{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:04:52Z","timestamp":1784192692656,"version":"3.55.0"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"13-14","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100010109","name":"Medizinische Universit\u00e4t Graz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010109","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010109","name":"Medical University of Graz","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010109","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Wien Klin Wochenschr"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The biopsy represents a\u00a0fundamental step towards diagnosing bone and soft tissue tumors. In the case of open biopsies it is recommended to resect the biopsy tract at wide resection of bone and soft tissue sarcomas (STS); however, nowadays this topic is subject to ongoing debate as a\u00a0worldwide shift from open to core-needle biopsies may lead to a\u00a0decreased risk of local recurrence (LR) in the biopsy tract.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We present three patients (male, 69\u00a0years; male, 63\u00a0years; female 76\u00a0years) with chondrosarcomas treated at the Department of Orthopaedics and Trauma, Medical University of Graz: two with sarcomas involving the distal femur and one in the proximal femur. Staging showed no evidence of distant metastases (DM). Wide resection and reconstruction with modular tumor endoprostheses were performed in all three patients with the biopsy tract included in the resection specimen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In all three patients, histological analysis of the resected specimen revealed viable tumor cell nests in the biopsy tract after an open biopsy technique.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The three presented cases demonstrate that tumor cell seeding occurs in biopsy tracts after an open biopsy in chondrosarcoma cases. Whether the risk of developing LR from these tumor cells differs between open and minimally invasive biopsy techniques or is affected by the use of neoadjuvant chemotherapy and\/or radiotherapy for other entities, requires larger cohorts and longer periods of follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00508-025-02677-6","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T13:14:15Z","timestamp":1766495655000},"page":"427-432","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tumor cells seeding in biopsy tracts after open biopsy in three patients with chondrosarcoma\u2014Case reports"],"prefix":"10.1007","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3728-9682","authenticated-orcid":false,"given":"Teodora","family":"Todorova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Anna","family":"Smolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena Maria","family":"Gilg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette","family":"Liegl-Atzwanger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasminka","family":"Igrec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Viertler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Leithner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,23]]},"reference":[{"key":"2677_CR1","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1590\/1413-78522014220200422","volume":"22","author":"MP Oliveira","year":"2014","unstructured":"Oliveira\u00a0MP, Lima\u00a0PM, Silva\u00a0HJ, Mello\u00a0RJ. Neoplasm seeding in biopsy tract of the musculoskeletal system. A\u00a0systematic review. Acta ortop bras. 2014;22:106\u201310.","journal-title":"Acta ortop bras"},{"key":"2677_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1590\/S0102-36162008000100002","volume":"43","author":"KL Siqueira","year":"2008","unstructured":"Siqueira\u00a0KL, Viola\u00a0DC, Jesus-Garcia\u00a0R, Gracitelli\u00a0GC. Correla\u00e7\u00e3o do tipo de bi\u00f3psia e sua validade diagn\u00f3stica nos tumores m\u00fasculo-esquel\u00e9ticos em distintas topografias. Rev bras ortop. 