{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:20:25Z","timestamp":1790349625299,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,9,11]],"date-time":"2021-09-11T00:00:00Z","timestamp":1631318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,9,11]],"date-time":"2021-09-11T00:00:00Z","timestamp":1631318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Bristol Myers Squibb"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Glioblastoma is an incurable disease with a poor prognosis. For caregivers of people with glioblastoma, the burden of care can be high. Patients often present with different clinical characteristics, which may impact caregiver burden in different ways. This study aimed to evaluate associations between patient clinical characteristics and caregiver burden\/quality of life (QoL).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Caregiver\u2013patient dyads were enrolled at 7 academic cancer centers in the United States. Eligible caregiver participants were self-reported as the primary caregiver of an adult living with glioblastoma and completed a caregiver burden survey. Eligible patients were age\u2009\u2265\u200918\u00a0years at glioblastoma diagnosis and alive when their respective caregiver entered the study, with the presence of cognitive dysfunction confirmed by the caregiver. Data were analyzed with descriptive statistics and multivariable analyses.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The final cohort included 167 dyads. Poor patient performance status resulted in patient difficulty with mental tasks, more caregiving tasks, and increased caregiving time. Language problems were reported in patients with left-sided lesions. Patient confusion was negatively associated with all caregiver domains: emotional health, social health, general health, ability to work, confidence in finances, and overall QoL. Better caregiver QoL was observed in patients with frontal lobe lesions versus non-frontal lobe lesions.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This study reinforced that patient performance status is a critical clinical factor that significantly affects caregiver burden, caregiving tasks, and caregiver time. Additionally, patient confusion affects multiple facets of caregiver burden\/QoL. These results could be used to support guided intervention for caregiver support, customized to the patient experience.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00520-021-06514-0","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T12:04:13Z","timestamp":1631448253000},"page":"1365-1375","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Caregiver burden by treatment and clinical characteristics of patients with glioblastoma"],"prefix":"10.1007","volume":"30","author":[{"given":"Trang H.","family":"Au","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor","family":"Willis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maija","family":"Reblin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine B.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phioanh Leia","family":"Nghiemphu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennie W.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Colman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam L.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Ryan","family":"Ormond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnab","family":"Chakravarti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Willmarth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyothi","family":"Menon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hillevi","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre H.","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia M.","family":"Ulrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prianka","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Korytowsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Stenehjem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6637-6359","authenticated-orcid":false,"given":"Diana","family":"Brixner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,11]]},"reference":[{"key":"6514_CR1","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1038\/s41388-017-0045-7","volume":"37","author":"Z An","year":"2018","unstructured":"An Z, Aksoy O, Zheng T, Fan QW, Weiss WA (2018) Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies. Oncogene 37:1561\u20131575","journal-title":"Oncogene"},{"key":"6514_CR2","doi-asserted-by":"publisher","first-page":"e0145106","DOI":"10.1371\/journal.pone.0145106","volume":"10","author":"SM