{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:19:55Z","timestamp":1782260395403,"version":"3.54.5"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T00:00:00Z","timestamp":1528329600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1007\/s00520-018-4271-5","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T01:52:30Z","timestamp":1528336350000},"page":"4039-4048","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Inverse relationship between reduced fatigue and severity of anemia in oncology patients treated with integrative medicine: understanding the paradox"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4058-3672","authenticated-orcid":false,"given":"Eran","family":"Ben-Arye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofer","family":"Dahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilanit","family":"Shalom-Sharabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah","family":"Samuels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,6,7]]},"reference":[{"issue":"15","key":"4271_CR1","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1200\/JCO.2011.34.6148","volume":"30","author":"D Goldstein","year":"2012","unstructured":"Goldstein D, Bennett BK, Webber K, Boyle F, de Souza PL, Wilcken NR, Scott EM, Toppler R, Murie P, O\u2019Malley L, McCourt J, Friedlander M, Hickie IB, Lloyd AR (2012) Cancer-related fatigue in women with breast cancer: outcomes of a 5-year prospective cohort study. J Clin Oncol 30(15):1805\u20131801","journal-title":"J Clin Oncol"},{"key":"4271_CR2","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.breast.2017.04.012","volume":"34","author":"A Fabi","year":"2017","unstructured":"Fabi A, Falcicchio C, Giannarelli D, Maggi G, Cognetti F, Pugliese P (2017) The course of cancer related fatigue up to ten years in early breast cancer patients: what impact in clinical practice? Breast 34:44\u201352","journal-title":"Breast"},{"issue":"6","key":"4271_CR3","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.ctrv.2014.01.004","volume":"40","author":"RH Koornstra","year":"2014","unstructured":"Koornstra RH, Peters M, Donofrio S, van den Borne B, de Jong FA (2014) Management of fatigue in patients with cancer\u2014a practical overview. Cancer Treat Rev 40(6):791\u2013799","journal-title":"Cancer Treat Rev"},{"issue":"4","key":"4271_CR4","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1007\/s00520-016-3520-8","volume":"25","author":"Anita R. Peoples","year":"2016","unstructured":"Peoples AR, Roscoe JA, Block RC, Heckler CE, Ryan JL, Mustian KM, Janelsins MC, Peppone LJ, Moore DF Jr, Coles C, Hoelzer KL, Morrow GR, Dozier AM. Nausea and disturbed sleep as predictors of cancer-related fatigue in breast cancer patients: a multicenter NCORP study. Support Care Cancer 2017;25(4):1271\u20131278","journal-title":"Supportive Care in Cancer"},{"issue":"5","key":"4271_CR5","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1007\/s00520-015-2996-y","volume":"24","author":"CE Heckler","year":"2016","unstructured":"Heckler CE, Garland SN, Peoples AR, Perlis ML, Shayne M, Morrow GR, Kamen C, Hoefler J, Roscoe JA (2016) Cognitive behavioral therapy for insomnia, but not armodafinil, improves fatigue in cancer survivors with insomnia: a randomized placebo-controlled trial. Support Care Cancer 24(5):2059\u20132066","journal-title":"Support Care Cancer"},{"issue":"17","key":"4271_CR6","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1200\/JCO.2014.59.1081","volume":"33","author":"H Waart van","year":"2015","unstructured":"van Waart H, Stuiver MM, van Harten WH, Geleijn E, Kieffer JM, Buffart LM, de Maaker-Berkhof M, Boven E, Schrama J, Geenen MM, Meerum Terwogt JM, van Bochove A, Lustig V, van den Heiligenberg SM, Smorenburg CH, Hellendoorn-van Vreeswijk JA, Sonke GS, Aaronson NK (2015) Effect of low-intensity physical activity and moderate- to high-intensity physical exercise during adjuvant chemotherapy on physical fitness, fatigue, and chemotherapy completion rates: results of the PACES randomized clinical trial. J Clin Oncol 33(17):1918\u20131927","journal-title":"J Clin Oncol"},{"issue":"2","key":"4271_CR7","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/s12032-013-0511-1","volume":"30","author":"E Ben-Arye","year":"2013","unstructured":"Ben-Arye E, Schiff E, Zollman