{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:06:35Z","timestamp":1790431595596,"version":"4.1.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,9,15]],"date-time":"2016-09-15T00:00:00Z","timestamp":1473897600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1007\/s00520-016-3402-0","type":"journal-article","created":{"date-parts":[[2016,9,15]],"date-time":"2016-09-15T03:40:33Z","timestamp":1473910833000},"page":"365-369","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Weight loss versus muscle loss: re-evaluating inclusion criteria for future cancer cachexia interventional trials"],"prefix":"10.1007","volume":"25","author":[{"given":"Eric J.","family":"Roeland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D.","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandahl H.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Seibert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Heavey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Revta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gallivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vickie E.","family":"Baracos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,9,15]]},"reference":[{"key":"3402_CR1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1080\/01635581.2014.894103","volume":"66","author":"M Barret","year":"2014","unstructured":"Barret M, Antoun S, Dalban C, et al. (2014) Sarcopenia is linked to treatment toxicity in patients with metastatic colorectal cancer. Nutr Cancer 66:583\u2013589","journal-title":"Nutr Cancer"},{"key":"3402_CR2","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.clnu.2010.07.012","volume":"30","author":"C Gray","year":"2011","unstructured":"Gray C, MacGillivray TJ, Eeley C, et al. (2011) Magnetic resonance imaging with k-means clustering objectively measures whole muscle volume compartments in sarcopenia\/cancer cachexia. Clin Nutr 30:106\u2013111","journal-title":"Clin Nutr"},{"key":"3402_CR3","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1158\/1078-0432.CCR-08-2242","volume":"15","author":"CM Prado","year":"2009","unstructured":"Prado CM, Baracos VE, McCargar LJ, et al. (2009) Sarcopenia as a determinant of chemotherapy toxicity and time to tumor progression in metastatic breast cancer patients receiving capecitabine treatment. Clin Cancer Res 15:2920\u20132926","journal-title":"Clin Cancer Res"},{"key":"3402_CR4","doi-asserted-by":"crossref","first-page":"340","DOI":"10.3109\/0284186X.2014.953259","volume":"54","author":"GB Stene","year":"2015","unstructured":"Stene GB, Helbostad JL, Amundsen T, et al. (2015) Changes in skeletal muscle mass during palliative chemotherapy in patients with advanced lung cancer. Acta Oncol 54:340\u2013348","journal-title":"Acta Oncol"},{"key":"3402_CR5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s13539-012-0075-5","volume":"3","author":"AE Utech","year":"2012","unstructured":"Utech AE, Tadros EM, Hayes TG, et al. (2012) Predicting survival in cancer patients: the role of cachexia and hormonal, nutritional and inflammatory markers. J Cachex Sarcopenia Muscle 3:245\u2013251","journal-title":"J Cachex Sarcopenia Muscle"},{"key":"3402_CR6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13539-010-0002-6","volume":"1","author":"S Haehling von","year":"2010","unstructured":"von Haehling S, Anker SD (2010) Cachexia as a major underestimated and unmet medical need: facts and numbers. J Cachex Sarcopenia Muscle 1:1\u20135","journal-title":"J Cachex Sarcopenia Muscle"},{"key":"3402_CR7","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1093\/jnci\/89.23.1763","volume":"89","author":"MJ Tisdale","year":"1997","unstructured":"Tisdale MJ (1997) Biology of cachexia. J Natl Cancer Inst 89:1763\u20131773","journal-title":"J Natl Cancer Inst"},{"key":"3402_CR8","doi-asserted-by":"crossref","unstructured":"Temel JS, Abernethy AP, Currow DC, et al (2016) Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): results from two randomised, double-blind, phase 3 trials. Lancet Oncol","DOI":"10.1016\/S1470-2045(15)00558-6"},{"key":"3402_CR9","doi-asserted-by":"crossref","first-page":"3394","DOI":"10.1200\/JCO.2005.05.1847","volume":"24","author":"F Strasser","year":"2006","unstructured":"Strasser F, Luftner D, Possinger K, et al. (2006) Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled clinical trial from the