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Peer reviewed guidance to investigate and manage GI dysfunction following cancer treatment has been published. This study reviewed gastrointestinal symptoms of women previously treated for gynaecological cancer and considered whether suggested algorithms could be amended to optimise management for this cohort.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Demographic and clinical data recorded for patients attending a specialist consequences of cancer treatment gastroenterology service prospectively are reported using median and range. The Wilcoxon signed rank test analysed changes in symptoms between initial assessment to discharge from the service.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Between April 2013 and March 2016, 220 women, with a median age of 57\u00a0years (range 24\u201383\u00a0years), treated for gynaecological cancer (cervical (50%)), endometrial (28%), ovarian (15%), vaginal or vulval (7%) attended. Twelve gastrointestinal symptoms were statistically significantly reduced by time of discharge from the specialist gastroenterology clinic including bowel frequency \u2265\u20094\/day (88%), type 6 or 7 stool consistency (36%), urgency (31%) and incontinence (21%). General quality of life improved from a median score of 4 at first assessment to a median of 6 at discharge (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001). A median of four (range, 1\u20139) diagnoses were made.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Women with gastrointestinal symptoms after cancer treatment benefit from a systematic management approach. After excluding disease recurrence, a proposed investigational algorithm and the oncology team includes FBC, U&amp;Es, LFTs, thyroid function test, vitamin B<jats:sub>12<\/jats:sub>, vitamin D, a hydrogen methane breath test and a SeHCAT scan. If rectal bleeding is present, iron studies, flexible sigmoidoscopy or colonoscopy should be performed. Patients with normal investigations or symptoms not responding to treatment require gastroenterology input.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00520-020-05309-z","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T09:02:32Z","timestamp":1580288552000},"page":"4881-4889","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A proposed tailored investigational algorithm for women treated for gynaecological cancer with long-term gastrointestinal consequences"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7678-859X","authenticated-orcid":false,"given":"Ann","family":"Muls","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Lalondrelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Kabir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Norton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ailsa","family":"Hart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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Dr. Taylor has nothing to disclose. Dr. Lalondrelle reports personal fees from Sanofi Genzyme, grants from MSD, personal fees from Roche, grants and personal fees from Elekta, outside the submitted work. Mr. Mohammed has nothing to disclose. Professor Norton reports personal fees from Takeda, personal fees from Tillotts Pharma, personal fees from Ferring, outside the submitted work. Professor Hart has served as a consultant, advisory board member or speaker for AbbVie, Atlantic, Bristol-Myers Squibb, Celltrion, Falk, Ferring, Janssen, MSD, Napp Pharmaceuticals, Pfizer, Pharmacosmos, Shire and Takeda. She also serves on the Global Steering Committee for Genentech. Professor Andreyev reports non-financial support from GE Healthcare and manufacturers of SeHCAT, outside the submitted work.The corresponding author has full control over the primary data.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}}]}}