{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T08:00:12Z","timestamp":1792828812358,"version":"4.5.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T00:00:00Z","timestamp":1579824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T00:00:00Z","timestamp":1579824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Health Research Board","award":["XX99XX"],"award-info":[{"award-number":["XX99XX"]}]},{"DOI":"10.13039\/501100000771","name":"Prostate Cancer UK","doi-asserted-by":"crossref","award":["xx99xx"],"award-info":[{"award-number":["xx99xx"]}],"id":[{"id":"10.13039\/501100000771","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Northern Ireland R&D","award":["xx99xx"],"award-info":[{"award-number":["xx99xx"]}]},{"name":"National Cancer Control Programme","award":["xx99xx"],"award-info":[{"award-number":["xx99xx"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Pain, fatigue and depression are common sequelae of a cancer diagnosis. The extent to which these occur together in prostate cancer survivors is unknown. We (i) investigated prevalence of the pain-fatigue-depression symptom cluster and (ii) identified factors associated with experiencing the symptom cluster among prostate cancer survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Men in Ireland diagnosed with prostate cancer 2\u201318\u00a0years previously were identified from population-based cancer registries and sent postal questionnaires. Cancer-related pain and fatigue were measured using the EORTC QLQ-C30 and depression using the DASS-21. Cut-offs to define \u2018caseness\u2019 were pain \u2265\u200925, fatigue \u2265\u200939 and depression \u2265\u200910. Associations between survivor-related factors, clinical variables and specific prostate cancer physical symptoms and the symptom cluster were assessed using multivariate logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 3348 men participated (response rate\u2009=\u200954%). Twenty-four percent had clinically significant pain, 19.7% had clinically significant fatigue, and 14.4% had depression; 7.3% had all three symptoms. In multivariate analysis, factors significantly associated with the symptom cluster were living in Northern Ireland, experiencing back pain at diagnosis and being affected by incontinence, loss of sexual desire, bowel problems, gynecomastia and hot flashes post-treatment. There was a strong association between the cluster and health-related quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The pain-fatigue-depression symptom cluster is present in 1 in 13 prostate cancer survivors. Physical after-effects of prostate cancer treatment are associated with this cluster. More attention should be paid to identifying and supporting survivors who experience multiple symptoms; this may help health-related quality of life improve among the growing population of prostate cancer survivors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00520-019-05268-0","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T05:02:50Z","timestamp":1579842170000},"page":"4813-4824","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Pain, fatigue and depression symptom cluster in survivors of prostate cancer"],"prefix":"10.1007","volume":"28","author":[{"given":"Manisha","family":"Baden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances J.","family":"Drummond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Gavin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9515-1722","authenticated-orcid":false,"given":"Linda","family":"Sharp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,24]]},"reference":[{"issue":"6","key":"5268_CR1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, Ferlay J, Soeromataram I et al (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68(6):394\u2013424","journal-title":"CA Cancer J Clin"},{"issue":"5","key":"5268_CR2","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.eururo.2016.05.043","volume":"70","author":"MCS Wong","year":"2016","unstructured":"Wong MCS, Goggins WB, Wang HHX et al (2016) Global incidence and mortality for prostate cancer: analysis of temporal patterns and trends in 36 countries. Eur Urol 70(5):862\u2013874","journal-title":"Eur