{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:55:34Z","timestamp":1787756134182,"version":"build-2784847793"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T00:00:00Z","timestamp":1652918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T00:00:00Z","timestamp":1652918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Medical Health Science and Technology Project of Zhejiang Provincial Health Commission","award":["No.2017KY059"],"award-info":[{"award-number":["No.2017KY059"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1007\/s00520-022-07126-y","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T02:03:34Z","timestamp":1652925814000},"page":"7031-7038","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A real-world study of infectious complications of venetoclax combined with decitabine or azacitidine in adult acute myeloid leukemia"],"prefix":"10.1007","volume":"30","author":[{"given":"Li-xia","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-rong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-nai","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-jing","family":"qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-yan","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-juan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-tao","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-yuan","family":"Mai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-zhuo","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-jin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-hu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,19]]},"reference":[{"issue":"13","key":"7126_CR1","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1056\/NEJMoa0901409","volume":"361","author":"B L\u00f6wenberg","year":"2009","unstructured":"L\u00f6wenberg B, Ossenkoppele GJ, van Putten W, Schouten HC, Graux C, Ferrant A, Sonneveld P, Maertens J, Jongen-Lavrencic M, von Lilienfeld-Toal M, Biemond BJ, Vellenga E, van Marwijk KM, Verdonck LF, Beck J, D\u00f6hner H, Gratwohl A, Pabst T, Verhoef G (2009) High-dose daunorubicin in older patients with acute myeloid leukemia. N Engl J Med 361(13):1235\u20131248. https:\/\/doi.org\/10.1056\/NEJMoa0901409","journal-title":"N Engl J Med"},{"issue":"33","key":"7126_CR2","doi-asserted-by":"publisher","first-page":"4417","DOI":"10.1200\/jco.2011.35.7525","volume":"29","author":"RB Walter","year":"2011","unstructured":"Walter RB, Othus M, Borthakur G, Ravandi F, Cortes JE, Pierce SA, Appelbaum FR, Kantarjian HA, Estey EH (2011) Prediction of early death after induction therapy for newly diagnosed acute myeloid leukemia with pretreatment risk scores: a novel paradigm for treatment assignment. Journal of clinical oncology\u202f: official journal of the American Society of Clinical Oncology 29(33):4417\u20134423. https:\/\/doi.org\/10.1200\/jco.2011.35.7525","journal-title":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology"},{"issue":"10","key":"7126_CR3","doi-asserted-by":"publisher","first-page":"3547","DOI":"10.1182\/blood-2007-06-095844","volume":"110","author":"E Atallah","year":"2007","unstructured":"Atallah E, Cortes J, O\u2019Brien S, Pierce S, Rios MB, Estey E, Markman M, Keating M, Freireich EJ, Kantarjian H (2007) Establishment of baseline toxicity expectations with standard frontline chemotherapy in acute myelogenous leukemia. Blood 110(10):3547\u20133551. https:\/\/doi.org\/10.1182\/blood-2007-06-095844","journal-title":"Blood"},{"issue":"6","key":"7126_CR4","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.3109\/10428194.2011.636812","volume":"53","author":"G Cannas","year":"2012","unstructured":"Cannas G, Pautas C, Raffoux E, Quesnel B, de Botton S, de Revel T, Reman O, Gardin C, Elhamri M, Boissel N, Fenaux P, Michallet M, Castaigne S, Dombret H, Thomas X (2012) Infectious complications in adult acute myeloid leukemia: