{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:51:34Z","timestamp":1792101094516,"version":"4.4.0"},"reference-count":86,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2013,7,6]],"date-time":"2013-07-06T00:00:00Z","timestamp":1373068800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1007\/s00520-013-1871-y","type":"journal-article","created":{"date-parts":[[2013,7,5]],"date-time":"2013-07-05T04:28:57Z","timestamp":1372998537000},"page":"3191-3207","source":"Crossref","is-referenced-by-count":124,"title":["Systematic review of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the management of oral mucositis in cancer patients"],"prefix":"10.1007","volume":"21","author":[{"name":"For The Mucositis Study Group of the Multinational Association of Supportive Care in Cancer\/International Society of Oral Oncology (MASCC\/ISOO)","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah P.","family":"Saunders","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel B.","family":"Epstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Elad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Allemano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Bossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne D.","family":"van de Wetering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil G.","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carin","family":"Potting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karis K.","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Freidank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Bowen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristopher","family":"Dennis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh V.","family":"Lalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,7,6]]},"reference":[{"issue":"4","key":"1871_CR1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s005200050179","volume":"6","author":"IA Adamietz","year":"1998","unstructured":"Adamietz IA et al (1998) Prophylaxis with povidone\u2013iodine against induction of oral mucositis by radiochemotherapy. Support Care Cancer 6(4):373\u2013377","journal-title":"Support Care Cancer"},{"issue":"1","key":"1871_CR2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/07357909509024890","volume":"13","author":"RR Allison","year":"1995","unstructured":"Allison RR et al (1995) Symptomatic acute mucositis can be minimized or prophylaxed by the combination of sucralfate and fluconazole. Cancer Invest 13(1):16\u201322","journal-title":"Cancer Invest"},{"issue":"2","key":"1871_CR3","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.ijrobp.2005.07.301","volume":"64","author":"D Alterio","year":"2006","unstructured":"Alterio D et al (2006) Tetracaine oral gel in patients treated with radiotherapy for head-and-neck cancer: final results of a phase II study. Int J Radiat Oncol Biol Phys 64(2):392\u2013395","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"9","key":"1871_CR4","first-page":"30","volume":"16","author":"Anonymous","year":"2009","unstructured":"Anonymous (2009) The clinical effectiveness of Gelclair in the management of oral mucositis. Aust Nurs J 16(9):30\u201333","journal-title":"Aust Nurs J"},{"issue":"2","key":"1871_CR5","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/hed.21165","volume":"32","author":"V Bar Ad","year":"2010","unstructured":"Bar Ad V, Weinstein G et al (2010) Gabapentin for the treatment of pain related to radiation-induced mucositis in patients with head and neck tumors treated with intensity-modulated radiation therapy. Head & Neck 32(2):173\u2013177","journal-title":"Head & Neck"},{"issue":"17","key":"1871_CR6","doi-asserted-by":"crossref","first-page":"4206","DOI":"10.1002\/cncr.25274","volume":"116","author":"V Bar Ad","year":"2010","unstructured":"Bar Ad V, Weinstein G et al (2010) Gabapentin for the treatment of pain syndrome related to radiation-induced mucositis in patients with head and neck cancer treated with concurrent chemoradiotherapy. Cancer 116(17):4206\u20134213","journal-title":"Cancer"},{"issue":"6","key":"1871_CR7","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/s00520-006-0066-1","volume":"14","author":"A Barasch","year":"2006","unstructured":"Barasch A et al (2006) Antimicrobials, mucosal coating agents, anesthetics, analgesics, and nutritional supplements for alimentary tract mucositis. Support Care Cancer 