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Inter-rater and intra-rater reliability and measurement error (secondary aims) were assessed in a subgroup of study participants.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Among the 112 children (56 patients and 56 age- and gender-matched healthy controls) evaluated, correlation between CTCAE and ped-mTNS scores was as expected (moderate (<jats:italic>r<\/jats:italic> = 0.60)). Moreover, as expected, patients had significantly higher ped-mTNS scores and more frequent symptoms of VIPN compared with controls (both <jats:italic>p<\/jats:italic> &lt; .001). Reliability as measured within the intra-rater group (<jats:italic>n<\/jats:italic> = 10) (intra-class correlation coefficient (ICC<jats:sub>agreement<\/jats:sub>) = 0.64, standard error of measurement (SEM<jats:sub>agreement<\/jats:sub>) = 2.92, and smallest detectable change (SDC<jats:sub>agreement<\/jats:sub>) = 8.1) and within the inter-rater subgroup (<jats:italic>n<\/jats:italic> = 10) (ICC<jats:sub>agreement<\/jats:sub> = 0.63, SEM<jats:sub>agreement<\/jats:sub> = 3.7, and SDC<jats:sub>agreement<\/jats:sub> = 10.26) indicates insufficient reliability.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The Dutch version of the ped-mTNS appears to have good construct validity for assessing VIPN in a Dutch pediatric oncology population, whereas reliability appears to be insufficient and measurement error high. To improve standardization of VIPN assessment in children, future research aimed at evaluating and further optimizing the psychometric characteristics of the ped-mTNS is needed.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00520-019-05106-3","type":"journal-article","created":{"date-parts":[[2019,11,16]],"date-time":"2019-11-16T02:02:49Z","timestamp":1573869769000},"page":"2867-2873","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Measuring vincristine-induced peripheral neuropathy in children with cancer: validation of the Dutch pediatric\u2013modified Total Neuropathy Score"],"prefix":"10.1007","volume":"28","author":[{"given":"S. M.","family":"Schouten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0424-2085","authenticated-orcid":false,"given":"M. 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Informed consent was obtained from all parents of participating children and from participants themselves in case they were 12 years or older.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}