analysis of the Acute Leukemia French Association-9802 prospective multicenter clinical trial. Leuk Lymphoma 53(6):1068\u20131076. https:\/\/doi.org\/10.3109\/10428194.2011.636812","journal-title":"Leuk Lymphoma"},{"issue":"12","key":"7126_CR5","doi-asserted-by":"publisher","first-page":"4187","DOI":"10.1007\/s00520-018-4292-0","volume":"26","author":"H Kato","year":"2018","unstructured":"Kato H, Fujita H, Akiyama N, Kimura SI, Hiramoto N, Hosono N, Takahashi T, Shigeno K, Minamiguchi H, Miyatake J, Handa H, Kanda Y, Yoshida M, Miyawaki S, Ohtake S, Naoe T, Kiyoi H, Matsumura I, Miyazaki Y (2018) Infectious complications in adults undergoing intensive chemotherapy for acute myeloid leukemia in 2001\u20132005 using the Japan Adult Leukemia Study Group AML201 protocols. Supportive care in cancer\u202f: official journal of the Multinational Association of Supportive Care in Cancer 26(12):4187\u20134198. https:\/\/doi.org\/10.1007\/s00520-018-4292-0","journal-title":"Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer"},{"issue":"10","key":"7126_CR6","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1182\/blood-2018-03-828269","volume":"132","author":"M Konopleva","year":"2018","unstructured":"Konopleva M, Letai A (2018) BCL-2 inhibition in AML: an unexpected bonus? Blood 132(10):1007\u20131012. https:\/\/doi.org\/10.1182\/blood-2018-03-828269","journal-title":"Blood"},{"issue":"2","key":"7126_CR7","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.beha.2019.05.008","volume":"32","author":"VA Guerra","year":"2019","unstructured":"Guerra VA, DiNardo C, Konopleva M (2019) Venetoclax-based therapies for acute myeloid leukemia. Best Pract Res Clin Haematol 32(2):145\u2013153. https:\/\/doi.org\/10.1016\/j.beha.2019.05.008","journal-title":"Best Pract Res Clin Haematol"},{"issue":"1","key":"7126_CR8","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1182\/blood-2018-08-868752","volume":"133","author":"CD DiNardo","year":"2019","unstructured":"DiNardo CD, Pratz K, Pullarkat V, Jonas BA, Arellano M, Becker PS, Frankfurt O, Konopleva M, Wei AH, Kantarjian HM, Xu T, Hong WJ, Chyla B, Potluri J, Pollyea DA, Letai A (2019) Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia. Blood 133(1):7\u201317. https:\/\/doi.org\/10.1182\/blood-2018-08-868752","journal-title":"Blood"},{"issue":"7","key":"7126_CR9","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1056\/NEJMoa2012971","volume":"383","author":"CD DiNardo","year":"2020","unstructured":"DiNardo CD, Jonas BA, Pullarkat V, Thirman MJ, Garcia JS, Wei AH, Konopleva M, D\u00f6hner H, Letai A, Fenaux P, Koller E, Havelange V, Leber B, Esteve J, Wang J, Pejsa V, H\u00e1jek R, Porkka K, Ill\u00e9s \u00c1, Lavie D, Lemoli RM, Yamamoto K, Yoon SS, Jang JH, Yeh SP, Turgut M, Hong WJ, Zhou Y, Potluri J, Pratz KW (2020) Azacitidine and venetoclax in previously untreated acute myeloid leukemia. N Engl J Med 383(7):617\u2013629. https:\/\/doi.org\/10.1056\/NEJMoa2012971","journal-title":"N Engl J Med"},{"issue":"15","key":"7126_CR10","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1200\/jco.18.01600","volume":"37","author":"AH Wei","year":"2019","unstructured":"Wei AH, Strickland SA Jr, Hou JZ, Fiedler W, Lin TL, Walter RB, Enjeti A, Tiong IS, Savona M, Lee S, Chyla B, Popovic R, Salem AH, Agarwal S, Xu T, Fakouhi KM, Humerickhouse R, Hong WJ, Hayslip J, Roboz GJ (2019) Venetoclax combined with low-dose cytarabine for previously untreated patients with acute myeloid leukemia: results from a phase Ib\/II study. Journal of clinical oncology: official journal of the American Society of Clinical Oncology 37(15):1277\u20131284. https:\/\/doi.org\/10.1200\/jco.18.01600","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology"},{"issue":"24","key":"7126_CR11","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1182\/blood.2020004856","volume":"135","author":"AH