{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:53:24Z","timestamp":1769601204380,"version":"3.49.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["481119\/2011-6"],"award-info":[{"award-number":["481119\/2011-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1007\/s00520-016-3279-y","type":"journal-article","created":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T07:48:48Z","timestamp":1463471328000},"page":"4393-4398","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Chamomile infusion cryotherapy to prevent oral mucositis induced by chemotherapy: a pilot study"],"prefix":"10.1007","volume":"24","author":[{"given":"Paula Elaine Diniz","family":"dos Reis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia A.","family":"Ciol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilce Santos","family":"de Melo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Tadeu de Souza","family":"Figueiredo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 Ferreira","family":"Leite","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nat\u00e1lia de Melo","family":"Manzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"issue":"10","key":"3279_CR1","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1002\/cncr.28592","volume":"120","author":"RV Lalla","year":"2014","unstructured":"Lalla RV, Bowen J, Barasch A et al (2014) MASCC\/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer 120(10):1453\u20131461. doi: 10.1002\/cncr.28592","journal-title":"Cancer"},{"issue":"8","key":"3279_CR2","first-page":"1161","volume":"97","author":"M Baydar","year":"2005","unstructured":"Baydar M, Dikilitas M, Sevinc A, Aydogdu I (2005) Prevention of oral mucositis due to 5-fluorouracil treatment with oral cryotherapy. J Natl Med Assoc 97(8):1161\u20131164","journal-title":"J Natl Med Assoc"},{"issue":"6","key":"3279_CR3","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1007\/s00520-006-0055-4","volume":"14","author":"JA Jones","year":"2006","unstructured":"Jones JA, Avritscher EB, Cooksley CD, Michelet M, Bekele BN, Elting LS (2006) Epidemiology of treatment-associated mucosal injury after treatment with newer regimens for lymphoma, breast, lung, or colorectal cancer. Support Care Cancer 14(6):505\u2013515. doi: 10.1007\/s00520-006-0055-4","journal-title":"Support Care Cancer"},{"issue":"Suppl 6","key":"3279_CR4","doi-asserted-by":"publisher","first-page":"vi78","DOI":"10.1093\/annonc\/mdr391","volume":"22","author":"DE Peterson","year":"2011","unstructured":"Peterson DE, Bensadoun RJ, Roila F, ESMO Guidelines Working Group (2011) Management of oral and gastrointestinal mucositis: ESMO Clinical Practice Guidelines. Ann Oncol 22(Suppl 6):vi78\u201384. doi: 10.1093\/annonc\/mdr391","journal-title":"Ann Oncol"},{"issue":"7","key":"3279_CR5","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1002\/cncr.23328","volume":"112","author":"JB Sorensen","year":"2008","unstructured":"Sorensen JB, Skovsgaard T, Bork E, Damstrup L, Ingeberg S (2008) Double-blind, placebo-controlled, randomized study of chlorhexidine prophylaxis for 5-fluorouracil-based chemotherapy-induced oral mucositis with nonblinded randomized comparison to oral cooling (cryotherapy) in gastrointestinal malignancies. Cancer 112(7):1600\u20131606. doi: 10.1002\/cncr.23328","journal-title":"Cancer"},{"issue":"4","key":"3279_CR6","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.ejon.2011.07.008","volume":"16","author":"N Katranci","year":"2012","unstructured":"Katranci N, Ovayolu N, Ovayolu O, Sevinc A (2012) Evaluation of the effect of cryotherapy in preventing oral mucositis associated with chemotherapy\u2014a randomized controlled trial. Eur J Oncol Nurs 16(4):339\u2013344. doi: 10.1016\/j.ejon.2011.07.008","journal-title":"Eur J Oncol Nurs"},{"issue":"1","key":"3279_CR7","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/s00520-012-1562-0","volume":"21","author":"DE Peterson","year":"2013","unstructured":"Peterson DE, Ohrn K, Bowen J et al (2013) Systematic review of oral cryotherapy for management of oral mucositis caused by cancer therapy. Support Care Cancer 21(1):327\u2013332. doi: 10.1007\/s00520-012-1562-0","journal-title":"Support Care Cancer"},{"issue":"4","key":"3279_CR8","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1111\/jan.12867","volume":"72","author":"NM Manzi","year":"2015","unstructured":"Manzi NM, Silveira RCCP, Reis PED (2015) Prophilaxis for mucositis induced by ambulatory chemotherapy: systematic review. J Adv Nurs 72(4):735\u2013746. doi: 10.1111\/jan.12867","journal-title":"J Adv Nurs"},{"key":"3279_CR9","doi-asserted-by":"publisher","DOI":"10.1002\/14651858","author":"P Riley","year":"2015","unstructured":"Riley P, Glenny AM, Worthington HV, Littlewood A, Clarkson JE, McCabe MG (2015) Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy. Cochrane Database Syst Rev. doi: 10.1002\/14651858","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"3279_CR10","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.ejon.2006.05.002","volume":"11","author":"E Papadeas","year":"2007","unstructured":"Papadeas E, Naxakis S, Riga M, Kalofonos C (2007) Prevention of 5-fluorouracil-related stomatitis by oral cryotherapy: a randomized controlled study. Eur J Oncol Nurs 11(1):60\u201365. doi: 10.1016\/j.ejon.2006.05.002","journal-title":"Eur J Oncol Nurs"},{"issue":"4","key":"3279_CR11","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.oraloncology.2006.04.011","volume":"43","author":"RM Logan","year":"2007","unstructured":"Logan