{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T11:40:05Z","timestamp":1749987605851,"version":"3.41.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T00:00:00Z","timestamp":1487116800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1007\/s00520-017-3626-7","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T08:47:59Z","timestamp":1487148479000},"page":"2205-2213","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intra-oral administration of rebamipide liquid prevents tongue injuries induced by X-ray irradiation in rats"],"prefix":"10.1007","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7676-3264","authenticated-orcid":false,"given":"Takako","family":"Nakashima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Uematsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazushi","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,2,15]]},"reference":[{"key":"3626_CR1","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1002\/cncr.22484","volume":"109","author":"DM Keefe","year":"2007","unstructured":"Keefe DM, Schubert MM, Elting LS, Sonis ST, Epstein JB, Raber-Durlacher JE, Migliorati CA, McGuire DB, Hutchins RD, Peterson DE, Mucositis Study Section of the Multinational Association of Supportive Care in Cancer and the International Society for Oral Oncology (2007) Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer 109:820\u2013831","journal-title":"Cancer"},{"key":"3626_CR2","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1002\/cncr.28592","volume":"120","author":"RV Lalla","year":"2014","unstructured":"Lalla RV, Bowen J, Barasch A, Elting L, Epstein J, Keefe DM, DB MG, Migliorati C, Nicolatou-Galitis O, Peterson DE, Raber-Durlacher JE, Sonis ST, Elad S, Mucositis Guidelines Leadership Group of the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC\/ISOO) (2014a) MASCC\/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer 120:1453\u20131461","journal-title":"Cancer"},{"key":"3626_CR3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ijom.2011.10.011","volume":"41","author":"A Rodr\u00edguez-Caballero","year":"2012","unstructured":"Rodr\u00edguez-Caballero A, Torres-Lagares D, Robles-Garc\u00eda M, Pach\u00f3n-Ib\u00e1\u00f1ez J, Gonz\u00e1lez-Padilla D, Guti\u00e9rrez-P\u00e9rez JL (2012) Cancer treatment-induced oral mucositis: a critical review. Int J Oral Maxillofac Surg 41:225\u2013238","journal-title":"Int J Oral Maxillofac Surg"},{"key":"3626_CR4","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cden.2007.10.002","volume":"52","author":"RV Lalla","year":"2008","unstructured":"Lalla RV, Sonis ST, Peterson DE (2008) Management of oral mucositis in patients who have cancer. Dent Clin N Am 52:61\u201377","journal-title":"Dent Clin N Am"},{"key":"3626_CR5","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1007\/s00520-013-1884-6","volume":"21","author":"SB Jensen","year":"2013","unstructured":"Jensen SB, Jarvis V, Zadik Y, Barasch A, Ariyawardana A, Hovan A, Yarom N, Lalla RV, Bowen J, Elad S, Mucositis Study Group of the Multinational Association of Supportive Care in Cancer\/International Society of Oral Oncology (MASCC\/ISOO) (2013) Systematic review of miscellaneous agents for the management of oral mucositis in cancer patients. Support Care Cancer 21:3223\u20133232","journal-title":"Support Care Cancer"},{"key":"3626_CR6","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.suponc.2011.04.009","volume":"9","author":"JM Bowen","year":"2011","unstructured":"Bowen JM, Gibson RJ, Keefe DM (2011) Animal models of mucositis: implications for therapy. J Support Oncol 9:161\u2013168","journal-title":"J Support Oncol"},{"key":"3626_CR7","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1124\/jpet.113.208405","volume":"347","author":"T Nakashima","year":"2013","unstructured":"Nakashima T, Uematsu N, Shibamori M, Sakurai K, Ishida T (2013) Establishment of an X-ray irradiation-induced glossitis model in rats: biphasic elevation of proinflammatory cytokines and chemokines. J Pharmacol Exp Ther 347:660\u2013668","journal-title":"J Pharmacol Exp Ther"},{"key":"3626_CR8","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1002\/cncr.20162","volume":"100","author":"ST Sonis","year":"2004","unstructured":"Sonis ST, Elting LS, Keefe D, Peterson DE, Schubert M, Hauer-Jensen M, Bekele BN, Raber-Durlacher J, Donnelly JP, Rubenstein EB, Mucositis Study Section of the Multinational Association for Supportive Care in Cancer; International Society for Oral Oncology (2004a) Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 100:1995\u20132025","journal-title":"Cancer"},{"key":"3626_CR9","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.1248\/cpb.33.3775","volume":"33","author":"M Uchida","year":"1985","unstructured":"Uchida M, Tabusa F, Komatsu M, Morita S, Kanbe T, Nakagawa K (1985) Studies on 2(1H)-quinolinone derivatives as gastric antiulcer active agents. 