{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:44:28Z","timestamp":1790808268468,"version":"4.1.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1007\/s00520-022-06805-0","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T14:02:21Z","timestamp":1643810541000},"page":"4465-4475","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Biopsychosocial risk factors for pain and pain-related disability 1\u00a0year after surgery for breast cancer"],"prefix":"10.1007","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1283-6185","authenticated-orcid":false,"given":"Lore","family":"Dams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elien","family":"Van der Gucht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Haenen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magalie","family":"Lauwers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie","family":"De Pauw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tinne","family":"Steurs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nele","family":"Devoogdt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Smeets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Bernar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa","family":"De Vrieze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"De Groef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira","family":"Meeus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,2]]},"reference":[{"issue":"3","key":"6805_CR1","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.bja.2020.04.088","volume":"125","author":"L Wang","year":"2020","unstructured":"Wang L, Cohen JC, Devasenapathy N et al (2020) Prevalence and intensity of persistent post-surgical pain following breast cancer surgery: a systematic review and meta-analysis of observational studies. Br J Anaesth 125(3):346\u2013357","journal-title":"Br J Anaesth"},{"key":"6805_CR2","doi-asserted-by":"crossref","unstructured":"Sung H, Ferlay J, Siegel RL et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021","DOI":"10.3322\/caac.21660"},{"issue":"4","key":"6805_CR3","doi-asserted-by":"publisher","first-page":"217","DOI":"10.2991\/jegh.k.191008.001","volume":"9","author":"C Mattiuzzi","year":"2019","unstructured":"Mattiuzzi C, Lippi G (2019) Current Cancer Epidemiology. J Epidemiol Glob Health 9(4):217\u2013222","journal-title":"J Epidemiol Glob Health"},{"key":"6805_CR4","doi-asserted-by":"publisher","first-page":"457","DOI":"10.2147\/JPR.S105892","volume":"9","author":"M Due\u00f1as","year":"2016","unstructured":"Due\u00f1as M, Ojeda B, Salazar A, Mico JA, Failde I (2016) A review of chronic pain impact on patients, their social environment and the health care system. J Pain Res 9:457\u2013467","journal-title":"J Pain Res"},{"issue":"5","key":"6805_CR5","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1589\/jpts.27.1361","volume":"27","author":"VT Ferreira","year":"2015","unstructured":"Ferreira VT, Dibai-Filho AV, Kelly de Oliveira A, Gomes CA, Melo ES, Maria de Almeida A (2015) Assessing the impact of pain on the life of breast cancer survivors using the Brief Pain Inventory. J Phys Ther Sci. 27(5):1361\u20133","journal-title":"J Phys Ther Sci."},{"issue":"2","key":"6805_CR6","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1136\/rapm-2018-000040","volume":"44","author":"AS Habib","year":"2019","unstructured":"Habib AS, Kertai MD, Cooter M, Greenup RA, Hwang S (2019) Risk factors for severe acute pain and persistent pain after surgery for breast cancer: a prospective observational study. Reg Anesth Pain Med 44(2):192\u2013199","journal-title":"Reg Anesth Pain Med"},{"issue":"12","key":"6805_CR7","doi-asserted-by":"publisher","first-page":"3607","DOI":"10.1007\/s00520-017-3824-3","volume":"25","author":"L Leysen","year":"2017","unstructured":"Leysen L, Beckw\u00e9e D, Nijs J et al (2017) Risk factors of pain in breast cancer survivors: a systematic review and meta-analysis. Support Care Cancer 25(12):3607\u20133643","journal-title":"Support Care Cancer"},{"issue":"7","key":"6805_CR8","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1002\/ejp.1014","volume":"21","author":"D Nishimura","year":"2017","unstructured":"Nishimura D, Kosugi S, Onishi Y et al (2017) Psychological and endocrine factors and pain after mastectomy. Eur J Pain 21(7):1144\u20131153","journal-title":"Eur J Pain"},{"issue":"2","key":"6805_CR9","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.pain.2013.09.028","volume":"155","author":"J Bruce","year":"2014","unstructured":"Bruce J, Thornton AJ, Powell R et al (2014) Psychological, surgical, and sociodemographic predictors of pain outcomes after breast cancer surgery: a population-based cohort study. Pain 155(2):232\u2013243","journal-title":"Pain"},{"issue":"8","key":"6805_CR10","doi-asserted-by":"publisher","first-page":"995","DOI":"10.6004\/jnccn.2015.0120","volume":"13","author":"MK Mejdahl","year":"2015","unstructured":"Mejdahl MK, Mertz BG, Bidstrup PE, Andersen KG (2015) Preoperative distress predicts persistent pain after breast cancer treatment: a prospective cohort study. J Natl Compr Canc Netw. 13(8):995\u20131003 (quiz 1003)","journal-title":"J Natl Compr Canc Netw."