Aoun","year":"2015","unstructured":"Aoun SM, Deas K, Howting D, Lee G (2015) Exploring the support needs of family caregivers of patients with brain cancer using the CSNAT: a comparative study with other cancer groups. PLoS One 10:e0145106","journal-title":"PLoS One"},{"key":"6514_CR3","doi-asserted-by":"crossref","unstructured":"Au T, Bauer H, Ma J, Nelson R, Watanabe A, Singh P, Korytowsky B, Wilson E, Willmarth N, Cohen A, Colman H, Stenehjem D, Brixner D (2017) Hout-19. Development of a novel burden survey for caregivers of glioblastoma multiforme (GBM) patients. Neuro-Oncology 19:vi110\u2013vi110","DOI":"10.1093\/neuonc\/nox168.450"},{"key":"6514_CR4","doi-asserted-by":"crossref","unstructured":"Au TH, Bauer H, Menon J, Willis C, Iacob E, Ma J, Watanabe A, Nelson R, Korytowsky B, Singh P, Marshall A, Willmarth N, Nghiemphu PL, Dovek L, Peters KB, Balajonda B, Cohen AL, Colman H, Stenehjem DD, Brixner DI (2018) Impact of glioblastoma (GBM)-related cognitive dysfunction (CD) on caregiver burden: preliminary results from multi-site study in the U.S. J Clin Oncol 36:16\u201316","DOI":"10.1200\/JCO.2018.36.34_suppl.16"},{"key":"6514_CR5","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.cell.2013.09.034","volume":"155","author":"CW Brennan","year":"2013","unstructured":"Brennan CW, Verhaak RG, McKenna A, Campos B, Noushmehr H, Salama SR, Zheng S, Chakravarty D, Sanborn JZ, Berman SH, Beroukhim R, Bernard B, Wu CJ, Genovese G, Shmulevich I, Barnholtz-Sloan J, Zou L, Vegesna R, Shukla SA, Ciriello G, Yung WK, Zhang W, Sougnez C, Mikkelsen T, Aldape K, Bigner DD, Van Meir EG, Prados M, Sloan A, Black KL, Eschbacher J, Finocchiaro G, Friedman W, Andrews DW, Guha A, Iacocca M, O\u2019Neill BP, Foltz G, Myers J, Weisenberger DJ, Penny R, Kucherlapati R, Perou CM, Hayes DN, Gibbs R, Marra M, Mills GB, Lander E, Spellman P, Wilson R, Sander C, Weinstein J, Meyerson M, Gabriel S, Laird PW, Haussler D, Getz G, Chin L, Network TR (2013) The somatic genomic landscape of glioblastoma. Cell 155:462\u2013477","journal-title":"Cell"},{"key":"6514_CR6","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1111\/hex.12434","volume":"20","author":"L Brom","year":"2017","unstructured":"Brom L, De Snoo-Trimp JC, Onwuteaka-Philipsen BD, Widdershoven GAM, Stiggelbout AM, Pasman HRW (2017) Challenges in shared decision making in advanced cancer care: a qualitative longitudinal observational and interview study. Health Expect 20:69\u201384","journal-title":"Health Expect"},{"key":"6514_CR7","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1038\/nature07385","volume":"455","author":"Cancer Genome Atlas Research Network","year":"2008","unstructured":"Cancer Genome Atlas Research Network (2008) Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455:1061\u20131068","journal-title":"Nature"},{"key":"6514_CR8","doi-asserted-by":"publisher","first-page":"e2583","DOI":"10.1097\/MD.0000000000002583","volume":"95","author":"JR Chen","year":"2016","unstructured":"Chen JR, Yao Y, Xu HZ, Qin ZY (2016) Isocitrate dehydrogenase (IDH)1\/2 mutations as prognostic markers in patients with glioblastomas. Medicine (Baltimore) 95:e2583","journal-title":"Medicine (Baltimore)"},{"key":"6514_CR9","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1097\/CCO.0000000000000581","volume":"31","author":"MB Coomans","year":"2019","unstructured":"Coomans MB, van der Linden SD, Gehring K, Taphoorn MJB (2019) Treatment of cognitive deficits in brain tumour patients: current status and future directions. Curr Opin Oncol 31:540\u2013547","journal-title":"Curr Opin Oncol"},{"key":"6514_CR10","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1016\/j.ajpath.2015.02.023","volume":"185","author":"I Crespo","year":"2015","unstructured":"Crespo I, Vital AL, Gonzalez-Tablas M, Patino Mdel C, Otero A, Lopes MC, de Oliveira C, Domingues P, Orfao A, Tabernero MD (2015) Molecular and genomic alterations in glioblastoma multiforme. Am J Pathol 185:1820\u20131833","journal-title":"Am J Pathol"},{"key":"6514_CR11","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1037\/a0033756","volume":"33","author":"JA Deatrick","year":"2014","unstructured":"Deatrick JA, Hobbie W, Ogle S, Fisher MJ, Barakat L, Hardie T, Reilly M, Li Y, Ginsberg JP (2014) Competence in caregivers of adolescent and young adult childhood brain tumor survivors. Health Psychol 33:1103\u20131112","journal-title":"Health Psychol"},{"key":"6514_CR12","doi-asserted-by":"publisher","first-page":"197","DOI":"10.15586\/codon.glioblastoma.2017.ch11","volume-title":"Glioblastoma","author":"C