2-(4-chlorobenzoylamino)-3-[2(1H)\u2013quinolinon-4-yl]propionic acid and related compounds. Chem Pharm Bull 33:3775\u20133786","journal-title":"Chem Pharm Bull"},{"key":"3626_CR10","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0014-2999(87)90649-2","volume":"142","author":"K Yamasaki","year":"1987","unstructured":"Yamasaki K, Kanbe T, Chijiwa T, Ishiyama H, Morita S (1987) Gastric mucosal protection by OPC-12759, a novel antiulcer compound, in the rat. Eur J Pharmacol 142:23\u201329","journal-title":"Eur J Pharmacol"},{"issue":"8","key":"3626_CR11","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1007\/BF01308601","volume":"38","author":"A Kleine","year":"1993","unstructured":"Kleine A, Kluge S, Peskar BM (1993) Stimulation of prostaglandin biosynthesis mediates gastroprotective effect of rebamipide in rats. Dig Dis Sci 38(8):1441\u20131449","journal-title":"Dig Dis Sci"},{"key":"3626_CR12","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0022-3565(24)38925-6","volume":"295","author":"WH Sun","year":"2000","unstructured":"Sun WH, Tsuji S, Tsujii M, Gunawan ES, Kawai N, Kimura A, Kakiuchi Y, Yasumaru M, Iijima H, Okuda Y, Sasaki Y, Hori M, Kawano S (2000) Induction of cyclooxygenase-2 in rat gastric mucosa by rebamipide, a mucoprotective agent. J Pharmacol Exp Ther 295:447\u2013452","journal-title":"J Pharmacol Exp Ther"},{"key":"3626_CR13","first-page":"1327","volume":"43","author":"T Yoshikawa","year":"1993","unstructured":"Yoshikawa T, Naito Y, Nakamura S, Nishimura S, Kaneko T, Iinuma S, Takahashi S, Kondo M, Yamasaki K (1993) Effect of rebamipide on lipid peroxidation and gastric mucosal injury induced by indometacin in rats. Arzneimittelforschung 43:1327\u20131330","journal-title":"Arzneimittelforschung"},{"key":"3626_CR14","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0891-5849(94)00110-6","volume":"18","author":"Y Naito","year":"1995","unstructured":"Naito Y, Yoshikawa T, Tanigawa T, Sakurai K, Yamasaki K, Uchida M, Kondo M (1995) Hydroxyl radical scavenging by rebamipide and related compounds: electron paramagnetic resonance study. Free Radic Biol Med 18:117\u2013123","journal-title":"Free Radic Biol Med"},{"key":"3626_CR15","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S0022-3565(24)29550-1","volume":"297","author":"C Nagano","year":"2001","unstructured":"Nagano C, Azuma A, Ishiyama H, Sekiguchi K, Imagawa K, Kikuchi M (2001) Rebamipide suppresses formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide production by inhibiting fMLP-receptor binding in human neutrophils. J Pharmacol Exp Ther 297:388\u2013394","journal-title":"J Pharmacol Exp Ther"},{"key":"3626_CR16","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1007\/BF02088229","volume":"41","author":"N Yoshida","year":"1996","unstructured":"Yoshida N, Yoshikawa T, Iinuma S, Arai M, Takenaka S, Sakamoto K, Miyajima T, Nakamura Y, Yagi N, Naito Y, Mukai F, Kondo M (1996) Rebamipide protects against activation of neutrophils by Helicobacter pylori. Dig Dis Sci 41:1139\u20131144","journal-title":"Dig Dis Sci"},{"key":"3626_CR17","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0022-3565(24)37934-0","volume":"288","author":"CD Kim","year":"1999","unstructured":"Kim CD, Kim HH, Hong KW (1999) Inhibitory effect of rebamipide on the neutrophil adherence stimulated by conditioned media from Helicobacter pylori-infected gastric epithelial cells. J Pharmacol Exp Ther 288:133\u2013138","journal-title":"J Pharmacol Exp Ther"},{"issue":"4","key":"3626_CR18","doi-asserted-by":"crossref","DOI":"10.5037\/jomr.2011.2403","volume":"2","author":"T Yasuda","year":"2011","unstructured":"Yasuda T, Chiba H, Satomi T, Matsuo A, Kaneko T, Chikazu D, Miyamatsu H (2011) Preventive effect of rebamipide gargle on chemoradiotherapy-induced oral mucositis in patients with oral cancer: a pilot study. J Oral Maxillofac Res 2(4):e3","journal-title":"J Oral Maxillofac Res"},{"key":"3626_CR19","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1248\/bpb.b13-01006","volume":"37","author":"T Nakashima","year":"2014","unstructured":"Nakashima T, Sako N, Matsuda T, Uematsu N, Sakurai K, Ishida T (2014) Novel submicronized rebamipide liquid with moderate viscosity: significant effects on oral mucositis in animal models. Biol Pharm Bull 37:671\u2013678","journal-title":"Biol Pharm Bull"},{"key":"3626_CR20","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1254\/jjp.49.441","volume":"49","author":"K Yamasaki","year":"1989","unstructured":"Yamasaki K, Ishiyama H, Imaizumi