{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T02:39:46Z","timestamp":1788575986926,"version":"build-2803163510"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T00:00:00Z","timestamp":1625184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T00:00:00Z","timestamp":1625184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s00520-021-06337-z","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T05:02:34Z","timestamp":1625202154000},"page":"7931-7947","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Risk prediction models based on hematological\/body parameters for chemotherapy-induced adverse effects in Chinese colorectal cancer patients"],"prefix":"10.1007","volume":"29","author":[{"given":"Mingming","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiani","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houshan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0025-1315","authenticated-orcid":false,"given":"Wansheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,2]]},"reference":[{"key":"6337_CR1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, Ferlay J, Soerjomataram I et al (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68:394\u2013424. https:\/\/doi.org\/10.3322\/caac.21492","journal-title":"CA Cancer J Clin"},{"key":"6337_CR2","doi-asserted-by":"publisher","first-page":"e8242","DOI":"10.1097\/MD.0000000000008242","volume":"96","author":"Y Zhang","year":"2017","unstructured":"Zhang Y, Chen Z, Li J (2017) The current status of treatment for colorectal cancer in China: a systematic review. Medicine (Baltimore) 96:e8242. https:\/\/doi.org\/10.1097\/MD.0000000000008242","journal-title":"Medicine (Baltimore)"},{"key":"6337_CR3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3761\/j.issn.0254-1769.2017.01.001","volume":"52","author":"Y Chen","year":"2017","unstructured":"Chen Y, Zhang M, Qin H et al (2017) Correlation between oral chemotherapy adherence and illness perception in colorectal cancer patients: a longitudinal study. Chin J Nurs 52:8\u201313. https:\/\/doi.org\/10.3761\/j.issn.0254-1769.2017.01.001","journal-title":"Chin J Nurs"},{"key":"6337_CR4","doi-asserted-by":"publisher","first-page":"4289","DOI":"10.1245\/s10434-013-3217-x","volume":"20","author":"M Ychou","year":"2013","unstructured":"Ychou M, Rivoire M, Thezenas S et al (2013) A randomized phase II trial of three intensified chemotherapy regimens in first-line treatment of colorectal cancer patients with initially unresectable or not optimally resectable liver metastases. The METHEP trial Ann Surg Oncol 20:4289\u20134297. https:\/\/doi.org\/10.1245\/s10434-013-3217-x","journal-title":"The METHEP trial Ann Surg Oncol"},{"key":"6337_CR5","doi-asserted-by":"publisher","first-page":"359","DOI":"10.6004\/jnccn.2018.0021","volume":"16","author":"AB Benson","year":"2018","unstructured":"Benson AB, Venook AP, Al-Hawary MM et al (2018) NCCN Guidelines insights: colon cancer, Version 2.2018. J Natl Compr Canc Netw 16:359\u2013369. https:\/\/doi.org\/10.6004\/jnccn.2018.0021","journal-title":"J Natl Compr Canc Netw"},{"key":"6337_CR6","first-page":"383","volume":"41","author":"Y Hasegawa","year":"2014","unstructured":"Hasegawa Y, Iwata H, Hatanaka M (2014) A case of Stage IV sigmoid colon cancer that achieved long-term survival with oral anticancer drugs. Gan To Kagaku Ryoho 41:383\u2013385","journal-title":"Gan To Kagaku Ryoho"},{"issue":"Suppl 3","key":"6337_CR7","doi-asserted-by":"publisher","first-page":"e110","DOI":"10.4103\/0019-509X.154100","volume":"51","author":"QH Zheng","year":"2014","unstructured":"Zheng QH, Wu XL, Che XL et al (2014) Chemotherapy combined with target drugs in the treatment of advanced colorectal cancer: a meta-analysis based on Chinese patients. Indian J Cancer 51(Suppl 