{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:29:47Z","timestamp":1772224187550,"version":"3.50.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T00:00:00Z","timestamp":1350000000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1007\/s00520-012-1622-5","type":"journal-article","created":{"date-parts":[[2012,10,11]],"date-time":"2012-10-11T13:36:04Z","timestamp":1349962564000},"page":"1025-1031","source":"Crossref","is-referenced-by-count":47,"title":["Topical agent therapy for prevention and treatment of radiodermatitis: a meta-analysis"],"prefix":"10.1007","volume":"21","author":[{"given":"Yuejiao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoude","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoling","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,10,12]]},"reference":[{"key":"1622_CR1","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/cncr.21324","volume":"104","author":"G Delaney","year":"2005","unstructured":"Delaney G, Jacob S, Featherstone C et al (2005) The role of radiotherapy in cancer treatment: estimating optimal utilization from a review of evidence-based clinical guidelines. Cancer 104:1129\u20131137","journal-title":"Cancer"},{"key":"1622_CR2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.canrad.2010.02.001","volume":"14","author":"S Benomar","year":"2010","unstructured":"Benomar S, Boutayeb S, Laiya I et al (2010) Treatment and prevention of acute radiation dermatitis. Cancer Radiother 14:213\u2013216","journal-title":"Cancer Radiother"},{"key":"1622_CR3","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00066-011-2204-z","volume":"187","author":"M Becker-Schiebe","year":"2011","unstructured":"Becker-Schiebe M, Mengs U, Schaefer M et al (2011) Topical use of a silymarin-based preparation to prevent radiodermatitis. Strahlenther Onkol 187:485\u2013491","journal-title":"Strahlenther Onkol"},{"key":"1622_CR4","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.clon.2005.04.013","volume":"17","author":"J Richardson","year":"2005","unstructured":"Richardson J, Smith JE, McIntyre M et al (2005) Aloe vera for preventing radiation-induced skin reactions: a systematic literature review. Clin Oncol 17:478\u2013484","journal-title":"Clin Oncol"},{"key":"1622_CR5","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1365-2354.2005.00510.x","volume":"14","author":"S D\u2019Haese","year":"2005","unstructured":"D\u2019Haese S, Bate T, Claes S et al (2005) Management of skin reactions during radiotherapy: a study of nursing practice. Eur J Canc Care 14:28\u201342","journal-title":"Eur J Canc Care"},{"key":"1622_CR6","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1188\/04.ONF.237-247","volume":"31","author":"MM Wickline","year":"2004","unstructured":"Wickline MM (2004) Prevention and treatment of acute radiation dermatitis: a literature review. Oncol Nurs Forum 31:237\u2013244","journal-title":"Oncol Nurs Forum"},{"key":"1622_CR7","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.ijrobp.2010.01.031","volume":"79","author":"RC Miller","year":"2011","unstructured":"Miller RC, Schwartz DJ, Sloan JA et al (2011) Mometasone furoate effect on acute skin toxicity in breast cancer patients receiving radiotherapy: a phase III double-blind, randomized trial from the north central cancer treatment group N06C4. Int J Radiat Oncol Biol Phys 79:1460\u20131466","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1622_CR8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0167-8140(01)00327-9","volume":"59","author":"A Bostrom","year":"2001","unstructured":"Bostrom A, Lindman H, Swarthing C et al (2001) Potent corticosteroid cream (mometasone furoate) significantly reduce radiation dermatitis: results from a double-blind, randomized study. Radiot Oncol 59:257\u2013265","journal-title":"Radiot Oncol"},{"key":"1622_CR9","doi-asserted-by":"crossref","first-page":"209","DOI":"10.4103\/0378-6323.32755","volume":"73","author":"S Omidvari","year":"2007","unstructured":"Omidvari S, Saboori H, Mohammadianpanah M et al (2007) Topical betamethason for prevention of radiation dermatitis. Indian J Dermatol Veneraol Leprol 73:209\u2013216","journal-title":"Indian J Dermatol Veneraol Leprol"},{"key":"1622_CR10","doi-asserted-by":"crossref","first-page":"180","DOI":"10.4103\/0019-509X.29424","volume":"43","author":"PN Shukla","year":"2006","unstructured":"Shukla PN, Gairola M, Mohanti BK et al (2006) Prophylactic beclomethasone spray to the skin during postoperative radiotherapy of carcinoma breast: a prospective randomized study. Indian J Canc 43:180\u2013184","journal-title":"Indian J Canc"},{"key":"1622_CR11","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/00002820-200006000-00010","volume":"23","author":"SS Mak","year":"2000","unstructured":"Mak SS, Alexander M, Wai-man W et al (2000) The effects of hydrocolloid dressing and gentian violet on radiation-induced moist desquamation wound healing. Canc Nurs 23:220\u2013229","journal-title":"Canc Nurs"},{"key":"1622_CR12","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s12094-010-0465-0","volume":"12","author":"JP Masferrer","year":"2010","unstructured":"Masferrer JP, Mej\u00eda MM, Fern\u00e1ndez MV et al (2010) Prophylaxis with a cream containing urea reduces the