{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:56:07Z","timestamp":1792500967350,"version":"4.5.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2006,6,7]],"date-time":"2006-06-07T00:00:00Z","timestamp":1149638400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1007\/s00520-006-0063-4","type":"journal-article","created":{"date-parts":[[2006,6,6]],"date-time":"2006-06-06T09:00:25Z","timestamp":1149584425000},"page":"802-817","source":"Crossref","is-referenced-by-count":175,"title":["The prevention and management of acute skin reactions related to radiation therapy: a systematic review and practice guideline"],"prefix":"10.1007","volume":"14","author":[{"given":"Amanda","family":"Bolderston","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy S.","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca K. S.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Holden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Robb-Blenderman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"and the Supportive Care Guidelines Group of Cancer Care Ontario Program in Evidence-based Care","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,6,7]]},"reference":[{"key":"63_CR1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1054\/homp.1999.0328","volume":"89","author":"A Balzarini","year":"2000","unstructured":"Balzarini A, Felisi E, Martini A et al (2000) Efficacy of homeopathic treatment of skin reactions during radiotherapy for breast cancer: a randomized, double-blind clinical trial. Br Homeopath J 89:8\u201312","journal-title":"Br Homeopath J"},{"key":"63_CR2","first-page":"732","volume":"8","author":"AM Barkham","year":"1993","unstructured":"Barkham AM (1993) Radiotherapy skin reactions and treatments. Prof Nurse 8:732\u2013736","journal-title":"Prof Nurse"},{"key":"63_CR3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0820-5930(09)60014-1","volume":"34","author":"A Bolderston","year":"2002","unstructured":"Bolderston A (2002) Skin care recommendations during radiotherapy: a survey of Canadian practice. Can J Med Radiat Technol 34:3\u201311","journal-title":"Can J Med Radiat Technol"},{"key":"63_CR4","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0167-8140(01)00327-9","volume":"59","author":"A Bostrom","year":"2001","unstructured":"Bostrom A, Lindman H, Swartling C et al (2001) Potent corticosteroid cream (mometasone furoate) significantly reduces acute radiation dermatitis: results from a double-blind, randomized study. Radiother Oncol 59:257\u2013265","journal-title":"Radiother Oncol"},{"key":"63_CR5","unstructured":"British Columbia Cancer Agency (2000) Cancer management manual: supportive care\u2014guidelines for the care of radiation skin reactions. Available at: http:\/\/www.bccancer.bc.ca\/HPI\/CancerManagementGuidelines\/SupportiveCare\/RadiationSkinReactions\/default.htm . Accessed: February 18, 2004"},{"key":"63_CR6","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1200\/JCO.1995.13.2.502","volume":"13","author":"GP Browman","year":"1995","unstructured":"Browman GP, Levine MN, Mohide EA et al (1995) The practice guidelines development cycle: a conceptual tool for practice guidelines development and implementation. J Clin Oncol 13:502\u2013512","journal-title":"J Clin Oncol"},{"key":"63_CR7","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0360-3016(97)00095-3","volume":"38","author":"SE Burch","year":"1997","unstructured":"Burch SE, Parker SA, Vann AM et al (1997) Measurement of 6-MV X-ray surface dose when topical agents are applied prior to external beam irradiation. Int J Radiat Oncol Biol Phys 38:447\u2013451","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"63_CR8","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0936-6555(05)80971-9","volume":"4","author":"IR Campbell","year":"1992","unstructured":"Campbell IR, Illingworth MH (1992) Can patients wash during radiotherapy to the breast or chest wall? A randomized controlled trial. Clin Oncol 4:78\u201382","journal-title":"Clin Oncol"},{"key":"63_CR9","first-page":"105","volume":"12","author":"J Campbell","year":"1996","unstructured":"Campbell J, Lane C (1996) Developing a skin-care protocol in radiotherapy. Prof Nurse 12:105\u2013108","journal-title":"Prof Nurse"},{"key":"63_CR10","unstructured":"Canadian Cancer Society (2003) [document online]. Available at: http:\/\/www.cancer.ca\/ccs\/internet\/standard\/0,3182,3172_369269_429281_langId-en,00.html . Accessed: November 17, 2003"},{"key":"63_CR11","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1007\/s002800170006","volume":"47","author":"PS Dale","year":"2001","unstructured":"Dale PS, Tamhankar CP, George D et al (2001) Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects. Cancer Chemother Pharmacol 47:S29\u2013S34 (Suppl)","journal-title":"Cancer Chemother Pharmacol"},{"key":"63_CR12","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1440-1673.1997.tb00672.x","volume":"41","author":"G Delaney","year":"1997","unstructured":"Delaney G, Fisher R, Hook C et al (1997) Sulcrafate cream in the management of moist desquamation during radiotherapy. Australas Radiol 41:270\u2013275","journal-title":"Australas Radiol"},{"key":"63_CR13","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/PL00002350","volume":"176","author":"J Dunst","year":"2000","unstructured":"Dunst J, Semlin S, Pigorsch S et al (2000) Intermittent use of amifostine during postoperative radiochemotherapy and acute toxicity in rectal cancer patients. Strahlenther Onkol 176:416\u2013421","journal-title":"Strahlenther Onkol"},{"key":"63_CR14","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1080\/02841860152619188","volume":"40","author":"JF Evensen","year":"2001","unstructured":"Evensen JF, Bjordal K, Jacobsen A et al (2001) Effects of Na-sucrose octasulfate on skin and mucosa reactions during radiotherapy of head and neck cancers. Acta Oncol 40:751\u2013755","journal-title":"Acta Oncol"},{"key":"63_CR15","first-page":"305","volume":"8","author":"E Fenig","year":"2001","unstructured":"Fenig E, Brenner B, Katz A et al (2001) Topical biafine and lipiderm for the prevention of radiation dermatitis: a randomized prospective trial. Oncol Rep 8:305\u2013309","journal-title":"Oncol Rep"},{"key":"63_CR16","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/S0360-3016(00)00782-3","volume":"48","author":"J Fisher","year":"2000","unstructured":"Fisher J, Scott C, Stevens R et al (2000) Randomized phase III study comparing best supportive care to biafine as a prophylactic agent for radiation-induced skin toxicity for women undergoing breast irradiation: radiation therapy oncology group (RTOG) 97-13. Int J Radiat Oncol Biol Phys 48:1307\u20131310","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"63_CR17","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0190-9622(79)70001-6","volume":"1","author":"PJ Frosch","year":"1979","unstructured":"Frosch PJ, Kligman AM (1979) The soap chamber test: a new method for assessing the irritancy of soaps. J Am Acad Dermatol 1:35\u201341","journal-title":"J Am Acad Dermatol"},{"key":"63_CR18","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1007\/s002800170005","volume":"47","author":"MS Gujral","year":"2001","unstructured":"Gujral MS, Patnaik PM, Kaul R et al (2001) Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers. Cancer Chemother Pharmacol 47:S23\u2013S28 (Suppl)","journal-title":"Cancer Chemother Pharmacol"},{"key":"63_CR19","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0360-3016(93)90958-X","volume":"26","author":"EC Halperin","year":"1993","unstructured":"Halperin EC, Gaspar L, George S et al (1993) A double-blind, randomized, prospective trial to evaluate topical vitamin C solution for the prevention of radiation dermatitis. Int J Radiat Oncol Biol Phys 26:413\u2013416","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"63_CR20","first-page":"A239","volume":"16","author":"MB Hazuka","year":"1997","unstructured":"Hazuka MB, Goebel RH, McCutchan S et al (1997) A new approach to the prevention of radiation-induced skin desquamation using a polymer adhesive skin sealant (PASS): final results of a prospective study (meeting abstract). Proc Am Soc Clin Oncol 16:A239","journal-title":"Proc Am Soc Clin Oncol"},{"key":"63_CR21","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1097\/00002820-200212000-00007","volume":"25","author":"S Heggie","year":"2002","unstructured":"Heggie S, Bryant GP, Tripcony L et al (2002) A phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue. Cancer Nurs 25:442\u2013451","journal-title":"Cancer Nurs"},{"key":"63_CR22","first-page":"141","volume":"36","author":"R Kaul","year":"1999","unstructured":"Kaul R, Mishra BK, Sutradar P et al (1999) The role of Wobe-Mugos in reducing acute sequele of radiation in head and neck cancers\u2014a clinical phase III randomized trial. Indian J Cancer 