{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T19:21:45Z","timestamp":1784920905552,"version":"3.55.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:00:00Z","timestamp":1641340800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:00:00Z","timestamp":1641340800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s00520-021-06639-2","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T14:07:06Z","timestamp":1641391626000},"page":"3321-3327","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Nutritional status alterations after chimeric antigen receptor T cell therapy in patients with hematological malignancies: a retrospective study"],"prefix":"10.1007","volume":"30","author":[{"given":"Shuyi","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxia","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiyun","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linqin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houli","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxian","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,5]]},"reference":[{"issue":"10","key":"6639_CR1","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/nrd.2017.196","volume":"16","author":"A Mullard","year":"2017","unstructured":"Mullard A (2017) FDA approves first CAR T therapy. Nature Reviews Drug Discovery 16(10):669\u2013669. https:\/\/doi.org\/10.1038\/nrd.2017.196","journal-title":"Nature Reviews Drug Discovery"},{"issue":"12","key":"6639_CR2","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1038\/nrd.2017.249","volume":"16","author":"A Mullard","year":"2017","unstructured":"Mullard A (2017) Second anticancer CAR T therapy receives FDA approval. Nature Reviews Drug Discovery 16(12):818\u2013818. https:\/\/doi.org\/10.1038\/nrd.2017.249","journal-title":"Nature Reviews Drug Discovery"},{"issue":"12","key":"6639_CR3","doi-asserted-by":"publisher","first-page":"2548","DOI":"10.7150\/ijbs.34213","volume":"15","author":"S Ma","year":"2019","unstructured":"Ma S et al (2019) Current progress in CAR-T cell therapy for solid tumors. Int J Biol Sci 15(12):2548\u20132560","journal-title":"Int J Biol Sci"},{"issue":"22","key":"6639_CR4","doi-asserted-by":"publisher","first-page":"8655","DOI":"10.3390\/ijms21228655","volume":"21","author":"WY Lin","year":"2020","unstructured":"Lin WY et al (2020) Gene modified CAR-T cellular therapy for hematologic malignancies. Int J Mol Sci 21(22):8655","journal-title":"Int J Mol Sci"},{"issue":"5","key":"6639_CR5","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1056\/NEJMoa1709919","volume":"378","author":"JH Park","year":"2018","unstructured":"Park JH et al (2018) Long-term follow-up of CD19 CAR therapy in acute lymphoblastic leukemia. N Engl J Med 378(5):449\u2013459","journal-title":"N Engl J Med"},{"key":"6639_CR6","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.blre.2018.11.002","volume":"34","author":"JN Brudno","year":"2019","unstructured":"Brudno JN, Kochenderfer JN (2019) Recent advances in CAR T-cell toxicity: mechanisms, manifestations and management. Blood Rev 34:45\u201355","journal-title":"Blood Rev"},{"issue":"1","key":"6639_CR7","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/nrclinonc.2017.148","volume":"15","author":"SS Neelapu","year":"2018","unstructured":"Neelapu SS et al (2018) Chimeric antigen receptor T-cell therapy - assessment and management of toxicities. Nat Rev Clin Oncol 15(1):47\u201362","journal-title":"Nat Rev Clin Oncol"},{"issue":"6","key":"6639_CR8","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1007\/s00005-020-00599-x","volume":"68","author":"K Skorka","year":"2020","unstructured":"Skorka K et al (2020) The application of CAR-T cells in haematological malignancies. Arch Immunol Ther Exp (Warsz) 68(6):34","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"issue":"7","key":"6639_CR9","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1002\/jso.23304","volume":"107","author":"M La Torre","year":"2013","unstructured":"La Torre M et al (2013) Malnutrition and pancreatic surgery: prevalence