Wei","year":"2020","unstructured":"Wei AH, Montesinos P, Ivanov V, DiNardo CD, Novak J, Laribi K, Kim I, Stevens DA, Fiedler W, Pagoni M, Samoilova O, Hu Y, Anagnostopoulos A, Bergeron J, Hou JZ, Murthy V, Yamauchi T, McDonald A, Chyla B, Gopalakrishnan S, Jiang Q, Mendes W, Hayslip J, Panayiotidis P (2020) Venetoclax plus LDAC for newly diagnosed AML ineligible for intensive chemotherapy: a phase 3 randomized placebo-controlled trial. Blood 135(24):2137\u20132145. https:\/\/doi.org\/10.1182\/blood.2020004856","journal-title":"Blood"},{"issue":"24","key":"7126_CR12","doi-asserted-by":"publisher","first-page":"4642","DOI":"10.1200\/jco.2003.04.036","volume":"21","author":"BD Cheson","year":"2003","unstructured":"Cheson BD, Bennett JM, Kopecky KJ, B\u00fcchner T, Willman CL, Estey EH, Schiffer CA, Doehner H, Tallman MS, Lister TA, Lo-Coco F, Willemze R, Biondi A, Hiddemann W, Larson RA, L\u00f6wenberg B, Sanz MA, Head DR, Ohno R, Bloomfield CD (2003) Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia. Journal of clinical oncology\u202f: official journal of the American Society of Clinical Oncology 21(24):4642\u20134649. https:\/\/doi.org\/10.1200\/jco.2003.04.036","journal-title":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology"},{"issue":"11","key":"7126_CR13","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1007\/s00277-017-3098-3","volume":"96","author":"WJ Heinz","year":"2017","unstructured":"Heinz WJ, Buchheidt D, Christopeit M, von Lilienfeld-Toal M, Cornely OA, Einsele H, Karthaus M, Link H, Mahlberg R, Neumann S, Ostermann H, Penack O, Ruhnke M, Sandherr M, Schiel X, Vehreschild JJ, Weissinger F, Maschmeyer G (2017) Diagnosis and empirical treatment of fever of unknown origin (FUO) in adult neutropenic patients: guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO). Ann Hematol 96(11):1775\u20131792. https:\/\/doi.org\/10.1007\/s00277-017-3098-3","journal-title":"Ann Hematol"},{"key":"7126_CR14","doi-asserted-by":"publisher","unstructured":"Chinese Society of Hematology, Chinese Medical Association, Chinese Medical Doctor Association, Hematology Branch (2020) Chinese guidelines for the clinical application of antibacterial drugs for agranulocytosis with fever (2020). Zhonghua xue ye xue za zhi 41(12):969-78. https:\/\/doi.org\/10.3760\/cma.j.issn.0253-2727.2020.12.001","DOI":"10.3760\/cma.j.issn.0253-2727.2020.12.001"},{"issue":"4","key":"7126_CR15","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1093\/cid\/ciq147","volume":"52","author":"AG Freifeld","year":"2011","unstructured":"Freifeld AG, Bow EJ, Sepkowitz KA, Boeckh MJ, Ito JI, Mullen CA, Raad II, Rolston KV, Young JA, Wingard JR (2011) Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 Update by the Infectious Diseases Society of America. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America 52(4):427\u2013431. https:\/\/doi.org\/10.1093\/cid\/ciq147","journal-title":"Clinical infectious diseases: an official publication of the Infectious Diseases Society of America"},{"issue":"24","key":"7126_CR16","doi-asserted-by":"publisher","first-page":"4326","DOI":"10.1182\/bloodadvances.2019000937","volume":"3","author":"DA Pollyea","year":"2019","unstructured":"Pollyea DA, Amaya M, Strati P, Konopleva MY (2019) Venetoclax for AML: changing the treatment paradigm. Blood Adv 3(24):4326\u20134335. https:\/\/doi.org\/10.1182\/bloodadvances.2019000937","journal-title":"Blood Adv"},{"issue":"2","key":"7126_CR17","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/s1470-2045(18)30010-x","volume":"19","author":"CD DiNardo","year":"2018","unstructured":"DiNardo CD, Pratz KW, Letai A, Jonas BA, Wei AH, Thirman M, Arellano M, Frattini MG, Kantarjian H, Popovic R, Chyla B, Xu T, Dunbar M, Agarwal SK, Humerickhouse R, Mabry M, Potluri J, Konopleva M, Pollyea DA (2018) Safety and preliminary efficacy of venetoclax with decitabine or