3):e110-112. https:\/\/doi.org\/10.4103\/0019-509X.154100","journal-title":"Indian J Cancer"},{"key":"6337_CR8","doi-asserted-by":"publisher","first-page":"2444","DOI":"10.1200\/JCO.2014.60.4587","volume":"33","author":"RD Hofheinz","year":"2015","unstructured":"Hofheinz RD, Gencer D, Schulz H et al (2015) Mapisal versus urea cream as prophylaxis for capecitabine-associated hand-foot syndrome: a randomized phase III trial of the AIO quality of life working group. J Clin Oncol 33:2444\u20132449. https:\/\/doi.org\/10.1200\/JCO.2014.60.4587","journal-title":"J Clin Oncol"},{"key":"6337_CR9","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1001\/jamaoncol.2017.1269","volume":"3","author":"YS Yap","year":"2017","unstructured":"Yap YS, Kwok LL, Syn N et al (2017) Predictors of hand-foot syndrome and pyridoxine for prevention of capecitabine-induced hand-foot syndrome: a randomized clinical trial. JAMA Oncol 3:1538\u20131545. https:\/\/doi.org\/10.1001\/jamaoncol.2017.1269","journal-title":"JAMA Oncol"},{"key":"6337_CR10","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1634\/theoncologist.2017-0637","volume":"23","author":"SL Chan","year":"2018","unstructured":"Chan SL, Chan AWH, Mo F et al (2018) Association between serum folate level and toxicity of capecitabine during treatment for colorectal cancer. Oncologist 23:1436\u20131445. https:\/\/doi.org\/10.1634\/theoncologist.2017-0637","journal-title":"Oncologist"},{"key":"6337_CR11","doi-asserted-by":"publisher","first-page":"6422","DOI":"10.18632\/oncotarget.3289","volume":"6","author":"X Garc\u00eda-Gonz\u00e1lez","year":"2015","unstructured":"Garc\u00eda-Gonz\u00e1lez X, Cortejoso L, Garc\u00eda MI et al (2015) Variants in CDA and ABCB1 are predictors of capecitabine-related adverse reactions in colorectal cancer. Oncotarget 6:6422\u20136430. https:\/\/doi.org\/10.18632\/oncotarget.3289","journal-title":"Oncotarget"},{"key":"6337_CR12","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1016\/j.ijrobp.2015.12.374","volume":"94","author":"NB Newman","year":"2016","unstructured":"Newman NB, Sidhu MK, Baby R et al (2016) Long-term bone marrow suppression during postoperative chemotherapy in rectal cancer patients after preoperative chemoradiation therapy. Int J Radiat Oncol Biol Phys 94:1052\u20131060. https:\/\/doi.org\/10.1016\/j.ijrobp.2015.12.374","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"6337_CR13","doi-asserted-by":"publisher","first-page":"561","DOI":"10.2147\/PPA.S80327","volume":"9","author":"K Kawakami","year":"2015","unstructured":"Kawakami K, Nakamoto E, Yokokawa T et al (2015) Patients\u2019 self-reported adherence to capecitabine on XELOX treatment in metastatic colorectal cancer: findings from a retrospective cohort analysis. Patient Prefer Adherence 9:561\u2013567. https:\/\/doi.org\/10.2147\/PPA.S80327","journal-title":"Patient Prefer Adherence"},{"key":"6337_CR14","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1111\/j.1365-2354.2009.01121.x","volume":"19","author":"A L\u00f3pez-Pousa","year":"2010","unstructured":"L\u00f3pez-Pousa A, Rif\u00e0 J, Casas de Tejerina A et al (2010) Risk assessment model for first-cycle chemotherapy-induced neutropenia in patients with solid tumours. Eur J Cancer Care (Engl) 19:648\u2013655. https:\/\/doi.org\/10.1111\/j.1365-2354.2009.01121.x","journal-title":"Eur J Cancer Care (Engl)"},{"key":"6337_CR15","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1002\/ptr.6068","volume":"32","author":"B Deng","year":"2018","unstructured":"Deng B, Sun W (2018) Herbal medicine for hand-foot syndrome induced by fluoropyrimidines: A systematic review and meta-analysis. Phytother Res 32:1211\u20131228. https:\/\/doi.org\/10.1002\/ptr.6068","journal-title":"Phytother