a0A, Bandeira\u00a0F. Epidemiology of Primary Hyperparathyroidism and its Non-classical Manifestations in the City of Recife. Brazil Clin Med Insights Endocrinol Diabetes. 2013;6:69\u201374. https:\/\/doi.org\/10.4137\/CMED.S13147.","journal-title":"Brazil Clin Med Insights Endocrinol Diabetes"},{"issue":"6","key":"2670_CR66","first-page":"410","volume":"32","author":"C De Crea","year":"2012","unstructured":"De Crea\u00a0C, Traini\u00a0E, Oragano\u00a0L, Bellantone\u00a0C, Raffaelli\u00a0M, Lombardi\u00a0CP. Are brown tumours a\u00a0forgotten disease in developed countries? Acta Otorhinolaryngol Ital. 2012;32(6):410\u20135.","journal-title":"Acta Otorhinolaryngol Ital"},{"issue":"2","key":"2670_CR67","doi-asserted-by":"publisher","first-page":"R33","DOI":"10.1530\/EJE-21-1044","volume":"186","author":"J Bollerslev","year":"2022","unstructured":"Bollerslev\u00a0J, Rejnmark\u00a0L, Zahn\u00a0A, Heck\u00a0A, Appelman-Dijkstra\u00a0NM, Cardoso\u00a0L, Hannan\u00a0FM, Cetani\u00a0F, Sikj\u00e6r\u00a0T, Formenti\u00a0AM, Bj\u00f6rnsdottir\u00a0S, Schalin-Jantti\u00a0C, Belaya\u00a0Z, Gibb\u00a0FW, Lapauw\u00a0B, Amrein\u00a0K, Wicke\u00a0C, Grasemann\u00a0C, Krebs\u00a0M, Ryh\u00e4nen\u00a0EM, Makay\u00a0O, Minisola\u00a0S, Gaujoux\u00a0S, Bertocchio\u00a0JP, Hassan-Smith\u00a0ZK, Linglart\u00a0A, Winter\u00a0EM, Kollmann\u00a0M, Zmierczak\u00a0HG, Tsourdi\u00a0E, Pilz\u00a0S, Siggelkow\u00a0H, Gittoes\u00a0NJ, Marcocci\u00a0C, Kamenicky\u00a0P. 2021 PARAT Working Group. European Expert Consensus on Practical Management of Specific Aspects of Parathyroid Disorders in Adults and in Pregnancy: Recommendations of the ESE Educational Program of Parathyroid Disorders. Eur J Endocrinol. 2022;186(2):R33\u2013R63. https:\/\/doi.org\/10.1530\/EJE-21-1044.","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"2670_CR68","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1111\/cen.12398","volume":"80","author":"VN Shah","year":"2014","unstructured":"Shah\u00a0VN, Shah\u00a0CS, Bhadada\u00a0SK, Rao\u00a0DS. Effect of 25\u00a0(OH) D replacements in patients with primary hyperparathyroidism (PHPT) and coexistent vitamin\u00a0D deficiency on serum 25(OH) D, calcium and PTH levels: a\u00a0meta-analysis and review of literature. Clin Endocrinol (oxf). 2014;80(6):797\u2013803. https:\/\/doi.org\/10.1111\/cen.12398.","journal-title":"Clin Endocrinol (oxf)"},{"issue":"6","key":"2670_CR69","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1530\/eje.0.1460783","volume":"146","author":"E Vignali","year":"2002","unstructured":"Vignali\u00a0E, Picone\u00a0A, Materazzi\u00a0G, Steffe\u00a0S, Berti\u00a0P, Cianferotti\u00a0L, Cetani\u00a0F, Ambrogini\u00a0E, Miccoli\u00a0P, Pinchera\u00a0A, Marcocci\u00a0C. A\u00a0quick intraoperative parathyroid hormone assay in the surgical management of patients with primary hyperparathyroidism: a\u00a0study of 206 consecutive cases. Eur J Endocrinol. 2002;146(6):783\u20138. https:\/\/doi.org\/10.1530\/eje.0.1460783.","journal-title":"Eur J Endocrinol"},{"issue":"11","key":"2670_CR70","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1002\/jbmr.4685","volume":"37","author":"Z Ye","year":"2022","unstructured":"Ye\u00a0Z, Silverberg\u00a0SJ, Sreekanta\u00a0A, Tong\u00a0K, Wang\u00a0Y, Chang\u00a0Y, Zhang\u00a0M, Guyatt\u00a0G, Tangamornsuksun\u00a0W, Zhang\u00a0Y, Manja\u00a0V, Bakaa\u00a0L, Couban\u00a0RJ, Brandi\u00a0ML, Clarke\u00a0B, Khan\u00a0AA, Mannstadt\u00a0M, Bilezikian\u00a0JP. The Efficacy and Safety of Medical and Surgical Therapy in Patients with Primary Hyperparathyroidism: A\u00a0Systematic Review and Meta-Analysis of Randomized Controlled Trials. J\u00a0Bone Miner Res. 2022;37(11):2351\u201372. https:\/\/doi.org\/10.1002\/jbmr.4685.","journal-title":"J Bone Miner Res"},{"issue":"7","key":"2670_CR71","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1308\/rcsann.2017.0092","volume":"99","author":"P Rajeev","year":"2017","unstructured":"Rajeev\u00a0P, Movseysan\u00a0A, Baharani\u00a0A. Changes in bone