Urol"},{"issue":"4","key":"5268_CR3","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3322\/caac.21235","volume":"64","author":"CE DeSantis","year":"2014","unstructured":"DeSantis CE, Lin CC, Mariotto AB, Siegel RL, Stein KD, Kramer JL, Alteri R, Robbins AS, Jemal A (2014) Cancer treatment and survivorship statistics. CA Cancer J Clin 64(4):252\u2013271","journal-title":"CA Cancer J Clin"},{"key":"5268_CR4","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1186\/1471-2407-14-767","volume":"14","author":"L Sharp","year":"2014","unstructured":"Sharp L, Deady S, Gallagher P et al (2014) The magnitude and characteristics of the population of cancer survivors: using population-based estimates of cancer prevalence to inform service planning for survivorship care. BMC Cancer 14:767","journal-title":"BMC Cancer"},{"issue":"15","key":"5268_CR5","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1056\/NEJMoa1606220","volume":"375","author":"FC Hamdy","year":"2016","unstructured":"Hamdy FC, Donovan J, Lane AJ et al (2016) 10-year outcomes after monitoring, surgery, or radiotherapy for localized prostate cancer. N Engl J Med 375(15):1415\u20131424","journal-title":"N Engl J Med"},{"issue":"3","key":"5268_CR6","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/bju.13329","volume":"118","author":"JK Bernat","year":"2016","unstructured":"Bernat JK, Wittman DA, Hawley ST et al (2016) Symptom burden and information needs in prostate cancer survivors: a case for tailored long-term survivorship care. BJU Int 118(3):372\u2013378","journal-title":"BJU Int"},{"issue":"2","key":"5268_CR7","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2190\/PM.40.2.c","volume":"40","author":"CB Harrington","year":"2010","unstructured":"Harrington CB, Hansen JA, Moskowitz M, Todd BL, Feuerstein M (2010) It's not over when it's over: long-term symptoms in cancer survivors--a systematic review. Int J Psychiatry Med 40(2):163\u2013181","journal-title":"Int J Psychiatry Med"},{"issue":"8","key":"5268_CR8","doi-asserted-by":"crossref","first-page":"531.e1","DOI":"10.1016\/j.urolonc.2017.03.028","volume":"35","author":"MA van Stam","year":"2017","unstructured":"van Stam MA, van der Poel HG, Bosch JLHR et al (2017) Prevalence and correlates of mental health problems in prostate cancer survivors: a case-control study comparing survivors with general population peers. Urol Oncol 35(8):531.e1\u2013531.e7","journal-title":"Urol Oncol"},{"issue":"4","key":"5268_CR9","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1177\/0269216310367842","volume":"24","author":"A Aktas","year":"2010","unstructured":"Aktas A, Walsh D, Rybicki L et al (2010) Symptom clusters: myth or reality? Palliat Med 24(4):373\u2013385","journal-title":"Palliat Med"},{"issue":"4","key":"5268_CR10","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1177\/1049909110364048","volume":"27","author":"J Kirkova","year":"2010","unstructured":"Kirkova J, Walsh D, Aktas A, Davis MP (2010) Cancer symptom clusters: old concept but new data. Am J Hosp Palliat Care 27(4):282\u2013288","journal-title":"Am J Hosp Palliat Care"},{"issue":"3","key":"5268_CR11","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.jpainsymman.2018.12.006","volume":"57","author":"M Jhamb","year":"2019","unstructured":"Jhamb M, Abdel-Kader K, Yabes J et al (2019) Comparison of fatigue, pain, and depression in patients with advanced kidney disease and cancer \u2013 symptom burden and clusters. J Pain Symptom Manag 57(3):566\u2013575","journal-title":"J Pain Symptom Manag"},{"issue":"4","key":"5268_CR12","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.soncn.2016.08.002","volume":"32","author":"DL Kelly","year":"2016","unstructured":"Kelly DL, Dickinson K, Hsiao CP, Lukkahatai N, Saligan LN (2016) Biological basis for the clustering of symptoms. Semin Oncol Nurs 32(4):351\u2013360","journal-title":"Semin Oncol Nurs"},{"key":"5268_CR13","doi-asserted-by":"crossref","unstructured":"Miaskowski C, Barsevick A, Berger A, Casagrande R, Grady PA, Jacobsen P, Kutner J, Patrick D, Zimmerman L, Xiao C, Matocha M, Marden S (2017) Advancing symptom science through symptom cluster research: expert panel proceedings and recommendations. J Natl Cancer Inst 109(4)","DOI":"10.1093\/jnci\/djw253"},{"issue":"6","key":"5268_CR14","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1007\/s00520-013-1751-5","volume":"21","author":"B