incidence and severity of radio-induced dermatitis. Clin Transl Oncol 12:43\u201348","journal-title":"Clin Transl Oncol"},{"key":"1622_CR13","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1211\/jpp.62.06.0015","volume":"62","author":"L Rizza","year":"2010","unstructured":"Rizza L, D\u2019Agostino A, Girlando A et al (2010) Evaluation of the effect of topical agents on radiation-induced skin disease by reflectance spectrophotometry. J Pharma Pharmacol 62:779\u2013785","journal-title":"J Pharma Pharmacol"},{"key":"1622_CR14","doi-asserted-by":"crossref","first-page":"268","DOI":"10.12968\/jowc.2008.17.6.29589","volume":"17","author":"S Gollins","year":"2008","unstructured":"Gollins S, Gaffney C, Slade S et al (2008) RCT on gentian violet versus a hydrogel dressing for radiotherapy-induced moist skin desquamation. J Wound Care 17:268\u2013275","journal-title":"J Wound Care"},{"key":"1622_CR15","first-page":"193","volume":"27","author":"M Hongbing","year":"2007","unstructured":"Hongbing M, Xiaozhi Z, Minghua B et al (2007) Clinical effect of Lianbai liquid in prevention and treatment of dermal injury caused by radiotherapy. J Tradit Chin Med 27:193\u2013196","journal-title":"J Tradit Chin Med"},{"key":"1622_CR16","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0167-8140(96)01882-8","volume":"42","author":"V Liguori","year":"1997","unstructured":"Liguori V, Guillemin C, Pesce GF et al (1997) Double-blind, randomized clinical study comparing hyaluronic acid cream to placebo in patients treated with radiotherapy. Radiot Oncol 42:155\u2013161","journal-title":"Radiot Oncol"},{"key":"1622_CR17","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1046\/j.1365-2133.2002.04751.x","volume":"146","author":"M Schmuth","year":"2002","unstructured":"Schmuth M, Wimmer MA, Hofer S et al (2002) Topical corticosteroid therapy for acute radiation dermatitis: a prospective, randomized, double-blind study. Br J Dermatol 146:983\u2013991","journal-title":"Br J Dermatol"},{"key":"1622_CR18","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0360-3016(96)00320-3","volume":"36","author":"MS Williams","year":"1996","unstructured":"Williams MS, Burk M, Loprinzi CL et al (1996) Phase III double-blind evaluation of an Aloe vera gel as a prophylactic agent for radiation-induced skin toxicity. Int J Radiat Oncol Biol Phys 36:345\u2013349","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1622_CR19","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1097\/00002820-200212000-00007","volume":"25","author":"S Heggie","year":"2002","unstructured":"Heggie S, Bryant GP, Tripcony L et al (2002) A phase III study on the efficacy of topical Aloe vera gel on irradiated breast tissue. Canc Nurs 25:442\u2013451","journal-title":"Canc Nurs"},{"key":"1622_CR20","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1188\/10.ONF.619-626","volume":"37","author":"TK Gosselin","year":"2010","unstructured":"Gosselin TK, Schneider SM, Plambeck MA et al (2010) A prospective randomized, placebo-controlled skin care study in women diagnosed with breast cancer undergoing radiation therapy. Oncol Nurs Forum 37:619\u2013626","journal-title":"Oncol Nurs Forum"},{"key":"1622_CR21","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/S0360-3016(00)00782-3","volume":"48","author":"J Fisher","year":"2000","unstructured":"Fisher J, Scott C, Stevens R et al (2000) Randomized phase III study comparing best supportive care to biafine as a prophylactic agent for radiation-induced skin toxicity for women undergoing breast irradiation: radiation therapy oncology group (RTOG) 97-13. Int J Radiat Oncol Biol Phys 48:1307\u20131310","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1622_CR22","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1097\/00002820-200511000-00005","volume":"28","author":"SS Mak","year":"2005","unstructured":"Mak SS, Zee CY, Molassiotis A et al (2005) A comparison of wound treatments in nasopharyngeal cancer patients receiving radiation therapy. Canc Nurs 28:436\u2013445","journal-title":"Canc Nurs"},{"key":"1622_CR23","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1440-1673.1997.tb00672.x","volume":"41","author":"G Delaney","year":"1997","unstructured":"Delaney G, Fisher R, Hook C et al (1997) Sucralfate cream in the management of moist desquamation during radiotherapy. Australas Radiol 41:270\u2013275","journal-title":"Australas Radiol"},{"key":"1622_CR24","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1200\/JCO.2005.04.9148","volume":"24","author":"EA Elliott","year":"2006","unstructured":"Elliott EA, Wright JR, Swann S et al (2006) Phase III trial of an emulsion containing trolamine for the prevention of radiation dermatitis in patients with advanced squamous cell carcinoma of the head and neck: results of radiation therapy oncology group trial 99-13. J Clin Oncol 24:2092\u20132096","journal-title":"J Clin Oncol"},{"key":"1622_CR25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","volume":"17","author":"AR Jadad","year":"1996","unstructured":"Jadad AR, Moore RA et al (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17:1\u201312","journal-title":"Control Clin Trials"},{"key":"1622_CR26","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","volume":"21","author":"JP