{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T15:34:40Z","timestamp":1762011280286,"version":"build-2065373602"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T00:00:00Z","timestamp":1552521600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004045","name":"Karadeniz Teknik \u00dcniversitesi","doi-asserted-by":"publisher","award":["THD-2018-7356"],"award-info":[{"award-number":["THD-2018-7356"]}],"id":[{"id":"10.13039\/501100004045","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1007\/s00520-019-04731-2","type":"journal-article","created":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T14:11:54Z","timestamp":1552572714000},"page":"4273-4281","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Uroprotective effect of pantoprazole against cyclophosphamide-induced cystitis in mice"],"prefix":"10.1007","volume":"27","author":[{"given":"Seckin","family":"Engin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif Nur","family":"Barut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burak","family":"Barut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9057-0634","authenticated-orcid":false,"given":"Mine","family":"Kadioglu Duman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cansu","family":"Kaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gokcen","family":"Kerimoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arzu","family":"Ozel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,3,14]]},"reference":[{"issue":"1\u20132","key":"4731_CR1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0378-4347(01)00279-1","volume":"764","author":"F Baumann","year":"2001","unstructured":"Baumann F, Preiss R (2001) Cyclophosphamide and related anticancer drugs. J Chromatogr B 764(1\u20132):173\u2013192","journal-title":"J Chromatogr B"},{"issue":"5","key":"4731_CR2","first-page":"146","volume":"17","author":"RA Fleming","year":"1997","unstructured":"Fleming RA (1997) An overview of cyclophosphamide and ifosfamide pharmacology. Pharmacotherapy 17(5):146\u2013154","journal-title":"Pharmacotherapy"},{"issue":"2","key":"4731_CR3","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/tcm.1770050202","volume":"5","author":"PE Mirkes","year":"1985","unstructured":"Mirkes PE (1985) Cyclophosphamide teratogenesis - a review. Teratogen Carcin Mut 5(2):75\u201388","journal-title":"Teratogen Carcin Mut"},{"issue":"1","key":"4731_CR4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0300-483X(87)90116-8","volume":"45","author":"JM Patel","year":"1987","unstructured":"Patel JM (1987) Stimulation of cyclophosphamide-induced pulmonary microsomal lipid-peroxidation by oxygen. Toxicology 45(1):79\u201391","journal-title":"Toxicology"},{"issue":"5","key":"4731_CR5","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/S0022-5347(17)41173-6","volume":"141","author":"LA Levine","year":"1989","unstructured":"Levine LA, Richie JP (1989) Urological complications of cyclophosphamide. J Urol 141(5):1063\u20131069","journal-title":"J Urol"},{"issue":"2","key":"4731_CR6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.4103\/0970-1591.65380","volume":"26","author":"R Manikandan","year":"2010","unstructured":"Manikandan R, Kumar S, Dorairajan LN (2010) Hemorrhagic cystitis: a challenge to the urologist. Indian J Urol 26(2):159\u2013166","journal-title":"Indian J Urol"},{"issue":"5","key":"4731_CR7","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s10565-006-0078-0","volume":"23","author":"A Korkmaz","year":"2007","unstructured":"Korkmaz A, Topal T, Oter S (2007) Pathophysiological aspects of cyclophosphamide and ifosfamide induced hemorrhagic cystitis; implication of reactive oxygen and nitrogen species as well as PARP activation. Cell Biol Toxicol 23(5):303\u2013312","journal-title":"Cell Biol Toxicol"},{"issue":"6","key":"4731_CR8","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1016\/S0022-5347(05)68870-2","volume":"161","author":"AMS Assreuy","year":"1999","unstructured":"Assreuy AMS, Martins GJ, Moreira MEF, Brito