{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:38:41Z","timestamp":1782401921742,"version":"3.54.5"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2015,10,6]],"date-time":"2015-10-06T00:00:00Z","timestamp":1444089600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1007\/s00520-015-2964-6","type":"journal-article","created":{"date-parts":[[2015,10,6]],"date-time":"2015-10-06T04:37:28Z","timestamp":1444106248000},"page":"1779-1788","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Tight junction defects are seen in the buccal mucosa of patients receiving standard dose chemotherapy for cancer"],"prefix":"10.1007","volume":"24","author":[{"given":"Hannah R.","family":"Wardill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Logan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne M.","family":"Bowen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ysabella Z. A.","family":"Van Sebille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel J.","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,6]]},"reference":[{"issue":"4","key":"2964_CR1","doi-asserted-by":"crossref","first-page":"p. 277","DOI":"10.1038\/nrc1318","volume":"4","author":"S.T. Sonis","year":"2004","unstructured":"Sonis ST (2004) The pathobiology of mucositis. Nat Rev Cancer 4(4):p. 277\u2013p. 284","journal-title":"Nat Rev Cancer"},{"issue":"9","key":"2964_CR2","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s40273-013-0081-2","volume":"31","author":"A. Carlotto","year":"2013","unstructured":"Carlotto A et al. (2013) The economic burden of toxicities associated with cancer treatment: review of the literature and analysis of nausea and vomiting, diarrhoea, oral mucositis and fatigue. PharmacoEconomics 31(9):753\u2013766","journal-title":"PharmacoEconomics"},{"issue":"1","key":"2964_CR3","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00280-007-0570-0","volume":"62","author":"R.M. Logan","year":"2008","unstructured":"Logan RM et al. (2008) Characterisation of mucosal changes in the alimentary tract following administration of irinotecan: implications for the pathobiology of mucositis. Cancer Chemother Pharmacol 62(1):33\u201341","journal-title":"Cancer Chemother Pharmacol"},{"issue":"4","key":"2964_CR4","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/CCO.0b013e3281214412","volume":"19","author":"D.M. Keefe","year":"2007","unstructured":"Keefe DM (2007) Intestinal mucositis: mechanisms and management. Curr Opin Oncol 19(4):323\u2013327","journal-title":"Curr Opin Oncol"},{"issue":"5","key":"2964_CR5","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1136\/gut.47.5.632","volume":"47","author":"D.M. Keefe","year":"2000","unstructured":"Keefe DM et al. (2000) Chemotherapy for cancer causes apoptosis that precedes hypoplasia in crypts of the small intestine in humans. Gut 47(5):632\u2013637","journal-title":"Gut"},{"issue":"1","key":"2964_CR6","first-page":"21","volume":"2","author":"S.T. Sonis","year":"2004","unstructured":"Sonis ST (2004) A biological approach to mucositis. J Support Oncol 2(1):21\u201332 discussion 35-6","journal-title":"J Support Oncol"},{"issue":"1","key":"2964_CR7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1053\/j.soncn.2003.10.003","volume":"20","author":"S.T. Sonis","year":"2004","unstructured":"Sonis ST (2004) Pathobiology of mucositis. Semin Oncol Nurs 20(1):11\u201315","journal-title":"Semin Oncol Nurs"},{"issue":"7","key":"2964_CR8","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1007\/s00520-013-1810-y","volume":"21","author":"N. Al-Dasooqi","year":"2013","unstructured":"Al-Dasooqi N et al. (2013) Emerging evidence on the pathobiology of mucositis. Support Care Cancer 21(7):2075\u20132083","journal-title":"Support Care Cancer"},{"issue":"3","key":"2964_CR9","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.bbamem.2007.08.018","volume":"1778","author":"L. Gonzalez-Mariscal","year":"2008","unstructured":"Gonzalez-Mariscal