36:141\u2013148","journal-title":"Indian J Cancer"},{"key":"63_CR23","first-page":"40","volume":"97","author":"A Korinko","year":"1997","unstructured":"Korinko A, Yurick A (1997) Maintaining skin integrity during radiotherapy. Am J Nurs 97:40\u201344","journal-title":"Am J Nurs"},{"key":"63_CR24","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1200\/JCO.2000.18.11.2226","volume":"18","author":"MI Koukourakis","year":"2000","unstructured":"Koukourakis MI, Frangiadaki C, Stavroulaki A et al (2000) Subcutaneous amifostine during fractionated radiotherapy: a randomized phase II study in pelvic tumours J Clin Oncol 18:2226\u20132233","journal-title":"J Clin Oncol"},{"key":"63_CR25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1046\/j.1524-475x.2001.00187.x","volume":"9","author":"JR Kouvaris","year":"2001","unstructured":"Kouvaris JR, Kouloulias VE, Plataniotis GA et al (2001) Dermatits during radiation for vulvar carcinoma: prevention and treatment with granulocyte-macrophage colony-stimulating factor impregnated gauze. Wound Repair Regen 9:187\u2013193","journal-title":"Wound Repair Regen"},{"key":"63_CR26","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0167-8140(97)00231-4","volume":"47","author":"Y Lievens","year":"1998","unstructured":"Lievens Y, Haustermans K, Van den Weyngaert D et al (1998) Does sucralfate reduce the acute side-effects in head and neck cancer treated with radiotherapy? A double-blind randomized trial. Radiother Oncol 47:149\u2013153","journal-title":"Radiother Oncol"},{"key":"63_CR27","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0167-8140(96)01882-8","volume":"42","author":"V Liguori","year":"1997","unstructured":"Liguori V, Guillemin C, Pesce GF et al (1997) Double-blind, randomized clinical study comparing hyaluronic acid cream to placebo in patients treated with radiotherapy. Radiother Oncol 42:155\u2013161","journal-title":"Radiother Oncol"},{"key":"63_CR28","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.3109\/02841869609100721","volume":"35","author":"E L\u00f8kkevik","year":"1996","unstructured":"L\u00f8kkevik E, Skovlund E, Reitan JB et al (1996) Skin treatment with bepanthen cream versus no cream during radiotherapy. Acta Oncol 35:1021\u20131026","journal-title":"Acta Oncol"},{"key":"63_CR29","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3109\/02841869109092456","volume":"30","author":"AG Maiche","year":"1991","unstructured":"Maiche AG, Grohn P, Maki-Hokkonen H (1991) Effect of chamomile cream and almond ointment on acute radiation skin reaction. Acta Oncol 30:395\u2013396","journal-title":"Acta Oncol"},{"key":"63_CR30","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3109\/02841869409098406","volume":"33","author":"A Maiche","year":"1994","unstructured":"Maiche A, Isokangas O, Grohn P (1994) Skin protection by sucralfate cream during electron beam therapy. Acta Oncol 33:201\u2013203","journal-title":"Acta Oncol"},{"key":"63_CR31","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/00002820-200006000-00010","volume":"23","author":"SS Mak","year":"2000","unstructured":"Mak SS, Lolassiotis A, Wan W et al (2000) The effects of hydrocolloid dressing and gentian violet on radiation-induced moist desquamation wound healing. Cancer Nurs 23:220\u2013229","journal-title":"Cancer Nurs"},{"key":"63_CR32","first-page":"543","volume":"28","author":"DL Olsen","year":"2001","unstructured":"Olsen DL, Raub W, Bradley C et al (2001) The effect of aloe vera gel\/mild soap alone in preventing skin reaction in patients undergoing radiation therapy. Oncol Nurs Forum 28:543\u2013547","journal-title":"Oncol Nurs Forum"},{"key":"63_CR33","volume-title":"Manual for radiation oncology nursing practice and education","author":"Oncology Nursing Society (ONS)","year":"1998","unstructured":"Oncology Nursing Society (ONS) (1998) Manual for radiation oncology nursing practice and education. Oncology Nursing Society, Pittsburgh, PA"},{"key":"63_CR34","first-page":"11","volume-title":"Principles and practice of radiation oncology","author":"CA Perez","year":"1998","unstructured":"Perez CA, Brady LW (1998) Principles and practice of radiation oncology, 3rd edn. Lippincott-Raven, Philadelphia, PA, p 11","edition":"3"},{"key":"63_CR35","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1200\/JCO.2004.07.063","volume":"22","author":"P Pommier","year":"2004","unstructured":"Pommier P, Gomez F, Sunyach MP et al (2004) Phase III randomized