Res"},{"key":"6337_CR16","doi-asserted-by":"publisher","first-page":"6925","DOI":"10.7150\/jca.47631","volume":"11","author":"Y Deng","year":"2020","unstructured":"Deng Y, Yao H, Chen W et al (2020) Profiling of polar urine metabolite extracts from Chinese colorectal cancer patients to screen for potential diagnostic and adverse-effect biomarkers. J Cancer 11:6925\u20136938. https:\/\/doi.org\/10.7150\/jca.47631","journal-title":"J Cancer"},{"key":"6337_CR17","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1146\/annurev-nutr-071714-034330","volume":"35","author":"PM Ueland","year":"2015","unstructured":"Ueland PM, Ulvik A, Rios-Avila L et al (2015) Direct and functional biomarkers of Vitamin B6 status. Annu Rev Nutr 35:33\u201370. https:\/\/doi.org\/10.1146\/annurev-nutr-071714-034330","journal-title":"Annu Rev Nutr"},{"key":"6337_CR18","doi-asserted-by":"publisher","first-page":"2932","DOI":"10.1002\/ijc.29345","volume":"136","author":"H Zuo","year":"2015","unstructured":"Zuo H, Ueland PM, Eussen SJPM et al (2015) Markers of vitamin B6 status and metabolism as predictors of incident cancer: the Hordaland Health Study. Int J Cancer 136:2932\u20132939. https:\/\/doi.org\/10.1002\/ijc.29345","journal-title":"Int J Cancer"},{"key":"6337_CR19","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.clnu.2013.06.012","volume":"32","author":"JAE Langius","year":"2013","unstructured":"Langius JAE, Zandbergen MC, Eerenstein SEJ et al (2013) Effect of nutritional interventions on nutritional status, quality of life and mortality in patients with head and neck cancer receiving (chemo)radiotherapy: a systematic review. Clin Nutr 32:671\u2013678. https:\/\/doi.org\/10.1016\/j.clnu.2013.06.012","journal-title":"Clin Nutr"},{"key":"6337_CR20","doi-asserted-by":"publisher","first-page":"CD010578","DOI":"10.1002\/14651858.CD010578.pub2","volume":"11","author":"J Visser","year":"2018","unstructured":"Visser J, McLachlan MH, Maayan N, Garner P (2018) Community-based supplementary feeding for food insecure, vulnerable and malnourished populations - an overview of systematic reviews. Cochrane Database Syst Rev 11:CD010578. https:\/\/doi.org\/10.1002\/14651858.CD010578.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"6337_CR21","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1182\/blood-2015-08-607929","volume":"127","author":"X Sim","year":"2016","unstructured":"Sim X, Poncz M, Gadue P, French DL (2016) Understanding platelet generation from megakaryocytes: implications for in vitro-derived platelets. Blood 127:1227\u20131233. https:\/\/doi.org\/10.1182\/blood-2015-08-607929","journal-title":"Blood"},{"key":"6337_CR22","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.3781\/j.issn.1000-7431.2018.11.564","volume":"38","author":"W Chen","year":"2018","unstructured":"Chen W, Li M, Yao H et al (2018) Application values of tumor markers and inflammatory markers in diagnosis of colorectal cancer and prediction of chemotherapy-related adverse effects. Tumor 38:1038\u20131047. https:\/\/doi.org\/10.3781\/j.issn.1000-7431.2018.11.564","journal-title":"Tumor"},{"key":"6337_CR23","doi-asserted-by":"publisher","first-page":"878","DOI":"10.13748\/j.cnki.issn1007-7693.2018.06.020","volume":"35","author":"R Xu","year":"2018","unstructured":"Xu R, Li J, Yuan Y et al (2018) Preliminary study on prediction model of adverse reactions in patients with lymphatic tumors after chemotherapy with high dose methotrexat. Chinese Journal of Modern Applied Pharmacy 35:878\u2013883. https:\/\/doi.org\/10.13748\/j.cnki.issn1007-7693.2018.06.020","journal-title":"Chinese Journal of Modern Applied Pharmacy"},{"key":"6337_CR24","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1093\/annonc\/mdn655","volume":"20","author":"M Moreau","year":"2009","unstructured":"Moreau M, Klastersky J, Schwarzbold A et