14(6):528\u2013532","journal-title":"Support Care Cancer"},{"issue":"4","key":"1871_CR8","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00520-006-0171-1","volume":"15","author":"C Barber","year":"2007","unstructured":"Barber C et al (2007) Comparing pain control and ability to eat and drink with standard therapy vs Gelclair: a preliminary, double centre, randomised controlled trial on patients with radiotherapy-induced oral mucositis. Support Care Cancer 15(4):427\u2013440","journal-title":"Support Care Cancer"},{"issue":"3","key":"1871_CR9","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/0030-4220(91)90301-R","volume":"71","author":"G Barker","year":"1991","unstructured":"Barker G et al (1991) The effects of sucralfate suspension and diphenhydramine syrup plus kaolin\u2013pectin on radiotherapy-induced mucositis. Oral Surg Oral Med Oral Pathol 71(3):288\u2013293","journal-title":"Oral Surg Oral Med Oral Pathol"},{"issue":"1","key":"1871_CR10","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S1368-8375(00)00054-3","volume":"37","author":"LA Bellm","year":"2001","unstructured":"Bellm LA et al (2001) Assessment of various topical oral formulations by bone marrow transplant recipients. Oral Oncol 37(1):42\u201349","journal-title":"Oral Oncol"},{"issue":"3","key":"1871_CR11","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0885-3924(94)00130-D","volume":"10","author":"A Berger","year":"1995","unstructured":"Berger A et al (1995) Oral capsaicin provides temporary relief for oral mucositis pain secondary to chemotherapy\/radiation therapy. J Pain Symptom Manage 10(3):243\u2013248","journal-title":"J Pain Symptom Manage"},{"issue":"6988","key":"1871_CR12","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1136\/bmj.310.6988.1169","volume":"310","author":"OJ Bergmann","year":"1995","unstructured":"Bergmann OJ et al (1995) Acyclovir given as prophylaxis against oral ulcers in acute myeloid leukaemia: randomised, double blind, placebo controlled trial. BMJ 310(6988):1169\u20131172","journal-title":"BMJ"},{"issue":"5","key":"1871_CR13","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S1368-8375(97)00039-0","volume":"33","author":"E Bondi","year":"1997","unstructured":"Bondi E et al (1997) Local antimicrobial therapy of oral mucositis in paediatric patients undergoing bone marrow transplantation. Oral Oncol 33(5):322\u2013326","journal-title":"Oral Oncol"},{"key":"1871_CR14","unstructured":"Bowen J, Elad S, Hutchins R, Lalla RV, for the Mucositis Study Group of MASCC\/ISOO (2012). Methodology for the MASCC\/ISOO Mucositis Guidelines Update. Support Care Cancer. 21(1):303\u20138"},{"issue":"6","key":"1871_CR15","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1128\/AAC.33.6.862","volume":"33","author":"GJ Bubley","year":"1989","unstructured":"Bubley GJ et al (1989) Effect of acyclovir on radiation- and chemotherapy-induced mouth lesions. Antimicrob Agents Chemother 33(6):862\u2013865","journal-title":"Antimicrob Agents Chemother"},{"issue":"18","key":"1871_CR16","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1517\/14656560802504508","volume":"9","author":"Q Cai","year":"2008","unstructured":"Cai Q et al (2008) Efficacy and safety of transdermal fentanyl for treatment of oral mucositis pain caused by chemotherapy. Expert Opin Pharmacother 9(18):3137\u20133144","journal-title":"Expert Opin Pharmacother"},{"issue":"4","key":"1871_CR17","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1177\/019459989010200404","volume":"102","author":"SB Carnel","year":"1990","unstructured":"Carnel SB et al (1990) Treatment of radiation- and chemotherapy-induced stomatitis. Otolaryngol Head Neck Surg 102(4):326\u2013330","journal-title":"Otolaryngol. Head Neck Surg"},{"issue":"8","key":"1871_CR18","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/(SICI)1097-0347(199912)21:8<760::AID-HED12>3.0.CO;2-#","volume":"21","author":"DL Carter","year":"1999","unstructured":"Carter DL et al (1999) Double blind randomized trial of sucralfate vs placebo during radical radiotherapy for head and neck cancers. Head Neck 21(8):760\u2013766","journal-title":"Head Neck"},{"issue":"7","key":"1871_CR19","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1023\/A:1011119721267","volume":"12","author":"L Castagna","year":"2001","unstructured":"Castagna L et al (2001) Prevention of mucositis in bone marrow transplantation: a double blind randomised controlled trial