Fernandes","year":"2017","unstructured":"Fernandes C, Costa A, Os\u00f3rio L, Lago RC, Linhares P, Carvalho B, Caeiro C (2017) Current standards of care in glioblastoma therapy. In: De Vleeschouwer S (ed) Glioblastoma. Codon Publications, Brisbane, pp 197\u2013242"},{"key":"6514_CR13","doi-asserted-by":"publisher","first-page":"102","DOI":"10.3390\/cancers8110102","volume":"8","author":"L Fritz","year":"2016","unstructured":"Fritz L, Dirven L, Reijneveld JC, Koekkoek JAF, Stiggelbout AM, Pasman HR, Taphoorn MJ (2016) Advance care planning in glioblastoma patients. Cancers (Basel) 8:102","journal-title":"Cancers (Basel)"},{"key":"6514_CR14","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1007\/s00520-010-1021-8","volume":"19","author":"S Goebel","year":"2011","unstructured":"Goebel S, von Harscher M, Mehdorn HM (2011) Comorbid mental disorders and psychosocial distress in patients with brain tumours and their spouses in the early treatment phase. Support Care Cancer 19:1797\u20131805","journal-title":"Support Care Cancer"},{"key":"6514_CR15","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1093\/annonc\/mdi210","volume":"16","author":"EK Grov","year":"2005","unstructured":"Grov EK, Dahl AA, Moum T, Foss\u00e5 SD (2005) Anxiety, depression, and quality of life in caregivers of patients with cancer in late palliative phase. Ann Oncol 16:1185\u20131191","journal-title":"Ann Oncol"},{"key":"6514_CR16","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1056\/NEJMoa043331","volume":"352","author":"ME Hegi","year":"2005","unstructured":"Hegi ME, Diserens AC, Gorlia T, Hamou MF, de Tribolet N, Weller M, Kros JM, Hainfellner JA, Mason W, Mariani L, Bromberg JE, Hau P, Mirimanoff RO, Cairncross JG, Janzer RC, Stupp R (2005) MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 352:997\u20131003","journal-title":"N Engl J Med"},{"key":"6514_CR17","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s11060-009-9993-2","volume":"97","author":"K Hilverda","year":"2010","unstructured":"Hilverda K, Bosma I, Heimans JJ, Postma TJ, Vandertop WP, Slotman BJ, Buter J, Reijneveld JC, Klein M (2010) Cognitive functioning in glioblastoma patients during radiotherapy and temozolomide treatment: initial findings. J Neurooncol 97:89\u201394","journal-title":"J Neurooncol"},{"key":"6514_CR18","first-page":"47","volume":"1","author":"DI Jacobs","year":"2014","unstructured":"Jacobs DI, Kumthekar P, Stell BV, Grimm SA, Rademaker AW, Rice L, Chandler JP, Muro K, Marymont M, Helenowski IB, Wagner LI, Raizer JJ (2014) Concordance of patient and caregiver reports in evaluating quality of life in patients with malignant gliomas and an assessment of caregiver burden. Neurooncol Pract 1:47\u201354","journal-title":"Neurooncol Pract"},{"key":"6514_CR19","first-page":"350","volume":"47","author":"J Lee","year":"2019","unstructured":"Lee J, Hall CWR (2019) The impact of gliomas on cognition and capacity. J Am Acad Psychiatry Law 47:350\u2013359","journal-title":"J Am Acad Psychiatry Law"},{"key":"6514_CR20","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.jnci.2016.07.001","volume":"28","author":"S Mallick","year":"2016","unstructured":"Mallick S, Benson R, Hakim A, Rath GK (2016) Management of glioblastoma after recurrence: a changing paradigm. J Egypt Natl Canc Inst 28:199\u2013210","journal-title":"J Egypt Natl Canc Inst"},{"key":"6514_CR21","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1016\/S1470-2045(12)70265-6","volume":"13","author":"A Malmstr\u00f6m","year":"2012","unstructured":"Malmstr\u00f6m A, Gr\u00f8nberg BH, Marosi C, Stupp R, Frappaz D, Schultz H, Abacioglu U, Tavelin B, Lhermitte B, Hegi ME, Rosell J, Henriksson R (2012) Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trial. Lancet Oncol 13:916\u2013926","journal-title":"Lancet Oncol"},{"key":"6514_CR22","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1177\/1534735417689882","volume":"17","author":"K Milbury","year":"2018","unstructured":"Milbury K, Mallaiah S, Mahajan A, Armstrong T, Weathers SP, Moss KE, Goktepe N, Spelman A, Cohen L (2018) Yoga program for high-grade glioma patients undergoing radiotherapy and their family caregivers. Integr Cancer Ther 17:332\u2013336","journal-title":"Integr Cancer Ther"},{"key":"6514_CR23","unstructured":"National Alliance for Caregiving (2016) Cancer caregiving in the U.S.: an intense, episodic, and challenging care experience. https:\/\/www.caregiving.org\/wp-content\/uploads\/2020\/05\/CancerCaregivingReport_FINAL_June-17-2016.pdf. Accessed