RM, Gibson RJ, Sonis ST, Keefe DM (2007) Nuclear factor-kB (NF-kB) and cyclooxygenase-2 (COX-2) expression in the oral mucosa following cancer chemotherapy. Oral Oncol 43(4):395\u2013401. doi: 10.1016\/j.oraloncology.2006.04.011","journal-title":"Oral Oncol"},{"issue":"5","key":"3279_CR12","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.ctrv.2007.03.001","volume":"33","author":"RM Logan","year":"2007","unstructured":"Logan RM, Stringer AM, Bowen JM, Yeoh AS, Gibson RJ, Sonis ST, Keefe DM (2007) The role of pro-inflammatory cytokines in cancer treatment-induced alimentary tract mucositis: pathobiology, animal models and cytotoxic drugs. Cancer Treat Rev 33(5):448\u2013460. doi: 10.1016\/j.ctrv.2007.03.001","journal-title":"Cancer Treat Rev"},{"issue":"7","key":"3279_CR13","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1111\/.j.1601-0825.2010.01681.x","volume":"16","author":"ST Sonis","year":"2010","unstructured":"Sonis ST (2010) New thoughts on the initiation of mucositis. Oral Dis 16(7):597\u2013600. doi: 10.1111\/.j.1601-0825.2010.01681.x","journal-title":"Oral Dis"},{"issue":"6","key":"3279_CR14","doi-asserted-by":"publisher","first-page":"895","DOI":"10.3892\/mmr.2010.377","volume":"3","author":"JK Srivastava","year":"2010","unstructured":"Srivastava JK, Shankar E, Gupta S (2010) Chamomile: a herbal medicine of the past with a bright future. Mol Med Rep 3(6):895\u2013901. doi: 10.3892\/mmr.2010.377","journal-title":"Mol Med Rep"},{"key":"3279_CR15","first-page":"123","volume":"3","author":"EB Ferreira","year":"2015","unstructured":"Ferreira EB, Vasques CI, Jesus CAC, Reis PED (2015) Topical effects of Chamomilla recutita in skin damage: a literature review. Pharmacol Online 3:123\u2013130","journal-title":"Pharmacol Online"},{"issue":"3","key":"3279_CR16","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/(SICI)1097-0142(19960201)77:3<522::AID-CNCR14>3.0.CO;2-6","volume":"77","author":"P Fidler","year":"1996","unstructured":"Fidler P, Loprinzi CL, O\u2019Fallon JR, Leitch JM, Lee JK, Hayes DL, Novotny P, Clemens-Schutjer D, Bartel J, Michalak JC (1996) Prospective evaluation of a chamomile mouthwash for prevention of 5-FU-induced oral mucositis. Cancer 77(3):522\u2013525","journal-title":"Cancer"},{"issue":"4","key":"3279_CR17","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1097\/NCC.0000000000000194","volume":"38","author":"FTMM Braga","year":"2015","unstructured":"Braga FTMM, Santos ACF, Bueno PCP, Silveira RCCP, Santos CB, Bastos JK, Carvalho EC (2015) Use of Chamomilla recutita in the prevention and treatment of oral mucositis in patients undergoing hematopoietic stem cell transplantation: a randomized, controlled, phase II clinical trial. Cancer Nurs 38(4):322\u2013329. doi: 10.1097\/NCC.0000000000000194","journal-title":"Cancer Nurs"},{"issue":"1","key":"3279_CR18","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1200\/JCO.1997.15.1.246","volume":"15","author":"MJ O\u2019Connell","year":"1997","unstructured":"O\u2019Connell MJ, Mailliard JA, Kahn MJ, Macdonald JS, Haller DG, Mayer RJ, Wieand HS (1997) Controlled trial of fluorouracil and low-dose leucovorin given for 6 months as postoperative adjuvant therapy for colon cancer. J Clin Oncol 15(1):246\u2013250","journal-title":"J Clin Oncol"},{"issue":"1","key":"3279_CR19","doi-asserted-by":"publisher","first-page":"03","DOI":"10.1590\/S0104-11692011000100002","volume":"19","author":"PED Reis","year":"2011","unstructured":"Reis PED, Carvalho EC, Bueno PCP, Bastos JK (2011) Clinical application of Chamomilla recutita in phlebitis: dose response curve study. Rev Lat Am Enfermagem 19(1):03\u201310. doi: 10.1590\/S0104-11692011000100002","journal-title":"Rev Lat Am Enfermagem"},{"key":"3279_CR20","unstructured":"World Health Organization (1979) Handbook for reporting results of cancer treatment. Geneva, Switzerland. http:\/\/apps.who.int\/iris\/bitstream\/10665\/37200\/1\/WHO_OFFSET_48.pdf . Accessed 31 Jan 2016"},{"issue":"1","key":"3279_CR21","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2015-000140","volume":"1","author":"M Sendlbeck","year":"2015","unstructured":"Sendlbeck M, Araujo EG, Schett G, Englbrecht M (2015) Psychometric properties of three single-item pain scales in patients with rheumatoid arthritis seen during routine clinical care: a comparative perspective on construct validity, reproducibility and internal responsiveness. RMD Open 1(1), e000140. doi: 10.1136\/rmdopen-2015-000140","journal-title":"RMD Open"},{"issue":"6","key":"3279_CR22","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1111\/j.1365-2702.2005.01156.x","volume":"14","author":"S Nikoletti","year":"2005","unstructured":"Nikoletti S, Hyde S, Shaw T, Myers H, Kristjanson LJ (2005) Comparison of plain ice and flavoured ice for preventing oral mucositis associated with the use of 5 fluorouracil. J Clin Nurs 14(6):750\u2013753. doi: 10.1111\/j.1365-2702.2005.01156.x","journal-title":"J Clin Nurs"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-016-3279-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00520-016-3279-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-016-3279-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T22:06:47Z","timestamp":1559081207000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00520-016-3279-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,17]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["3279"],"URL":"https:\/\/doi.org\/10.1007\/s00520-016-3279-y","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,17]]}}}