C, Heusser P, Mountford P, Frenkel M, Bar-Sela G, Lavie O (2013) Integrating complementary medicine in supportive cancer care models across four continents. Med Oncol 30(2):511","journal-title":"Med Oncol"},{"issue":"3","key":"4271_CR8","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1007\/s12032-011-0068-9","volume":"29","author":"L Guo","year":"2012","unstructured":"Guo L, Bai SP, Zhao L, Wang XH (2012) Astragalus polysaccharide injection integrated with vinorelbine and cisplatin for patients with advanced non-small cell lung cancer: effects on quality of life and survival. Med Oncol 29(3):1656\u20131662","journal-title":"Med Oncol"},{"issue":"29\u201330","key":"4271_CR9","first-page":"493","volume":"111","author":"W Tr\u00f6ger","year":"2014","unstructured":"Tr\u00f6ger W, Galun D, Reif M, Schumann A, Stankovi\u0107 N, Mili\u0107evi\u0107 M (2014) Quality of life of patients with advanced pancreatic cancer during treatment with mistletoe: a randomized controlled trial. Dtsch Arztebl Int 111(29\u201330):493\u2013502","journal-title":"Dtsch Arztebl Int"},{"issue":"16","key":"4271_CR10","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1093\/jnci\/djt181","volume":"105","author":"DL Barton","year":"2013","unstructured":"Barton DL, Liu H, Dakhil SR, Linquist B, Sloan JA, Nichols CR, McGinn TW, Stella PJ, Seeger GR, Sood A, Loprinzi CL (2013) Wisconsin Ginseng (Panax quinquefolius) to improve cancer-related fatigue: a randomized, double-blind trial, N07C2. J Natl Cancer Inst 105(16):1230\u20131238","journal-title":"J Natl Cancer Inst"},{"issue":"36","key":"4271_CR11","doi-asserted-by":"publisher","first-page":"4470","DOI":"10.1200\/JCO.2012.41.6222","volume":"30","author":"A Molassiotis","year":"2012","unstructured":"Molassiotis A, Bardy J, Finnegan-John J, Mackereth P, Ryder DW, Filshie J, Ream E, Richardson A (2012) Acupuncture for cancer-related fatigue in patients with breast cancer: a pragmatic randomized controlled trial. J Clin Oncol 30(36):4470\u20134476","journal-title":"J Clin Oncol"},{"issue":"11","key":"4271_CR12","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1001\/jamaoncol.2016.1867","volume":"2","author":"SM Zick","year":"2016","unstructured":"Zick SM, Sen A, Wyatt GK, Murphy SL, Arnedt JT, Harris RE (2016) Investigation of 2 types of self-administered acupressure for persistent cancer-related fatigue in breast cancer survivors: a randomized clinical trial. JAMA Oncol 2(11):1470\u20131476","journal-title":"JAMA Oncol"},{"issue":"23","key":"4271_CR13","doi-asserted-by":"publisher","first-page":"3667","DOI":"10.1002\/cncr.30189","volume":"122","author":"H Mao","year":"2016","unstructured":"Mao H, Mao JJ, Guo M, Cheng K, Wei J, Shen X, Shen X (2016) Effects of infrared laser moxibustion on cancer-related fatigue: a randomized, double-blind, placebo-controlled trial. Cancer 122(23):3667\u20133672","journal-title":"Cancer"},{"issue":"9","key":"4271_CR14","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1002\/cncr.27904","volume":"119","author":"Z Chen","year":"2013","unstructured":"Chen Z, Meng Z, Milbury K, Bei W, Zhang Y, Thornton B, Liao Z, Wei Q, Chen J, Guo X, Liu L, McQuade J, Kirschbaum C, Cohen L (2013) Qigong improves quality of life in women undergoing radiotherapy for breast cancer: results of a randomized controlled trial. Cancer 119(9):1690\u20131698","journal-title":"Cancer"},{"issue":"3","key":"4271_CR15","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.jpainsymman.2015.11.020","volume":"51","author":"LL Zhang","year":"2016","unstructured":"Zhang LL, Wang SZ, Chen HL, Yuan AZ (2016) Tai chi exercise for cancer-related fatigue in patients with lung cancer undergoing chemotherapy: a randomized controlled trial. J Pain Symptom Manag 51(3):504\u2013511","journal-title":"J Pain Symptom Manag"},{"issue":"12","key":"4271_CR16","doi-asserted-by":"publisher","first-page":"3411","DOI":"10.1007\/s00520-015-2690-0","volume":"23","author":"E Ben-Arye","year":"2015","unstructured":"Ben-Arye E, Samuels N, Schiff E, Raz OG, Sharabi IS, Lavie O (2015) Quality-of-life outcomes in patients with gynecological cancer referred to integrative oncology treatment during chemotherapy. Support Care Cancer 23(12):3411\u20133419","journal-title":"Support Care