May 2020"},{"key":"6514_CR24","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1093\/geront\/40.6.738","volume":"40","author":"C Nijboer","year":"2000","unstructured":"Nijboer C, Triemstra M, Tempelaar R, Mulder M, Sanderman R, van den Bos GA (2000) Patterns of caregiver experiences among partners of cancer patients. Gerontologist 40:738\u2013746","journal-title":"Gerontologist"},{"key":"6514_CR25","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1093\/annonc\/mdw205","volume":"27","author":"RD Nipp","year":"2016","unstructured":"Nipp RD, El-Jawahri A, Fishbein JN, Gallagher ER, Stagl JM, Park ER, Jackson VA, Pirl WF, Greer JA, Temel JS (2016) Factors associated with depression and anxiety symptoms in family caregivers of patients with incurable cancer. Ann Oncol 27:1607\u20131612","journal-title":"Ann Oncol"},{"key":"6514_CR26","doi-asserted-by":"publisher","first-page":"757","DOI":"10.3171\/2014.11.JNS13295","volume":"122","author":"A Niranjan","year":"2015","unstructured":"Niranjan A, Kano H, Iyer A, Kondziolka D, Flickinger JC, Lunsford LD (2015) Role of adjuvant or salvage radiosurgery in the management of unresected residual or progressive glioblastoma multiforme in the pre-bevacizumab era. J Neurosurg 122:757\u2013765","journal-title":"J Neurosurg"},{"key":"6514_CR27","unstructured":"ORIEN (2020) Oncology Research Information Exchange Network. https:\/\/www.oriencancer.org\/. Accessed May 2020"},{"key":"6514_CR28","doi-asserted-by":"publisher","first-page":"142","DOI":"10.5195\/JMLA.2018.319","volume":"106","author":"EF Patridge","year":"2018","unstructured":"Patridge EF, Bardyn TP (2018) Research Electronic Data Capture (REDCap). J Med Libr Assoc 106:142\u2013144","journal-title":"J Med Libr Assoc"},{"key":"6514_CR29","doi-asserted-by":"crossref","unstructured":"Scott JG, Chao ST, Suh JH, Cooper A, Reiner AS, Nayak L, Panageas K, Abrey LE, Iwamoto FM (2010) Prognostic factors for glioblastoma (GBM) in individuals age 70 and older: a study of 446 patients from two tertiary centers. J Clin Oncol 28:2034","DOI":"10.1200\/jco.2010.28.15_suppl.2034"},{"key":"6514_CR30","doi-asserted-by":"crossref","unstructured":"Sharma N, Chakrabarti S, Grover S (2016) Gender differences in caregiving among family - caregivers of people with mental illnesses. World J Psychiatry 6:7\u201317","DOI":"10.5498\/wjp.v6.i1.7"},{"key":"6514_CR31","doi-asserted-by":"publisher","first-page":"266","DOI":"10.4103\/1793-5482.161166","volume":"10","author":"G Singh","year":"2015","unstructured":"Singh G, Mehrotra A, Sardhara J, Das KK, Jamdar J, Pal L, Srivastava AK, Sahu RN, Jaiswal AK, Behari S (2015) Multiple glioblastomas: are they different from their solitary counterparts? Asian J Neurosurg 10:266\u2013271","journal-title":"Asian J Neurosurg"},{"key":"6514_CR32","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1016\/j.clineuro.2012.01.026","volume":"114","author":"AM Stark","year":"2012","unstructured":"Stark AM, van de Bergh J, Hedderich J, Mehdorn HM, Nabavi A (2012) Glioblastoma: clinical characteristics, prognostic factors and survival in 492 patients. Clin Neurol Neurosurg 114:840\u2013845","journal-title":"Clin Neurol Neurosurg"},{"key":"6514_CR33","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-77244-8","volume-title":"Clinical prediction models: a practical approach to development, validation, and updating","author":"EW Steyerberg","year":"2009","unstructured":"Steyerberg EW (2009) Clinical prediction models: a practical approach to development, validation, and updating. Springer, New York"},{"key":"6514_CR34","doi-asserted-by":"crossref","unstructured":"Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross JG, Eisenhauer E, Mirimanoff RO, European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups, National Cancer Institute of Canada Clinical Trials Group (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352:987\u2013996","DOI":"10.1056\/NEJMoa043330"},{"key":"6514_CR35","doi-asserted-by":"crossref","unstructured":"Tamimi AF, Juweid M (2017) Epidemiology and outcome of glioblastoma. In: De Vleeschouwer S (ed) Glioblastoma,\u00a0Chapter 8. Codon Publications, Brisbane","DOI":"10.15586\/codon.glioblastoma.2017.ch8"},{"key":"6514_CR36","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1158\/1055-9965.EPI-14-0275","volume":"23","author":"JP Thakkar","year":"2014","unstructured":"Thakkar JP, Dolecek TA, Horbinski C, Ostrom QT, Lightner DD, Barnholtz-Sloan JS, Villano JL (2014) Epidemiologic and molecular prognostic review of glioblastoma. Cancer