of sucralfate. Ann Oncol 12(7):953\u2013955","journal-title":"Ann Oncol"},{"issue":"1","key":"1871_CR20","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/00004836-199901000-00009","volume":"28","author":"M Cengiz","year":"1999","unstructured":"Cengiz M et al (1999) Sucralfate in the prevention of radiation-induced oral mucositis. J Clin Gastroenterol 28(1):40\u201343","journal-title":"J Clin Gastroenterol"},{"issue":"10","key":"1871_CR21","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1002\/cncr.10938","volume":"95","author":"LC Cerchietti","year":"2002","unstructured":"Cerchietti LC et al (2002) Effect of topical morphine for mucositis-associated pain following concomitant chemoradiotherapy for head and neck carcinoma. Cancer 95(10):2230\u20132236","journal-title":"Cancer"},{"issue":"1\u20132","key":"1871_CR22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0304-3959(03)00227-6","volume":"105","author":"LC Cerchietti","year":"2003","unstructured":"Cerchietti LC et al (2003) Potential utility of the peripheral analgesic properties of morphine in stomatitis-related pain: a pilot study. Pain 105(1\u20132):265\u2013273","journal-title":"Pain"},{"issue":"5","key":"1871_CR23","first-page":"3707","volume":"21","author":"S Chiara","year":"2001","unstructured":"Chiara S et al (2001) Sucralfate in the treatment of chemotherapy-induced stomatitis: a double-blind, placebo-controlled pilot study. Anticancer Res 21(5):3707\u20133710","journal-title":"Anticancer Res"},{"issue":"3","key":"1871_CR24","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0304-3959(97)00059-6","volume":"72","author":"BA Coda","year":"1997","unstructured":"Coda BA et al (1997) Comparative efficacy of patient-controlled administration of morphine, hydromorphone, or sufentanil for the treatment of oral mucositis pain following bone marrow transplantation. Pain 72(3):333\u2013346","journal-title":"Pain"},{"issue":"5","key":"1871_CR25","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/S0022-3476(96)70156-7","volume":"129","author":"JJ Collins","year":"1996","unstructured":"Collins JJ et al (1996) Patient-controlled analgesia for mucositis pain in children: a three-period crossover study comparing morphine and hydromorphone. J Pediatr 129(5):722\u2013728","journal-title":"J Pediatr"},{"issue":"3","key":"1871_CR26","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1365-2354.2007.00855.x","volume":"17","author":"R Corvo","year":"2008","unstructured":"Corvo R et al (2008) Effects of fluconazole in the prophylaxis of oropharyngeal candidiasis in patients undergoing radiotherapy for head and neck tumour: results from a double-blind placebo-controlled trial. Eur J Cancer Care (Engl) 17(3):270\u2013277","journal-title":"Eur J Cancer Care (Engl)"},{"issue":"12","key":"1871_CR27","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/sj.bmt.1704515","volume":"33","author":"F Demarosi","year":"2004","unstructured":"Demarosi F et al (2004) Transdermal fentanyl in HSCT patients: an open trial using transdermal fentanyl for the treatment of oral mucositis pain. Bone Marrow Transplant 33(12):1247\u20131251","journal-title":"Bone Marrow Transplant"},{"issue":"1","key":"1871_CR28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1081\/CNV-120016400","volume":"21","author":"MJ Dodd","year":"2003","unstructured":"Dodd MJ et al (2003) Radiation-induced mucositis: a randomized clinical trial of micronized sucralfate versus salt & soda mouthwashes. Cancer Invest 21(1):21\u201333","journal-title":"Cancer Invest"},{"issue":"6","key":"1871_CR29","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1080\/02841860152619179","volume":"40","author":"E Ehrnrooth","year":"2001","unstructured":"Ehrnrooth E et al (2001) Randomized trial of opioids versus tricyclic antidepressants for radiation-induced mucositis pain in head and neck cancer. Acta Oncol 40(6):745\u2013750","journal-title":"Acta Oncol"},{"key":"1871_CR30","unstructured":"Elad S, Bowen J, Zadik Y, Lalla RV, for the Mucositis Study Group of MASCC\/ISOO (2012). Development of the MASCC\/ISOO Mucositis Guidelines: Considerations Underlying the Process. Support Care Cancer. 