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This study aims to determine the impact of HPV status on nutritional outcomes for adult\u00a0patients with OPC undergoing any treatment modality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic literature review was conducted up to and including\u00a0July 2021 of PubMed, Embase, CENTRAL, CINAHL, and Web of Science to identify studies conducted in adults (&gt;18 years)\u00a0with known OPC reporting on any outcome(s) related to nutrition, according to HPV status (OPC+\u2009versus OPC\u2212). Bias was assessed using QUIPS tool, with certainty of evidence assessed using GRADE system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Six studies (total\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009635) all at moderate-high risk of bias were included. Three studies reported on weight change (\n                      <jats:italic>n<\/jats:italic>\n                      = 255), three\u00a0feeding tube dependency (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009380), three feeding tube timing of\u00a0placement\u00a0(prophylactic or reactive)\u00a0and\/or utilisation (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009255),  two nutritional\u00a0(energy and\/or protein) intake (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009230), and one nutritional status (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200983). Patients with OPC+\u2009may experience greater weight loss, may have higher utilisation of reactive feeding tubes (both GRADE low certainty, downgraded due to serious bias and imprecision), and may have lower feeding tube dependency rates (GRADE low certainty, downgraded due to serious bias and inconsistency) versus OPC\u2212\u2009. It is uncertain whether nutritional intake and nutritional status differed between populations (GRADE very low certainty, downgraded due to serious bias and very serious imprecision).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Further, high-quality research is needed to\u00a0understand optimal nutritional care practices for patients with OPC\u2009+\u2009to achieve positive health outcomes into survivorship.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00520-022-07056-9","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T16:05:14Z","timestamp":1651075514000},"page":"7191-7204","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The changing face of head and neck cancer: are patients with human papillomavirus-positive disease at greater nutritional risk? 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