Epidemiol Biomarkers Prev 23:1985\u20131996","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"6514_CR37","first-page":"540236","volume":"2014","author":"XW Wang","year":"2014","unstructured":"Wang XW, Ciccarino P, Rossetto M, Boisselier B, Marie Y, Desestret V, Gleize V, Mokhtari K, Sanson M, Labussiere M (2014) IDH mutations: genotype-phenotype correlation and prognostic impact. Biomed Res Int 2014:540236","journal-title":"Biomed Res Int"},{"key":"6514_CR38","doi-asserted-by":"crossref","unstructured":"Weitzner MA, Jacobsen PB, Wagner H Jr, Friedland J, Cox C (1999) The Caregiver Quality of Life Index\u2013Cancer (CQOLC) scale: development and validation of an instrument to measure quality of life of the family caregiver of patients with cancer. Qual Life Res 8:55\u201363","DOI":"10.1023\/A:1026407010614"},{"key":"6514_CR39","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/nrneurol.2014.100","volume":"10","author":"W Wick","year":"2014","unstructured":"Wick W, Weller M, van den Bent M, Sanson M, Weiler M, von Deimling A, Plass C, Hegi M, Platten M, Reifenberger G (2014) MGMT testing\u2013the challenges for biomarker-based glioma treatment. Nat Rev Neurol 10:372\u2013385","journal-title":"Nat Rev Neurol"},{"key":"6514_CR40","doi-asserted-by":"publisher","first-page":"e68782","DOI":"10.1371\/journal.pone.0068782","volume":"8","author":"P Zou","year":"2013","unstructured":"Zou P, Xu H, Chen P, Yan Q, Zhao L, Zhao P, Gu A (2013) IDH1\/IDH2 mutations define the prognosis and molecular profiles of patients with gliomas: a meta-analysis. PLoS One 8:e68782","journal-title":"PLoS One"}],"updated-by":[{"DOI":"10.1007\/s00520-021-06691-y","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000}}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-021-06514-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-021-06514-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-021-06514-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T09:11:32Z","timestamp":1641287492000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-021-06514-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,11]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["6514"],"URL":"https:\/\/doi.org\/10.1007\/s00520-021-06514-0","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s00520-021-06691-y","asserted-by":"object"}]},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,11]]},"assertion":[{"value":"12 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2021","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00520-021-06691-y","URL":"https:\/\/doi.org\/10.1007\/s00520-021-06691-y","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the institutional review boards of all study centers involved in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Caregivers and patients gave written informed consent to participate in the study; patients had given broad consent previously to have access to their medical records, which were used in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors consented to publish this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Alexandre H. Watanabe, Nicole Willmarth, and Adam L. Cohen have no conflicts of interest.Maija Reblin has received grants from Bristol Myers Squibb.Phioanh Leia Nghiemphu has received grants from Genentech and Novartis.Junjie Ma was an employee of the University of Utah at the time this study was conducted, is currently employed by Amgen Inc., and has received grants from Bristol Myers Squibb.Jyothi Menon was an employee of the University of Utah at the time this study was conducted, and has received grants from Bristol Myers Squibb.D. Ryan Ormond has received research funding from Agios, the American Cancer Society, American Heart Association, and Medtronic and is currently employed by Amgen Inc.Katherine B. Peters received grant\/research support from Bristol Myers Squibb.Jennie W. Taylor received grant support from AbbVie, Agios, and Bristol Myers Squibb.Howard Coleman reports personal fees from Adastra Pharmaceuticals, Bayer, Best Doctors\/Teladoc, Forma Therapeutics, Karyopharm Therapeutics, Orbus, and Private Health.Beata Korytowsky was an employee and shareholder of Bristol Myers Squibb at the time of study.Alexander Marshall and Prianka Singh are employees of Bristol Myers Squibb.David Stenehjem reports grants from Bristol Myers Squibb, and personal fees from Bristol Myers Squibb, Dracen Pharmaceuticals, Iterion Pharmaceuticals, Molecular Templates, and Salarius Pharmaceuticals.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}