al (2009) A general chemotherapy myelotoxicity score to predict febrile neutropenia in hematological malignancies. Ann Oncol 20:513\u2013519. https:\/\/doi.org\/10.1093\/annonc\/mdn655","journal-title":"Ann Oncol"},{"key":"6337_CR25","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.1007\/s00520-013-1843-2","volume":"21","author":"A Molassiotis","year":"2013","unstructured":"Molassiotis A, Stamataki Z, Kontopantelis E (2013) Development and preliminary validation of a risk prediction model for chemotherapy-related nausea and vomiting. Support Care Cancer 21:2759\u20132767. https:\/\/doi.org\/10.1007\/s00520-013-1843-2","journal-title":"Support Care Cancer"},{"key":"6337_CR26","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1007\/s00520-009-0737-9","volume":"18","author":"PJ Hesketh","year":"2010","unstructured":"Hesketh PJ, Aapro M, Street JC, Carides AD (2010) Evaluation of risk factors predictive of nausea and vomiting with current standard-of-care antiemetic treatment: analysis of two phase III trials of aprepitant in patients receiving cisplatin-based chemotherapy. Support Care Cancer 18:1171\u20131177. https:\/\/doi.org\/10.1007\/s00520-009-0737-9","journal-title":"Support Care Cancer"},{"key":"6337_CR27","doi-asserted-by":"publisher","first-page":"3691","DOI":"10.1007\/s00520-018-4224-z","volume":"26","author":"A Razzaghdoust","year":"2018","unstructured":"Razzaghdoust A, Mofid B, Moghadam M (2018) Development of a simplified multivariable model to predict neutropenic complications in cancer patients undergoing chemotherapy. Support Care Cancer 26:3691\u20133699. https:\/\/doi.org\/10.1007\/s00520-018-4224-z","journal-title":"Support Care Cancer"},{"key":"6337_CR28","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1186\/s12885-016-2934-5","volume":"16","author":"SH Seo","year":"2016","unstructured":"Seo SH, Kim S-E, Kang Y-K et al (2016) Association of nutritional status-related indices and chemotherapy-induced adverse events in gastric cancer patients. BMC Cancer 16:900. https:\/\/doi.org\/10.1186\/s12885-016-2934-5","journal-title":"BMC Cancer"},{"key":"6337_CR29","first-page":"20","volume":"2004","author":"Y He","year":"2004","unstructured":"He Y, Jian Z, OuYang M et al (2004) Using mini-nutritional assessment to investigate the nutritional status of the aged hospitalized patients. Chin J Clin Nutr 2004:20\u201323","journal-title":"Chin J Clin Nutr"},{"key":"6337_CR30","doi-asserted-by":"publisher","unstructured":"Lei B, Zheng G (2015) Chemotherapy-induced myelosuppression of non-small cell lung cancer: clinical analysis of risk factors and development of a predictive model. Journal of Clinical Medical Literature 2: https:\/\/doi.org\/10.16281\/j.cnki.jocml.2015.36.01","DOI":"10.16281\/j.cnki.jocml.2015.36.01"},{"key":"6337_CR31","unstructured":"National Institutes of Health, National Cancer Institute (2009) Common terminology criteria for adverse events (CTCAE) Version 4.0. U.S.DEPARTMENT OF HEALTH AND HUMAN SERVICES"},{"key":"6337_CR32","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1016\/j.spinee.2019.06.018","volume":"19","author":"SS Han","year":"2019","unstructured":"Han SS, Azad TD, Suarez PA, Ratliff JK (2019) A machine learning approach for predictive models of adverse events following spine surgery. Spine J 19:1772\u20131781. https:\/\/doi.org\/10.1016\/j.spinee.2019.06.018","journal-title":"Spine J"},{"key":"6337_CR33","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/j.jaad.2014.03.019","volume":"71","author":"KK Miller","year":"2014","unstructured":"Miller KK, Gorcey L, McLellan BN (2014) Chemotherapy-induced hand-foot syndrome and nail changes: a review of clinical presentation, etiology, pathogenesis, and management. J Am Acad Dermatol 