turnover markers in primary hyperparathyroidism and response to surgery. Ann R Coll Surg Engl. 2017;99(7):559\u201362. https:\/\/doi.org\/10.1308\/rcsann.2017.0092.","journal-title":"Ann R Coll Surg Engl"},{"issue":"10","key":"2670_CR72","doi-asserted-by":"publisher","first-page":"e1922","DOI":"10.1210\/clinem\/dgae326","volume":"109","author":"N Kongsaree","year":"2024","unstructured":"Kongsaree\u00a0N, Thanyajaroen\u00a0T, Dechates\u00a0B, Therawit\u00a0P, Mahikul\u00a0W, Ngaosuwan\u00a0K. Skeletal effect of parathyroidectomy on patients with primary hyperparathyroidism: A\u00a0Systematic Review and Meta-Analysis. J\u00a0Clin Endocrinol Metab. 2024;109(10):e1922\u2013e35. https:\/\/doi.org\/10.1210\/clinem\/dgae326.","journal-title":"J Clin Endocrinol Metab"},{"key":"2670_CR73","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.jss.2025.01.003","volume":"306","author":"Z Song","year":"2025","unstructured":"Song\u00a0Z, Reddy\u00a0S, Wu\u00a0C, Gillis\u00a0A, Fazendin\u00a0J, Lindeman\u00a0B, Chen\u00a0H. Changes in Bone Mineral Density After Parathyroidectomy in Patients With Primary Hyperparathyroidism. J\u00a0Surg Res. 2025;306:431\u20136. https:\/\/doi.org\/10.1016\/j.jss.2025.01.003.","journal-title":"J Surg Res"},{"issue":"4","key":"2670_CR74","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.jocd.2020.12.005","volume":"24","author":"R Khan","year":"2021","unstructured":"Khan\u00a0R, Martin\u00a0J, Das\u00a0G. The Impact of Observation Versus Parathyroidectomy on Bone Mineral Density and Fracture Risk Determined by FRAX Tool in Patients With Primary Hyperparathyroidism. J\u00a0Clin Densitom. 2021;24(4):571\u201380. https:\/\/doi.org\/10.1016\/j.jocd.2020.12.005.","journal-title":"J Clin Densitom"},{"issue":"6","key":"2670_CR75","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1530\/EJE-13-0547","volume":"169","author":"S Norenstedt","year":"2013","unstructured":"Norenstedt\u00a0S, Pernow\u00a0Y, Brismar\u00a0K, S\u00e4\u00e4f\u00a0M, Ekip\u00a0A, Granath\u00a0F, Zedenius\u00a0J, Nilsson\u00a0IL. Primary hyperparathyroidism and metabolic risk factors, impact of parathyroidectomy and vitamin\u00a0D supplementation, and results of a\u00a0randomized double-blind study. Eur J Endocrinol. 2013;169(6):795\u2013804. https:\/\/doi.org\/10.1530\/EJE-13-0547.","journal-title":"Eur J Endocrinol"},{"issue":"4","key":"2670_CR76","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1002\/jbmr.2102","volume":"29","author":"S Norenstedt","year":"2014","unstructured":"Norenstedt\u00a0S, Pernow\u00a0Y, Zedenius\u00a0J, Nordenstr\u00f6m\u00a0J, S\u00e4\u00e4f\u00a0M, Granath\u00a0F, Nilsson\u00a0IL. Vitamin\u00a0D supplementation after parathyroidectomy: effect on bone mineral density\u2014a randomized double-blind study. J\u00a0Bone Miner Res. 2014;29(4):960\u20137. https:\/\/doi.org\/10.1002\/jbmr.2102.","journal-title":"J Bone Miner Res"},{"issue":"1","key":"2670_CR77","doi-asserted-by":"publisher","first-page":"101703","DOI":"10.1016\/j.ando.2025.101703","volume":"86","author":"S Barraud","year":"2025","unstructured":"Barraud\u00a0S, Lopez\u00a0AG, Sokol\u00a0E, Menegaux\u00a0F, Briet\u00a0C. Chapter\u00a014: Post surgical follow-up of primary hyperparathyroidism. Ann Endocrinol (paris). 2025;86(1):101703. https:\/\/doi.org\/10.1016\/j.ando.2025.101703.","journal-title":"Ann Endocrinol (paris)"},{"issue":"11","key":"2670_CR78","doi-asserted-by":"publisher","first-page":"715","DOI":"10.7326\/M15-1232","volume":"164","author":"MW Yeh","year":"2016","unstructured":"Yeh\u00a0MW, Zhou\u00a0H, Adams\u00a0AL, Ituarte\u00a0PH, Li\u00a0N, Liu\u00a0IL, Haigh\u00a0PI. The Relationship of Parathyroidectomy and Bisphosphonates with fracture risk in primary hyperparathyroidism: An observational study. Ann Intern Med. 2016;164(11):715\u201323. https:\/\/doi.org\/10.7326\/M15-1232.","journal-title":"Ann Intern Med"},{"issue":"3","key":"2670_CR79","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1007\/s12020-020-02401-6","volume":"69","author":"D Miyaoka","year":"2020","unstructured":"Miyaoka\u00a0D, Imanishi\u00a0Y, Kato\u00a0E, Toi\u00a0N, Nagata\u00a0Y, Kurajoh\u00a0M, Yamada\u00a0S, Inaba\u00a0M, Emoto\u00a0M. Effects of denosumab as compared with parathyroidectomy regarding calcium, renal, and bone involvement in osteoporotic patients with primary hyperparathyroidism. Endocrine. 