L, Tapia R, Chamorro D (2008) Crosstalk of tight junction components with signaling pathways. Biochim Biophys Acta 1778(3):729\u2013756","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"2964_CR10","doi-asserted-by":"crossref","first-page":"236","DOI":"10.4161\/cbt.27222","volume":"15","author":"H.R. Wardill","year":"2014","unstructured":"Wardill HR et al. (2014) Irinotecan disrupts tight junction proteins within the gut: implications for chemotherapy-induced gut toxicity. Cancer Biol Ther 15(2):236\u2013244","journal-title":"Cancer Biol Ther"},{"issue":"5","key":"2964_CR11","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00280-012-1989-5","volume":"70","author":"H.R. Wardill","year":"2012","unstructured":"Wardill HR, Bowen JM, Gibson RJ (2012) Chemotherapy-induced gut toxicity: are alterations to intestinal tight junctions pivotal? Cancer Chemother Pharmacol 70(5):627\u2013635","journal-title":"Cancer Chemother Pharmacol"},{"issue":"4","key":"2964_CR12","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1042\/cs0920385","volume":"92","author":"D.M. Keefe","year":"1997","unstructured":"Keefe DM et al. (1997) Effect of high-dose chemotherapy on intestinal permeability in humans. Clin Sci 92(4):385\u2013389","journal-title":"Clin Sci"},{"issue":"2","key":"2964_CR13","doi-asserted-by":"crossref","first-page":"236","DOI":"10.4161\/cbt.27222","volume":"15","author":"H.R. Wardill","year":"2014","unstructured":"Wardill HR et al. (2014) Irinotecan disrupts tight junction proteins within the gut: implications for chemotherapy-induced gut toxicity. Cancer Biol Ther 15(2):236\u2013244","journal-title":"Cancer Biol Ther"},{"issue":"4","key":"2964_CR14","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00280-013-2238-2","volume":"72","author":"K. Hamada","year":"2013","unstructured":"Hamada K et al. (2013) Disruption of ZO-1\/claudin-4 interaction in relation to inflammatory responses in methotrexate-induced intestinal mucositis. Cancer Chemother Pharmacol 72(4):757\u2013765","journal-title":"Cancer Chemother Pharmacol"},{"issue":"6","key":"2964_CR15","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s00280-010-1253-9","volume":"66","author":"K. Hamada","year":"2010","unstructured":"Hamada K et al. (2010) Zonula Occludens-1 alterations and enhanced intestinal permeability in methotrexate-treated rats. Cancer Chemother Pharmacol 66(6):1031\u20131038","journal-title":"Cancer Chemother Pharmacol"},{"issue":"4","key":"2964_CR16","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/MPG.0b013e318247240d","volume":"54","author":"S. Beutheu Youmba","year":"2012","unstructured":"Beutheu Youmba S et al. (2012) Methotrexate modulates tight junctions through NF-kappaB, MEK, and JNK pathways. J Pediatr Gastroenterol Nutr 54(4):463\u2013470","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"2","key":"2964_CR17","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jss.2010.10.003","volume":"173","author":"T. Nakao","year":"2012","unstructured":"Nakao T et al. (2012) Irinotecan injures tight junction and causes bacterial translocation in rat. J Surg Res 173(2):341\u2013347","journal-title":"J Surg Res"},{"issue":"6","key":"2964_CR18","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.coph.2009.06.022","volume":"9","author":"K.L. Edelblum","year":"2009","unstructured":"Edelblum KL, Turner JR (2009) The tight junction in inflammatory disease: communication breakdown. Curr Opin Pharmacol 9(6):715\u2013720","journal-title":"Curr Opin Pharmacol"},{"issue":"3","key":"2964_CR19","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.imbio.2012.05.016","volume":"218","author":"S.A. Rebuffat","year":"2013","unstructured":"Rebuffat SA et al. (2013) IL-1beta and TSH disturb thyroid epithelium integrity in autoimmune thyroid diseases. Immunobiology 218(3):285\u2013291","journal-title":"Immunobiology"},{"key":"2964_CR20","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1749-6632.2009.04062.x","volume":"1165","author":"J.D. Schulzke","year":"2009","unstructured":"Schulzke