{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:24:48Z","timestamp":1786980288179,"version":"build-2736575974"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T00:00:00Z","timestamp":1459382400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1007\/s00520-016-3139-9","type":"journal-article","created":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T23:25:43Z","timestamp":1459380343000},"page":"3687-3693","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Bisphosphonate-related osteonecrosis of the jaw: a review of the potential efficacy of low-level laser therapy"],"prefix":"10.1007","volume":"24","author":[{"given":"S.","family":"Latifyan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. T.","family":"Genot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Klastersky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,3,31]]},"reference":[{"key":"3139_CR1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00520-013-2017-y","volume":"22","author":"S-H Lee","year":"2014","unstructured":"Lee S-H et al. (2014) Use of bisphosphonates and the risk of osteonecrosis among cancer patients: a systemic review and meta-analysis of the observational studies. Support Care Cancer 22:553\u2013560","journal-title":"Support Care Cancer"},{"issue":"6","key":"3139_CR2","doi-asserted-by":"crossref","first-page":"vi168","DOI":"10.1093\/annonc\/mdm250","volume":"18","author":"G Campisi","year":"2007","unstructured":"Campisi G et al. (2007) Bisphosphonate-related osteonecrosis of the jaw (BRONJ): run dental management designs and issues in diagnosis. Ann Oncol 18(6):vi168\u2013vi172","journal-title":"Ann Oncol"},{"key":"3139_CR3","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nrendo.2010.195","volume":"7","author":"CA Migliorati","year":"2011","unstructured":"Migliorati CA et al. (2011) Osteonecrosis of the jaw and bisphosphonates in cancer: a narrative review, Nature 2011. Nat Rev Endocrinol 7:34\u201342","journal-title":"Nat Rev Endocrinol"},{"key":"3139_CR4","unstructured":"American Association of Oral and Maxillofacial Surgeons Position Paper on Bisphosphonate-Related Osteonecrosis of the Jaws. Advisory Task Force on Bisphosphonate-Related Osteonecrosis of the Jaws. J Oral Maxillofac Surg 2007; 65: 369"},{"key":"3139_CR5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1146\/annurev.med.60.063007.134350","volume":"60","author":"SL Ruggiero","year":"2009","unstructured":"Ruggiero SL et al. (2009) Bisphosphonate-related osteonecrosis of the Jaw: Diagnosis, prevention, and management. Annu Rev Med 60:85\u201396","journal-title":"Annu Rev Med"},{"issue":"4","key":"3139_CR6","first-page":"181","volume":"59","author":"P Vescovi","year":"2010","unstructured":"Vescovi P et al. (2010) Bisphosphonate-related osteonecrosis of the jaw (BRONJ) therapy. A critical review. Minerva Stomatol 59(4):181\u2013213","journal-title":"Minerva Stomatol"},{"key":"3139_CR7","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1600-0714.2011.01091.x","volume":"41","author":"P Vescovi","year":"2012","unstructured":"Vescovi P et al. (2012) Bisphosphonate-related osteonecrosis of the jaws: a concise review of the literature and a report of a single-centre experience with 151 patients. J Oral Pathol Med 41:214\u2013221","journal-title":"J Oral Pathol Med"},{"issue":"6","key":"3139_CR8","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s10103-011-0974-2","volume":"26","author":"B Atalay","year":"2011","unstructured":"Atalay B et al. (2011) Bisphosphonate-related osteonecrosis: laser-assisted surgical treatment or conventional surgery? Lasers Med Sci 26(6):815\u2013823","journal-title":"Lasers Med Sci"},{"issue":"7","key":"3139_CR9","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1089\/pho.2010.2835","volume":"29","author":"U Romeo","year":"2011","unstructured":"Romeo U et al. (2011) Observation of pain control in patients with bisphosphonate-induced osteonecrosis using low level laser therapy: preliminary results. Photomed Laser Surg 29(7):447\u2013452","journal-title":"Photomed Laser Surg"},{"issue":"2","key":"3139_CR10","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1089\/pho.2009.2501","volume":"28","author":"M Scoletta","year":"2010","unstructured":"Scoletta M et al. (2010) Effect of low-level laser irradiation on bisphonate-induced osteonecrosis of the jaws: preliminary results of a prospective study. Photomed Laser Surg 28(2):179\u2013184","journal-title":"Photomed Laser Surg"},{"key":"3139_CR11","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.oraloncology.2011.08.010","volume":"48","author":"MAT