21(1):309\u201312"},{"issue":"19","key":"1871_CR31","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1200\/JCO.2002.05.046","volume":"20","author":"S El-Sayed","year":"2002","unstructured":"El-Sayed S et al (2002) Prophylaxis of radiation-associated mucositis in conventionally treated patients with head and neck cancer: a double-blind, phase III, randomized, controlled trial evaluating the clinical efficacy of an antimicrobial lozenge using a validated mucositis scoring system. J Clin Oncol 20(19):3956\u20133963","journal-title":"J Clin Oncol"},{"issue":"6","key":"1871_CR32","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/0030-4220(92)90009-F","volume":"73","author":"JB Epstein","year":"1992","unstructured":"Epstein JB et al (1992) Efficacy of chlorhexidine and nystatin rinses in prevention of oral complications in leukemia and bone marrow transplantation. Oral Surg Oral Med Oral Pathol 73(6):682\u2013689","journal-title":"Oral Surg Oral Med Oral Pathol"},{"issue":"3","key":"1871_CR33","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/0360-3016(94)90195-3","volume":"28","author":"JB Epstein","year":"1994","unstructured":"Epstein JB, Wong FL (1994) The efficacy of sucralfate suspension in the prevention of oral mucositis due to radiation therapy. Int J Radiat Oncol Biol Phys 28(3):693\u2013698","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"8","key":"1871_CR34","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S1368-8375(01)00005-7","volume":"37","author":"JB Epstein","year":"2001","unstructured":"Epstein JB et al (2001) Oral topical doxepin rinse: analgesic effect in patients with oral mucosal pain due to cancer or cancer therapy. Oral Oncol 37(8):632\u2013637","journal-title":"Oral Oncol"},{"issue":"2","key":"1871_CR35","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1754-4505.2008.00015.x","volume":"28","author":"JB Epstein","year":"2008","unstructured":"Epstein JB (2008) Doxepin rinse for management of mucositis pain in patients with cancer: one week follow-up of topical therapy. Spec Care Dentist 28(2):73\u201377","journal-title":"Spec. Care Dentist"},{"issue":"1","key":"1871_CR36","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S1368-8375(99)00075-5","volume":"36","author":"D Etiz","year":"2000","unstructured":"Etiz D et al (2000) Clinical and histopathological evaluation of sucralfate in prevention of oral mucositis induced by radiation therapy in patients with head and neck malignancies. Oral Oncol 36(1):116\u2013120","journal-title":"Oral Oncol"},{"issue":"6","key":"1871_CR37","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1080\/02841860152619188","volume":"40","author":"JF Evensen","year":"2001","unstructured":"Evensen JF et al (2001) Effects of Na-sucrose octasulfate on skin and mucosa reactions during radiotherapy of head and neck cancers\u2014a randomized prospective study. Acta Oncol 40(6):751\u2013755","journal-title":"Acta Oncol"},{"issue":"7","key":"1871_CR38","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1080\/1042819031000079159","volume":"44","author":"FJ Giles","year":"2003","unstructured":"Giles FJ et al (2003) A phase III, randomized, double-blind, placebo-controlled, multinational trial of iseganan for the prevention of oral mucositis in patients receiving stomatotoxic chemotherapy (PROMPT-CT trial). Leuk Lymphoma 44(7):1165\u20131172","journal-title":"Leuk Lymphoma"},{"issue":"6","key":"1871_CR39","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.leukres.2003.10.021","volume":"28","author":"FJ Giles","year":"2004","unstructured":"Giles FJ et al (2004) A phase III, randomized, double-blind, placebo-controlled, study of iseganan for the reduction of stomatitis in patients receiving stomatotoxic chemotherapy. Leuk Res 28(6):559\u2013565","journal-title":"Leuk Res"},{"issue":"6","key":"1871_CR40","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1177\/030089169608200614","volume":"82","author":"F Giorgi","year":"1996","unstructured":"Giorgi F et al (1996) Sucralfate prophylaxis of fluorouracil-induced stomatitis. Tumori 82(6):585\u2013587","journal-title":"Tumori"},{"issue":"1","key":"1871_CR41","doi-asserted-by":"crossref","first-page":"67","DOI":"10.5055\/jom.2010.0007","volume":"6","author":"A Gupta","year":"2010","unstructured":"Gupta A, Duckles B, Giordano J (2010) Use of sublingual methadone for treating pain of chemotherapy-induced oral mucositis. J Opioid Manag 6(1):67\u201369","journal-title":"J Opioid Manag"},{"issue":"7","key":"1871_CR42","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/0895-4356(96)00019-4","volume":"49","author":"DC Hadorn","year":"1996","unstructured":"Hadorn DC et al (1996) Rating