JD et al. (2009) Epithelial tight junctions in intestinal inflammation. Ann N Y Acad Sci 1165:294\u2013300","journal-title":"Ann N Y Acad Sci"},{"issue":"7","key":"2964_CR21","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.4161\/cbt.7.7.6207","volume":"7","author":"R.M. Logan","year":"2008","unstructured":"Logan RM et al. (2008) Serum levels of NFkappaB and pro-inflammatory cytokines following administration of mucotoxic drugs. Cancer Biol Ther 7(7):1139\u20131145","journal-title":"Cancer Biol Ther"},{"issue":"5","key":"2964_CR22","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1365-2613.2011.00771.x","volume":"92","author":"N. Al-Dasooqi","year":"2011","unstructured":"Al-Dasooqi N et al. (2011) Irinotecan-induced alterations in intestinal cell kinetics and extracellular matrix component expression in the dark agouti rat. Int J Exp Pathol 92(5):357\u2013365","journal-title":"Int J Exp Pathol"},{"issue":"2","key":"2964_CR23","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1128\/MCB.06029-11","volume":"32","author":"P.M. Cummins","year":"2012","unstructured":"Cummins PM (2012) Occludin: one protein, many forms. Mol Cell Biol 32(2):242\u2013250","journal-title":"Mol Cell Biol"},{"issue":"2","key":"2964_CR24","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/SPC.0b013e32835f3e8c","volume":"7","author":"H.R. Wardill","year":"2013","unstructured":"Wardill HR, Bowen JM (2013) Chemotherapy-induced mucosal barrier dysfunction: an updated review on the role of intestinal tight junctions. Curr Opin Support Palliat Care 7(2):155\u2013161","journal-title":"Curr Opin Support Palliat Care"},{"issue":"1","key":"2964_CR25","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1743-7563.2006.00038.x","volume":"2","author":"R.J. Gibson","year":"2006","unstructured":"Gibson RJ et al. (2006) Apoptosis occurs early in the basal layer of the oral mucosa following cancer chemotherapy. Asia Pac J Clin Oncol 2(1):10","journal-title":"Asia Pac J Clin Oncol"},{"key":"2964_CR26","doi-asserted-by":"crossref","unstructured":"Al-Azri AR et al. (2014) Involvement of matrix metalloproteinases (MMP-3 and MMP-9) in the pathogenesis of irinotecan-induced oral mucositis, J Oral Pathol Med","DOI":"10.1111\/jop.12255"},{"issue":"2","key":"2964_CR27","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jss.2010.10.003","volume":"173","author":"T. Nakao","year":"2012","unstructured":"Nakao T et al. (2012) Irinotecan injures tight junction and causes bacterial translocation in rat. J Surg Res 173(2):341\u2013347","journal-title":"J Surg Res"},{"issue":"11","key":"2964_CR28","doi-asserted-by":"crossref","first-page":"p. e113273","DOI":"10.1371\/journal.pone.0113273","volume":"9","author":"H. Nassour","year":"2014","unstructured":"Nassour H, Dubreuil JD (2014) Escherichia coli STb enterotoxin dislodges claudin-1 from epithelial tight junctions. PLoS One 9(11):p. e113273","journal-title":"PLoS One"},{"issue":"8","key":"2964_CR29","doi-asserted-by":"crossref","first-page":"p. 2819","DOI":"10.1128\/IAI.00455-13","volume":"81","author":"C. Ngendahayo Muzika","year":"2013","unstructured":"Ngendahayo Muzika C, Dubreuil JD (2013) Escherichia coli heat-stable toxin b impairs intestinal epithelial barrier function by altering tight junction proteins. Infect Immun 81(8):p. 2819\u2013p. 2827","journal-title":"Infect Immun"},{"issue":"2","key":"2964_CR30","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1167\/iovs.08-2606","volume":"50","author":"K. Kimura","year":"2009","unstructured":"Kimura K, Teranishi S, Nishida T (2009) Interleukin-1beta-induced disruption of barrier function in cultured human corneal epithelial cells. Invest Ophthalmol Vis Sci 50(2):597\u2013603","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"10","key":"2964_CR31","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1258\/ebm.2010.010082","volume":"235","author":"N. Al-Dasooqi","year":"2010","unstructured":"Al-Dasooqi