{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T21:22:10Z","timestamp":1771190530439,"version":"3.50.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2007,8,14]],"date-time":"2007-08-14T00:00:00Z","timestamp":1187049600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2007,11,7]]},"DOI":"10.1007\/s00520-007-0309-9","type":"journal-article","created":{"date-parts":[[2007,8,13]],"date-time":"2007-08-13T12:07:01Z","timestamp":1187006821000},"page":"1341-1347","source":"Crossref","is-referenced-by-count":87,"title":["Diagnosis and management of hyponatremia in cancer patients"],"prefix":"10.1007","volume":"15","author":[{"given":"Harry","family":"Raftopoulos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,8,14]]},"reference":[{"key":"309_CR1","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1056\/NEJM200005253422107","volume":"342","author":"HJ Adrogu\u00e9","year":"2000","unstructured":"Adrogu\u00e9 HJ, Madias NE (2000) Hyponatremia. N Engl J Med 342:1581\u20131589","journal-title":"N Engl J Med"},{"key":"309_CR2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.7326\/0003-4819-102-2-164","volume":"102","author":"RJ Anderson","year":"1985","unstructured":"Anderson RJ, Chung H-M, Kluge R, Schrier RW (1985) Hyponatremia: a prospective analysis of its epidemiology and the pathogenetic role of vasopressin. Ann Intern Med 102:164\u2013168","journal-title":"Ann Intern Med"},{"key":"309_CR3","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/0002-9343(67)90096-4","volume":"42","author":"FC Bartter","year":"1967","unstructured":"Bartter FC, Schwartz WB (1967) The syndrome of inappropriate secretion of antidiuretic hormone. Am J Med 42:790\u2013806","journal-title":"Am J Med"},{"key":"309_CR4","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0950-351X(89)80006-0","volume":"3","author":"PH Baylis","year":"1989","unstructured":"Baylis PH (1989) Regulation of vasopressin secretion. Baillieres Clin Endocrinol Metab 3:313\u2013330","journal-title":"Baillieres Clin Endocrinol Metab"},{"key":"309_CR5","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/S1357-2725(03)00139-0","volume":"35","author":"PH Baylis","year":"2003","unstructured":"Baylis PH (2003) The syndrome of inappropriate antidiuretic hormone secretion. Int J Biochem Cell Biol 35:1495\u20131499","journal-title":"Int J Biochem Cell Biol"},{"key":"309_CR6","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/BF01788840","volume":"4","author":"T Berghmans","year":"1996","unstructured":"Berghmans T (1996) Hyponatremia related to medical anticancer treatment. Support Care Cancer 4:341\u2013350","journal-title":"Support Care Cancer"},{"key":"309_CR7","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s005200050284","volume":"8","author":"T Berghmans","year":"1999","unstructured":"Berghmans T, Paesmans M, Body JJ (1999) A prospective study on hyponatraemia in medical cancer patients: epidemiology, aetiology and differential diagnosis. Support Care Cancer 8:192\u2013197","journal-title":"Support Care Cancer"},{"key":"309_CR8","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0031-3955(16)36873-0","volume":"37","author":"PL Berry","year":"1990","unstructured":"Berry PL, Belsha CW (1990) Hyponatremia. Pediatr Clin North Am 37:351\u2013363","journal-title":"Pediatr Clin North Am"},{"key":"309_CR9","doi-asserted-by":"crossref","first-page":"823","DOI":"10.3109\/02841868909092315","volume":"28","author":"D Bissett","year":"1989","unstructured":"Bissett D, Cornford EJ, Sokal M (1989) Hyponatraemia following cisplatin chemotherapy. Acta Oncol 28:823","journal-title":"Acta Oncol"},{"key":"309_CR10","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/jnci\/82.4.305","volume":"82","author":"DP Bliss Jr","year":"1990","unstructured":"Bliss DP Jr, Battey JF, Linnoila RI, Birrer MJ, Gazdar AF, Johnson