71:787\u2013794. https:\/\/doi.org\/10.1016\/j.jaad.2014.03.019","journal-title":"J Am Acad Dermatol"},{"key":"6337_CR34","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1177\/0091270004268321","volume":"44","author":"YS Heo","year":"2004","unstructured":"Heo YS, Chang HM, Kim TW et al (2004) Hand-foot syndrome in patients treated with capecitabine-containing combination chemotherapy. J Clin Pharmacol 44:1166\u20131172. https:\/\/doi.org\/10.1177\/0091270004268321","journal-title":"J Clin Pharmacol"},{"key":"6337_CR35","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1038\/bjc.2012.434","volume":"107","author":"R-D Hofheinz","year":"2012","unstructured":"Hofheinz R-D, Heinemann V, von Weikersthal LF et al (2012) Capecitabine-associated hand-foot-skin reaction is an independent clinical predictor of improved survival in patients with colorectal cancer. Br J Cancer 107:1678\u20131683. https:\/\/doi.org\/10.1038\/bjc.2012.434","journal-title":"Br J Cancer"},{"key":"6337_CR36","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1093\/annonc\/mdr400","volume":"23","author":"RX Zhang","year":"2012","unstructured":"Zhang RX, Wu XJ, Wan DS et al (2012) Celecoxib can prevent capecitabine-related hand-foot syndrome in stage II and III colorectal cancer patients: result of a single-center, prospective randomized phase III trial. Ann Oncol 23:1348\u20131353. https:\/\/doi.org\/10.1093\/annonc\/mdr400","journal-title":"Ann Oncol"},{"key":"6337_CR37","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.clinthera.2014.02.007","volume":"36","author":"CA Forbes","year":"2014","unstructured":"Forbes CA, Worthy G, Harker J et al (2014) Dose efficiency of erythropoiesis-stimulating agents for the treatment of patients with chemotherapy-induced anemia: a systematic review. Clin Ther 36:594\u2013610. https:\/\/doi.org\/10.1016\/j.clinthera.2014.02.007","journal-title":"Clin Ther"},{"key":"6337_CR38","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1177\/2472555218777968","volume":"23","author":"KK Javarappa","year":"2018","unstructured":"Javarappa KK, Tsallos D, Heckman CA (2018) A multiplexed screening assay to evaluate chemotherapy-induced myelosuppression using healthy peripheral blood and bone marrow. SLAS Discov 23:687\u2013696. https:\/\/doi.org\/10.1177\/2472555218777968","journal-title":"SLAS Discov"},{"key":"6337_CR39","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1038\/clpt.2008.220","volume":"85","author":"E H\u00e9nin","year":"2009","unstructured":"H\u00e9nin E, You B, VanCutsem E et al (2009) A dynamic model of hand-and-foot syndrome in patients receiving capecitabine. Clin Pharmacol Ther 85:418\u2013425. https:\/\/doi.org\/10.1038\/clpt.2008.220","journal-title":"Clin Pharmacol Ther"},{"key":"6337_CR40","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1080\/14740338.2016.1238067","volume":"15","author":"V Nikolaou","year":"2016","unstructured":"Nikolaou V, Syrigos K, Saif MW (2016) Incidence and implications of chemotherapy related hand-foot syndrome. Expert Opin Drug Saf 15:1625\u20131633. https:\/\/doi.org\/10.1080\/14740338.2016.1238067","journal-title":"Expert Opin Drug Saf"},{"key":"6337_CR41","doi-asserted-by":"publisher","first-page":"754","DOI":"10.3389\/fimmu.2018.00754","volume":"9","author":"NR Sproston","year":"2018","unstructured":"Sproston NR, Ashworth JJ (2018) Role of c-reactive protein at sites of inflammation and infection. Front Immunol 9:754. https:\/\/doi.org\/10.3389\/fimmu.2018.00754","journal-title":"Front Immunol"},{"key":"6337_CR42","doi-asserted-by":"publisher","first-page":"25516","DOI":"10.18632\/oncotarget.8334","volume":"7","author":"J You","year":"2016","unstructured":"You J, Zhu G-Q, Xie L et al (2016) Preoperative platelet to lymphocyte ratio is a valuable prognostic biomarker in patients with