},{"issue":"1","key":"6805_CR11","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.jpain.2015.10.001","volume":"17","author":"S Baudic","year":"2016","unstructured":"Baudic S, Jayr C, Albi-Feldzer A et al (2016) Effect of alexithymia and emotional repression on postsurgical pain in women with breast cancer: a prospective longitudinal 12-month study. J Pain 17(1):90\u2013100","journal-title":"J Pain"},{"key":"6805_CR12","doi-asserted-by":"crossref","unstructured":"Schreiber KL, Zinboonyahgoon N, Flowers KM et al. (2021) Prediction of persistent pain severity and impact 12 months after breast surgery using comprehensive preoperative assessment of biopsychosocial pain modulators. Ann Surg Oncol","DOI":"10.1245\/s10434-020-09479-2"},{"issue":"2","key":"6805_CR13","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s10549-020-05681-8","volume":"182","author":"L Mustonen","year":"2020","unstructured":"Mustonen L, Vollert J, Rice ASC, Kalso E, Harno H (2020) Sensory profiles in women with neuropathic pain after breast cancer surgery. Breast Cancer Res Treat 182(2):305\u2013315","journal-title":"Breast Cancer Res Treat"},{"issue":"4","key":"6805_CR14","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1002\/ejp.1520","volume":"24","author":"ME Martland","year":"2020","unstructured":"Martland ME, Rashidi AS, Bennett MI et al (2020) The use of quantitative sensory testing in cancer pain assessment: A systematic review. Eur J Pain 24(4):669\u2013684","journal-title":"Eur J Pain"},{"issue":"2","key":"6805_CR15","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1002\/ejp.1140","volume":"22","author":"L Arendt-Nielsen","year":"2018","unstructured":"Arendt-Nielsen L, Morlion B, Perrot S et al (2018) Assessment and manifestation of central sensitisation across different chronic pain conditions. Eur J Pain 22(2):216\u2013241","journal-title":"Eur J Pain"},{"issue":"18","key":"6805_CR16","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1212\/01.wnl.0000282763.29778.59","volume":"70","author":"RD Treede","year":"2008","unstructured":"Treede RD, Jensen TS, Campbell JN et al (2008) Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology 70(18):1630\u20131635","journal-title":"Neurology"},{"issue":"4","key":"6805_CR17","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1111\/j.1533-2500.2011.00493.x","volume":"12","author":"TG Mayer","year":"2012","unstructured":"Mayer TG, Neblett R, Cohen H et al (2012) The development and psychometric validation of the central sensitization inventory. Pain Pract 12(4):276\u2013285","journal-title":"Pain Pract"},{"issue":"2","key":"6805_CR18","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/aas.12641","volume":"60","author":"KG Andersen","year":"2015","unstructured":"Andersen KG, Duriaud HM, Aasvang EK, Kehlet H (2015) Association between sensory dysfunction and pain 1 week after breast cancer surgery: a psychophysical study. Acta Anaesthesiol Scand 60(2):259\u2013269","journal-title":"Acta Anaesthesiol Scand"},{"issue":"2","key":"6805_CR19","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s10880-011-9274-z","volume":"19","author":"SA Reid-Arndt","year":"2012","unstructured":"Reid-Arndt SA, Cox CR (2012) Stress, coping and cognitive deficits in women after surgery for breast cancer. J Clin Psychol Med Settings 19(2):127\u2013137","journal-title":"J Clin Psychol Med Settings"},{"issue":"1","key":"6805_CR20","doi-asserted-by":"publisher","first-page":"e025742","DOI":"10.1136\/bmjopen-2018-025742","volume":"9","author":"A De Groef","year":"2019","unstructured":"De Groef A, Devoogdt N, Van der Gucht E et al (2019) EduCan trial: study protocol for a randomised controlled trial on the effectiveness of pain neuroscience education after breast cancer surgery on pain, physical, emotional and work-related functioning. BMJ Open. 9(1):e025742","journal-title":"BMJ Open."