and outcomes. J Surg Oncol 107(7):702\u2013708","journal-title":"J Surg Oncol"},{"issue":"6","key":"6639_CR10","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.bjhh.2014.06.001","volume":"36","author":"S Lemos Pdos","year":"2014","unstructured":"Lemos Pdos S, de Oliveira FL, Caran EM (2014) Nutritional status of children and adolescents at diagnosis of hematological and solid malignancies. Rev Bras Hematol Hemoter 36(6):420\u20133","journal-title":"Rev Bras Hematol Hemoter"},{"issue":"Suppl 2","key":"6639_CR11","doi-asserted-by":"publisher","first-page":"S35","DOI":"10.1016\/j.ejon.2005.09.001","volume":"9","author":"M von Meyenfeldt","year":"2005","unstructured":"von Meyenfeldt M (2005) Cancer-associated malnutrition: an introduction. Eur J Oncol Nurs 9(Suppl 2):S35\u2013S38","journal-title":"Eur J Oncol Nurs"},{"key":"6639_CR12","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1186\/1471-2407-14-828","volume":"14","author":"P Mondello","year":"2014","unstructured":"Mondello P et al (2014) Emerging markers of cachexia predict survival in cancer patients. BMC Cancer 14:828","journal-title":"BMC Cancer"},{"issue":"2","key":"6639_CR13","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.cmet.2012.06.011","volume":"16","author":"KC Fearon","year":"2012","unstructured":"Fearon KC, Glass DJ, Guttridge DC (2012) Cancer cachexia: mediators, signaling, and metabolic pathways. Cell Metab 16(2):153\u2013166","journal-title":"Cell Metab"},{"issue":"1","key":"6639_CR14","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1186\/s12885-020-6698-6","volume":"20","author":"LJ Xia","year":"2020","unstructured":"Xia LJ et al (2020) Significance of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio and prognostic nutritional index for predicting clinical outcomes in T1\u20132 rectal cancer. BMC Cancer 20(1):208","journal-title":"BMC Cancer"},{"issue":"5","key":"6639_CR15","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1097\/MCO.0000000000000389","volume":"20","author":"H Jager-Wittenaar","year":"2017","unstructured":"Jager-Wittenaar H, Ottery FD (2017) Assessing nutritional status in cancer: role of the Patient-Generated Subjective Global Assessment. Curr Opin Clin Nutr Metab Care 20(5):322\u2013329","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"7","key":"6639_CR16","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1007\/s00520-011-1122-z","volume":"19","author":"A Cessot","year":"2011","unstructured":"Cessot A et al (2011) Defining the clinical condition of cancer patients: it is time to switch from performance status to nutritional status. Support Care Cancer 19(7):869\u2013870","journal-title":"Support Care Cancer"},{"issue":"7","key":"6639_CR17","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1002\/pbc.24272","volume":"59","author":"E Co-Reyes","year":"2012","unstructured":"Co-Reyes E et al (2012) Malnutrition and obesity in pediatric oncology patients: causes, consequences, and interventions. Pediatr Blood Cancer 59(7):1160\u20131167","journal-title":"Pediatr Blood Cancer"},{"issue":"2","key":"6639_CR18","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1001\/jama.293.2.203","volume":"293","author":"BJ Lange","year":"2005","unstructured":"Lange BJ et al (2005) Mortality in overweight and underweight children with acute myeloid leukemia. JAMA 293(2):203\u2013211","journal-title":"JAMA"},{"issue":"5","key":"6639_CR19","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1007\/s00535-013-0787-0","volume":"48","author":"H Suzuki","year":"2013","unstructured":"Suzuki H et al (2013) Cancer cachexia\u2013pathophysiology and management. J Gastroenterol 48(5):574\u2013594","journal-title":"J Gastroenterol"},{"issue":"1","key":"6639_CR20","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s00520-015-2813-7","volume":"24","author":"M Planas","year":"2016","unstructured":"Planas M et al (2016) Prevalence of hospital malnutrition in cancer patients: a sub-analysis of the PREDyCES(R) study. Support Care Cancer 24(1):429\u2013435","journal-title":"Support Care