azacitidine in elderly patients with previously untreated acute myeloid leukaemia: a non-randomised, open-label, phase 1b study. Lancet Oncol 19(2):216\u2013228. https:\/\/doi.org\/10.1016\/s1470-2045(18)30010-x","journal-title":"Lancet Oncol"},{"key":"7126_CR18","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/1756-8722-6-32","volume":"6","author":"L Pleyer","year":"2013","unstructured":"Pleyer L, Stauder R, Burgstaller S, Schreder M, Tinchon C, Pfeilstocker M, Steinkirchner S, Melchardt T, Mitrovic M, Girschikofsky M, Lang A, Krippl P, Sliwa T, Egle A, Linkesch W, Voskova D, Angermann H, Greil R (2013) Azacitidine in patients with WHO-defined AML - results of 155 patients from the Austrian Azacitidine Registry of the AGMT-Study Group. J Hematol Oncol 6:32. https:\/\/doi.org\/10.1186\/1756-8722-6-32","journal-title":"J Hematol Oncol"},{"issue":"4","key":"7126_CR19","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1200\/jco.2009.23.9178","volume":"28","author":"AF Cashen","year":"2010","unstructured":"Cashen AF, Schiller GJ, O\u2019Donnell MR, DiPersio JF (2010) Multicenter, phase II study of decitabine for the first-line treatment of older patients with acute myeloid leukemia. Journal of clinical oncology\u202f: official journal of the American Society of Clinical Oncology 28(4):556\u2013561. https:\/\/doi.org\/10.1200\/jco.2009.23.9178","journal-title":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology"},{"issue":"30","key":"7126_CR20","doi-asserted-by":"publisher","first-page":"3506","DOI":"10.1200\/jco.20.00572","volume":"38","author":"CC Chua","year":"2020","unstructured":"Chua CC, Roberts AW, Reynolds J, Fong CY, Ting SB, Salmon JM, MacRaild S, Ivey A, Tiong IS, Fleming S, Brown FC, Loo S, Majewski IJ, Bohlander SK, Wei AH (2020) Chemotherapy and venetoclax in elderly acute myeloid leukemia trial (CAVEAT): a phase Ib dose-escalation study of venetoclax combined with modified intensive chemotherapy. Journal of clinical oncology\u202f: official journal of the American Society of Clinical Oncology 38(30):3506\u20133517. https:\/\/doi.org\/10.1200\/jco.20.00572","journal-title":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology"},{"issue":"10","key":"7126_CR21","doi-asserted-by":"publisher","first-page":"e724","DOI":"10.1016\/s2352-3026(20)30210-6","volume":"7","author":"CD DiNardo","year":"2020","unstructured":"DiNardo CD, Maiti A, Rausch CR, Pemmaraju N, Naqvi K, Daver NG, Kadia TM, Borthakur G, Ohanian M, Alvarado Y, Issa GC, Montalban-Bravo G, Short NJ, Yilmaz M, Bose P, Jabbour EJ, Takahashi K, Burger JA, Garcia-Manero G, Jain N, Kornblau SM, Thompson PA, Estrov Z, Masarova L, Sasaki K, Verstovsek S, Ferrajoli A, Weirda WG, Wang SA, Konoplev S, Chen Z, Pierce SA, Ning J, Qiao W, Ravandi F, Andreeff M, Welch JS, Kantarjian HM, Konopleva MY (2020) 10-day decitabine with venetoclax for newly diagnosed intensive chemotherapy ineligible, and relapsed or refractory acute myeloid leukaemia: a single-centre, phase 2 trial. The Lancet Haematology 7(10):e724\u2013e736. https:\/\/doi.org\/10.1016\/s2352-3026(20)30210-6","journal-title":"The Lancet Haematology"},{"issue":"5","key":"7126_CR22","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1513\/AnnalsATS.201304-097OC","volume":"10","author":"JB Garcia","year":"2013","unstructured":"Garcia JB, Lei X, Wierda W, Cortes JE, Dickey BF, Evans SE, Ost DE (2013) Pneumonia during remission induction chemotherapy in patients with acute leukemia. Ann Am Thorac Soc 10(5):432\u2013440. https:\/\/doi.org\/10.1513\/AnnalsATS.201304-097OC","journal-title":"Ann Am Thorac Soc"},{"issue":"11","key":"7126_CR23","doi-asserted-by":"publisher","first-page":"5449","DOI":"10.1007\/s00520-020-05379-z","volume":"28","author":"J Pandian","year":"2020","unstructured":"Pandian J, Raghavan V, Manuprasad A, Shenoy PK, Nair CK (2020) Infection at diagnosis-a unique challenge