Cancer"},{"issue":"7","key":"4271_CR17","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1007\/s00432-017-2368-8","volume":"143","author":"I Shalom-Sharabi","year":"2017","unstructured":"Shalom-Sharabi I, Samuels N, Lavie O, Lev E, Keinan-Boker L, Schiff E, Ben-Arye E (2017) Effect of a patient-tailored integrative medicine program on gastro-intestinal concerns and quality of life in patients with breast and gynecologic cancer. J Cancer Res Clin Oncol 143(7):1243\u20131254","journal-title":"J Cancer Res Clin Oncol"},{"issue":"3","key":"4271_CR18","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.pec.2012.02.011","volume":"89","author":"E Ben-Arye","year":"2012","unstructured":"Ben-Arye E, Schiff E, Shapira C, Frenkel M, Shalom T, Steiner M (2012) Modeling an integrative oncology program within a community-centered oncology service in Israel. Patient Educ Couns 89(3):423\u2013429","journal-title":"Patient Educ Couns"},{"issue":"3","key":"4271_CR19","doi-asserted-by":"publisher","first-page":"194","DOI":"10.3322\/caac.21397","volume":"67","author":"H Greenlee","year":"2017","unstructured":"Greenlee H, DuPont-Reyes MJ, Balneaves LG, Carlson LE, Cohen MR, Deng G, Johnson JA, Mumber M, Seely D, Zick SM, Boyce LM, Tripathy D (2017) Clinical practice guidelines on the evidence-based use of integrative therapies during and after breast cancer treatment. CA Cancer J Clin 67(3):194\u2013232","journal-title":"CA Cancer J Clin"},{"key":"4271_CR20","doi-asserted-by":"publisher","first-page":"3807","DOI":"10.1007\/s00520-017-3812-7.","volume":"25","author":"CS Cheng","year":"2017","unstructured":"Cheng CS, Chen LY, Ning ZY, Zhang CY, Chen H, Chen Z, Zhu XY, Xie J (2017 Jul 13) Acupuncture for cancer-related fatigue in lung cancer patients: a randomized, double blind, placebo-controlled pilot trial. Support Care Cancer 25:3807\u20133814. \n                    https:\/\/doi.org\/10.1007\/s00520-017-3812-7.","journal-title":"Support Care Cancer"},{"issue":"2","key":"4271_CR21","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1177\/082585979100700202","volume":"7","author":"E Bruera","year":"1991","unstructured":"Bruera E, Kuehn N, Miller M, Selmser P, Macmillan K (1991) The Edmonton symptom assessment system (ESAS): a simple method for the assessment of palliative care patients. J Palliative Care 7(2):6\u20139","journal-title":"J Palliative Care"},{"issue":"6","key":"4271_CR22","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/j.jpainsymman.2012.06.007","volume":"45","author":"Wendy H. Oldenmenger","year":"2013","unstructured":"Oldenmenger W, de Raaf P, de Klerk C, van der Rijt C (2012) Cut points on 0\u201310 numeric rating scales for symptoms included in the Edmonton symptom assessment scale in cancer patients: a systematic review. J Pain Symp Manage. \n                    https:\/\/doi.org\/10.1016\/j.jpainsymman.2012.06.007","journal-title":"Journal of Pain and Symptom Management"},{"issue":"5","key":"4271_CR23","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","volume":"85","author":"N Aaronson","year":"1993","unstructured":"Aaronson N, Ahmedzai S, Bergman B, Bullinger M et al (1993) The European Organization for Research and Treatment of Cancer QLQ-C30: a quality of life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85(5):365\u2013376","journal-title":"J Natl Cancer Inst"},{"issue":"1","key":"4271_CR24","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.ctim.2006.03.006","volume":"15","author":"C Paterson","year":"2007","unstructured":"Paterson C, Thomas K, Manasse A, Cooke H, Peace G (2007) Measure Yourself Concerns and Wellbeing (MYCaW): an individualised questionnaire for evaluating outcome in cancer support care that includes complementary therapies. Complement Ther Med 15(1):38\u201345","journal-title":"Complement Ther Med"},{"issue":"2","key":"4271_CR25","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.jpainsymman.2015.09.011","volume":"51","author":"T Yamaguchi","year":"2016","unstructured":"Yamaguchi T, Morita T, Nitto A, Takahashi N, Miyamoto S, Nishie H, Matsuoka J, Sakurai H, Ishihara T, Tarumi Y, Ogawa A (2016) Establishing cutoff points for defining symptom severity using the Edmonton Symptom Assessment System-Revised Japanese Version. J Pain Symptom Manag 51(2):292\u2013297","journal-title":"J Pain Symptom