GAC, Cavada BS, Ribeiro RA et al (1999) Prevention of cyclophosphamide-induced hemorrhagic cystitis by glucose-mannose binding plant lectins. J Urol 161(6):1988\u20131993","journal-title":"J Urol"},{"issue":"8768","key":"4731_CR9","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/0140-6736(91)91290-B","volume":"338","author":"D D'Cruz","year":"1991","unstructured":"D'Cruz D, Haga HJ, Hughes GR (1991) Allergic reactions to mesna. Lancet 338(8768):705\u2013706","journal-title":"Lancet"},{"issue":"5","key":"4731_CR10","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/cbf.1347","volume":"25","author":"S Sadir","year":"2007","unstructured":"Sadir S, Deveci S, Korkmaz A, Oter S (2007) Alpha-tocopherol, beta-carotene and melatonin administration protects cyclophosphamide-induced oxidative damage to bladder tissue in rats. Cell Biochem Funct 25(5):521\u2013526","journal-title":"Cell Biochem Funct"},{"issue":"3","key":"4731_CR11","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s10787-010-0055-3","volume":"19","author":"TP Hamsa","year":"2011","unstructured":"Hamsa TP, Kuttan G (2011) Protective role of Ipomoea obscura (L.) on cyclophosphamide-induced uro- and nephrotoxicities by modulating antioxidant status and pro-inflammatory cytokine levels. Inflammopharmacology 19(3):155\u2013167","journal-title":"Inflammopharmacology"},{"issue":"6","key":"4731_CR12","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/s11894-008-0098-4","volume":"10","author":"JM Shin","year":"2008","unstructured":"Shin JM, Sachs G (2008) Pharmacology of proton pump inhibitors. Curr Gastroenterol Rep 10(6):528\u2013534","journal-title":"Curr Gastroenterol Rep"},{"issue":"7","key":"4731_CR13","doi-asserted-by":"crossref","first-page":"925","DOI":"10.2165\/00003495-200868070-00004","volume":"68","author":"V Boparai","year":"2008","unstructured":"Boparai V, Rajagopalan J, Triadafilopoulos G (2008) Guide to the use of proton pump inhibitors in adult patients. Drugs 68(7):925\u2013947","journal-title":"Drugs"},{"issue":"11","key":"4731_CR14","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1007\/s10620-009-0951-9","volume":"54","author":"RR Kedika","year":"2009","unstructured":"Kedika RR, Souza RF, Spechler SJ (2009) Potential anti-inflammatory effects of proton pump inhibitors: a review and discussion of the clinical implications. Dig Dis Sci 54(11):2312\u20132317","journal-title":"Dig Dis Sci"},{"issue":"1","key":"4731_CR15","doi-asserted-by":"crossref","first-page":"F85","DOI":"10.1152\/ajprenal.00041.2016","volume":"311","author":"MG Oliveira de","year":"2016","unstructured":"de Oliveira MG, Calmasini FB, Alexandre EC, De Nucci G, Monica FZ, Antunes E (2016) Activation of soluble guanylyl cyclase by BAY 58-2667 improves bladder function in cyclophosphamide-induced cystitis in mice. Am J Physiol Renal Physiol 311(1):F85\u2013F93","journal-title":"Am J Physiol Renal Physiol"},{"issue":"12","key":"4731_CR16","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1007\/s11255-014-0833-8","volume":"46","author":"I Keles","year":"2014","unstructured":"Keles I, Bozkurt MF, Cemek M, Karalar M, Hazini A, Alpdagtas S, Keles H, Yildiz T, Ceylan C, Buyukokuroglu ME (2014) Prevention of cyclophosphamide-induced hemorrhagic cystitis by resveratrol: a comparative experimental study with mesna. Int Urol Nephrol 46(12):2301\u20132310","journal-title":"Int Urol Nephrol"},{"issue":"6","key":"4731_CR17","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00223-012-9601-x","volume":"90","author":"T Histing","year":"2012","unstructured":"Histing T, Stenger D, Scheuer C, Metzger W, Garcia P, Holstein JH, Klein M, Pohlemann T, Menger MD (2012) Pantoprazole, a proton pump inhibitor, delays fracture healing in mice. Calcif Tissue Int 90(6):507\u2013514","journal-title":"Calcif Tissue Int"},{"issue":"1","key":"4731_CR18","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1365-2141.1971.tb00790.x","volume":"20","author":"J Stocks","year":"1971","unstructured":"Stocks J, Dormandy