in acute myeloid leukemia treatment in developing world. Supportive care in cancer\u202f: official journal of the Multinational Association of Supportive Care in Cancer 28(11):5449\u20135454. https:\/\/doi.org\/10.1007\/s00520-020-05379-z","journal-title":"Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer"},{"issue":"30","key":"7126_CR24","doi-asserted-by":"publisher","first-page":"3043","DOI":"10.1200\/jco.18.00374","volume":"36","author":"RA Taplitz","year":"2018","unstructured":"Taplitz RA, Kennedy EB, Bow EJ, Crews J, Gleason C, Hawley DK, Langston AA, Nastoupil LJ, Rajotte M, Rolston KV, Strasfeld L, Flowers CR (2018) antimicrobial prophylaxis for adult patients with cancer-related immunosuppression: ASCO and IDSA clinical practice guideline update. Journal of clinical oncology\u202f: official journal of the American Society of Clinical Oncology 36(30):3043\u20133054. https:\/\/doi.org\/10.1200\/jco.18.00374","journal-title":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology"},{"issue":"10","key":"7126_CR25","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1056\/NEJMoa044097","volume":"353","author":"G Bucaneve","year":"2005","unstructured":"Bucaneve G, Micozzi A, Menichetti F, Martino P, Dionisi MS, Martinelli G, Allione B, D\u2019Antonio D, Buelli M, Nosari AM, Cilloni D, Zuffa E, Cantaffa R, Specchia G, Amadori S, Fabbiano F, Deliliers GL, Lauria F, Fo\u00e0 R, Del Favero A (2005) Levofloxacin to prevent bacterial infection in patients with cancer and neutropenia. N Engl J Med 353(10):977\u2013987. https:\/\/doi.org\/10.1056\/NEJMoa044097","journal-title":"N Engl J Med"},{"issue":"1","key":"7126_CR26","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.jinf.2017.10.009","volume":"76","author":"M Mikulska","year":"2018","unstructured":"Mikulska M, Averbuch D, Tissot F, Cordonnier C, Akova M, Calandra T, Ceppi M, Bruzzi P, Viscoli C (2018) Fluoroquinolone prophylaxis in haematological cancer patients with neutropenia: ECIL critical appraisal of previous guidelines. J Infect 76(1):20\u201337. https:\/\/doi.org\/10.1016\/j.jinf.2017.10.009","journal-title":"J Infect"},{"issue":"12 Pt 1","key":"7126_CR27","doi-asserted-by":"publisher","first-page":"979","DOI":"10.7326\/0003-4819-142-12_part_1-200506210-00008","volume":"142","author":"A Gafter-Gvili","year":"2005","unstructured":"Gafter-Gvili A, Fraser A, Paul M, Leibovici L (2005) Meta-analysis: antibiotic prophylaxis reduces mortality in neutropenic patients. Ann Intern Med 142(12 Pt 1):979\u2013995. https:\/\/doi.org\/10.7326\/0003-4819-142-12_part_1-200506210-00008","journal-title":"Ann Intern Med"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-022-07126-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-022-07126-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-022-07126-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T05:11:57Z","timestamp":1655788317000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-022-07126-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,19]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["7126"],"URL":"https:\/\/doi.org\/10.1007\/s00520-022-07126-y","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,19]]},"assertion":[{"value":"14 December 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the clinical research ethics committee of the First Affiliated Hospital, College of Medicine, Zhejiang University (Reference Number 2021-IIT-558).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The informed consent was waived because this study was a retrospective study with review of related data through the electronic medical record.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The informed consent was waived because this study was a retrospective study with review of related data through the electronic medical record.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}