BE (1990) Expression of the atrial natriuretic factor gene in small cell lung cancer tumors and tumor cell lines. J Natl Cancer Inst 82:305\u2013310","journal-title":"J Natl Cancer Inst"},{"key":"309_CR11","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1093\/jjco\/hye085","volume":"31","author":"N Boku","year":"2001","unstructured":"Boku N, Ohtsu A, Nagashima F, Muto M, Shinkai T, Yoshida A (2001) Retrospective study of hyponatremia in gastric cancer patients treated with a combination chemotherapy of 5-fluorouracil and cisplatin: a possible warning sign of severe hematological toxicities? Jpn J Clin Oncol 31:382\u2013387","journal-title":"Jpn J Clin Oncol"},{"key":"309_CR12","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1002\/1097-0142(19950515)75:10<2442::AID-CNCR2820751009>3.0.CO;2-Q","volume":"75","author":"BG Campling","year":"1995","unstructured":"Campling BG, Sarda IR, Baer KA, Pang SC, Baker HM, Lofters WS, Flynn TG (1995) Secretion of atrial natriuretic peptide and vasopressin by small cell lung cancer. Cancer 75:2442\u20132451","journal-title":"Cancer"},{"key":"309_CR13","unstructured":"Cancer Therapy Evaluation Program (2006) Common terminology criteria for adverse events, version 3.0. DCTD, NCI, NIH, DHHS; March 31, 2003. Available at: http:\/\/ctep.cancer.gov . Publish date: August 9, 2006. Accessed on November 15, 2006"},{"key":"309_CR14","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/00000421-200208000-00005","volume":"25","author":"L Cao","year":"2002","unstructured":"Cao L, Joshi P, Sumoza D (2002) Renal salt-wasting syndrome in a patient with cisplatin-induced hyponatremia: case report. Am J Clin Oncol 25:344\u2013346","journal-title":"Am J Clin Oncol"},{"key":"309_CR15","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1002\/1097-0142(19800501)45:9<2414::AID-CNCR2820450929>3.0.CO;2-4","volume":"45","author":"RL Comis","year":"1980","unstructured":"Comis RL, Miller M, Ginsberg SJ (1980) Abnormalities in water homeostasis in small cell anaplastic lung cancer. Cancer 45:2414\u20132421","journal-title":"Cancer"},{"key":"309_CR16","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/00000441-200307000-00004","volume":"326","author":"G Decaux","year":"2003","unstructured":"Decaux G, Soupart A (2003) Treatment of symptomatic hyponatremia. Am J Med Sci 326:25\u201330","journal-title":"Am J Med Sci"},{"key":"309_CR17","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/bjc.1993.425","volume":"68","author":"HS Dhaliwal","year":"1993","unstructured":"Dhaliwal HS, Rohatiner AZS, Gregory W, Richards MA, Johnson PWM, Whelan JS, Gallagher CJ, Matthews J, Ganesan TS, Barnett MJ, Waxman JH, Stansfeld AG, Wrigley PFM, Slevin ML, Malpas JS, Lister TA (1993) Combination chemotherapy for intermediate and high grade non-Hodgkin\u2019s lymphoma. Br J Cancer 68:767\u2013774","journal-title":"Br J Cancer"},{"key":"309_CR18","doi-asserted-by":"crossref","first-page":"264","DOI":"10.3109\/02841869509093969","volume":"34","author":"A Weshi el","year":"1995","unstructured":"el Weshi A, Thieblemont C, Cottin V, Barbet N, Catimel G (1995) Cisplatin-induced hyponatremia and renal sodium wasting. Acta Oncol 34:264\u2013265","journal-title":"Acta Oncol"},{"key":"309_CR19","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1159\/000169022","volume":"16","author":"MS Elisaf","year":"1996","unstructured":"Elisaf MS, Konstantinides A, Siamopoulos KC (1996) Chronic hyponatremia due to reset osmostat in a patient with colon cancer. Am J Nephrol 16:349\u2013351","journal-title":"Am J Nephrol"},{"key":"309_CR20","first-page":"905","volume":"88","author":"SJ Ellis","year":"1995","unstructured":"Ellis SJ (1995) Severe hyponatraemia: complications and treatment. QJM 88:905\u2013909","journal-title":"QJM"},{"key":"309_CR21","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0025-7125(05)70535-6","volume":"81","author":"LF