Cancer"},{"issue":"6","key":"6639_CR21","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1016\/j.jamcollsurg.2014.06.017","volume":"219","author":"DE Sanford","year":"2014","unstructured":"Sanford DE et al (2014) Severe nutritional risk predicts decreased long-term survival in geriatric patients undergoing pancreaticoduodenectomy for benign disease. J Am Coll Surg 219(6):1149\u20131156","journal-title":"J Am Coll Surg"},{"issue":"1","key":"6639_CR22","doi-asserted-by":"publisher","first-page":"136","DOI":"10.4049\/jimmunol.1301158","volume":"192","author":"DC Saucillo","year":"2014","unstructured":"Saucillo DC et al (2014) Leptin metabolically licenses T cells for activation to link nutrition and immunity. J Immunol 192(1):136\u2013144","journal-title":"J Immunol"},{"issue":"5","key":"6639_CR23","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.smim.2015.10.006","volume":"27","author":"FM Wensveen","year":"2015","unstructured":"Wensveen FM et al (2015) Interactions between adipose tissue and the immune system in health and malnutrition. Semin Immunol 27(5):322\u2013333","journal-title":"Semin Immunol"},{"issue":"13","key":"6639_CR24","doi-asserted-by":"publisher","first-page":"3297","DOI":"10.1158\/1078-0432.CCR-16-1799","volume":"23","author":"Y Hu","year":"2017","unstructured":"Hu Y et al (2017) Potent anti-leukemia activities of chimeric antigen receptor\u2013modified T cells against CD19 in Chinese patients with relapsed\/refractory acute lymphocytic leukemia. Clin Cancer Res 23(13):3297\u20133306","journal-title":"Clin Cancer Res"},{"issue":"303","key":"6639_CR25","doi-asserted-by":"publisher","first-page":"303ra139","DOI":"10.1126\/scitranslmed.aac5415","volume":"7","author":"DL Porter","year":"2015","unstructured":"Porter DL et al (2015) Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia. Science Translational Medicine 7(303):303ra139-303ra139","journal-title":"Science Translational Medicine"},{"issue":"8","key":"6639_CR26","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1056\/NEJMoa1103849","volume":"365","author":"DL Porter","year":"2011","unstructured":"Porter DL et al (2011) Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med 365(8):725\u2013733","journal-title":"N Engl J Med"},{"issue":"2","key":"6639_CR27","doi-asserted-by":"publisher","first-page":"e28065","DOI":"10.1002\/pbc.28065","volume":"67","author":"TW McLean","year":"2020","unstructured":"McLean TW et al (2020) Hypoalbuminemia in children with cancer treated with chemotherapy. Pediatr Blood Cancer 67(2):e28065","journal-title":"Pediatr Blood Cancer"},{"issue":"3","key":"6639_CR28","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1007\/s00520-019-04952-5","volume":"28","author":"M Yilmaz","year":"2020","unstructured":"Yilmaz M et al (2020) The effect of malnutrition on mortality in hospitalized patients with hematologic malignancy. Support Care Cancer 28(3):1441\u20131448","journal-title":"Support Care Cancer"},{"issue":"5","key":"6639_CR29","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s13312-015-0642-x","volume":"52","author":"S Tandon","year":"2015","unstructured":"Tandon S et al (2015) Effect of pre-treatment nutritional status, folate and vitamin B12 levels on induction chemotherapy in children with acute lymphoblastic leukemia. Indian Pediatr 52(5):385\u2013389","journal-title":"Indian Pediatr"},{"issue":"2","key":"6639_CR30","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1159\/000205530","volume":"81","author":"A Marini","year":"1989","unstructured":"Marini A et al (1989) Serum cholesterol and triglycerides in hematological malignancies. Acta Haematol 81(2):75\u201379","journal-title":"Acta Haematol"},{"issue":"11","key":"6639_CR31","doi-asserted-by":"publisher","first-page":"5569","DOI":"10.1007\/s00520-020-05478-x","volume":"28","author":"Y Jiang","year":"2020","unstructured":"Jiang Y et al (2020) Nutrition and metabolism status alteration in advanced hepatocellular carcinoma patients treated with anti-PD-1 immunotherapy. Support Care Cancer 28(11):5569\u20135579","journal-title":"Support