{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:33:55Z","timestamp":1760646835688,"version":"3.37.3"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2018,5,12]],"date-time":"2018-05-12T00:00:00Z","timestamp":1526083200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1007\/s00520-018-4255-5","type":"journal-article","created":{"date-parts":[[2018,5,12]],"date-time":"2018-05-12T19:53:04Z","timestamp":1526154784000},"page":"3873-3882","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Matrix metalloproteinase expression is altered in the small and large intestine following fractionated radiation in vivo"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8302-6449","authenticated-orcid":false,"given":"Romany L.","family":"Stansborough","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noor","family":"Al-Dasooqi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma H.","family":"Bateman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne M.","family":"Bowen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy M. K.","family":"Keefe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard M.","family":"Logan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann S. J.","family":"Yeoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric E. K.","family":"Yeoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea M.","family":"Stringer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel J.","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,5,12]]},"reference":[{"key":"4255_CR1","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1258\/ebm.2010.010082","volume":"235","author":"N Al-Dasooqi","year":"2010","unstructured":"Al-Dasooqi N, Gibson RJ, Bowen JM, Logan RM, Stringer AM, Keefe DM (2010) Matrix metalloproteinases are possible mediators for the development of alimentary tract mucositis in the dark agouti rat. Exp Biol Med (Maywood) 235:1244\u20131256","journal-title":"Exp Biol Med (Maywood)"},{"key":"4255_CR2","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s00384-006-0225-3","volume":"22","author":"E Angenete","year":"2007","unstructured":"Angenete E, Langenskiold M, Falk P, Ivarsson ML (2007) Matrix metalloproteinases in rectal mucosa, tumour and plasma: response after preoperative irradiation. Int J Color Dis 22:667\u2013674","journal-title":"Int J Color Dis"},{"key":"4255_CR3","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.3109\/02841860903150510","volume":"48","author":"E Angenete","year":"2009","unstructured":"Angenete E, Oresland T, Falk P, Breimer M, Hultborn R, Ivarsson ML (2009) Preoperative radiotherapy and extracellular matrix remodeling in rectal mucosa and tumour matrix metalloproteinases and plasminogen components. Acta Oncol 48:1144\u20131151","journal-title":"Acta Oncol"},{"key":"4255_CR4","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1159\/000100111","volume":"39","author":"A Bedirli","year":"2007","unstructured":"Bedirli A, Kerem M, Karahacioglu E, Ofluoglu E, Yilmaz TU, Pasaoglu H, Tater OP, Sakrak O, Pak Y (2007) Effects of two conventional preoperative radiation schedules on anastomotic healing in the rat colon. Eur Surg Res 39:141\u2013147","journal-title":"Eur Surg Res"},{"key":"4255_CR5","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.yexmp.2011.11.007","volume":"92","author":"S Cameron","year":"2012","unstructured":"Cameron S, Schwartz A, Sultan S, Schaefer IM, Hermann R, Rave-Frank M, Hess CF, Christiansen H, Ramadori G (2012) Radiation-induced damage in different segments of the rat intestine after external beam irradiation of the liver. Exp Mol Pathol 92:243\u2013258","journal-title":"Exp Mol Pathol"},{"issue":"6","key":"4255_CR6","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1053\/j.gastro.2005.09.017","volume":"129","author":"Florencia E. Castaneda","year":"2005","unstructured":"Castaneda FE, Walia B, Vijay-Kumar M, Patel NR, Roser S, Kolachala VL, Rojas M, Wang L, Oprea G, Garg P, Gewirtz AT, Roman J, Merlin D, Sitaraman SV (2005) Targeted deletion of metalloproteinase 9 attenuates experimental colitis in mice: central role of epithelial-derived MMP. Gastroenterol 129:1991\u20132008","journal-title":"Gastroenterology"},{"key":"4255_CR7","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1517\/14728222.2013.740012","volume":"17","author":"MH Chien","year":"2013","unstructured":"Chien MH, Lin CW, Cheng CW, Wen YC, Yang SF (2013) Matrix metalloproteinase-2 as a target for head and neck cancer therapy. Expert Opin Ther Targets 17:203\u2013216","journal-title":"Expert Opin Ther Targets"},{"key":"4255_CR8","first-page":"1512","volume":"5","author":"R Sousa Abreu de","year":"2009","unstructured":"de Sousa Abreu R, Penalva LO, Marcotte EM, Vogel C (2009) Global signatures of protein and mRNA expression levels. Mol BioSyst 5:1512\u20131526","journal-title":"Mol BioSyst"},{"key":"4255_CR9","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1136\/gutjnl-2017-313789","volume":"67","author":"S Gerassy-Vainberg","year":"2018","unstructured":"Gerassy-Vainberg S, Blatt A, Danin-Poleg Y, Gershovich K, Sabo E, Nevelsky A, Daniel S, Dahan A, Ziv O, Dheer R, Abreu MT, Koren O, Kashi Y, Chowers Y (2018) Radiation induces proinflammatory dysbiosis: transmission of inflammatory susceptibility by host cytokine induction. Gut 67:97\u2013107","journal-title":"Gut"},{"key":"4255_CR10","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1002\/cncr.28592","volume":"120","author":"RV Lalla","year":"2014","unstructured":"Lalla RV, Bowen J, Barasch A, Elting L, Epstein J, Keefe DM, McGuire DB, Migliorati C, Nicolatou-Galitis O, Peterson DE, Raber-Durlacher JE, Sonis ST, Elad S (2014) MASCC\/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer 120:1453\u20131461","journal-title":"Cancer"},{"key":"4255_CR11","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.4161\/cbt.7.7.6207","volume":"7","author":"RM Logan","year":"2008","unstructured":"Logan RM, Stringer AM, Bowen JM, Gibson RJ, Sonis ST, Keefe DM (2008) Serum levels of NFkappaB and pro-inflammatory cytokines following administration of mucotoxic drugs. Cancer Biol Ther 7:1139\u20131145","journal-title":"Cancer Biol Ther"},{"key":"4255_CR12","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.semcdb.2007.07.003","volume":"19","author":"AM Manicone","year":"2008","unstructured":"Manicone AM, McGuire JK (2008) Matrix metalloproteinases as modulators of inflammation. Semin Cell Dev Biol 19:34\u201341","journal-title":"Semin Cell Dev Biol"},{"key":"4255_CR13","doi-asserted-by":"publisher","first-page":"2599","DOI":"10.1002\/jcp.25430","volume":"231","author":"R Mittal","year":"2016","unstructured":"Mittal R, Patel AP, Debs LH, Nguyen D, Patel K, Grati M, Mittal J, Yan D, Chapagain P, Liu XZ (2016) Intricate functions of matrix metalloproteinases in physiological and pathological conditions. J Cell Physiol 231:2599\u20132621","journal-title":"J Cell Physiol"},{"key":"4255_CR14","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.cardiores.2005.12.002","volume":"69","author":"H Nagase","year":"2006","unstructured":"Nagase H, Visse R, Murphy G (2006) Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc Res 69:562\u2013573","journal-title":"Cardiovasc Res"},{"key":"4255_CR15","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1748-717X-5-22","volume":"5","author":"Z Ong","year":"2010","unstructured":"Ong Z, Gibson RJ, Bowen JM, Stringer AM, Darby JM, Logan RM, Yeoh ASJ, Keefe DM (2010) Pro-inflammatory cytokines play a key role in the development of radiotherapy-induced gastrointestinal mucositis. Radiat Oncol 5:22","journal-title":"Radiat Oncol"},{"key":"4255_CR16","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1080\/00365520410003470","volume":"39","author":"MT Salmela","year":"2004","unstructured":"Salmela MT, Pender SL, Karjalainen-Lindsberg ML, Puolakkainen P, Macdonald TT, Saarialho-Kere U (2004) Collagenase-1 (MMP-1), matrilysin-1 (MMP-7), and stromelysin-2 (MMP-10) are expressed by migrating enterocytes during intestinal wound healing. Scand J Gastroenterol 39:1095\u20131104","journal-title":"Scand J Gastroenterol"},{"key":"4255_CR17","doi-asserted-by":"crossref","first-page":"3340","DOI":"10.4049\/jimmunol.161.7.3340","volume":"161","author":"U