{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T01:42:13Z","timestamp":1791769333918,"version":"4.3.4"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2015,11,7]],"date-time":"2015-11-07T00:00:00Z","timestamp":1446854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1007\/s00520-015-2997-x","type":"journal-article","created":{"date-parts":[[2015,11,7]],"date-time":"2015-11-07T00:02:05Z","timestamp":1446854525000},"page":"2075-2084","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Sarcopenia and inflammation are independent predictors of survival in male patients newly diagnosed with small cell lung cancer"],"prefix":"10.1007","volume":"24","author":[{"given":"Se-Il","family":"Go","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Jung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haa-Na","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myoung Hee","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Jung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Nyeo","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok-Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Hun","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyeong-Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,11,7]]},"reference":[{"key":"2997_CR1","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1067\/mlc.2001.113504","volume":"137","author":"JE Morley","year":"2001","unstructured":"Morley JE, Baumgartner RN, Roubenoff R, Mayer J, Nair KS (2001) Sarcopenia. J Lab Clin Med 137:231\u2013243","journal-title":"J Lab Clin Med"},{"key":"2997_CR2","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","volume":"12","author":"K Fearon","year":"2011","unstructured":"Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, Jatoi A, Loprinzi C, MacDonald N, Mantovani G, Davis M, Muscaritoli M, Ottery F, Radbruch L, Ravasco P, Walsh D, Wilcock A, Kaasa S, Baracos VE (2011) Definition and classification of cancer cachexia: an international consensus. Lancet Oncol 12:489\u2013495","journal-title":"Lancet Oncol"},{"key":"2997_CR3","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1093\/oxfordjournals.aje.a009520","volume":"147","author":"RN Baumgartner","year":"1998","unstructured":"Baumgartner RN, Koehler KM, Gallagher D, Romero L, Heymsfield SB, Ross RR, Garry PJ, Lindeman RD (1998) Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 147:755\u2013763","journal-title":"Am J Epidemiol"},{"key":"2997_CR4","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-003697","volume":"4","author":"J Collins","year":"2014","unstructured":"Collins J, Noble S, Chester J, Coles B, Byrne A (2014) The assessment and impact of sarcopenia in lung cancer: a systematic literature review. BMJ Open 4, e003697","journal-title":"BMJ Open"},{"key":"2997_CR5","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S1470-2045(08)70153-0","volume":"9","author":"CM Prado","year":"2008","unstructured":"Prado CM, Lieffers JR, McCargar LJ, Reiman T, Sawyer MB, Martin L, Baracos VE (2008) Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study. Lancet Oncol 9:629\u2013635","journal-title":"Lancet Oncol"},{"key":"2997_CR6","doi-asserted-by":"publisher","first-page":"2920","DOI":"10.1158\/1078-0432.CCR-08-2242","volume":"15","author":"CM Prado","year":"2009","unstructured":"Prado CM, Baracos VE, McCargar LJ, Reiman T, Mourtzakis M, Tonkin K, Mackey JR, Koski S, Pituskin E, Sawyer MB (2009) Sarcopenia as a determinant of chemotherapy toxicity and time to tumor progression in metastatic breast cancer patients receiving capecitabine treatment. Clin Cancer Res 15:2920\u20132926","journal-title":"Clin Cancer Res"},{"key":"2997_CR7","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1007\/s00520-014-2418-6","volume":"23","author":"HW Jung","year":"2015","unstructured":"Jung HW, Kim JW, Kim JY, Kim SW, Yang HK, Lee JW, Lee KW, Kim DW, Kang SB, Kim KI, Kim CH, Kim JH (2015) Effect of muscle mass on toxicity and survival in patients with colon cancer undergoing adjuvant chemotherapy. Support Care Cancer 23:687\u2013694","journal-title":"Support Care Cancer"},{"key":"2997_CR8","doi-asserted-by":"publisher","first-page":"6973","DOI":"10.1158\/1078-0432.CCR-09-1525","volume":"15","author":"BH Tan","year":"2009","unstructured":"Tan BH, Birdsell