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Influencing factors of CRF in allo-HSCT candidates have not been studied so far. Aim was to identify potentially influencing factors on CRF.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>To assess CRF, a maximal cardiopulmonary exercise test (CPET) was performed on average 2.6\u2009\u00b1\u20097.2\u00a0days prior to admission. A regression analysis was conducted, with the following predictors: gender, age, body mass index (BMI), time between last therapy and allo-HSCT (t_Therapies), number of cardiotoxic therapies (n_Cardiotox), number of transplantations (n_Transplantations), comorbidity index (HCT-CI), hemoglobin level of the last 3\u00a0months (area under the curve), and physical activity.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 194 patients performed a CPET. VO<jats:sub>2peak<\/jats:sub> was significantly reduced compared with reference data. In total, VO<jats:sub>2peak<\/jats:sub> was 21.4\u00a0ml\/min\/kg (\u2212\u200927.5%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Men showed a significant larger percentage difference from reference value (\u2212\u200929.1%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) than women (\u2212\u200924.4%). VO<jats:sub>2peak<\/jats:sub> was significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) influenced by age (\u03b2\u2009=\u2009\u2212\u20090.11), female gender (\u03b2\u2009=\u2009\u2212\u20093.01), BMI (\u03b2\u2009=\u2009\u2212\u20090.44), n_Cardiotox (\u03b2\u2009=\u2009\u2212\u20090.73), hemoglobin level (\u03b2\u2009=\u20090.56), and physical activity prior to diagnosis (\u03b2\u2009=\u20090.10).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Our study demonstrates a decreased CRF indicating the potential need of prehabilitative exercise. We revealed some influencing factors on CRF. Those patients could benefit the most from exercise.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00520-020-05485-y","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T16:03:37Z","timestamp":1588608217000},"page":"359-367","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Influencing factors of cardiorespiratory fitness in allogeneic stem cell transplant candidates prior to transplantation"],"prefix":"10.1007","volume":"29","author":[{"given":"Matthias","family":"Limbach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rea","family":"Kuehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Dreger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Luft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"Rosenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus","family":"Kleindienst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Friedmann-Bette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bondong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bohus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5971-5436","authenticated-orcid":false,"given":"Joachim","family":"Wiskemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,4]]},"reference":[{"key":"5485_CR1","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1038\/bmt.2016.20","volume":"51","author":"JR Passweg","year":"2016","unstructured":"Passweg JR, Baldomero H, Bader P, Bonini C, Cesaro S, Dreger P, Duarte RF, Dufour C, Kuball J, Farge-Bancel D, Gennery A, Kroger N, Lanza F, Nagler A, Sureda A, Mohty M (2016) Hematopoietic stem cell transplantation in Europe 2014: more than 40 000 transplants annually. 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