trial of calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer. J Clin Oncol 22:1447\u20131453","journal-title":"J Clin Oncol"},{"key":"63_CR36","first-page":"775","volume":"143","author":"ME Potera","year":"1982","unstructured":"Potera ME, Lookingbill DP, Stryker JA (1982) Prophylaxis of radiation dermatitis with a topical cortisone cream. Radiother Oncol 143:775\u2013777","journal-title":"Radiother Oncol"},{"key":"63_CR37","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0167-8140(00)00322-4","volume":"58","author":"I Roy","year":"2001","unstructured":"Roy I, Fortin A, Larochelle M (2001) The impact of skin washing with water and soap during breast irradiation: a randomized study. Radiother Oncol 58:333\u2013339","journal-title":"Radiother Oncol"},{"key":"63_CR38","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1046\/j.1365-2133.2002.04751.x","volume":"146","author":"M Schmuth","year":"2002","unstructured":"Schmuth M, Wimmer MA, Hofer S et al (2002) Topical corticosteroid therapy for acute radiation dermatitis: a prospective, randomized, double-blind study. Br J Dermatol 146:983\u2013991","journal-title":"Br J Dermatol"},{"key":"63_CR39","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00066-002-0912-0","volume":"6","author":"U Schreck","year":"2002","unstructured":"Schreck U, Paulsen F, Bamberg M et al (2002) Intraindividual comparison of two different skin care conceptions in patients undergoing radiotherapy of the head-and-neck region. Strahlenther Onkol 6:321\u2013329","journal-title":"Strahlenther Onkol"},{"key":"63_CR40","first-page":"11","volume":"13","author":"JA Shell","year":"1986","unstructured":"Shell JA, Stanutz F, Grimm J (1986) Comparison of moisture vapor permeable (MVP) dressings to conventional dressings for management of radiation skin reactions. Oncol Nurs Forum 13:11\u201316","journal-title":"Oncol Nurs Forum"},{"key":"63_CR41","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0167-8140(97)00115-1","volume":"46","author":"P Simonen","year":"1998","unstructured":"Simonen P, Hamilton C, Ferguson S et al (1998) Do inflammatory processes contribute to radiation induced erythema observed in the skin of humans? Radiother Oncol 46:73\u201382","journal-title":"Radiother Oncol"},{"key":"63_CR42","volume-title":"Oncology nursing","author":"CC Snyder","year":"1986","unstructured":"Snyder CC (1986) Oncology nursing. Little, Brown and Company, Boston, MA"},{"key":"63_CR43","doi-asserted-by":"crossref","unstructured":"Snyder DS, Greenberg RA (1977) Radiographic measurement of topical corticosteriod-induced atrophy. J Invest Dermatol 279\u2013281","DOI":"10.1111\/1523-1747.ep12507493"},{"key":"63_CR44","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0360-3016(01)01576-0","volume":"51","author":"E Szumacher","year":"2001","unstructured":"Szumacher E, Wighton A, Franssen E et al (2001) Phase II study assessing the effectiveness of biafine cream as a prophylactic agent for radiation-induced acute skin toxicity to the breast in women undergoing radiotherapy with concomitant CMF chemotherapy. Int J Radiat Oncol Biol Phys 51:81\u201386","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"63_CR45","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0167-8140(99)00146-2","volume":"54","author":"C Westbury","year":"2000","unstructured":"Westbury C, Hines F, Hawkes E et al (2000) Advice on hair and scalp care during cranial radiotherapy: a prospective randomized trial. Radiother Oncol 54:109\u2013116","journal-title":"Radiother Oncol"},{"key":"63_CR46","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0360-3016(96)00320-3","volume":"36","author":"MS Williams","year":"1996","unstructured":"Williams MS, Burk M, Loprinzi CL et al (1996) Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity. Int J Radiat Oncol Biol Phys 36:345\u2013349","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-006-0063-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00520-006-0063-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-006-0063-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T02:01:37Z","timestamp":1559095297000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00520-006-0063-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,7]]},"references-count":46,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["63"],"URL":"https:\/\/doi.org\/10.1007\/s00520-006-0063-4","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,7]]}}}