LA, Martin L, Baracos VE, Fearon KC (2009) Sarcopenia in an overweight or obese patient is an adverse prognostic factor in pancreatic cancer. Clin Cancer Res 15:6973\u20136979","journal-title":"Clin Cancer Res"},{"key":"2997_CR9","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1200\/JCO.2012.45.2722","volume":"31","author":"L Martin","year":"2013","unstructured":"Martin L, Birdsell L, Macdonald N, Reiman T, Clandinin MT, McCargar LJ, Murphy R, Ghosh S, Sawyer MB, Baracos VE (2013) Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index. J Clin Oncol 31:1539\u20131547","journal-title":"J Clin Oncol"},{"key":"2997_CR10","unstructured":"Stene GB, Helbostad JL, Amundsen T, Sorhaug S, Hjelde H, Kaasa S, Gronberg BH (2014) Changes in skeletal muscle mass during palliative chemotherapy in patients with advanced lung cancer. Acta Oncol 1\u20139"},{"key":"2997_CR11","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1503\/cmaj.1031527","volume":"172","author":"SM Alibhai","year":"2005","unstructured":"Alibhai SM, Greenwood C, Payette H (2005) An approach to the management of unintentional weight loss in elderly people. CMAJ 172:773\u2013780","journal-title":"CMAJ"},{"key":"2997_CR12","doi-asserted-by":"publisher","first-page":"E883","DOI":"10.1152\/ajpendo.00353.2004","volume":"288","author":"MJ Toth","year":"2005","unstructured":"Toth MJ, Matthews DE, Tracy RP, Previs MJ (2005) Age-related differences in skeletal muscle protein synthesis: relation to markers of immune activation. Am J Physiol Endocrinol Metab 288:E883\u2013891","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2997_CR13","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1096\/fasebj.12.10.871","volume":"12","author":"YP Li","year":"1998","unstructured":"Li YP, Schwartz RJ, Waddell ID, Holloway BR, Reid MB (1998) Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-kappaB activation in response to tumor necrosis factor alpha. FASEB J 12:871\u2013880","journal-title":"FASEB J"},{"key":"2997_CR14","doi-asserted-by":"crossref","first-page":"R1165","DOI":"10.1152\/ajpregu.2000.279.4.R1165","volume":"279","author":"YP Li","year":"2000","unstructured":"Li YP, Reid MB (2000) NF-kappaB mediates the protein loss induced by TNF-alpha in differentiated skeletal muscle myotubes. Am J Physiol Regul Integr Comp Physiol 279:R1165\u20131170","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2997_CR15","doi-asserted-by":"publisher","first-page":"R393","DOI":"10.1152\/ajpregu.00716.2007","volume":"294","author":"KA Baltgalvis","year":"2008","unstructured":"Baltgalvis KA, Berger FG, Pena MM, Davis JM, Muga SJ, Carson JA (2008) Interleukin-6 and cachexia in ApcMin\/+ mice. Am J Physiol Regul Integr Comp Physiol 294:R393\u2013401","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2997_CR16","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.3390\/ijms11041509","volume":"11","author":"SJ Meng","year":"2010","unstructured":"Meng SJ, Yu LJ (2010) Oxidative stress, molecular inflammation and sarcopenia. Int J Mol Sci 11:1509\u20131526","journal-title":"Int J Mol Sci"},{"key":"2997_CR17","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3892\/ol.2013.1735","volume":"7","author":"T Watanabe","year":"2014","unstructured":"Watanabe T, Shibata M, Nishiyama H, Soeda S, Furukawa S, Gonda K, Takenoshita S, Fujimori K (2014) Serum levels of rapid turnover proteins are decreased and related to systemic inflammation in patients with ovarian cancer. Oncol Lett 7:373\u2013377","journal-title":"Oncol Lett"},{"key":"2997_CR18","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001113","author":"G Malietzis","year":"2015","unstructured":"Malietzis G, Johns N, Al-Hassi HO, Knight SC, Kennedy RH, Fearon KC, Aziz O, Jenkins JT (2015) Low muscularity and myosteatosis is related to the host systemic inflammatory response in patients undergoing surgery for colorectal cancer. Ann Surg. doi: 10.1097\/SLA.0000000000001113","journal-title":"Ann Surg"},{"key":"2997_CR19","first-page":"349546","volume":"2014","author":"SI Kim","year":"2014","unstructured":"Kim SI, Kim HS, Kim TH, Suh DH, Kim K, No JH, Chung HH, Kim YB, Song YS (2014) Impact of underweight after treatment on prognosis of advanced-stage ovarian cancer. J Immunol Res 2014:349546","journal-title":"J