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SV-R received honoraria and research funding from Amgen. MSC and RC have no disclosures. ON-G has received travel support from Novartis and travel support and honoraria from Amgen. CP has participated as an investigator in an Amgen trial. SF has received research funding and travel support and honoraria from Amgen and salary support from the National Institute for Health Research (NIHR). DJ, JZ, and HM are employees of and own stock in Amgen. MS has served as a consultant to and received honoraria from Amgen.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol was reviewed and approved by an independent ethics committee or institutional review board at each study center before enrollment of patients at that center.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}}]}}