Martins","year":"2012","unstructured":"Martins MAT et al. (2012) Association of laser phototherapy with PRP improves healing of bisphosphonate-related osteonecrosis of the jaws in cancer patients: a preliminary study. Oral Oncol 48:79\u201384","journal-title":"Oral Oncol"},{"issue":"8","key":"3139_CR12","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1089\/pho.2014.3742","volume":"32","author":"MA Altay","year":"2014","unstructured":"Altay MA et al. (2014) Low-level laser therapy supported surgical treatment of bisphosphonate related osteonecrosis of jaws: a retrospective analysis of 11 cases. Photomed Laser Surg 32(8):468\u2013475","journal-title":"Photomed Laser Surg"},{"issue":"6","key":"3139_CR13","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s10103-009-0654-7","volume":"24","author":"F Angiero","year":"2009","unstructured":"Angiero F et al. (2009) Osteonecrosis of the jaws caused by bisphosphonates: evaluation of a new therapeutic approach using the Er: YAG laser. Lasers Med Sci 24(6):849\u2013856","journal-title":"Lasers Med Sci"},{"issue":"4","key":"3139_CR14","doi-asserted-by":"crossref","first-page":"e680","DOI":"10.4317\/medoral.18812","volume":"18","author":"P Vescovi","year":"2013","unstructured":"Vescovi P et al. (2013) Case series of 589 tooth extractions in patients under bisphosphonates therapy, Proposal of a clinical protocol supported by Nd: YAG low-level laser therapy. Med Oral Patol Oral Cir Bucal 18(4):e680\u2013e685","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"3139_CR15","doi-asserted-by":"crossref","first-page":"107690","DOI":"10.1155\/2014\/107690","volume":"2014","author":"P Vescovi","year":"2014","unstructured":"Vescovi P et al. (2014) Conservative surgical management of stage I bisphosphonate-related osteonecrosis of the jaw. Int J Dent 2014:107690","journal-title":"Int J Dent"},{"issue":"11","key":"3139_CR16","first-page":"1144","volume":"117","author":"S St\u00fcbinger","year":"2007","unstructured":"St\u00fcbinger S et al. (2007) Le laser Er: YAG dans le domaine de la chirurgie dento-alv\u00e9olaire. Rev Mens Suisse Odontostomatol 117(11):1144\u20131146","journal-title":"Rev Mens Suisse Odontostomatol"},{"issue":"1","key":"3139_CR17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1089\/pho.2007.2026","volume":"26","author":"ME Gerbi","year":"2008","unstructured":"Gerbi ME et al. (2008) Infrared laser light further improves bone healing when associated with bone morphogenic proteins: An in vivo study in a rodent model. Photomed Laser Surg 26(1):55\u201360","journal-title":"Photomed Laser Surg"},{"issue":"2","key":"3139_CR18","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s10103-013-1382-6","volume":"30","author":"JY Lee","year":"2015","unstructured":"Lee JY et al. (2015) Effect of low-level laser therapy on oral keratinocytes exposed to bisphosphonate. Lasers Med Sci 30(2):635\u2013643","journal-title":"Lasers Med Sci"},{"key":"3139_CR19","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1007\/s00520-008-0439-8","volume":"16","author":"MT Genot-Klastersky","year":"2008","unstructured":"Genot-Klastersky MT et al. (2008) The use of low-energy laser (LEL) for the prevention of chemotherapy-and\/or radiotherapy-induced oral mucositis in cancer patients: results from two prospective studies. Support Care Cancer 16:1381\u20131387","journal-title":"Support Care Cancer"},{"key":"3139_CR20","doi-asserted-by":"crossref","first-page":"vi78","DOI":"10.1093\/annonc\/mdr391","volume":"6","author":"DE Peterson","year":"2011","unstructured":"Peterson DE et al. (2011) ESMO Guidelines working group. Management of oral and gastrointestinal mucositis: ESMO Clinical Practice Guidelines. Ann Oncol 6:vi78\u2013vi84","journal-title":"Ann Oncol"},{"issue":"10","key":"3139_CR21","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1002\/cncr.28592","volume":"120","author":"RV Lalla","year":"2014","unstructured":"Lalla RV et al. (2014) Mucositis guidelines leadership group of the multinational association of supportive care in cancer and international society of oral oncology. MASCC\/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer 120(10):1453\u20131461","journal-title":"Cancer"},{"key":"3139_CR22","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/lsm.1900050105","volume":"5","author":"E Mester","year":"1985","unstructured":"Mester E, Mester AF, Mester A (1985) The biomedical effects of laser application. Lasers Surg Med 5:31\u201339","journal-title":"Lasers Surg Med"},{"key":"3139_CR23","first-page":"53","volume":"2","author":"TI Karu","year":"1988","unstructured":"Karu TI (1988) Molecular mechanism of the therapeutic effect of low-intensity laser radiation. Lasers Life Sci 2:53\u201374","journal-title":"Lasers Life Sci"},{"key":"3139_CR24","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1046\/j.1523-1747.2003.12130.x","volume":"120","author":"Y Zhang","year":"2003","unstructured":"Zhang Y, Song S, Fong CC, Tsang CH, Yang Z, Yang M (2003) cDNA microarray analysis of gene expression profiles in human fibroblast cells irradiated with red light. J Investig Dermatol 120:849\u2013857","journal-title":"J Investig Dermatol"},{"key":"3139_CR25","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1011-1344(03)00058-7","volume":"70","author":"I Garavello-Freitas","year":"2003","unstructured":"Garavello-Freitas I, Baranauskas V, Joazeiro PP, et al. (2003) Low-power laser irradiation improves histomorphometrical parameters and bone matrix organization during tibia wound healing in rats. J Photochem Photobiol B 70:81\u201389","journal-title":"J Photochem Photobiol B"},{"key":"3139_CR26","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/1523-1747.ep12583090","volume":"107","author":"HS Yu","year":"1996","unstructured":"Yu HS, Chang KL, Yu CL, Chen JW, Chen GS (1996) Low-energy helium-neon laser irradiation stimulates interleukin-1 alpha and interleukin-8 release from cultured human keratinocytes. J Investig Dermatol 107:593\u2013596","journal-title":"J Investig Dermatol"},{"key":"3139_CR27","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/lsm.1062","volume":"28","author":"N Kipshidze","year":"2001","unstructured":"Kipshidze N, Nikolaychik V, Keelan MH, Shankar LR, Khanna A, Kornowski R, Leon M, Moses J (2001) Low-power helium: neon laser irradiation enhances production of vascular endothelial growth factor and promotes growth of endothelial cells in vitro. Lasers Surg Med 28:355\u2013364","journal-title":"Lasers Surg Med"},{"key":"3139_CR28","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1751-1097.1994.tb05017.x","volume":"59","author":"W Yu","year":"1994","unstructured":"Yu W, Naim JO, Lanzafame RJ (1994) The effect of laser irradiation on the release of bFGF from 3T3 fibroblasts. Photochem Photobiol 59:167\u2013170","journal-title":"Photochem Photobiol"},{"issue":"2","key":"3139_CR29","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1089\/pho.2005.23.187","volume":"23","author":"GA Maiya","year":"2005","unstructured":"Maiya GA, Kumar P, Rao L (2005) \u201cEffect of low intensity helium-neon (He\u2013Ne) laser irradiation on diabetic wound healing dynamics\u201d. Photomed Laser Surg 23(2):187\u2013190","journal-title":"Photomed Laser Surg"},{"key":"3139_CR30","first-page":"171","volume":"137","author":"N Pourreau-Schneider","year":"1990","unstructured":"Pourreau-Schneider N, Ahmed A, Soudry M, Jacquemier J, Kopp F, Franquin JC, Martin PM (1990) Helium-neon laser treatment transforms fibroblasts into myofibroblasts. Am J Pathol 137:171\u2013178","journal-title":"Am J Pathol"},{"key":"3139_CR31","doi-asserted-by":"crossref","first-page":"107","DOI":"10.5978\/islsm.94-OR-04","volume":"6","author":"S Rajaratnam","year":"1994","unstructured":"Rajaratnam S, Bolton P, Dyson M (1994) Macrophage responsiveness to laser therapy with varying pulsing frequencies. Laser Ther 6:107\u2013112","journal-title":"Laser Ther"},{"key":"3139_CR32","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1089\/pho.2007.2076","volume":"25","author":"S Rochkind","year":"2007","unstructured":"Rochkind S, Leider-Trejo L, Nissan M, et al. (2007) Efficacy of 780-nm laser phototherapy on peripheral nerve regeneration after neurotube reconstruction procedure (double-blind randomized study). Photomed Laser Surg 25:137\u2013143","journal-title":"Photomed Laser Surg"},{"key":"3139_CR33","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1089\/pho.2007.2093","volume":"25","author":"S Rochkind","year":"2007","unstructured":"Rochkind S, Drory V, Alon M, et al. (2007) Laser phototherapy (780 nm), a new modality in treatment of long-term incomplete peripheral nerve injury: a randomized double-blind placebo-controlled study. Photomed Laser Surg 25:436\u2013442","journal-title":"Photomed Laser Surg"},{"issue":"3\u20134","key":"3139_CR34","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s00508-008-0932-6","volume":"120","author":"E Stein","year":"2008","unstructured":"Stein E, Koehn J, Sutter W, Wendtlandt G, Wanschitz F, Thurnher D, et al. (2008) Initial effects of low-level laser therapy on growth and differentiation of human osteoblast-like cells. Wien Klin Wochenschr 120(3\u20134):112\u2013117","journal-title":"Wien