the quality of evidence for clinical practice guidelines. J Clin Epidemiol 49(7):749\u2013754","journal-title":"J Clin Epidemiol"},{"issue":"2","key":"1871_CR43","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0304-3959(90)90062-I","volume":"40","author":"HF Hill","year":"1990","unstructured":"Hill HF et al (1990) Self-administration of morphine in bone marrow transplant patients reduces drug requirement. Pain 40(2):121\u2013129","journal-title":"Pain"},{"issue":"4","key":"1871_CR44","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2165\/00003088-199120040-00006","volume":"20","author":"HF Hill","year":"1991","unstructured":"Hill HF et al (1991) A computer-based system for controlling plasma opioid concentration according to patient need for analgesia. Clin Pharmacokinet 20(4):319\u2013330","journal-title":"Clin Pharmacokinet"},{"issue":"4","key":"1871_CR45","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/1097-0142(19910215)67:4<873::AID-CNCR2820670403>3.0.CO;2-3","volume":"67","author":"HF Hill","year":"1991","unstructured":"Hill HF et al (1991) Patient-controlled analgesic administration. A comparison of steady-state morphine infusions with bolus doses. Cancer 67(4):873\u2013882","journal-title":"Cancer"},{"issue":"3","key":"1871_CR46","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0304-3959(92)90235-4","volume":"49","author":"HF Hill","year":"1992","unstructured":"Hill HF et al (1992) Patient-controlled analgesic infusions: alfentanil versus morphine. Pain 49(3):301\u2013310","journal-title":"Pain"},{"issue":"9","key":"1871_CR47","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/j.1460-9592.2010.03358.x","volume":"20","author":"PJ James","year":"2010","unstructured":"James PJ, Howard RF, Williams DG (2010) The addition of ketamine to a morphine nurse- or patient-controlled analgesia infusion (PCA\/NCA) increases analgesic efficacy in children with mucositis pain. Paediatr Anaesth 20(9):805\u2013811","journal-title":"Paediatr Anaesth"},{"issue":"5","key":"1871_CR48","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1002\/cncr.22484","volume":"109","author":"DM Keefe","year":"2007","unstructured":"Keefe DM et al (2007) Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer 109(5):820\u2013831","journal-title":"Cancer"},{"issue":"10","key":"1871_CR49","doi-asserted-by":"crossref","first-page":"4488","DOI":"10.1016\/j.transproceed.2005.11.038","volume":"37","author":"JG Kim","year":"2005","unstructured":"Kim JG et al (2005) Effectiveness of transdermal fentanyl patch for treatment of acute pain due to oral mucositis in patients receiving stem cell transplantation. Transplant Proc 37(10):4488\u20134491","journal-title":"Transplant Proc"},{"issue":"2","key":"1871_CR50","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1177\/08959374940080022501","volume":"8","author":"V Kjaerheim","year":"1994","unstructured":"Kjaerheim V, Waaler SM (1994) Experiments with triclosan-containing mouthrinses: dose response\u2014and an attempt to locate the receptor site(s) of triclosan in the mouth. Adv Dent Res 8(2):302\u2013306","journal-title":"Adv Dent Res"},{"issue":"1\u20132","key":"1871_CR51","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0304-3959(98)00211-5","volume":"80","author":"M Krajnik","year":"1999","unstructured":"Krajnik M et al (1999) Potential uses of topical opioids in palliative care\u2014report of 6 cases. Pain 80(1\u20132):121\u2013125","journal-title":"Pain"},{"issue":"12","key":"1871_CR52","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1200\/JCO.1992.10.12.1963","volume":"10","author":"FG LeVeque","year":"1992","unstructured":"LeVeque FG et al (1992) Clinical evaluation of MGI 209, an anesthetic, film-forming agent for relief from painful oral ulcers associated with chemotherapy. J Clin Oncol 10(12):1963\u20131968","journal-title":"J Clin Oncol"},{"issue":"2","key":"1871_CR53","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0167-8140(97)00231-4","volume":"47","author":"Y Lievens","year":"1998","unstructured":"Lievens Y et al (1998) Does sucralfate reduce the acute side-effects in head and neck cancer treated with radiotherapy? A double-blind randomized trial. Radiother Oncol 47(2):149\u2013153","journal-title":"Radiother Oncol"},{"key":"1871_CR54","first-page":"54","volume":"16","author":"RM Logan","year":"2002","unstructured":"Logan RM (2002) Oral mucositis\u2014current concepts and