Care Cancer"},{"issue":"1","key":"6639_CR32","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4103\/1117-1936.170285","volume":"18","author":"SE Idogun","year":"2011","unstructured":"Idogun SE, Omoti CE (2011) Effects of chemotherapy on plasma lipids and lipoproteins in Nigerian patients with haematological malignancy. Niger Postgrad Med J 18(1):16\u201319","journal-title":"Niger Postgrad Med J"},{"issue":"3","key":"6639_CR33","doi-asserted-by":"publisher","first-page":"465","DOI":"10.2478\/s11658-008-0014-9","volume":"13","author":"M Kuliszkiewicz-Janus","year":"2008","unstructured":"Kuliszkiewicz-Janus M, Malecki R, Mohamed AS (2008) Lipid changes occuring in the course of hematological cancers. Cell Mol Biol Lett 13(3):465\u2013474","journal-title":"Cell Mol Biol Lett"},{"key":"6639_CR34","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.3389\/fimmu.2018.01055","volume":"9","author":"Y Alwarawrah","year":"2018","unstructured":"Alwarawrah Y, Kiernan K, MacIver NJ (2018) Changes in nutritional status impact immune cell metabolism and function. Front Immunol 9:1055","journal-title":"Front Immunol"},{"issue":"4","key":"6639_CR35","first-page":"401","volume":"6","author":"JM Argiles","year":"2003","unstructured":"Argiles JM, Busquets S, Lopez-Soriano FJ (2003) Cytokines in the pathogenesis of cancer cachexia. Curr Opin Clin Nutr Metab Care 6(4):401\u2013406","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"1","key":"6639_CR36","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s40425-018-0343-9","volume":"6","author":"A Shimabukuro-Vornhagen","year":"2018","unstructured":"Shimabukuro-Vornhagen A et al (2018) Cytokine release syndrome. J Immunother Cancer 6(1):56","journal-title":"J Immunother Cancer"},{"issue":"3","key":"6639_CR37","first-page":"577","volume":"11","author":"O Najera","year":"2004","unstructured":"Najera O et al (2004) Flow cytometry study of lymphocyte subsets in malnourished and well-nourished children with bacterial infections. Clin Diagn Lab Immunol 11(3):577\u2013580","journal-title":"Clin Diagn Lab Immunol"},{"issue":"2","key":"6639_CR38","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1080\/10245332.2017.1365458","volume":"23","author":"S Elmoamly","year":"2018","unstructured":"Elmoamly S, Afif A (2018) Can biomarkers of coagulation, platelet activation, and inflammation predict mortality in patients with hematological malignancies? Hematology 23(2):89\u201395","journal-title":"Hematology"},{"issue":"6","key":"6639_CR39","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1111\/bjh.15105","volume":"180","author":"MA Kharfan-Dabaja","year":"2018","unstructured":"Kharfan-Dabaja MA et al (2018) Hypoalbuminaemia segregates different prognostic subgroups within the refined standard risk acute graft-versus-host disease score. Br J Haematol 180(6):854\u2013862","journal-title":"Br J Haematol"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-021-06639-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-021-06639-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-021-06639-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T06:03:18Z","timestamp":1700028198000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-021-06639-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,5]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["6639"],"URL":"https:\/\/doi.org\/10.1007\/s00520-021-06639-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-360196\/v1","asserted-by":"object"}]},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,5]]},"assertion":[{"value":"28 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"These clinical trials were performed according to the ethical principles of the Declaration of Helsinki. Approval was granted by the Medical Ethics Committee of the First Affiliated Hospital of Medical College, Zhejiang University (ChiCTR-ORN-16008948, ChiCTR1800015575, ChiCTR-OIC-17011310, ChiCTR1800017404).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Obtained.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}