TL (1971) The autoxidation of human red cell lipids induced by hydrogen peroxide. Br J Haematol 20(1):95\u2013111","journal-title":"Br J Haematol"},{"issue":"3","key":"4731_CR19","doi-asserted-by":"crossref","first-page":"188","DOI":"10.5213\/inj.1632548.274","volume":"20","author":"MI Donmez","year":"2016","unstructured":"Donmez MI, Inci K, Zeybek ND, Dogan HS, Ergen A (2016) The early histological effects of Intravesical instillation of platelet-rich plasma in cystitis models. Int Neurourol J 20(3):188\u2013196","journal-title":"Int Neurourol J"},{"issue":"10","key":"4731_CR20","first-page":"1103","volume":"28","author":"TN Gomes","year":"1995","unstructured":"Gomes TN, Santos CC, Souza-Filho MV, Cunha FQ, Ribeiro RA (1995) Participation of TNF-alpha and IL-1 in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis. Braz J Med Biol Res 28(10):1103\u20131108","journal-title":"Braz J Med Biol Res"},{"issue":"5","key":"4731_CR21","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1016\/S0022-5347(05)65134-8","volume":"167","author":"RA Ribeiro","year":"2002","unstructured":"Ribeiro RA, Freitas HC, Campos MC, Santos CC, Figueiredo FC, Brito GA et al (2002) Tumor necrosis factor-alpha and interleukin-1beta mediate the production of nitric oxide involved in the pathogenesis of ifosfamide induced hemorrhagic cystitis in mice. J Urol 167(5):2229\u20132234","journal-title":"J Urol"},{"issue":"6","key":"4731_CR22","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1097\/01.ju.0000085593.31396.d8","volume":"170","author":"A Korkmaz","year":"2003","unstructured":"Korkmaz A, Oter S, Deveci S, Ozgurtas T, Topal T, Sadir S et al (2003) Involvement of nitric oxide and hyperbaric oxygen in the pathogenesis of cyclophosphamide induced hemorrhagic cystitis in rats. J Urol 170(6 Pt 1):2498\u20132502","journal-title":"J Urol"},{"issue":"3","key":"4731_CR23","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/0090-4295(82)90633-1","volume":"20","author":"MJ Droller","year":"1982","unstructured":"Droller MJ, Saral R, Santos G (1982) Prevention of cyclophosphamide-induced hemorrhagic cystitis. Urology 20(3):256\u2013258","journal-title":"Urology"},{"issue":"3","key":"4731_CR24","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1152\/physrev.00038.2003","volume":"84","author":"KE Andersson","year":"2004","unstructured":"Andersson KE, Arner A (2004) Urinary bladder contraction and relaxation: physiology and pathophysiology. Physiol Rev 84(3):935\u2013986","journal-title":"Physiol Rev"},{"issue":"1\u20132","key":"4731_CR25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.autneu.2005.07.005","volume":"122","author":"D Giglio","year":"2005","unstructured":"Giglio D, Ryberg AT, To K, Delbro DS, Tobin G (2005) Altered muscarinic receptor subtype expression and functional responses in cyclophosphamide induced cystitis in rats. Auton Neurosci-Basic 122(1\u20132):9\u201320","journal-title":"Auton Neurosci-Basic"},{"issue":"1","key":"4731_CR26","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.neulet.2008.02.065","volume":"436","author":"A Kageyama","year":"2008","unstructured":"Kageyama A, Fujino T, Taki Y, Kato Y, Nozawa Y, Ito Y, Yamada S (2008) Alteration of muscarinic and purinergic receptors in urinary bladder of rats with cyclophosphamide-induced interstitial cystitis. Neurosci Lett 436(1):81\u201384","journal-title":"Neurosci Lett"},{"issue":"4","key":"4731_CR27","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s11255-015-0926-z","volume":"47","author":"Y Sugino","year":"2015","unstructured":"Sugino Y, O'Malley KJ, Wang Z, Tyagi P, Birder LA, Ogawa O et al (2015) Laser-capture microdissection for analysis of cell type-specific gene expression of muscarinic receptor subtypes in the rat bladder with cyclophosphamide-induced cystitis. Int Urol Nephrol 47(4):637\u2013642","journal-title":"Int Urol Nephrol"},{"issue":"2","key":"4731_CR28","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1742-7843.2007.00014.x","volume":"100","author":"D