management. Ann R Australas Coll Dent Surg 16:54\u201357","journal-title":"Ann R Australas Coll Dent Surg"},{"issue":"3","key":"1871_CR55","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1200\/JCO.1997.15.3.1235","volume":"15","author":"CL Loprinzi","year":"1997","unstructured":"Loprinzi CL et al (1997) Phase III controlled evaluation of sucralfate to alleviate stomatitis in patients receiving fluorouracil-based chemotherapy. J Clin Oncol 15(3):1235\u20131238","journal-title":"J Clin Oncol"},{"issue":"3","key":"1871_CR56","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0304-3959(91)90109-B","volume":"46","author":"AM Mackie","year":"1991","unstructured":"Mackie AM, Coda BC, Hill HF (1991) Adolescents use patient-controlled analgesia effectively for relief from prolonged oropharyngeal mucositis pain. Pain 46(3):265\u2013269","journal-title":"Pain"},{"issue":"1","key":"1871_CR57","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0360-3016(94)90533-9","volume":"30","author":"TA Makkonen","year":"1994","unstructured":"Makkonen TA et al (1994) Sucralfate mouth washing in the prevention of radiation-induced mucositis: a placebo-controlled double-blind randomized study. Int J Radiat Oncol Biol Phys 30(1):177\u2013182","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"1871_CR58","first-page":"135","volume":"1","author":"RH Matthews","year":"1996","unstructured":"Matthews RH, Ercal N (1996) Prevention of mucositis in irradiated head and neck cancer patients. J Exp Ther Oncol 1(2):135\u2013138","journal-title":"J Exp Ther Oncol"},{"issue":"2","key":"1871_CR59","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0360-3016(96)00531-7","volume":"37","author":"R Meredith","year":"1997","unstructured":"Meredith R et al (1997) Sucralfate for radiation mucositis: results of a double-blind randomized trial. Int J Radiat Oncol Biol Phys 37(2):275\u2013279","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"1871_CR60","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ijrobp.2012.11.014","volume":"85","author":"R Miller","year":"2013","unstructured":"Miller R et al (2013) Doxepin rinse significantly reduces mouth pain for head and neck cancer patients who receive radiation therapy. Int J Radiat Oncol Biol Phys 85(1):21","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"1871_CR61","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3109\/15360281003743294","volume":"24","author":"K Newport","year":"2010","unstructured":"Newport K, Coyne P (2010) Topical cocaine for relief of mucosal pain. J Pain Palliat Care Pharmacother 24(2):149\u2013151","journal-title":"J Pain Palliat Care Pharmacother"},{"issue":"1","key":"1871_CR62","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s00520-005-0835-2","volume":"14","author":"O Nicolatou-Galitis","year":"2006","unstructured":"Nicolatou-Galitis O et al (2006) Effect of fluconazole antifungal prophylaxis on oral mucositis in head and neck cancer patients receiving radiotherapy. Support Care Cancer 14(1):44\u201351","journal-title":"Support Care Cancer"},{"issue":"1","key":"1871_CR63","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00520-002-0378-8","volume":"11","author":"M Nottage","year":"2003","unstructured":"Nottage M et al (2003) Sucralfate mouthwash for prevention and treatment of 5-fluorouracil-induced mucositis: a randomized, placebo-controlled trial. Support Care Cancer 11(1):41\u201347","journal-title":"Support Care Cancer"},{"issue":"11","key":"1871_CR64","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1002\/(SICI)1097-0142(19970601)79:11<2193::AID-CNCR18>3.0.CO;2-R","volume":"79","author":"SH Okuno","year":"1997","unstructured":"Okuno SH et al (1997) A randomized trial of a nonabsorbable antibiotic lozenge given to alleviate radiation-induced mucositis. Cancer 79(11):2193\u20132199","journal-title":"Cancer"},{"issue":"4","key":"1871_CR65","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3109\/02841869009090032","volume":"29","author":"P Pfeiffer","year":"1990","unstructured":"Pfeiffer P et al (1990) A prospective pilot study on the effect of sucralfate mouth-swishing in reducing stomatitis during radiotherapy of the oral cavity. Acta Oncol 29(4):471\u2013473","journal-title":"Acta Oncol"},{"issue":"2","key":"1871_CR66","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3109\/02841869009126540","volume":"29","author":"P Pfeiffer","year":"1990","unstructured":"Pfeiffer