},{"issue":"8","key":"6805_CR21","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1111\/papr.12344","volume":"16","author":"HB Kjeldsen","year":"2016","unstructured":"Kjeldsen HB, Klausen TW, Rosenberg J (2016) Preferred presentation of the visual analog scale for measurement of postoperative pain. Pain Pract 16(8):980\u2013984","journal-title":"Pain Pract"},{"issue":"1","key":"6805_CR22","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1097\/01893697-201432010-00004","volume":"32","author":"S Harrington","year":"2014","unstructured":"Harrington S, Gilchrist L, Sander A (2014) Breast cancer EDGE task force outcomes: clinical measures of pain. Rehabil Oncol 32(1):13\u201321","journal-title":"Rehabil Oncol"},{"issue":"3","key":"6805_CR23","doi-asserted-by":"publisher","first-page":"974","DOI":"10.2466\/pms.1984.59.3.974","volume":"59","author":"CA Pollard","year":"1984","unstructured":"Pollard CA (1984) Preliminary validity study of the pain disability index. Percept Mot Skills 59(3):974","journal-title":"Percept Mot Skills"},{"key":"6805_CR24","doi-asserted-by":"crossref","unstructured":"Soer R, K\u00f6ke AJ, Vroomen PC et al. Extensive validation of the pain disability index in 3 groups of patients with musculoskeletal pain. Spine (Phila Pa 1976). 2013;38(9):E562\u20138.","DOI":"10.1097\/BRS.0b013e31828af21f"},{"issue":"1","key":"6805_CR25","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ejpain.2005.02.003","volume":"10","author":"RMW Rolke","year":"2006","unstructured":"Rolke RMW, Campbell KA, Schalber C, Caspari S, Birklein F, Treede RD (2006) Quantitative sensory testing: a comprehensive protocol for clinical trials. Eur J Pain 10(1):77\u201388","journal-title":"Eur J Pain"},{"issue":"3","key":"6805_CR26","first-page":"521","volume":"17","author":"YM-BA Granovsky","year":"2016","unstructured":"Granovsky YM-BA, Goldstein O, Sprecher E, Yarnitsky D (2016) CPM Test-retest reliability: \u201cstandard\u201d vs \u201csingle test-stimulus\u201d protocols. Pain Med. 17(3):521\u20139","journal-title":"Pain Med."},{"key":"6805_CR27","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1037\/1040-3590.7.4.524","volume":"7","author":"MJL Sullivan","year":"1995","unstructured":"Sullivan MJL, Bishop SR, Pivik J (1995) The Pain Catastrophizing Scale: development and validation. Psychol Assess 7:524\u2013532","journal-title":"Psychol Assess"},{"issue":"8","key":"6805_CR28","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1002\/1097-0142(20001015)89:8<1854::AID-CNCR28>3.0.CO;2-C","volume":"89","author":"SR Cohen","year":"2000","unstructured":"Cohen SR, Mount BM (2000) Living with cancer: \u201cgood\u201d days and \u201cbad\u201d days\u2013what produces them? Can the McGill quality of life questionnaire distinguish between them? Cancer 89(8):1854\u20131865","journal-title":"Cancer"},{"key":"6805_CR29","unstructured":"Portney LG (2020) Foundations of clinical research: applications to evidence-based practice. In: WM. PL, editor. Philadelphia: F.A. Davis Company"},{"issue":"1","key":"6805_CR30","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.jpainsymman.2012.06.016","volume":"46","author":"RR Edwards","year":"2013","unstructured":"Edwards RR, Mensing G, Cahalan C et al (2013) Alteration in pain modulation in women with persistent pain after lumpectomy: influence of catastrophizing. J Pain Symptom Manage 46(1):30\u201342","journal-title":"J Pain Symptom Manage"},{"key":"6805_CR31","first-page":"21","volume":"8","author":"LC Burns","year":"2015","unstructured":"Burns LC, Ritvo SE, Ferguson MK, Clarke H, Ze Seltzer, Katz J (2015) Pain catastrophizing as a risk factor for chronic pain after total knee arthroplasty: a systematic review. Journal of Pain Research. 8:21\u201332","journal-title":"Journal of Pain Research."},{"issue":"3 Suppl","key":"6805_CR32","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1016\/j.pain.2010.09.030","volume":"152","author":"CJ Woolf","year":"2011","unstructured":"Woolf CJ (2011) Central sensitization: implications for the diagnosis and treatment of pain. Pain 152(3 Suppl):S2-s15","journal-title":"Pain"},{"key":"6805_CR33","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.msksp.2018.04.009","volume":"36","author":"RA Coronado","year":"2018","unstructured":"Coronado RA, George SZ (2018) The Central Sensitization Inventory and Pain Sensitivity Questionnaire: an exploration of construct validity and associations with widespread pain sensitivity among individuals with shoulder pain. Musculoskelet Sci Pract 36:61\u201367","journal-title":"Musculoskelet Sci Pract"},{"key":"6805_CR34","doi-asserted-by":"crossref","unstructured":"Bezerra MC, Bittencourt JV, Reis FJJ, de Almeida RS, Meziat-Filho NAM, Nogueira LAC (2020) Central Sensitization Inventory is a useless instrument for detection of the impairment of the conditioned pain modulation in patients with chronic musculoskeletal pain. Joint Bone Spine. 