Schonbeck","year":"1998","unstructured":"Schonbeck U, Mach F, Libby P (1998) Generation of biologically active IL-1 beta by matrix metalloproteinases: a novel caspase-1-independent pathway of IL-1 beta processing. J Immunol 161:3340\u20133346","journal-title":"J Immunol"},{"key":"4255_CR18","doi-asserted-by":"publisher","first-page":"199","DOI":"10.3748\/wjg.v19.i2.199","volume":"19","author":"AK Shadad","year":"2013","unstructured":"Shadad AK, Sullivan FJ, Martin JD, Egan LJ (2013) Gastrointestinal radiation injury: prevention and treatment. World J Gastroenterol: WJG 19:199\u2013208","journal-title":"World J Gastroenterol: WJG"},{"key":"4255_CR19","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1177\/154411130201300502","volume":"13","author":"ST Sonis","year":"2002","unstructured":"Sonis ST (2002) The biologic role for nuclear factor-Kappab in disease and its potential involvement in mucosal injury associated with anti-neoplastic therapy. Crit Rev Oral Biol Med 13:380\u2013389","journal-title":"Crit Rev Oral Biol Med"},{"key":"4255_CR20","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-5438-0","volume-title":"Pathobiology of cancer regimen-related toxicities","author":"ST Sonis","year":"2013","unstructured":"Sonis ST, Keefe DM (2013) Pathobiology of cancer regimen-related toxicities. Springer, New York"},{"key":"4255_CR21","doi-asserted-by":"publisher","first-page":"241","DOI":"10.3109\/09553002.2016.1146830","volume":"92","author":"RL Stansborough","year":"2016","unstructured":"Stansborough RL, Al-Dasooqi N, Bateman EH, Keefe DM, Gibson RJ (2016) Radiotherapy-induced gut toxicity: involvement of matrix metalloproteinases and the intestinal microvasculature. Int J Radiat Biol 92:241\u2013248","journal-title":"Int J Radiat Biol"},{"issue":"6","key":"4255_CR22","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1007\/s00520-017-3601-3","volume":"25","author":"Romany L. Stansborough","year":"2017","unstructured":"Stansborough RL, Bateman EH, Al-Dasooqi N, Bowen JM, Keefe DM, Yeoh ASJ, Logan RM, Yeoh EEK, Stringer AM, Gibson RJ (2017) Fractionated abdominal irradiation induces intestinal microvascular changes in an in vivo model of radiotherapy-induced gut toxicity. Support Care Cancer 25:1973\u20131983","journal-title":"Supportive Care in Cancer"},{"key":"4255_CR23","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1146\/annurev.cellbio.17.1.463","volume":"17","author":"MD Sternlicht","year":"2001","unstructured":"Sternlicht MD, Werb Z (2001) How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol 17:463\u2013516","journal-title":"Annu Rev Cell Dev Biol"},{"key":"4255_CR24","doi-asserted-by":"publisher","first-page":"G875","DOI":"10.1152\/ajpgi.00088.2004","volume":"287","author":"C Strup-Perrot","year":"2004","unstructured":"Strup-Perrot C, Mathe D, Linard C, Violot D, Milliat F, Francois A, Bourhis J, Vozenin-Brotons MC (2004) Global gene expression profiles reveal an increase in mRNA levels of collagens, MMPs, and TIMPs in late radiation enteritis. Am J Physiol Gastrointest Liver Physiol 287:G875\u2013G885","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"4255_CR25","doi-asserted-by":"publisher","first-page":"6312","DOI":"10.3748\/wjg.v11.i40.6312","volume":"11","author":"C Strup-Perrot","year":"2005","unstructured":"Strup-Perrot C, Vozenin-Brotons MC, Vandamme M, Linard C, Mathe D (2005) Expression of matrix metalloproteinases and tissue inhibitor metalloproteinases increases in X-irradiated rat ileum despite the disappearance of CD8a T cells. World J Gastroenterol 11:6312\u20136321","journal-title":"World J Gastroenterol"},{"key":"4255_CR26","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1080\/00365520510023963","volume":"41","author":"C Strup-Perrot","year":"2006","unstructured":"Strup-Perrot C, Vozenin-Brotons MC, Vandamme M, Benderitter M, Mathe D (2006) Expression and activation of MMP-2, -3, -9, -14 are induced in rat colon after abdominal X-irradiation. Scand J Gastroenterol 41:60\u201370","journal-title":"Scand