Manag"},{"issue":"10","key":"4271_CR26","doi-asserted-by":"publisher","first-page":"2685","DOI":"10.1007\/s11136-013-0387-8","volume":"22","author":"CF Snyder","year":"2013","unstructured":"Snyder CF, Blackford AL, Okuyama T, Akechi T, Yamashita H, Toyama T, Carducci MA, Wu AW (2013) Using the EORTC-QLQ-C30 in clinical practice for patient management: identifying scores requiring a clinician\u2019s attention. Qual Life Res 22(10):2685\u20132691","journal-title":"Qual Life Res"},{"key":"4271_CR27","first-page":"459","volume":"22","author":"PB Ottevanger","year":"2002","unstructured":"Ottevanger PB, De Mulder PH, Grol RP et al (2002) Effects of quality of treatment on prognosis in primary breast cancer patients treated in daily practice. Anticancer Res 22:459\u2013465","journal-title":"Anticancer Res"},{"issue":"7","key":"4271_CR28","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1002\/cncr.22943","volume":"110","author":"JL Gabrilove","year":"2007","unstructured":"Gabrilove JL, Perez EA, Tomita DK, Rossi G, Cleeland CS (2007) Assessing symptom burden using the M. D. Anderson symptom inventory in patients with chemotherapy-induced anemia: results of a multicenter, open-label study (SURPASS) of patients treated with darbepoetin-alpha at a dose of 200 microg every 2 weeks. Cancer 110(7):1629\u20131640","journal-title":"Cancer"},{"issue":"11","key":"4271_CR29","doi-asserted-by":"publisher","first-page":"3039","DOI":"10.1007\/s00520-013-1862-z","volume":"21","author":"P Gasc\u00f3n","year":"2013","unstructured":"Gasc\u00f3n P, Rodr\u00edguez CA, Valent\u00edn V, Mata JG, Carulla J, Cassinello J, Colomer R, Bar\u00f3 E (2013) Usefulness of the PERFORM questionnaire to measure fatigue in cancer patients with anemia: a prospective, observational study. Support Care Cancer 21(11):3039\u20133049","journal-title":"Support Care Cancer"},{"issue":"2","key":"4271_CR30","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.jpainsymman.2011.03.025","volume":"43","author":"O Minton","year":"2012","unstructured":"Minton O, Strasser F, Radbruch L, Stone P (2012) Identification of factors associated with fatigue in advanced cancer: a subset analysis of the European palliative care research collaborative computerized symptom assessment data set. J Pain Symptom Manag 43(2):226\u2013235","journal-title":"J Pain Symptom Manag"},{"issue":"5","key":"4271_CR31","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1177\/1049909108319267","volume":"25","author":"K Hauser","year":"2008","unstructured":"Hauser K, Walsh D, Rybicki LA, Davis MP, Seyidova-Khoshknabi D (2008) Fatigue in advanced cancer: a prospective study. Am J Hosp Palliat Care 25(5):372\u2013378","journal-title":"Am J Hosp Palliat Care"},{"key":"4271_CR32","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.ijnurstu.2017.01.004","volume":"69","author":"TY Chuang","year":"2017","unstructured":"Chuang TY, Yeh ML, Chung YC (2017) A nurse facilitated mind-body interactive exercise (Chan-Chuang qigong) improves the health status of non-Hodgkin lymphoma patients receiving chemotherapy: randomised controlled trial. Int J Nurs Stud 69:25\u201333","journal-title":"Int J Nurs Stud"},{"key":"4271_CR33","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.1007\/s00432-017-2509-0","volume":"143","author":"I Shalom-Sharabi","year":"2017","unstructured":"Shalom-Sharabi I, Lavie O, Samuels N, Keinan-Boker L, Lev E, Ben-Arye E (2017) Can complementary medicine increase adherence to chemotherapy dosing protocol? A controlled study in an integrative oncology setting. J Cancer Res Clin Oncol 143:2535\u20132543. \n                    https:\/\/doi.org\/10.1007\/s00432-017-2509-0","journal-title":"J Cancer Res Clin Oncol"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00520-018-4271-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-018-4271-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-018-4271-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T19:04:10Z","timestamp":1559847850000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00520-018-4271-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,7]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["4271"],"URL":"https:\/\/doi.org\/10.1007\/s00520-018-4271-5","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,7]]},"assertion":[{"value":"23 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}]}}