Giglio","year":"2007","unstructured":"Giglio D, Aronsson P, Eriksson L, Tobin G (2007) In vitro characterization of parasympathetic and sympathetic responses in cyclophosphamide-induced cystitis in the rat. Basic Clin Pharmacol Toxicol 100(2):96\u2013108","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"5","key":"4731_CR29","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1016\/j.juro.2014.12.092","volume":"193","author":"M Liu","year":"2015","unstructured":"Liu M, Shen S, Kendig DM, Mahavadi S, Murthy KS, Grider JR, Qiao LY (2015) Inhibition of NMDAR reduces bladder hypertrophy and improves bladder function in cyclophosphamide induced cystitis. J Urol 193(5):1676\u20131683","journal-title":"J Urol"},{"key":"4731_CR30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/360438","volume":"2014","author":"A Ayala","year":"2014","unstructured":"Ayala A, Munoz MF, Arguelles S (2014) Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-Hydroxy-2-Nonenal. Oxidative Med Cell Longev 2014:1\u201331","journal-title":"Oxidative Med Cell Longev"},{"issue":"6","key":"4731_CR31","doi-asserted-by":"crossref","first-page":"1392.e1","DOI":"10.1016\/j.urology.2012.06.053","volume":"80","author":"O Sinanoglu","year":"2012","unstructured":"Sinanoglu O, Yener AN, Ekici S, Midi A, Aksungar FB (2012) The protective effects of spirulina in cyclophosphamide induced nephrotoxicity and urotoxicity in rats. Urology 80(6):1392.e1\u20131392.e6","journal-title":"Urology"},{"issue":"3","key":"4731_CR32","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00210-008-0355-y","volume":"379","author":"M Fornai","year":"2009","unstructured":"Fornai M, Colucci R, Antonioli L, Ghisu N, Tuccori M, Blandizzi C, del Tacca M (2009) Effects of pantoprazole on ulcer healing delay associated with NSAID treatment. Naunyn Schmiedeberg's Arch Pharmacol 379(3):305\u2013313","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"issue":"26","key":"4731_CR33","doi-asserted-by":"crossref","first-page":"4052","DOI":"10.3748\/wjg.v11.i26.4052","volume":"11","author":"C Blandizzi","year":"2005","unstructured":"Blandizzi C, Fornai M, Colucci R, Natale G, Lubrano V, Vassalle C, Antonioli L, Lazzeri G, del Tacca M (2005) Lansoprazole prevents experimental gastric injury induced by non-steroidal anti-inflammatory drugs through a reduction of mucosal oxidative damage. World J Gastroenterol 11(26):4052\u20134060","journal-title":"World J Gastroenterol"},{"issue":"13","key":"4731_CR34","doi-asserted-by":"crossref","first-page":"10993","DOI":"10.1074\/jbc.M210328200","volume":"278","author":"K Biswas","year":"2003","unstructured":"Biswas K, Bandyopadhyay U, Chattopadhyay I, Varadaraj A, Ali E, Banerjee RK (2003) A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical. J Biol Chem 278(13):10993\u201311001","journal-title":"J Biol Chem"},{"issue":"9","key":"4731_CR35","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/j.bcp.2006.01.009","volume":"71","author":"WA Simon","year":"2006","unstructured":"Simon WA, Sturm E, Hartmann HJ, Weser U (2006) Hydroxyl radical scavenging reactivity of proton pump inhibitors. Biochem Pharmacol 71(9):1337\u20131341","journal-title":"Biochem Pharmacol"},{"issue":"11","key":"4731_CR36","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.1016\/j.fct.2008.08.011","volume":"46","author":"K Bhatia","year":"2008","unstructured":"Bhatia K, Ahmad F, Rashid H, Raisuddin S (2008) Protective effect of S-allylcysteine against cyclophosphamide-induced bladder hemorrhagic cystitis in mice. Food Chem Toxicol 46(11):3368\u20133374","journal-title":"Food Chem Toxicol"},{"issue":"1","key":"4731_CR37","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00210-005-1075-1","volume":"372","author":"M Fornai","year":"2005","unstructured":"Fornai M, Natale G, Colucci R, Tuccori M, Carazzina G, Antonioli L, Baldi S, Lubrano V, Abramo A, Blandizzi C, del Tacca M (2005) Mechanisms of protection by pantoprazole against NSAID-induced gastric mucosal damage. Naunyn Schmiedebergs Arch