colorectal cancer. Oncotarget 7:25516. https:\/\/doi.org\/10.18632\/oncotarget.8334","journal-title":"Oncotarget"},{"key":"6337_CR43","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1186\/s12885-018-5042-x","volume":"18","author":"N Dimitriou","year":"2018","unstructured":"Dimitriou N, Felekouras E, Karavokyros I et al (2018) Neutrophils to lymphocytes ratio as a useful prognosticator for stage II colorectal cancer patients. BMC Cancer 18:1202. https:\/\/doi.org\/10.1186\/s12885-018-5042-x","journal-title":"BMC Cancer"},{"key":"6337_CR44","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nm.3814","volume":"21","author":"VG Sankaran","year":"2015","unstructured":"Sankaran VG, Weiss MJ (2015) Anemia: progress in molecular mechanisms and therapies. Nat Med 21:221\u2013230. https:\/\/doi.org\/10.1038\/nm.3814","journal-title":"Nat Med"},{"key":"6337_CR45","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1002\/wsbm.86","volume":"2","author":"J Seita","year":"2010","unstructured":"Seita J, Weissman IL (2010) Hematopoietic stem cell: self-renewal versus differentiation. Wiley Interdiscip Rev Syst Biol Med 2:640\u2013653. https:\/\/doi.org\/10.1002\/wsbm.86","journal-title":"Wiley Interdiscip Rev Syst Biol Med"},{"key":"6337_CR46","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1038\/nm.3647","volume":"20","author":"A Mendelson","year":"2014","unstructured":"Mendelson A, Frenette PS (2014) Hematopoietic stem cell niche maintenance during homeostasis and regeneration. Nat Med 20:833\u2013846. https:\/\/doi.org\/10.1038\/nm.3647","journal-title":"Nat Med"},{"key":"6337_CR47","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.ygyno.2006.01.031","volume":"103","author":"ME Gordinier","year":"2006","unstructured":"Gordinier ME, Dizon DS, Fleming EL et al (2006) Elevated body mass index does not increase the risk of palmar-plantar erythrodysesthesia in patients receiving pegylated liposomal doxorubicin. Gynecol Oncol 103:72\u201374. https:\/\/doi.org\/10.1016\/j.ygyno.2006.01.031","journal-title":"Gynecol Oncol"},{"key":"6337_CR48","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.ygyno.2009.04.007","volume":"114","author":"JL Tanyi","year":"2009","unstructured":"Tanyi JL, Smith JA, Ramos L et al (2009) Predisposing risk factors for palmar-plantar erythrodysesthesia when using liposomal doxorubicin to treat recurrent ovarian cancer. Gynecol Oncol 114:219\u2013224. https:\/\/doi.org\/10.1016\/j.ygyno.2009.04.007","journal-title":"Gynecol Oncol"},{"key":"6337_CR49","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1093\/annonc\/mdx100","volume":"28","author":"G Dranitsaris","year":"2017","unstructured":"Dranitsaris G, Molassiotis A, Clemons M et al (2017) The development of a prediction tool to identify cancer patients at high risk for chemotherapy-induced nausea and vomiting. Ann Oncol 28:1260\u20131267. https:\/\/doi.org\/10.1093\/annonc\/mdx100","journal-title":"Ann Oncol"},{"key":"6337_CR50","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s12032-018-1188-2","volume":"35","author":"A Watanabe","year":"2018","unstructured":"Watanabe A, Yang CC, Cheung WY (2018) Association of baseline patient characteristics with adjuvant chemotherapy toxicities in stage III colorectal cancer patients. Med Oncol 35:125. https:\/\/doi.org\/10.1007\/s12032-018-1188-2","journal-title":"Med Oncol"},{"key":"6337_CR51","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/codi.13807","volume":"20","author":"M Egenvall","year":"2018","unstructured":"Egenvall M, M\u00f6rner M, Martling A, Gunnarsson U (2018) Prediction of outcome after curative surgery for colorectal cancer: preoperative haemoglobin, C-reactive protein and albumin. Colorectal Dis 20:26\u201334. https:\/\/doi.org\/10.1111\/codi.13807","journal-title":"Colorectal