T, Kanbe T, Yabuuchi Y (1989) Effect of OPC-12759, a novel antiulcer agent, on chronic and acute experimental gastric ulcer, and gastric secretion in rats. Jpn J Pharmacol 49:441\u2013448","journal-title":"Jpn J Pharmacol"},{"key":"3626_CR21","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1097\/01.ico.0000126436.25751.fb","volume":"23","author":"H Urashima","year":"2004","unstructured":"Urashima H, Okamoto T, Takeji Y, Shinohara H, Fujisawa S (2004) Rebamipide increases the amount of mucin-like substances on the conjunctiva and cornea in the N-acetylcysteine-treated in vivo model. Cornea 23:613\u2013619","journal-title":"Cornea"},{"key":"3626_CR22","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1089\/jop.2011.0147","volume":"28","author":"H Urashima","year":"2012","unstructured":"Urashima H, Takeji Y, Okamoto T, Fujisawa S, Shinohara H (2012) Rebamipide increases mucin-like substance contents and periodic acid Schiff reagent-positive cells density in normal rabbits. J Ocul Pharmacol Ther 28:264\u2013270","journal-title":"J Ocul Pharmacol Ther"},{"key":"3626_CR23","doi-asserted-by":"crossref","first-page":"35S","DOI":"10.1023\/A:1018898612090","volume":"43","author":"S Iinuma","year":"1998","unstructured":"Iinuma S, Naito Y, Yoshikawa T, Takahashi S, Takemura T, Yoshida N, Kondo M (1998) In vitro studies indicating antioxidative properties of rebamipide. Dig Dis Sci 43:35S\u201339S","journal-title":"Dig Dis Sci"},{"key":"3626_CR24","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1586\/egh.10.25","volume":"4","author":"Y Naito","year":"2010","unstructured":"Naito Y, Yoshikawa T (2010) Rebamipide: a gastrointestinal protective drug with pleiotropic activities. Expert Rev Gastroenterol Hepatol 4:261\u2013270","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"3626_CR25","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1023\/A:1014716822702","volume":"47","author":"K Haruma","year":"2002","unstructured":"Haruma K, Ito M, Kido S, Manabe N, Kitadai Y, Sumii M, Tanaka S, Yoshihara M, Chayama K (2002) Long-term rebamipide therapy improves Helicobacter pylori-associated chronic gastritis. Dig Dis Sci 47:862\u2013867","journal-title":"Dig Dis Sci"},{"key":"3626_CR26","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S1368-8375(03)00148-9","volume":"40","author":"ST Sonis","year":"2004","unstructured":"Sonis ST, O\u2019Donnell KE, Popat R, Bragdon C, Phelan S, Cocks D, Epstein JB (2004b) The relationship between mucosal cyclooxygenase-2 (COX-2) expression and experimental radiation-induced mucositis. Oral Oncol 40:170\u2013176","journal-title":"Oral Oncol"},{"key":"3626_CR27","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/09553000701616080","volume":"84","author":"CJ Feng","year":"2008","unstructured":"Feng CJ, Guo JB, Jiang HW, Zhu SX, Li CY, Cheng B, Chen Y, Wang HY (2008) Spatio-temporal localization of HIF-1alpha and COX-2 during irradiation-induced oral mucositis in a rat model system. Int J Radiat Biol 84:35\u201345","journal-title":"Int J Radiat Biol"},{"key":"3626_CR28","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.oraloncology.2014.08.001","volume":"50","author":"RV Lalla","year":"2014","unstructured":"Lalla RV, Choquette LE, Curley KF, Dowsett RJ, Feinn RS, Hegde UP, Pilbeam CC, Salner AL, Sonis ST, Peterson DE (2014b) Randomized double-blind placebo-controlled trial of celecoxib for oral mucositis in patients receiving radiation therapy for head and neck cancer. Oral Oncol 50:1098\u20131103","journal-title":"Oral Oncol"},{"issue":"1","key":"3626_CR29","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jphs.2015.07.022","volume":"129","author":"M Shibamori","year":"2015","unstructured":"Shibamori M, Sato M, Uematsu N, Nakashima T, Sato A, Yamamura Y, Sasabe H, Umehara K, Sakurai K (2015) Rebamipide does not interfere with the antitumor effect of radiotherapy or chemotherapy in human oral tumor-bearing nude mice. J Pharmacol Sci 129(1):18\u201325","journal-title":"J Pharmacol Sci"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00520-017-3626-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-017-3626-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-017-3626-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T10:59:39Z","timestamp":1749985179000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00520-017-3626-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,15]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["3626"],"URL":"https:\/\/doi.org\/10.1007\/s00520-017-3626-7","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"type":"print","value":"0941-4355"},{"type":"electronic","value":"1433-7339"}],"subject":[],"published":{"date-parts":[[2017,2,15]]}}}