2008;43:7\u201314.","journal-title":"Rev bras ortop"},{"issue":"1","key":"2677_CR3","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1590\/S1516-31802006000100003","volume":"124","author":"R Chojniak","year":"2006","unstructured":"Chojniak\u00a0R, Isberner\u00a0RK, Viana\u00a0LM, Yu\u00a0LS, Aita\u00a0AA, Soares\u00a0FA. Computed tomography guided needle biopsy: experience from 1,300 procedures. Sao Paulo Med\u00a0J. 2006;124(1):10\u20134.","journal-title":"Sao Paulo Med J"},{"issue":"3","key":"2677_CR4","doi-asserted-by":"publisher","first-page":"375","DOI":"10.2106\/00004623-197961030-00010","volume":"61","author":"TM Moore","year":"1979","unstructured":"Moore\u00a0TM, Meyers\u00a0MH, Patzakis\u00a0MJ, Terry\u00a0R, Harvey\u00a0JP Jr. Closed biopsy of musculoskeletal lesions. J\u00a0Bone Joint Surg Am. 1979;61(3):375\u201380.","journal-title":"J Bone Joint Surg Am"},{"key":"2677_CR5","first-page":"492","volume":"69","author":"SR Cannon","year":"1987","unstructured":"Cannon\u00a0SR, Dyson\u00a0PHP. Relationship of the site of open biopsy of malignant bone tumors to local recurrence following resection and prosthetic replacement. J\u00a0Bone Joint Surg Br. 1987;69:492.","journal-title":"J Bone Joint Surg Br"},{"issue":"4","key":"2677_CR6","doi-asserted-by":"publisher","first-page":"616","DOI":"10.2106\/00004623-199304000-00018","volume":"75","author":"MA Simon","year":"1993","unstructured":"Simon\u00a0MA, Biermann\u00a0JS. Biopsy of bone and soft-tissue lesions. J\u00a0Bone Joint Surg Am. 1993;75(4):616\u201321.","journal-title":"J Bone Joint Surg Am"},{"issue":"2","key":"2677_CR7","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/s11999-016-5090-y","volume":"475","author":"I Barrientos-Ruiz","year":"2017","unstructured":"Barrientos-Ruiz\u00a0I, Ortiz-Cruz\u00a0EJ, Serrano-Montilla\u00a0J, Bernabeu-Taboada\u00a0D, Pozo-Kreilinger\u00a0JJ. Are Biopsy Tracts a\u00a0Concern for Seeding and Local Recurrence in Sarcomas? Clin Orthop Relat Res. 2017;475(2):511\u20138. https:\/\/doi.org\/10.1007\/s11999-016-5090-y.","journal-title":"Clin Orthop Relat Res"},{"key":"2677_CR8","first-page":"7","volume":"1","author":"R Mohana","year":"2007","unstructured":"Mohana\u00a0R, Faisham\u00a0W, Zulmi\u00a0W, Nawfar\u00a0AS, Effat\u00a0O, Salzihan\u00a0MS. The incidence of malignant infiltration in the biopsy tract of osteosarcoma. Malaysorthop\u00a0J. 2007;1:7\u201310.","journal-title":"Malaysorthop J"},{"issue":"5","key":"2677_CR9","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1590\/S1413-78522009000500005","volume":"17","author":"MB Ribeiro","year":"2009","unstructured":"Ribeiro\u00a0MB, Oliveira\u00a0CRG, Filippi\u00a0RZ, Baptista\u00a0AM, Caiero\u00a0MT, Saito\u00a0CF, et\u00a0al. Estudo histopatol\u00f3gico do trajeto de bi\u00f3psia de tumores musculoesquel\u00e9ticos malignos. Acta ortop bras. 2009;17(5):279\u201381.","journal-title":"Acta ortop bras"}],"container-title":["Wiener klinische Wochenschrift"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00508-025-02677-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00508-025-02677-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00508-025-02677-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:24:43Z","timestamp":1784190283000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00508-025-02677-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,23]]},"references-count":9,"journal-issue":{"issue":"13-14","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["2677"],"URL":"https:\/\/doi.org\/10.1007\/s00508-025-02677-6","relation":{},"ISSN":["0043-5325","1613-7671"],"issn-type":[{"value":"0043-5325","type":"print"},{"value":"1613-7671","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,23]]},"assertion":[{"value":"27 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"T.\u00a0Todorova, M.A.\u00a0Smolle, M.M.\u00a0Gilg, B.\u00a0Liegl-Atzwanger, J.\u00a0Igrec, C.\u00a0Viertler and A.\u00a0Leithner declare that they have no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants or on human tissue were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1975 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study. This study was approved by the local institutional review board (IRB-number: 1152\/2024).","order":2,"name":"Ethics","label":"Ethical standards","group":{"name":"EthicsHeading","label":"Declarations"}}]}}