Langston","year":"2013","unstructured":"Langston B, Armes J, Levy A, Tidey E, Ream E (2013) The prevalence and severity of fatigue in men with prostate cancer: a systematic review of the literature. Support Care Cancer 21(6):1761\u20131771","journal-title":"Support Care Cancer"},{"issue":"1","key":"5268_CR15","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1016\/j.ijrobp.2012.08.037","volume":"85","author":"N Pettersson","year":"2013","unstructured":"Pettersson N, Olsson C, Tucker SL et al (2013) Urethral pain among prostate cancer survivors 1 to 14 years after radiation therapy. Int J Radiat Oncol Biol Phys 85(1):e29\u2013e37","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"5268_CR16","doi-asserted-by":"crossref","unstructured":"Watts S, Leyden G, Birch B et al. (2014) Depression and anxiety in prostate cancer: a systematic review and meta-analysis of prevalence rates. BMJ open;4(3):e003901","DOI":"10.1136\/bmjopen-2013-003901"},{"issue":"1","key":"5268_CR17","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/annonc\/mdr034","volume":"23","author":"DJ Storey","year":"2012","unstructured":"Storey DJ, McLaren DB, Atkinson MA, Butcher I, Liggatt S, O'Dea R, Smyth JF, Sharpe M (2012) Clinically relevant fatigue in recurrence-free prostate cancer survivors. Ann Oncol 23(1):65\u201372","journal-title":"Ann Oncol"},{"issue":"4","key":"5268_CR18","doi-asserted-by":"crossref","first-page":"e006851","DOI":"10.1136\/bmjopen-2014-006851","volume":"5","author":"FJ Drummond","year":"2015","unstructured":"Drummond FJ, Kinnear H, Donnelly C et al (2015) Establishing a population-based patient-reported outcomes study (PROMs) using national cancer registries across two jurisdictions: the prostate cancer treatment, your experience (PiCTure) study. BMJ Open 5(4):e006851","journal-title":"BMJ Open"},{"issue":"3","key":"5268_CR19","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/bju.13036","volume":"116","author":"AT Gavin","year":"2015","unstructured":"Gavin AT, Drummond FJ, Donnelly C, O'Leary E, Sharp L, Kinnear HR (2015) Patient-reported 'ever had' and 'current' long-term physical symptoms after prostate cancer treatments. BJU Int 116(3):397\u2013406","journal-title":"BJU Int"},{"issue":"5","key":"5268_CR20","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1007\/s00520-015-3033-x","volume":"24","author":"FJ Drummond","year":"2016","unstructured":"Drummond FJ, O'Leary E, Gavin A, Kinnear H, Sharp L (2016) Mode of prostate cancer detection is associated with the psychological wellbeing of survivors: results from the PiCTure study. Support Care Cancer 24(5):2297\u20132307","journal-title":"Support Care Cancer"},{"key":"5268_CR21","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","volume":"85","author":"NK Aaronson","year":"1993","unstructured":"Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, Filiberti A, Flechtner H, Fleishman SB, de Haes JC (1993) The European Organisation for Research and Treatment of Cancer QLQ-C30: a quality of life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85:365\u2013376","journal-title":"J Natl Cancer Inst"},{"key":"5268_CR22","volume-title":"Manual for the depression anxiety stress scales","author":"SH Lovibond","year":"1995","unstructured":"Lovibond SH, Lovibond PF (1995) Manual for the depression anxiety stress scales, 2nd edn. Psychology Foundation, Sydney","edition":"2"},{"key":"5268_CR23","volume-title":"EORTC QLQ-C30 scoring manual","author":"P Fayers","year":"2001","unstructured":"Fayers P, Aaronson NK, Bjordal K, Groenvold M, Curran D, Bottomley A (2001) EORTC QLQ-C30 scoring manual, 3rd edn. European Organisation for Research and Treatment of Cancer, Brussels","edition":"3"},{"key":"5268_CR24","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12955-016-0489-4","volume":"14","author":"JM Giesinger","year":"2016","unstructured":"Giesinger JM, Kuijpers W, Young T et al (2016) Thresholds for clinical importance for four key domains of the EORTC QLQ-C30: physical functioning, emotional functioning, fatigue and pain. Health Qual Life Outcomes 14:87","journal-title":"Health Qual Life Outcomes"},{"key":"5268_CR25","doi-asserted-by":"crossref","unstructured":"Fleishman SB (2004) Treatment of symptom clusters: pain, depression, and fatigue. J Natl Cancer Inst Monogr (32):119\u2013123","DOI":"10.1093\/jncimonographs\/lgh028"},{"issue":"3","key":"5268_CR26","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.jpainsymman.2013.10.027","volume":"48","author":"ST Dong","year":"2014","unstructured":"Dong ST, Butow PN, Costa DSJ, Lovell MR, Agar M (2014) Symptom clusters in patients with advanced cancer: a systematic review of observational studies. J Pain Symptom Manag 48(3):411\u2013450","journal-title":"J Pain Symptom Manag"},{"issue":"11","key":"5268_CR27","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1007\/s00520-013-1885-5","volume":"21","author":"CC Reyes-Gibby","year":"2013","unstructured":"Reyes-Gibby CC, Swartz MD, Yu X, Wu X, Yennurajalingam S, Anderson KO, Spitz MR, Shete S (2013) Symptom clusters of pain, depressed mood, and fatigue in lung cancer: assessing the role of cytokine genes. Support Care Cancer 21(11):3117\u20133125","journal-title":"Support Care Cancer"},{"issue":"1","key":"5268_CR28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpainsymman.2010.10.261","volume":"42","author":"BJ Laird","year":"2011","unstructured":"Laird BJ, Scott AC, Colvin LA, McKeon A, Murray GD, Fearon KC, Fallon MT (2011) Pain, depression, and fatigue as a symptom cluster in advanced cancer. J Pain Symptom Manag 42(1):1\u201311","journal-title":"J Pain Symptom Manag"},{"issue":"18","key":"5268_CR29","doi-asserted-by":"crossref","first-page":"8522","DOI":"10.1200\/jco.2006.24.18_suppl.8522","volume":"24","author":"K Hauser","year":"2006","unstructured":"Hauser K, Rybicki L, Walsh D (2006) Do pain, depression and fatigue cluster in advanced cancer? J Clin Oncol 24(18):8522","journal-title":"J Clin Oncol"},{"key":"5268_CR30","unstructured":"Global Cancer Observatory. 27-Prostate cancer factsheet. Available at URL https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/27-Prostate-fact-sheet.pdf. Accessed 1st March 2019"},{"key":"5268_CR31","doi-asserted-by":"crossref","unstructured":"Wong LM, Neal DE. (2010) Where are we now with prostate cancer diagnosis? Trends Urol Men\u2019s Health 18\u201320","DOI":"10.1002\/tre.158"},{"issue":"10","key":"5268_CR32","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1111\/j.1464-410X.2008.07817.x","volume":"102","author":"SM Collin","year":"2008","unstructured":"Collin SM, Metcalfe C, Donovan J, Lane JA, Davis M, Neal D, Hamdy F, Martin RM (2008) Associations of lower urinary tract symptoms with prostate-specific antigen levels, and screen-detected localized and advanced prostate cancer: a case-control study nested within the UK population-based ProtecT (prostate testing for cancer and treatment) study. BJU Int 102(10):1400\u20131406","journal-title":"BJU Int"},{"issue":"4","key":"5268_CR33","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1177\/1557988314564593","volume":"10","author":"H Xiao","year":"2016","unstructured":"Xiao H, Tan F, Goovaerts P, Adunlin G, Ali AA, Gwede CK, Huang Y (2016) Impact of comorbidities on prostate cancer stage at diagnosis in Florida. Am J Mens Health 10(4):285\u2013295","journal-title":"Am J Mens Health"},{"key":"5268_CR34","unstructured":"National Cancer Registry Ireland. Cancer Trends 30. Prostate Cancer. NCRI, Cork, 2016. Available at URL: https:\/\/www.ncri.ie\/sites\/ncri\/files\/pubs\/prostateTrends2016.pdf. Accessed 1st December 2019"},{"issue":"12","key":"5268_CR35","doi-asserted-by":"crossref","first-page":"e012952","DOI":"10.1136\/bmjopen-2016-012952","volume":"6","author":"AT Gavin","year":"2016","unstructured":"Gavin AT, Donnelly D, Donnelly C, Drummond FJ, Morgan E, Gormley GJ, Sharp L (2016) Effect of investigation intensity and treatment differences on prostate cancer survivors physical symptoms, psychological well-being and health-related quality of life: a two country cross-sectional study. BMJ Open 6(12):e012952","journal-title":"BMJ Open"},{"issue":"4","key":"5268_CR36","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1111\/j.1743-6109.2008.01053.x","volume":"6","author":"RJ Wassersug","year":"2009","unstructured":"Wassersug RJ, Oliffe JL (2009) The social context for psychological distress from iatrogenic gynecomastia with suggestions for its management. J Sex Med 