Fried","year":"1997","unstructured":"Fried LF, Palevsky PM (1997) Hyponatremia and hypernatremia. Med Clin North Am 81:585\u2013609","journal-title":"Med Clin North Am"},{"key":"309_CR22","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1053\/gast.2003.50143","volume":"124","author":"AL Gerbes","year":"2003","unstructured":"Gerbes AL, Gulberg V, Gines P, Decaux G, Gross P, Gandjini H, Djian J (2003) Therapy of hyponatremia in cirrhosis with a vasopressin receptor antagonist: a randomized double-blind multicenter trial. Gastroenterology 124:933\u2013939","journal-title":"Gastroenterology"},{"key":"309_CR23","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1210\/jc.2005-2287","volume":"91","author":"JK Ghali","year":"2006","unstructured":"Ghali JK, Koren MJ, Taylor JR, Brooks-Asplund E, Fan K, Long WA, Smith N (2006) Efficacy and safety of oral conivaptan: a vasopressin receptor V1A\/V2 antagonist, assessed in a randomized, placebo-controlled trial in patients with euvolemic or hypervolemic hyponatremia. J Clin Endocrinol Metab 91:2145\u20132152","journal-title":"J Clin Endocrinol Metab"},{"key":"309_CR24","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1161\/01.CIR.0000070422.41439.04","volume":"107","author":"M Gheorghiade","year":"2003","unstructured":"Gheorghiade M, Niazi I, Ouyang J, Czerwiec F, Kambayashi J, Zampino M, Orlandi C (2003) Vasopressin V2-receptor blockade with tolvaptan in patients with chronic heart failure: results from a double-blind, randomized trial. Circulation 107:2690\u20132696","journal-title":"Circulation"},{"key":"309_CR25","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1001\/jama.291.16.1963","volume":"291","author":"M Gheorghiade","year":"2004","unstructured":"Gheorghiade M, Gattis WA, O\u2019Connor CM, Adams KF Jr, Elkayam U, Barbagelata A, Ghali JK, Benza RL, McGrew FA, Klapholz M, Ouyang J, Orlandi C (2004) Effects of tolvaptan, a vasopressin antagonist, in patients hospitalized with worsening heart failure: a randomized controlled trial. JAMA 291:1963\u20131971","journal-title":"JAMA"},{"key":"309_CR26","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3322\/canjclin.37.5.302","volume":"37","author":"DJ Glover","year":"1987","unstructured":"Glover DJ, Glick JH (1987) Metabolic oncologic emergencies. CA Cancer J Clin 37:302\u2013320","journal-title":"CA Cancer J Clin"},{"key":"309_CR27","first-page":"2387","volume":"69","author":"KP Goh","year":"2004","unstructured":"Goh KP (2004) Management of hyponatremia. Am Fam Phys 69:2387\u20132394","journal-title":"Am Fam Phys"},{"key":"309_CR28","first-page":"67","volume":"53","author":"AJ Gross","year":"1993","unstructured":"Gross AJ, Steinberg SM, Reilly JG, Bliss DP Jr, Brennan J, Le PT, Simmons A, Phelps R, Mulshine JL, Ihde DC, Johnson BE (1993) Atrial natriuretic factor and arginine vasopressin production in tumor cell lines from patients with lung cancer and their relationship to serum sodium. Cancer Res 53:67\u201374","journal-title":"Cancer Res"},{"key":"309_CR29","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1681\/ASN.V12suppl_1s10","volume":"12","author":"P Gross","year":"2001","unstructured":"Gross P, Reimann D, Henschkowski J, Damian M (2001) Treatment of severe hyponatremia: conventional and novel aspects. J Am Soc Nephrol 12:S10\u2013S14","journal-title":"J Am Soc Nephrol"},{"key":"309_CR30","doi-asserted-by":"crossref","first-page":"355A","DOI":"10.1097\/01.ASN.0000105993.63023.D8","volume":"15","author":"P Gross","year":"2004","unstructured":"Gross P, Bisaha JG, Smith N (2004) Conivaptan, a novel V1A and V2 antagonist, increased serum sodium and effective water clearance in patients with euvolemic or hypervolemic hyponatremia [abstract]. J Am Soc Nephrol 15:355A, Abstract SA-P0243","journal-title":"J