Higgins","year":"2002","unstructured":"Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21:1539\u20131558","journal-title":"Stat Med"},{"key":"1622_CR27","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","volume":"50","author":"CB Begg","year":"1994","unstructured":"Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50:1088\u20131101","journal-title":"Biometrics"},{"key":"1622_CR28","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","volume":"315","author":"M Egger","year":"1997","unstructured":"Egger M, Davey SG (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629\u2013634","journal-title":"BMJ"},{"key":"1622_CR29","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1188\/06.CJON.487-492","volume":"10","author":"J Aistars","year":"2005","unstructured":"Aistars J (2005) The validity of skin care protocols followed by women with breast cancer receiving external radiation. Clin J Oncol Nurs 10:487\u2013493","journal-title":"Clin J Oncol Nurs"},{"key":"1622_CR30","first-page":"11","volume":"13","author":"E Sitton","year":"1992","unstructured":"Sitton E (1992) Early and late radiation-induced skin alterations. part I: mechanisms of skin reactions. Oncol Nurs Forum 13:11\u201316","journal-title":"Oncol Nurs Forum"},{"key":"1622_CR31","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jaad.2005.08.054","volume":"54","author":"SR Hymes","year":"2006","unstructured":"Hymes SR, Strom EA, Fife C (2006) Radiation dermatitis: clinical presentation, pathophysiology, and treatment 2006. J Am Acad Dermatol 54:28\u201346","journal-title":"J Am Acad Dermatol"},{"key":"1622_CR32","first-page":"144","volume":"18","author":"CF Dunne-Daly","year":"1995","unstructured":"Dunne-Daly CF (1995) Skin and wound care in radiation oncology. Canc Nurs 18:144\u2013162","journal-title":"Canc Nurs"},{"key":"1622_CR33","doi-asserted-by":"crossref","first-page":"9991","DOI":"10.1073\/pnas.89.21.9991","volume":"89","author":"BN Cronstein","year":"1992","unstructured":"Cronstein BN, Kimmel SC, Levin RI et al (1992) A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1. Proc Natl Acad Sci 89:9991\u20139995","journal-title":"Proc Natl Acad Sci"},{"key":"1622_CR34","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1242\/jcs.036517","volume":"122","author":"TJ Shaw","year":"2009","unstructured":"Shaw TJ, Martin P (2009) Wound repair at a glance. J Cell Sci 122:3215\u20133223","journal-title":"J Cell Sci"},{"key":"1622_CR35","first-page":"45","volume-title":"Acute and chronic wounds: nursing management","author":"D Doughty","year":"1992","unstructured":"Doughty D (1992) Principles of wound healing and wound management. In: Bryant BA (ed) Acute and chronic wounds: nursing management. Moshy-Year Book, St Louis, p 45"},{"key":"1622_CR36","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0029-6465(22)00234-1","volume":"25","author":"AN Hotter","year":"1990","unstructured":"Hotter AN (1990) Wound healing and immunocompromise. Nurs Clin North Am 25:193\u2013203","journal-title":"Nurs Clin North Am"},{"key":"1622_CR37","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1742-481X.2008.00436.x","volume":"5","author":"A Olascoaga","year":"2008","unstructured":"Olascoaga A, Vilar-Compte D, Poitevin-Chacon A et al (2008) Wound healing in radiated skin: pathophysiology and treatment options. Int Wound J 5:246\u2013257","journal-title":"Int Wound J"},{"key":"1622_CR38","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2174\/156720107781023857","volume":"4","author":"R Braund","year":"2007","unstructured":"Braund R, Hook S, Medlicott NJ (2007) The role of topical growth factors in chronic wounds. Curr Drug Deliv 4:195\u2013204","journal-title":"Curr Drug Deliv"},{"key":"1622_CR39","doi-asserted-by":"crossref","first-page":"80S","DOI":"10.1016\/S0002-9610(98)00186-X","volume":"176","author":"MC Robson","year":"1998","unstructured":"Robson MC, Mustoe TA, Hunt TK (1998) The future of recombinant growth factors in wound healing. Am J Surg 176:80S\u201382S","journal-title":"Am J Surg"},{"key":"1622_CR40","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/00129334-200401000-00012","volume":"17","author":"R Goldman","year":"2004","unstructured":"Goldman R (2004) Growth factors and chronic wound healing: past, present, and future. Adv Skin Wound Care 17:24\u201335","journal-title":"Adv Skin Wound Care"},{"key":"1622_CR41","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0094-1298(20)32471-8","volume":"25","author":"DL Steed","year":"1998","unstructured":"Steed DL (1998) Modifying the wound healing response with exogenous growth factors. Clin Plast Surg 25:397\u2013405","journal-title":"Clin Plast Surg"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-012-1622-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00520-012-1622-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-012-1622-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T05:23:45Z","timestamp":1687757025000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00520-012-1622-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,12]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["1622"],"URL":"https:\/\/doi.org\/10.1007\/s00520-012-1622-5","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,12]]}}}