Immunol Res"},{"key":"2997_CR20","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/bjc.2014.317","volume":"111","author":"MH Kang","year":"2014","unstructured":"Kang MH, Go SI, Song HN, Lee A, Kim SH, Kang JH, Jeong BK, Kang KM, Ling H, Lee GW (2014) The prognostic impact of the neutrophil-to-lymphocyte ratio in patients with small-cell lung cancer. Br J Cancer 111:452\u2013460","journal-title":"Br J Cancer"},{"key":"2997_CR21","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1056\/NEJMoa003034","volume":"346","author":"K Noda","year":"2002","unstructured":"Noda K, Nishiwaki Y, Kawahara M, Negoro S, Sugiura T, Yokoyama A, Fukuoka M, Mori K, Watanabe K, Tamura T, Yamamoto S, Saijo N, Japan Clinical Oncology G (2002) Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer. N Engl J Med 346:85\u201391","journal-title":"N Engl J Med"},{"key":"2997_CR22","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1002\/1097-0142(20000801)89:3<523::AID-CNCR7>3.0.CO;2-6","volume":"89","author":"M Paesmans","year":"2000","unstructured":"Paesmans M, Sculier JP, Lecomte J, Thiriaux J, Libert P, Sergysels R, Bureau G, Dabouis G, Van Cutsem O, Mommen P, Ninane V, Klastersky J (2000) Prognostic factors for patients with small cell lung carcinoma: analysis of a series of 763 patients included in 4 consecutive prospective trials with a minimum follow-up of 5 years. Cancer 89:523\u2013533","journal-title":"Cancer"},{"key":"2997_CR23","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","volume":"45","author":"EA Eisenhauer","year":"2009","unstructured":"Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, Rubinstein L, Shankar L, Dodd L, Kaplan R, Lacombe D, Verweij J (2009) New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 45:228\u2013247","journal-title":"Eur J Cancer"},{"key":"2997_CR24","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S0140-6736(03)15268-3","volume":"363","author":"WHOE Consultation","year":"2004","unstructured":"Consultation WHOE (2004) Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 363:157\u2013163","journal-title":"Lancet"},{"key":"2997_CR25","doi-asserted-by":"publisher","first-page":"524","DOI":"10.6061\/clinics\/2015(07)10","volume":"70","author":"Y Yin","year":"2015","unstructured":"Yin Y, Wang J, Wang X, Gu L, Pei H, Kuai S, Zhang Y, Shang Z (2015) Prognostic value of the neutrophil to lymphocyte ratio in lung cancer: a meta-analysis. Clinics (Sao Paulo) 70:524\u2013530","journal-title":"Clinics (Sao Paulo)"},{"key":"2997_CR26","first-page":"3098","volume":"8","author":"B Peng","year":"2015","unstructured":"Peng B, Wang YH, Liu YM, Ma LX (2015) Prognostic significance of the neutrophil to lymphocyte ratio in patients with non-small cell lung cancer: a systemic review and meta-analysis. Int J Clin Exp Med 8:3098\u20133106","journal-title":"Int J Clin Exp Med"},{"key":"2997_CR27","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1634\/theoncologist.2012-0169","volume":"17","author":"E Fabbro Del","year":"2012","unstructured":"Del Fabbro E, Parsons H, Warneke CL, Pulivarthi K, Litton JK, Dev R, Palla SL, Brewster A, Bruera E (2012) The relationship between body composition and response to neoadjuvant chemotherapy in women with operable breast cancer. Oncologist 17:1240\u20131245","journal-title":"Oncologist"},{"key":"2997_CR28","volume":"7","author":"O Mir","year":"2012","unstructured":"Mir O, Coriat R, Blanchet B, Durand JP, Boudou-Rouquette P, Michels J, Ropert S, Vidal M, Pol S, Chaussade S, Goldwasser F (2012) Sarcopenia predicts early dose-limiting toxicities and pharmacokinetics of sorafenib in patients with hepatocellular carcinoma. PLoS One 7, e37563","journal-title":"PLoS One"},{"key":"2997_CR29","doi-asserted-by":"publisher","first-page":"2302","DOI":"10.1016\/j.biocel.2013.06.016","volume":"45","author":"V Baracos","year":"2013","unstructured":"Baracos V, Kazemi-Bajestani SM (2013) Clinical outcomes related to muscle mass in humans with cancer and catabolic illnesses. Int J Biochem Cell Biol 45:2302\u20132308","journal-title":"Int J Biochem Cell Biol"},{"key":"2997_CR30","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1093\/annonc\/mdp605","volume":"21","author":"S Antoun","year":"2010","unstructured":"Antoun S, Baracos VE, Birdsell