J Gastroenterol"},{"key":"4255_CR27","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.clon.2009.10.003","volume":"22","author":"VS Theis","year":"2010","unstructured":"Theis VS, Sripadam R, Ramani V, Lal S (2010) Chronic radiation enteritis. Clin Oncol (R Coll Radiol) 22:70\u201383","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"4255_CR28","doi-asserted-by":"publisher","first-page":"15007","DOI":"10.1523\/JNEUROSCI.1436-10.2010","volume":"30","author":"S Uchida","year":"2010","unstructured":"Uchida S, Hara K, Kobayashi A, Funato H, Hobara T, Otsuki K, Yamagata H, McEwen BS, Watanabe Y (2010) Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents. J Neurosci 30:15007\u201315018","journal-title":"J Neurosci"},{"key":"4255_CR29","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s00221-007-1062-5","volume":"183","author":"P Vikman","year":"2007","unstructured":"Vikman P, Ansar S, Henriksson M, Stenman E, Edvinsson L (2007) Cerebral ischemia induces transcription of inflammatory and extracellular-matrix-related genes in rat cerebral arteries. Exp Brain Res 183:499\u2013510","journal-title":"Exp Brain Res"},{"issue":"4","key":"4255_CR30","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1007\/s00520-015-2964-6","volume":"24","author":"Hannah R. Wardill","year":"2015","unstructured":"Wardill HR, Logan RM, Bowen JM, Van Sebille YZ, Gibson RJ (2016) Tight junction defects are seen in the buccal mucosa of patients receiving standard dose chemotherapy for cancer. Support Care Cancer 24:1779\u20131788","journal-title":"Supportive Care in Cancer"},{"key":"4255_CR31","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1002\/jcp.20948","volume":"211","author":"C Yan","year":"2007","unstructured":"Yan C, Boyd DD (2007) Regulation of matrix metalloproteinase gene expression. J Cell Physiol 211:19\u201326","journal-title":"J Cell Physiol"},{"key":"4255_CR32","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1016\/j.ijrobp.2005.04.041","volume":"63","author":"AS Yeoh","year":"2005","unstructured":"Yeoh AS, Bowen JM, Gibson RJ, Keefe DM (2005) Nuclear factor kappaB (NFkappaB) and cyclooxygenase-2 (Cox-2) expression in the irradiated colorectum is associated with subsequent histopathological changes. Int J Radiat Oncol Biol Phys 63:1295\u20131303","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4255_CR33","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1158\/1535-7163.MCT-07-0113","volume":"6","author":"AS Yeoh","year":"2007","unstructured":"Yeoh AS, Gibson RJ, Yeoh EE, Bowen JM, Stringer AM, Giam KA, Keefe DM (2007) A novel animal model to investigate fractionated radiotherapy-induced alimentary mucositis: the role of apoptosis, p53, nuclear factor-kappaB, COX-1, and COX-2. Mol Cancer Ther 6:2319\u20132327","journal-title":"Mol Cancer Ther"},{"key":"4255_CR34","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.3892\/etm.2015.2658","volume":"10","author":"H Yue","year":"2015","unstructured":"Yue H, Hu K, Liu W, Jiang J, Chen Y, Wang R (2015) Role of matrix metalloproteinases in radiation-induced lung injury in alveolar epithelial cells of Bama minipigs. Exp Ther Med 10:1437\u20131444","journal-title":"Exp Ther Med"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00520-018-4255-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-018-4255-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-018-4255-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T18:43:32Z","timestamp":1720291412000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00520-018-4255-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,12]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["4255"],"URL":"https:\/\/doi.org\/10.1007\/s00520-018-4255-5","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"type":"print","value":"0941-4355"},{"type":"electronic","value":"1433-7339"}],"subject":[],"published":{"date-parts":[[2018,5,12]]},"assertion":[{"value":"16 August 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors report no declarations of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}