2020;69(3):642\u20139. https:\/\/doi.org\/10.1007\/s12020-020-02401-6.","journal-title":"Endocrine"},{"issue":"1","key":"2670_CR80","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.surg.2019.04.059","volume":"167","author":"LE Orr","year":"2020","unstructured":"Orr\u00a0LE, Zhou\u00a0H, Zhu\u00a0CY, Haigh\u00a0PI, Adams\u00a0AL, Yeh\u00a0MW. Skeletal effects of combined medical and surgical management of primary hyperparathyroidism. Surgery. 2020;167(1):144\u20138. https:\/\/doi.org\/10.1016\/j.surg.2019.04.059.","journal-title":"Surgery"},{"issue":"11","key":"2670_CR81","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.1002\/jbmr.4689","volume":"37","author":"N Perrier","year":"2022","unstructured":"Perrier\u00a0N, Lang\u00a0BH, Farias\u00a0LCB, Poch\u00a0LL, Sywak\u00a0M, Almquist\u00a0M, Vriens\u00a0MR, Yeh\u00a0MW, Shariq\u00a0O, Duh\u00a0QY, Yeh\u00a0R, Vu\u00a0T, LiVolsi\u00a0V, Sitges-Serra\u00a0A. Surgical Aspects of Primary Hyperparathyroidism. J\u00a0Bone Miner Res. 2022;37(11):2373\u201390. https:\/\/doi.org\/10.1002\/jbmr.4689.","journal-title":"J Bone Miner Res"},{"issue":"4","key":"2670_CR82","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1530\/EJE-21-0322","volume":"185","author":"EM Ryh\u00e4nen","year":"2021","unstructured":"Ryh\u00e4nen\u00a0EM, Koski\u00a0AM, L\u00f6yttyniemi\u00a0E, V\u00e4lim\u00e4ki\u00a0MJ, Kiviniemi\u00a0U, Schalin-J\u00e4ntti\u00a0C. Postoperative zoledronic acid for osteoporosis in primary hyperparathyroidism: a\u00a0randomized placebo-controlled study. Eur J Endocrinol. 2021;185(4):515\u201324. https:\/\/doi.org\/10.1530\/EJE-21-0322.","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"2670_CR83","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s00423-019-01815-9","volume":"404","author":"MB Niederle","year":"2019","unstructured":"Niederle\u00a0MB, Foeger-Samwald\u00a0U, Riss\u00a0P, Selberherr\u00a0A, Scheuba\u00a0C, Pietschmann\u00a0P, Niederle\u00a0B, Kerschan-Schindl\u00a0K. Effectiveness of anti-osteoporotic treatment after successful parathyroidectomy for primary hyperparathyroidism: a\u00a0randomized, double-blind, placebo-controlled trial. Langenbecks Arch Surg. 2019;404(6):681\u201391. https:\/\/doi.org\/10.1007\/s00423-019-01815-9.","journal-title":"Langenbecks Arch Surg"}],"container-title":["Wiener klinische Wochenschrift"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00508-025-02670-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00508-025-02670-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00508-025-02670-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T07:03:30Z","timestamp":1776755010000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00508-025-02670-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,2]]},"references-count":83,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["2670"],"URL":"https:\/\/doi.org\/10.1007\/s00508-025-02670-z","relation":{},"ISSN":["0043-5325","1613-7671"],"issn-type":[{"value":"0043-5325","type":"print"},{"value":"1613-7671","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,2]]},"assertion":[{"value":"11 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Regarding this manuscript, K.\u00a0Kerschan-Schindl has received financial support from Servier Austria GmbH to conduct the study evaluating the efficacy of strontium after parathyroidectomy [\n                      \n                      ]. P.\u00a0Pietschmann has received research support and\/or honoraria from Amgen GmbH, Fresenius Kabi Austria GmbH, Shire Austria GmbH and UCB Pharma. K.\u00a0Gelles, M.\u00a0Butylina and R.\u00a0Crevenna declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}