N et al. (2010) Matrix metalloproteinases are possible mediators for the development of alimentary tract mucositis in the dark agouti rat. Exp Biol Med (Maywood) 235(10):1244\u20131256","journal-title":"Exp Biol Med (Maywood)"},{"issue":"4","key":"2964_CR32","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.oraloncology.2006.04.011","volume":"43","author":"R.M. Logan","year":"2007","unstructured":"Logan RM et al. (2007) Nuclear factor-kappaB (NF-kappaB) and cyclooxygenase-2 (COX-2) expression in the oral mucosa following cancer chemotherapy. Oral Oncol 43(4):395\u2013401","journal-title":"Oral Oncol"},{"issue":"12","key":"2964_CR33","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1038\/ajg.2011.257","volume":"106","author":"N. Bertiaux-Vandaele","year":"2011","unstructured":"Bertiaux-Vandaele N et al. (2011) The expression and the cellular distribution of the tight junction proteins are altered in irritable bowel syndrome patients with differences according to the disease subtype. Am J Gastroenterol 106(12):2165\u20132173","journal-title":"Am J Gastroenterol"},{"key":"2964_CR34","doi-asserted-by":"crossref","unstructured":"Ma, T.Y., et al., Mechanism of TNF-{alpha} modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression. Am J Physiol Gastrointes Liver Physiol, 2005. 288(3): p. G422-G430.","DOI":"10.1152\/ajpgi.00412.2004"},{"issue":"3","key":"2964_CR35","doi-asserted-by":"crossref","first-page":"G367","DOI":"10.1152\/ajpgi.00173.2003","volume":"286","author":"T.Y. Ma","year":"2004","unstructured":"Ma TY et al. (2004) TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation. Am J Physiol Gastrointes Liver Physiol 286(3):G367\u2013G376","journal-title":"Am J Physiol Gastrointes Liver Physiol"},{"issue":"8","key":"2964_CR36","doi-asserted-by":"crossref","first-page":"5653","DOI":"10.4049\/jimmunol.180.8.5653","volume":"180","author":"R. Al-Sadi","year":"2008","unstructured":"Al-Sadi R et al. (2008) Mechanism of IL-1beta-induced increase in intestinal epithelial tight junction permeability. J Immunol 180(8):5653\u20135661","journal-title":"J Immunol"},{"issue":"3","key":"2964_CR37","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s12253-013-9733-y","volume":"20","author":"N. Al-Dasooqi","year":"2014","unstructured":"Al-Dasooqi N, Wardill HR, Gibson RJ (2014) Gastrointestinal mucositis: the role of MMP-tight junction interactions in tissue injury. Pathol Oncol Res 20(3):485\u2013491","journal-title":"Pathol Oncol Res"},{"issue":"5","key":"2964_CR38","doi-asserted-by":"crossref","first-page":"L751","DOI":"10.1152\/ajplung.90578.2008","volume":"296","author":"P.D. Vermeer","year":"2009","unstructured":"Vermeer PD et al. (2009) MMP9 modulates tight junction integrity and cell viability in human airway epithelia. Am J Physiol Lung Cell Mol Physiol 296(5):L751\u2013L762","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"5","key":"2964_CR39","first-page":"2028","volume":"180","author":"S. Jeong","year":"2012","unstructured":"Jeong S et al. (2012) Interaction of clusterin and matrix metalloproteinase-9 and its implication for epithelial homeostasis and inflammation. Am J Physiol Gastrointes Liver Physiol 180(5):2028\u20132039","journal-title":"Am J Physiol Gastrointes Liver Physiol"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-015-2964-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00520-015-2964-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-015-2964-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T07:32:29Z","timestamp":1567236749000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00520-015-2964-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,6]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["2964"],"URL":"https:\/\/doi.org\/10.1007\/s00520-015-2964-6","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,6]]}}}