Cannabis-in-Cachexia-Study-Group. J Clin Oncol 24:3394\u20133400","journal-title":"J Clin Oncol"},{"key":"3402_CR10","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.3945\/ajcn.2008.27273","volume":"89","author":"JR Lieffers","year":"2009","unstructured":"Lieffers JR, Mourtzakis M, Hall KD, et al. (2009) A viscerally driven cachexia syndrome in patients with advanced colorectal cancer: contributions of organ and tumor mass to whole-body energy demands. Am J Clin Nutr 89:1173\u20131179","journal-title":"Am J Clin Nutr"},{"key":"3402_CR11","doi-asserted-by":"crossref","unstructured":"Roubenoff R, Kehayias JJ, Dawson-Hughes B, et al (1993) Use of dual-energy X-ray absorptiometry in body-composition studies: not yet a \u2018gold standard\u2019. Am J Clin Nutr (USA)","DOI":"10.1093\/ajcn\/58.5.589"},{"key":"3402_CR12","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1139\/H08-075","volume":"33","author":"M Mourtzakis","year":"2008","unstructured":"Mourtzakis M, Prado CMM, Lieffers JR, et al. (2008) A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care. Appl Physiol Nutr Metab 33:997\u20131006","journal-title":"Appl Physiol Nutr Metab"},{"key":"3402_CR13","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/SPC.0b013e328331124a","volume":"3","author":"CM Prado","year":"2009","unstructured":"Prado CM, Birdsell LA, Baracos VE (2009) The emerging role of computerized tomography in assessing cancer cachexia. Curr Opin Support Palliat Care 3:269\u2013275","journal-title":"Curr Opin Support Palliat Care"},{"key":"3402_CR14","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1152\/japplphysiol.00744.2004","volume":"97","author":"W Shen","year":"2004","unstructured":"Shen W, Punyanitya M, Wang Z, et al. (2004) Total body skeletal muscle and adipose tissue volumes: estimation from a single abdominal cross-sectional image. J Appl Physiol (1985) 97:2333\u20132338","journal-title":"J Appl Physiol (1985)"},{"key":"3402_CR15","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/ajcn\/80.2.271","volume":"80","author":"W Shen","year":"2004","unstructured":"Shen W, Punyanitya M, Wang Z, et al. (2004) Visceral adipose tissue: relations between single-slice areas and total volume. Am J Clin Nutr 80:271\u2013278","journal-title":"Am J Clin Nutr"},{"key":"3402_CR16","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/ajcn\/52.2.214","volume":"52","author":"SB Heymsfield","year":"1990","unstructured":"Heymsfield SB, Smith R, Aulet M, et al. (1990) Appendicular skeletal muscle mass: measurement by dual-photon absorptiometry. Am J Clin Nutr 52:214\u2013218","journal-title":"Am J Clin Nutr"},{"key":"3402_CR17","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","volume":"12","author":"K Fearon","year":"2011","unstructured":"Fearon K, Strasser F, Anker SD, et al. (2011) Definition and classification of cancer cachexia: an international consensus. Lancet Oncol 12:489\u2013495","journal-title":"Lancet Oncol"},{"key":"3402_CR18","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/jcsm.12083","volume":"6","author":"K Fearon","year":"2015","unstructured":"Fearon K, Argiles J, Baracos V, et al. (2015) Request for regulatory guidance for cancer cachexia intervention trials. J Cachex Sarcopenia Muscle 6:272\u2013274","journal-title":"J Cachex Sarcopenia Muscle"},{"key":"3402_CR19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11912-016-0522-0","volume":"18","author":"J Crawford","year":"2016","unstructured":"Crawford J, Prado CM, Johnston MA, et al. (2016) Study design and rationale for the phase 3 clinical development program of enobosarm, a selective androgen receptor modulator, for the prevention and treatment of muscle wasting in cancer patients (POWER trials). Curr Oncol Rep 18:1\u201311","journal-title":"Curr Oncol Rep"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-016-3402-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00520-016-3402-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-016-3402-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T14:10:08Z","timestamp":1568383808000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00520-016-3402-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,15]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["3402"],"URL":"https:\/\/doi.org\/10.1007\/s00520-016-3402-0","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,15]]}}}