L, Escudier B, Sawyer MB (2010) Low body mass index and sarcopenia associated with dose-limiting toxicity of sorafenib in patients with renal cell carcinoma. Ann Oncol 21:1594\u20131598","journal-title":"Ann Oncol"},{"key":"2997_CR31","doi-asserted-by":"publisher","first-page":"3264","DOI":"10.1158\/1078-0432.CCR-06-3067","volume":"13","author":"CM Prado","year":"2007","unstructured":"Prado CM, Baracos VE, McCargar LJ, Mourtzakis M, Mulder KE, Reiman T, Butts CA, Scarfe AG, Sawyer MB (2007) Body composition as an independent determinant of 5-fluorouracil-based chemotherapy toxicity. Clin Cancer Res 13:3264\u20133268","journal-title":"Clin Cancer Res"},{"key":"2997_CR32","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.canlet.2014.10.037","volume":"356","author":"Y Togashi","year":"2015","unstructured":"Togashi Y, Kogita A, Sakamoto H, Hayashi H, Terashima M, de Velasco MA, Sakai K, Fujita Y, Tomida S, Kitano M, Okuno K, Kudo M, Nishio K (2015) Activin signal promotes cancer progression and is involved in cachexia in a subset of pancreatic cancer. Cancer Lett 356:819\u2013827","journal-title":"Cancer Lett"},{"key":"2997_CR33","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1172\/JCI200420174","volume":"114","author":"S Acharyya","year":"2004","unstructured":"Acharyya S, Ladner KJ, Nelsen LL, Damrauer J, Reiser PJ, Swoap S, Guttridge DC (2004) Cancer cachexia is regulated by selective targeting of skeletal muscle gene products. J Clin Invest 114:370\u2013378","journal-title":"J Clin Invest"},{"key":"2997_CR34","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1513\/AnnalsATS.201307-229OC","volume":"11","author":"ML McDonald","year":"2014","unstructured":"McDonald ML, Diaz AA, Ross JC, San Jose Estepar R, Zhou L, Regan EA, Eckbo E, Muralidhar N, Come CE, Cho MH, Hersh CP, Lange C, Wouters E, Casaburi RH, Coxson HO, Macnee W, Rennard SI, Lomas DA, Agusti A, Celli BR, Black-Shinn JL, Kinney GL, Lutz SM, Hokanson JE, Silverman EK, Washko GR (2014) Quantitative computed tomography measures of pectoralis muscle area and disease severity in chronic obstructive pulmonary disease. A cross-sectional study. Ann Am Thorac Soc 11:326\u2013334","journal-title":"Ann Am Thorac Soc"},{"key":"2997_CR35","doi-asserted-by":"publisher","first-page":"2663","DOI":"10.1245\/s10434-014-4281-6","volume":"22","author":"Y Miyamoto","year":"2015","unstructured":"Miyamoto Y, Baba Y, Sakamoto Y, Ohuchi M, Tokunaga R, Kurashige J, Hiyoshi Y, Iwagami S, Yoshida N, Yoshida M, Watanabe M, Baba H (2015) Sarcopenia is a negative prognostic factor after curative resection of colorectal cancer. Ann Surg Oncol 22:2663\u20132668","journal-title":"Ann Surg Oncol"},{"key":"2997_CR36","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1007\/s11605-013-2348-5","volume":"17","author":"RM Dodson","year":"2013","unstructured":"Dodson RM, Firoozmand A, Hyder O, Tacher V, Cosgrove DP, Bhagat N, Herman JM, Wolfgang CL, Geschwind JF, Kamel IR, Pawlik TM (2013) Impact of sarcopenia on outcomes following intra-arterial therapy of hepatic malignancies. J Gastrointest Surg 17:2123\u20132132","journal-title":"J Gastrointest Surg"},{"key":"2997_CR37","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1093\/jnci\/83.12.855","volume":"83","author":"M Fukuoka","year":"1991","unstructured":"Fukuoka M, Furuse K, Saijo N, Nishiwaki Y, Ikegami H, Tamura T, Shimoyama M, Suemasu K (1991) Randomized trial of cyclophosphamide, doxorubicin, and vincristine versus cisplatin and etoposide versus alternation of these regimens in small-cell lung cancer. J Natl Cancer Inst 83:855\u2013861","journal-title":"J Natl Cancer Inst"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-015-2997-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00520-015-2997-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-015-2997-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-015-2997-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T09:49:47Z","timestamp":1567331387000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00520-015-2997-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,7]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["2997"],"URL":"https:\/\/doi.org\/10.1007\/s00520-015-2997-x","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,7]]}}}