Klin Wochenschr"},{"issue":"3","key":"3139_CR35","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/PL00011357","volume":"16","author":"M Yamamoto","year":"2001","unstructured":"Yamamoto M, Tamura K, Hiratsuka K, Abiko Y (2001) Stimulation of MCM3 gene expression in osteoblast by low level laser irradiation. Lasers Med Sci 16(3):213\u2013217","journal-title":"Lasers Med Sci"},{"key":"3139_CR36","doi-asserted-by":"crossref","unstructured":"Hilal Bayrama, Halime Kenarb, Ferda Ta\u015fara, Vas\u0131f Has\u0131rc\u0131b. Effect of low level laser therapy and zoledronate on the viability and ALP activity of Saos-2 cells; International Journal of Oral and Maxillofacial Surgery; 42\/1; 01\/2013, Pages 140\u2013146","DOI":"10.1016\/j.ijom.2012.03.026"},{"issue":"10","key":"3139_CR37","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/lsm.20583","volume":"39","author":"S Hagiwara","year":"2007","unstructured":"Hagiwara S, Iwasaka H, Okuda K, Noguchi T (2007) GaAlAs (830 nm) low-level laser enhances peripheral endogenous opioid analgesia in rats. Lasers Surg Med 39(10):797\u2013802","journal-title":"Lasers Surg Med"},{"issue":"1","key":"3139_CR38","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jphotobiol.2007.08.005","volume":"89","author":"R Albertini","year":"2007","unstructured":"Albertini R, Villaverde AB, Aimbire F, Salgado MA, Bjordal JM, Alves LP, Munin E, Costa MS (2007) Anti-inflammatory effects of low-level laser therapy (LLLT) with two different red wavelengths (660 nm and 684 nm) in carrageenan-induced rat paw edema. J Photochem Photobiol B 89(1):50\u201355","journal-title":"J Photochem Photobiol B"},{"issue":"2","key":"3139_CR39","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1161\/01.CIR.85.2.756","volume":"85","author":"D Gal","year":"1992","unstructured":"Gal D, Chokshi SK, Mosseri M, Clarke RH, Isner JM (1992) Percutaneous delivery of low-level laser energy reverses histamine-induced spasm in atherosclerotic Yucatan microswine. Circulation 85(2):756\u2013768","journal-title":"Circulation"},{"issue":"Issue 3","key":"3139_CR40","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s10103-011-1006-y","volume":"27","author":"TH Huang","year":"2012","unstructured":"Huang TH, Yu Chuan L, Kao CT (2012) Low-level diode laser therapy reduces lipopolysaccharide (LPS)-induced bone cell inflammation. Lasers Med Sci 27(Issue 3):621\u2013627","journal-title":"Lasers Med Sci"},{"issue":"1","key":"3139_CR41","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1089\/104454704773660912","volume":"22","author":"N Gutknecht","year":"2004","unstructured":"Gutknecht N, Franzen R, Schippers M, Lampert F (2004) Bactericidal effect of a 980- nm diode laser in the root canal wall dentin of bovine teeth. J Clin Laser Med Surg 22(1):9\u201313","journal-title":"J Clin Laser Med Surg"},{"key":"3139_CR42","doi-asserted-by":"crossref","unstructured":"Nussbaum EL, Lilge L, Mazzulli T (2002) Effects of 810 nm laser irradiation on in vitro growth of bacteria: comparison of continuous wave and frequency modulated light. Lasers Surg Med 31(5):343\u2013351","DOI":"10.1002\/lsm.10121"},{"key":"3139_CR43","doi-asserted-by":"crossref","unstructured":"Saad F, Brown JE, Van Barrios Poznak C et al. (2012) Incidence, risk factors and outcomes of osteonecrosis of the jaw: integrated analysis from three blinded active controlled phase III in cancer patients with bone metastases. Ann Oncol 23:1341\u20131347","DOI":"10.1093\/annonc\/mdr435"},{"key":"3139_CR44","unstructured":"Stopeck AT1, Lipton A, Body JJ et al. (2010) Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study. J Clin Oncol 28(35):5132\u20135139"},{"key":"3139_CR45","doi-asserted-by":"crossref","unstructured":"Sperandio FF, Giudice FS, Corr\u00eaa L et al. (2013) Low-level laser therapy can produce increased aggressiveness of dysplastic and oral cancer cell lines by modulation of Akt\/mTOR signaling pathway. J Biophotonics 6(10):839\u2013847","DOI":"10.1002\/jbio.201300015"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-016-3139-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00520-016-3139-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-016-3139-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T20:15:24Z","timestamp":1600373724000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00520-016-3139-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,31]]},"references-count":45,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["3139"],"URL":"https:\/\/doi.org\/10.1007\/s00520-016-3139-9","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,31]]}}}