Pharmacol 372(1):79\u201387","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"4","key":"4731_CR38","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00210-008-0314-7","volume":"378","author":"O Pastoris","year":"2008","unstructured":"Pastoris O, Verri M, Boschi F, Kastsiuchenka O, Balestra B, Pace F, Tonini M, Natale G (2008) Effects of esomeprazole on glutathione levels and mitochondrial oxidative phosphorylation in the gastric mucosa of rats treated with indomethacin. Naunyn Schmiedeberg's Arch Pharmacol 378(4):421\u2013429","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"issue":"4","key":"4731_CR39","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.etp.2010.09.003","volume":"64","author":"TP Hamsa","year":"2012","unstructured":"Hamsa TP, Kuttan G (2012) Tinospora cordifolia ameliorates urotoxic effect of cyclophosphamide by modulating GSH and cytokine levels. Exp Toxicol Pathol 64(4):307\u2013314","journal-title":"Exp Toxicol Pathol"},{"issue":"8","key":"4731_CR40","doi-asserted-by":"crossref","first-page":"944","DOI":"10.7150\/ijbs.15781","volume":"12","author":"PR Gore","year":"2016","unstructured":"Gore PR, Prajapati CP, Mahajan UB, Goyal SN, Belemkar S, Ojha S, Patil CR (2016) Protective effect of thymoquinone against cyclophosphamide-induced hemorrhagic cystitis through inhibiting DNA damage and upregulation of Nrf2 expression. Int J Biol Sci 12(8):944\u2013953","journal-title":"Int J Biol Sci"},{"issue":"11","key":"4731_CR41","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1038\/sj.onc.1209377","volume":"25","author":"C Rodriguez-Antona","year":"2006","unstructured":"Rodriguez-Antona C, Ingelman-Sundberg M (2006) Cytochrome P450 pharmacogenetics and cancer. Oncogene. 25(11):1679\u20131691","journal-title":"Oncogene."},{"issue":"4","key":"4731_CR42","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s40264-014-0144-0","volume":"37","author":"RS Wedemeyer","year":"2014","unstructured":"Wedemeyer RS, Blume H (2014) Pharmacokinetic drug interaction profiles of proton pump inhibitors: an update. Drug Saf 37(4):201\u2013211","journal-title":"Drug Saf"},{"issue":"3","key":"4731_CR43","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.phrs.2008.09.016","volume":"59","author":"V Savarino","year":"2009","unstructured":"Savarino V, Di Mario F, Scarpignato C (2009) Proton pump inhibitors in GORD an overview of their pharmacology, efficacy and safety. Pharmacol Res 59(3):135\u2013153","journal-title":"Pharmacol Res"},{"key":"4731_CR44","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.semcancer.2017.01.003","volume":"43","author":"E Spugnini","year":"2017","unstructured":"Spugnini E, Fais S (2017) Proton pump inhibition and cancer therapeutics: a specific tumor targeting or it is a phenomenon secondary to a systemic buffering? Semin Cancer Biol 43:111\u2013118","journal-title":"Semin Cancer Biol"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-019-04731-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00520-019-04731-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-019-04731-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T00:23:23Z","timestamp":1584059003000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00520-019-04731-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,14]]},"references-count":44,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["4731"],"URL":"https:\/\/doi.org\/10.1007\/s00520-019-04731-2","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"type":"print","value":"0941-4355"},{"type":"electronic","value":"1433-7339"}],"subject":[],"published":{"date-parts":[[2019,3,14]]},"assertion":[{"value":"19 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The experimental protocol was approved by the Local Ethics Committee of Faculty of Medicine (protocol approval number: 2016\/29) as Institutional Review Board. All animal studies were performed according to the Guide for the Care and Use of Laboratory Animals.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}