P et al (1990) Effect of prophylactic sucralfate suspension on stomatitis induced by cancer chemotherapy. A randomized, double-blind cross-over study. Acta Oncol 29(2):171\u2013173","journal-title":"Acta Oncol"},{"issue":"5","key":"1871_CR67","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/sj.bmt.1701370","volume":"22","author":"LC Pillitteri","year":"1998","unstructured":"Pillitteri LC, Clark RE (1998) Comparison of a patient-controlled analgesia system with continuous infusion for administration of diamorphine for mucositis. Bone Marrow Transplant 22(5):495\u2013498","journal-title":"Bone Marrow Transplant"},{"issue":"Suppl 2","key":"1871_CR68","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000246032","volume":"195","author":"R Rahn","year":"1997","unstructured":"Rahn R et al (1997) Povidone\u2013iodine to prevent mucositis in patients during antineoplastic radiochemotherapy. Dermatology 195(Suppl 2):57\u201361","journal-title":"Dermatology"},{"issue":"2","key":"1871_CR69","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0360-3016(02)02935-8","volume":"54","author":"K Saarilahti","year":"2002","unstructured":"Saarilahti K et al (2002) Comparison of granulocyte\u2013macrophage colony-stimulating factor and sucralfate mouthwashes in the prevention of radiation-induced mucositis: a double-blind prospective randomized phase III study. Int J Radiat Oncol Biol Phys 54(2):479\u2013485","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"1871_CR70","doi-asserted-by":"crossref","first-page":"466","DOI":"10.4103\/0973-1482.77109","volume":"6","author":"PS Satheeshkumar","year":"2010","unstructured":"Satheeshkumar PS et al (2010) Effectiveness of triclosan in the management of radiation-induced oral mucositis: a randomized clinical trial. J Cancer Res Ther 6(4):466\u2013472","journal-title":"J Cancer Res Ther"},{"issue":"4","key":"1871_CR71","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1007\/s00520-004-0595-4","volume":"12","author":"L Shaiova","year":"2004","unstructured":"Shaiova L et al (2004) Tolerability and effects of two formulations of oral transmucosal fentanyl citrate (OTFC; ACTIQ) in patients with radiation-induced oral mucositis. Support Care Cancer 12(4):268\u2013273","journal-title":"Support Care Cancer"},{"issue":"5","key":"1871_CR72","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1089\/jpm.2006.0262","volume":"10","author":"L Shaiova","year":"2007","unstructured":"Shaiova L et al (2007) Administration of morphine sulfate extended-release capsules via gastrostomy: dissolution study and case reports. J Palliat Med 10(5):1063\u20131067","journal-title":"J Palliat Med"},{"issue":"4","key":"1871_CR73","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S0022-3476(88)80397-4","volume":"113","author":"JL Shenep","year":"1988","unstructured":"Shenep JL et al (1988) Efficacy of oral sucralfate suspension in prevention and treatment of chemotherapy-induced mucositis. J Pediatr 113(4):758\u2013763","journal-title":"J Pediatr"},{"issue":"3","key":"1871_CR74","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1046\/j.1526-4637.2003.03032.x","volume":"4","author":"NE Slatkin","year":"2003","unstructured":"Slatkin NE, Rhiner M (2003) Topical ketamine in the treatment of mucositis pain. Pain Med 4(3):298\u2013303","journal-title":"Pain Med"},{"issue":"6","key":"1871_CR75","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1037\/0003-066X.55.6.620","volume":"55","author":"MR Somerfield","year":"2000","unstructured":"Somerfield MR, McCrae RR (2000) Stress and coping research. Methodological challenges, theoretical advances, and clinical applications. Am Psychol 55(6):620\u2013625","journal-title":"Am Psychol"},{"issue":"10","key":"1871_CR76","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1600-0714.1990.tb00792.x","volume":"19","author":"FK Spijkervet","year":"1990","unstructured":"Spijkervet FK et al (1990) Mucositis prevention by selective elimination of oral flora in irradiated head and neck cancer patients. J Oral Pathol Med 19(10):486\u2013489","journal-title":"J Oral Pathol Med"},{"issue":"7","key":"1871_CR77","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1038\/sj.bjc.6600824","volume":"88","author":"MA Stokman","year":"2003","unstructured":"Stokman MA et al (2003) Oral mucositis and selective elimination of oral flora in head and neck cancer patients receiving radiotherapy: a