Dis"},{"key":"6337_CR52","doi-asserted-by":"publisher","first-page":"3630","DOI":"10.1093\/jn\/133.11.3630","volume":"133","author":"L Hao","year":"2003","unstructured":"Hao L, Ma J, Stampfer MJ et al (2003) Geographical, seasonal and gender differences in folate status among Chinese adults. J Nutr 133:3630\u20133635. https:\/\/doi.org\/10.1093\/jn\/133.11.3630","journal-title":"J Nutr"},{"key":"6337_CR53","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1177\/0300985814529315","volume":"52","author":"CN Grimes","year":"2015","unstructured":"Grimes CN, Fry MM (2015) Nonregenerative anemia: mechanisms of decreased or ineffective erythropoiesis. Vet Pathol 52:298\u2013311. https:\/\/doi.org\/10.1177\/0300985814529315","journal-title":"Vet Pathol"},{"key":"6337_CR54","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1182\/blood.V128.22.2399.2399","volume":"128","author":"C Chao","year":"2016","unstructured":"Chao C, Xu L, Family L, Xu H (2016) A risk prediction model for severe chemotherapy-induced anemia in breast cancer patients. Blood 128:2399\u20132399. https:\/\/doi.org\/10.1182\/blood.V128.22.2399.2399","journal-title":"Blood"},{"key":"6337_CR55","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1093\/jjco\/hyr076","volume":"41","author":"M Ishizuka","year":"2011","unstructured":"Ishizuka M, Fujimoto Y, Itoh Y et al (2011) Relationship between hematotoxicity and serum albumin level in the treatment of head and neck cancers with concurrent chemoradiotherapy using cisplatin. Jpn J Clin Oncol 41:973\u2013979. https:\/\/doi.org\/10.1093\/jjco\/hyr076","journal-title":"Jpn J Clin Oncol"},{"key":"6337_CR56","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1016\/S1470-2045(05)70394-6","volume":"6","author":"G Dranitsaris","year":"2005","unstructured":"Dranitsaris G, Clemons M, Verma S et al (2005) Chemotherapy-induced anaemia during adjuvant treatment for breast cancer: development of a prediction model. Lancet Oncol 6:856\u2013863. https:\/\/doi.org\/10.1016\/S1470-2045(05)70394-6","journal-title":"Lancet Oncol"},{"key":"6337_CR57","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s00520-019-04780-7","volume":"28","author":"A Razzaghdoust","year":"2020","unstructured":"Razzaghdoust A, Mofid B, Peyghambarlou P (2020) Predictors of chemotherapy-induced severe anemia in cancer patients receiving chemotherapy. Support Care Cancer 28:155\u2013161. https:\/\/doi.org\/10.1007\/s00520-019-04780-7","journal-title":"Support Care Cancer"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-021-06337-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-021-06337-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-021-06337-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T12:38:35Z","timestamp":1635251915000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-021-06337-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,2]]},"references-count":57,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["6337"],"URL":"https:\/\/doi.org\/10.1007\/s00520-021-06337-z","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,2]]},"assertion":[{"value":"2 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Patients in this study were selected from a registered clinical trial (registered at , NCT03030508) at Shanghai Changzheng Hospital from January 2016 to June 2019. The ethics of this study was approved by the Biomedical Research Ethics Committee of Shanghai Changzheng Hospital (No. 2016SL007).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors have consented to publish this manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The funders had no role in study design, data collection and analysis, decision to publish, or manuscript preparation.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}}]}}