105127","DOI":"10.1016\/j.jbspin.2020.105127"},{"issue":"11","key":"6805_CR35","doi-asserted-by":"publisher","first-page":"3125","DOI":"10.1007\/s10067-018-4279-8","volume":"37","author":"J Gervais-Hup\u00e9","year":"2018","unstructured":"Gervais-Hup\u00e9 J, Pollice J, Sadi J, Carlesso LC (2018) Validity of the central sensitization inventory with measures of sensitization in people with knee osteoarthritis. Clin Rheumatol 37(11):3125\u20133132","journal-title":"Clin Rheumatol"},{"issue":"6","key":"6805_CR36","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1111\/papr.12672","volume":"18","author":"J Kregel","year":"2018","unstructured":"Kregel J, Schumacher C, Dolphens M et al (2018) Convergent validity of the Dutch central sensitization inventory: associations with psychophysical pain measures, quality of life, disability, and pain cognitions in patients with chronic spinal pain. Pain Pract 18(6):777\u2013787","journal-title":"Pain Pract"},{"key":"6805_CR37","doi-asserted-by":"crossref","unstructured":"Hendriks E, Voogt L, Lenoir D, Coppieters I, Ickmans K (2020) Convergent validity of the central sensitization inventory in chronic Whiplash-associated disorders; associations with quantitative sensory testing, pain intensity, fatigue, and psychosocial factors. Pain Med","DOI":"10.1093\/pm\/pnaa276"},{"issue":"8","key":"6805_CR38","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1111\/papr.12809","volume":"19","author":"JR Clark","year":"2019","unstructured":"Clark JR, Nijs J, Yeowell G, Holmes P, Goodwin PC (2019) Trait sensitivity, anxiety, and personality are predictive of central sensitization symptoms in patients with chronic low back pain. Pain Pract 19(8):800\u2013810","journal-title":"Pain Pract"},{"issue":"1","key":"6805_CR39","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.ejpain.2006.01.002","volume":"11","author":"PU Dijkstra","year":"2007","unstructured":"Dijkstra PU, Rietman JS, Geertzen JH (2007) Phantom breast sensations and phantom breast pain: a 2-year prospective study and a methodological analysis of literature. Eur J Pain 11(1):99\u2013108","journal-title":"Eur J Pain"},{"issue":"9","key":"6805_CR40","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1002\/pon.3523","volume":"23","author":"J Leung","year":"2014","unstructured":"Leung J, Pachana NA, McLaughlin D (2014) Social support and health-related quality of life in women with breast cancer: a longitudinal study. Psychooncology 23(9):1014\u20131020","journal-title":"Psychooncology"},{"key":"6805_CR41","doi-asserted-by":"publisher","first-page":"23","DOI":"10.2147\/JPR.S124665","volume":"11","author":"M Johannsen","year":"2018","unstructured":"Johannsen M, Frederiksen Y, Jensen AB, Zachariae R (2018) Psychosocial predictors of posttreatment pain after nonmetastatic breast cancer treatment: a systematic review and meta-analysis of prospective studies. J Pain Res 11:23\u201336","journal-title":"J Pain Res"},{"issue":"2","key":"6805_CR42","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1207\/S15324796ABM2402_06","volume":"24","author":"RD Kerns","year":"2002","unstructured":"Kerns RD, Rosenberg R, Otis JD (2002) Self-appraised problem solving and pain-relevant social support as predictors of the experience of chronic pain. Ann Behav Med 24(2):100\u2013105","journal-title":"Ann Behav Med"},{"issue":"9","key":"6805_CR43","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/j.jpain.2017.05.002","volume":"18","author":"KG Andersen","year":"2017","unstructured":"Andersen KG, Duriaud HM, Kehlet H, Aasvang EK (2017) The relationship between sensory loss and persistent pain 1 year after breast cancer surgery. J Pain 18(9):1129\u20131138","journal-title":"J Pain"},{"issue":"4","key":"6805_CR44","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1213\/ANE.0000000000004871","volume":"131","author":"N van Helmond","year":"2020","unstructured":"van Helmond N, Aarts HM, Timmerman H et al (2020) Is preoperative quantitative sensory testing related to persistent postsurgical pain? A Systematic Literature Review Anesth Analg 131(4):1146\u20131155","journal-title":"A Systematic Literature Review Anesth Analg"},{"key":"6805_CR45","doi-asserted-by":"crossref","unstructured":"Dams L, Haenen V, Van der Gucht E et al (2021) Absolute and relative reliability of a comprehensive quantitative sensory testing protocol in women treated for breast cancer. Pain Med","DOI":"10.1093\/pm\/pnab343"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-022-06805-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-022-06805-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-022-06805-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T03:18:02Z","timestamp":1648005482000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-022-06805-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,2]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["6805"],"URL":"https:\/\/doi.org\/10.1007\/s00520-022-06805-0","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,2]]},"assertion":[{"value":"17 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethical Committee of the University Hospitals of Leuven (s60702).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All included patients provided written informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}