double-blind randomised clinical trial. Br J Cancer 88(7):1012\u20131016","journal-title":"Br J Cancer"},{"issue":"3","key":"1871_CR78","first-page":"659","volume":"7","author":"C Strupp","year":"2000","unstructured":"Strupp C et al (2000) Transdermal fentanyl during high-dose chemotherapy and autologous stem cell support. Oncol Rep 7(3):659\u2013661","journal-title":"Oncol Rep"},{"issue":"2","key":"1871_CR79","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/bjc.1996.359","volume":"74","author":"RP Symonds","year":"1996","unstructured":"Symonds RP et al (1996) The reduction of radiation mucositis by selective decontamination antibiotic pastilles: a placebo-controlled double-blind trial. Br J Cancer 74(2):312\u2013317","journal-title":"Br J Cancer"},{"issue":"6","key":"1871_CR80","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s10637-008-9171-y","volume":"26","author":"E Topuz","year":"2008","unstructured":"Topuz E et al (2008) Effect of oral administration of kefir on serum proinflammatory cytokines on 5-FU induced oral mucositis in patients with colorectal cancer. Invest New Drugs 26(6):567\u2013572","journal-title":"Invest New Drugs"},{"issue":"3","key":"1871_CR81","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/S0360-3016(03)01627-4","volume":"58","author":"A Trotti","year":"2004","unstructured":"Trotti A et al (2004) A multinational, randomized phase III trial of iseganan HCl oral solution for reducing the severity of oral mucositis in patients receiving radiotherapy for head-and-neck malignancy. Int J Radiat Oncol Biol Phys 58(3):674\u2013681","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"7","key":"1871_CR82","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1007\/s00520-005-0792-9","volume":"13","author":"S Vokurka","year":"2005","unstructured":"Vokurka S et al (2005) The comparative effects of povidone\u2013iodine and normal saline mouthwashes on oral mucositis in patients after high-dose chemotherapy and APBSCT\u2014results of a randomized multicentre study. Support Care Cancer 13(7):554\u2013558","journal-title":"Support Care Cancer"},{"issue":"2","key":"1871_CR83","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0360-3016(01)01444-4","volume":"50","author":"OB Wijers","year":"2001","unstructured":"Wijers OB et al (2001) Mucositis reduction by selective elimination of oral flora in irradiated cancers of the head and neck: a placebo-controlled double-blind randomized study. Int J Radiat Oncol Biol Phys 50(2):343\u2013352","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"5","key":"1871_CR84","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1006\/phrs.1999.0613","volume":"41","author":"PC Woo","year":"2000","unstructured":"Woo PC et al (2000) Clarithromycin attenuates cyclophosphamide-induced mucositis in mice. Pharmacol Res 41(5):527\u2013532","journal-title":"Pharmacol Res"},{"issue":"1","key":"1871_CR85","doi-asserted-by":"crossref","first-page":"23","DOI":"10.7883\/yoken.JJID.2007.23","volume":"60","author":"S Yoneda","year":"2007","unstructured":"Yoneda S et al (2007) Effects of oral care on development of oral mucositis and microorganisms in patients with esophageal cancer. Jpn J Infect Dis 60(1):23\u201328","journal-title":"Jpn J Infect Dis"},{"issue":"5","key":"1871_CR86","first-page":"554","volume":"86","author":"KY Yuen","year":"2001","unstructured":"Yuen KY et al (2001) Effects of clarithromycin on oral mucositis in bone marrow transplant recipients. Haematologica 86(5):554\u2013555","journal-title":"Haematologica"}],"updated-by":[{"DOI":"10.1007\/s00520-014-2542-3","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2014,12,5]],"date-time":"2014-12-05T00:00:00Z","timestamp":1417737600000}}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-013-1871-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00520-013-1871-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-013-1871-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T22:52:02Z","timestamp":1715640722000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00520-013-1871-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,6]]},"references-count":86,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["1871"],"URL":"https:\/\/doi.org\/10.1007\/s00520-013-1871-y","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s00520-014-2542-3","asserted-by":"object"}]},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,6]]}}}