Am Soc Nephrol"},{"key":"309_CR31","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.me.44.020193.001445","volume":"44","author":"SR Gullans","year":"1993","unstructured":"Gullans SR, Verbalis JG (1993) Control of brain volume during hyperosmolar and hypoosmolar conditions. Annu Rev Med 44:289\u2013301","journal-title":"Annu Rev Med"},{"key":"309_CR32","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3816\/CLC.2003.n.033","volume":"5","author":"AV Iyer","year":"2003","unstructured":"Iyer AV, Krasnow SH, Dufour R, Arcenas AS (2003) Sodium-wasting nephropathy caused by cisplatin in a patient with small-cell lung cancer. Clin Lung Cancer 5:187\u2013189","journal-title":"Clin Lung Cancer"},{"key":"309_CR33","first-page":"625","volume":"6","author":"BJ Kinzie","year":"1987","unstructured":"Kinzie BJ (1987) Management of the syndrome of inappropriate secretion of antidiuretic hormone. Clin Pharm 6:625\u2013633","journal-title":"Clin Pharm"},{"key":"309_CR34","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1188\/03.CJON.425-430","volume":"7","author":"LA Langfeldt","year":"2003","unstructured":"Langfeldt LA, Cooley ME (2003) Syndrome of inappropriate antidiuretic hormone secretion in malignancy: review and implications for nursing management. Clin J Oncol Nurs 7:425\u2013430","journal-title":"Clin J Oncol Nurs"},{"key":"309_CR35","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1200\/JCO.1986.4.8.1191","volume":"4","author":"AF List","year":"1986","unstructured":"List AF, Hainsworth JD, Davis BW, Hande KR, Greco FA, Johnson DH (1986) The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in small-cell lung cancer. J Clin Oncol 4:1191\u20131198","journal-title":"J Clin Oncol"},{"issue":"Suppl 3","key":"309_CR36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1464-410X.90.s3.1.x","volume":"90","author":"S Nielsen","year":"2002","unstructured":"Nielsen S (2002) Renal aquaporins: an overview. BJU Int 90(Suppl 3):1\u20136","journal-title":"BJU Int"},{"issue":"Suppl 1","key":"309_CR37","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.1016\/0169-5002(94)91672-1","volume":"10","author":"K \u00d8sterlind","year":"1994","unstructured":"\u00d8sterlind K (1994) Factors confounding evaluation of treatment effect in lung cancer. Lung Cancer 10(Suppl 1):S97\u2013S103","journal-title":"Lung Cancer"},{"key":"309_CR38","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S1043-2760(03)00048-1","volume":"14","author":"BF Palmer","year":"2003","unstructured":"Palmer BF (2003) Hyponatremia in patients with central nervous system disease: SIADH versus CSW. Trends Endocrinol Metab 14:182\u2013187","journal-title":"Trends Endocrinol Metab"},{"key":"309_CR39","first-page":"373","volume":"16","author":"CM Poe","year":"1989","unstructured":"Poe CM, Taylor LM (1989) Syndrome of inappropriate antidiuretic hormone: assessment and nursing implications. Oncol Nurs Forum 16:373\u2013381","journal-title":"Oncol Nurs Forum"},{"key":"309_CR40","doi-asserted-by":"crossref","first-page":"71.e1","DOI":"10.1016\/j.amjmed.2005.09.026","volume":"119","author":"B Renneboog","year":"2006","unstructured":"Renneboog B, Musch W, Vandemergel X, Manto MU, Decaux G (2006) Mild chronic hyponatremia is associated with falls, unsteadiness, and attention deficits. Am J Med 119:71.e1\u201371.e8","journal-title":"Am J Med"},{"key":"309_CR41","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0889-8529(05)70207-3","volume":"30","author":"GL Robertson","year":"2001","unstructured":"Robertson GL (2001) Antidiuretic hormone. Normal and disordered function. Endocrinol Metab Clin North Am 30:671\u2013694","journal-title":"Endocrinol Metab Clin North Am"},{"key":"309_CR42","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1056\/NEJMoa065181","volume":"355","author":"RW Schrier","year":"2006","unstructured":"Schrier