{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T18:07:12Z","timestamp":1788977232538,"version":"build-2803163510"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005788","name":"Medical University of Vienna","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005788","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Wien Klin Wochenschr"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adults with Down syndrome are at increased risk of obesity and cardiometabolic disease; however, evidence regarding effective lifestyle interventions remains limited. This study evaluated the outcomes of a\u00a0multidisciplinary lifestyle program incorporating nutritional therapy in adults with Down syndrome attending a\u00a0specialized outpatient clinic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective observational study included adults with genetically confirmed Down syndrome aged \u2265\u202f18\u00a0years with overweight or obesity (body mass index, BMI&gt;\u202f25\u202fkg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) who participated in a\u00a0multidisciplinary lifestyle intervention between October 2016 and October 2017. The program combined individual nutritional counselling, nutrition and cooking workshops, supervised physical activity, psychological support, and caregiver involvement. Anthropometric measurements, body composition, dietary intake, and biochemical parameters were assessed at baseline, 5\u00a0months and 10\u00a0months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In this study nine participants met the inclusion criteria and five completed the intervention and follow-up assessments. Mean baseline BMI was 36.0\u202f\u00b1\u20096.0\u202fkg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Mean body weight decreased from 81.5 to 78.9\u202fkg, and 3 participants achieved clinically relevant weight loss (&gt;\u202f5% of baseline body weight). No statistically significant changes were observed in anthropometric, body composition, dietary, or biochemical outcomes. Descriptive analyses indicated reductions in fat mass and visceral fat among participants achieving weight loss. Participants also reported improvements in nutritional awareness, healthier food choices, and meal preparation practices.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This retrospective study demonstrates the feasibility of implementing a\u00a0multidisciplinary lifestyle intervention incorporating nutritional therapy for adults with Down syndrome and obesity in a\u00a0specialized outpatient setting. The findings provide preliminary clinical experience regarding the provision of a\u00a0tailored interventional approach in this population. Larger prospective studies are required to further evaluate multidisciplinary lifestyle programs and their long-term relevance for metabolic health and quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00508-026-02814-9","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:25:06Z","timestamp":1788974706000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of a\u00a0multidisciplinary lifestyle intervention in adults with Down syndrome","Ergebnisse einer multidisziplin\u00e4ren Lebensstilintervention bei Erwachsenen mit Down-Syndrom"],"prefix":"10.1007","author":[{"given":"Barbara","family":"Bauer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Thajer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"issue":"Pt\u00a02","key":"2814_CR1","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/j.1365-2788.2004.00616.x","volume":"49","author":"CA Melville","year":"2005","unstructured":"Melville\u00a0CA, et\u00a0al. 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