6(4):989\u20131000","journal-title":"J Sex Med"},{"issue":"1","key":"5268_CR37","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/NCC.0b013e318211fa92","volume":"35","author":"EA Grunfeld","year":"2012","unstructured":"Grunfeld EA, Halliday A, Martin P, Drudge-Coates L (2012) Andropause syndrome in men treated for metastatic prostate cancer: a qualitative study of the impact of symptoms. Cancer Nurs 35(1):63\u201369","journal-title":"Cancer Nurs"},{"issue":"6","key":"5268_CR38","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1093\/fampra\/cmh622","volume":"21","author":"S Horrocks","year":"2004","unstructured":"Horrocks S, Somerset M, Stoddart H, Peters TJ (2004) What prevents older people from seeking treatment for urinary incontinence? A qualitative exploration of barriers to the use of community continence services. Fam Pract 21(6):689\u2013696","journal-title":"Fam Pract"},{"issue":"7","key":"5268_CR39","doi-asserted-by":"crossref","first-page":"340.e7","DOI":"10.1016\/j.urolonc.2018.03.022","volume":"36","author":"A Sciarra","year":"2018","unstructured":"Sciarra A, Gentilucci A, Salciccia S et al (2018) Psychological and functional effect of different primary treatments for prostate cancer: a comparative prospective analysis. Urol Oncol 36(7):340.e7\u2013340.e21","journal-title":"Urol Oncol"},{"issue":"1","key":"5268_CR40","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ijrobp.2008.04.004","volume":"73","author":"F Mols","year":"2009","unstructured":"Mols F, Korfage IJ, Vingerhoets AJ et al (2009) Bowel, urinary, and sexual problems among long-term prostate cancer survivors: a population-based study. Int J Radiat Oncol Biol Phys 73(1):30\u201338","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"5268_CR41","doi-asserted-by":"crossref","unstructured":"Maguire R, Drummond FJ, Hanly P, Gavin A, Sharp L (2019) Problems sleeping with prostate cancer: exploring possible risk factors for sleep disturbance in a population-based sample of survivors. Support Care Cancer","DOI":"10.1007\/s00520-018-4633-z"},{"issue":"2","key":"5268_CR42","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.neucli.2017.03.001","volume":"47","author":"ME Medysky","year":"2017","unstructured":"Medysky ME, Temesi J, Culos-Reed SN, Millet GY (2017) Exercise, sleep and cancer-related fatigue: are they related? Neurophysiol Clin 47(2):111\u2013122","journal-title":"Neurophysiol Clin"},{"key":"5268_CR43","volume-title":"Cancer pain relief","author":"World Health Organization","year":"1986","unstructured":"World Health Organization (1986) Cancer pain relief. World Health Organization, Geneva"},{"issue":"4","key":"5268_CR44","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1177\/1534735418807555","volume":"17","author":"J Nakano","year":"2018","unstructured":"Nakano J, Hashizume K, Fukushima T, Ueno K, Matsuura E, Ikio Y, Ishii S, Morishita S, Tanaka K, Kusuba Y (2018) Effects of aerobic and resistance exercises on physical symptoms in cancer patients: a meta-analysis. Integr Cancer Ther 17(4):1048\u20131058","journal-title":"Integr Cancer Ther"},{"key":"5268_CR45","first-page":"273","volume-title":"Handbook of psycho-oncology: psychological care of the patient with cancer","author":"MJ Massie","year":"1989","unstructured":"Massie MJ, Holland JC (1989) Overview of normal reactions and prevalence of psychiatric disorders. In: Holland JC, Rowland JH (eds) Handbook of psycho-oncology: psychological care of the patient with cancer. Oxford University Press, New York, pp 273\u2013282"},{"key":"5268_CR46","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.1136\/bmj.e70","volume":"344","author":"DY Fong","year":"2012","unstructured":"Fong DY, Ho JW, Hui BP et al (2012) Physical activity for cancer survivors: meta-analysis of randomised controlled trials. BMJ 344:e70","journal-title":"BMJ"},{"issue":"5","key":"5268_CR47","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/ijn.12211","volume":"20","author":"D Larkin","year":"2014","unstructured":"Larkin D, Lopez V, Aromataris E (2014) Managing cancer-related fatigue in men with prostate cancer: a systematic review of non-pharmacological interventions. Int J Nurs Pract 20(5):549\u2013560","journal-title":"Int J Nurs