RW, Gross P, Gheorghiade M, Berl T, Verbalis JG, Czerwiec FS, Orlandi C, for the SALT Investigators (2006) Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremia. N Engl J Med 355:2099\u20132112","journal-title":"N Engl J Med"},{"key":"309_CR43","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0002-9343(57)90224-3","volume":"23","author":"WB Schwartz","year":"1957","unstructured":"Schwartz WB, Bennett W, Curelop S, Bartter FC (1957) A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone. Am J Med 23:529\u2013542","journal-title":"Am J Med"},{"key":"309_CR44","first-page":"504","volume":"16","author":"P Silverman","year":"1989","unstructured":"Silverman P, Distelhorst CW (1989) Metabolic emergencies in clinical oncology. Semin Oncol 16:504\u2013515","journal-title":"Semin Oncol"},{"key":"309_CR45","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1365-2796.1995.tb00907.x","volume":"238","author":"JB S\u00f8rensen","year":"1995","unstructured":"S\u00f8rensen JB, Andersen MK, Hansen HH (1995) Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in malignant disease. J Intern Med 238:97\u2013110","journal-title":"J Intern Med"},{"key":"309_CR46","doi-asserted-by":"crossref","first-page":"634","DOI":"10.2215\/CJN.00160106","volume":"1","author":"A Soupart","year":"2006","unstructured":"Soupart A, Gross P, Legros JJ, Alfoldi S, Annane D, Heshmati HM, Decaux G (2006) Successful long-term treatment of hyponatremia in syndrome of inappropriate antidiuretic hormone secretion with satavaptan (SR121463B), an orally active nonpeptide vasopressin V2-receptor antagonist. Clin J Am Soc Nephrol 1:634\u2013640","journal-title":"Clin J Am Soc Nephrol"},{"key":"309_CR47","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1023\/A:1008369932384","volume":"11","author":"SL Vanhees","year":"2000","unstructured":"Vanhees SL, Paridaens R, Vansteenkiste JF (2000) Syndrome of inappropriate antidiuretic hormone associated with chemotherapy-induced tumour lysis in small-cell lung cancer: case report and literature review. Ann Oncol 11:1061\u20131065","journal-title":"Ann Oncol"},{"key":"309_CR48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/jme.0.0290001","volume":"29","author":"JG Verbalis","year":"2002","unstructured":"Verbalis JG (2002) Vasopressin V2 receptor antagonists. J Mol Endocrinol 29:1\u20139","journal-title":"J Mol Endocrinol"},{"key":"309_CR49","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1053\/jhep.2003.50021","volume":"37","author":"F Wong","year":"2003","unstructured":"Wong F, Blei AT, Blendis LM, Thuluvath PJ (2003) A vasopressin receptor antagonist (VPA-985) improves serum sodium concentration in patients with hyponatremia: a multicenter, randomized, placebo-controlled trial. Hepatology 37:182\u2013191","journal-title":"Hepatology"},{"key":"309_CR50","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1159\/000106456","volume":"27","author":"D Zeltser","year":"2007","unstructured":"Zeltser D, Rosansky S, van Rensburg H, Verbalis JG, Smith N (2007) Assessment of the efficacy and safety of intravenous conivaptan in euvolemic and hypervolemic hyponatremia. Am J Nephrol 27:447\u2013457","journal-title":"Am J Nephrol"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-007-0309-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00520-007-0309-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-007-0309-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T17:06:52Z","timestamp":1629565612000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00520-007-0309-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,14]]},"references-count":50,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,11,7]]}},"alternative-id":["309"],"URL":"https:\/\/doi.org\/10.1007\/s00520-007-0309-9","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,14]]}}}