Pract"},{"issue":"10","key":"5268_CR48","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrclinonc.2014.127","volume":"11","author":"JE Bower","year":"2014","unstructured":"Bower JE (2014) Cancer-related fatigue\u2014mechanisms, risk factors, and treatments. Nat Rev Clin Oncol 11(10):597\u2013609","journal-title":"Nat Rev Clin Oncol"},{"issue":"6","key":"5268_CR49","doi-asserted-by":"crossref","first-page":"e309","DOI":"10.12788\/jcso.0384","volume":"15","author":"FJ Drummond","year":"2017","unstructured":"Drummond FJ, Gavin AT, Sharp L (2017) Supportive medications and interventions received by prostate cancer survivors: results from the PiCTure study. J Comm Support Oncol 15(6):e309","journal-title":"J Comm Support Oncol"},{"issue":"4","key":"5268_CR50","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.jpainsymman.2015.11.021","volume":"51","author":"ST Dong","year":"2016","unstructured":"Dong ST, Butow PN, Agar M, Lovell MR, Tong A (2016) Clinicians\u2019 perspectives on managing symptom clusters in advanced cancer: a semistructured interview study. J Pain Symptom Manag 51(4):706\u201371751","journal-title":"J Pain Symptom Manag"},{"issue":"6","key":"5268_CR51","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.jpainsymman.2017.08.007","volume":"54","author":"S Kecke","year":"2017","unstructured":"Kecke S, Ernst J, Einenkel J, Singer S, Hinz A (2017) Psychometric properties of the fatigue questionnaire EORTC QLQ-FA12 in a sample of female cancer patients. J Pain Symptom Manag 54(6):922\u2013928","journal-title":"J Pain Symptom Manag"},{"issue":"4","key":"5268_CR52","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jpainsymman.2011.04.023","volume":"43","author":"AC Zucca","year":"2012","unstructured":"Zucca AC, Boyes AW, Linden W, Girgis A (2012) All\u2019s well that ends well? Quality of life and physical symptom clusters in long-term cancer survivors across cancer types. J Pain Symptom Manag 43(4):720\u2013731","journal-title":"J Pain Symptom Manag"},{"issue":"6","key":"5268_CR53","doi-asserted-by":"crossref","first-page":"e12919","DOI":"10.1111\/ecc.12919","volume":"27","author":"JH Nho","year":"2018","unstructured":"Nho JH, Kim SR, Park MH, Kweon SS (2018) Symptom clusters and quality of life in breast cancer survivors after cancer treatment in a tertiary hospital in Korea. Eur J Cancer Care (Engl) 27(6):e12919","journal-title":"Eur J Cancer Care (Engl)"},{"issue":"9","key":"5268_CR54","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1177\/0193945917701688","volume":"40","author":"M Kim","year":"2018","unstructured":"Kim M, Kim K, Lim C, Kim JS (2018) Symptom clusters and quality of life according to the survivorship stage in ovarian cancer survivors. West J Nurs Res 40(9):1278\u20131300","journal-title":"West J Nurs Res"},{"issue":"6B","key":"5268_CR55","doi-asserted-by":"crossref","first-page":"E10","DOI":"10.1111\/bju.13122","volume":"117","author":"E Watson","year":"2016","unstructured":"Watson E, Shinkins B, Frith E, Neal D, Hamdy F, Walter F, Weller D, Wilkinson C, Faithfull S, Wolstenholme J, Sooriakumaran P, Kastner C, Campbell C, Neal R, Butcher H, Matthews M, Perera R, Rose P (2016) Symptoms, unmet needs, psychological well-being and health status in survivors of prostate cancer: implications for redesigning follow-up. BJU Int 117(6B):E10\u2013E19","journal-title":"BJU Int"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-019-05268-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00520-019-05268-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-019-05268-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T13:17:05Z","timestamp":1722345425000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00520-019-05268-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,24]]},"references-count":55,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["5268"],"URL":"https:\/\/doi.org\/10.1007\/s00520-019-05268-0","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,24]]},"assertion":[{"value":"8 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None of the authors have any conflicts of interest to declare. The authors (via the corresponding author, LS) have full control of all primary data and agree to allow the journal to review this data if requested.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}