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Demographic, clinical information and patient-reported outcome questionnaire data were collected at baseline.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Differences in healthcare experienced were found between CUP and non-CUP controls with CUP patients reporting higher scores for unmet medical communication\/information needs compared with non-CUP control patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.013) as well as greater uncertainty in illness (<jats:italic>p<\/jats:italic>\u2009=\u20090.042). Whilst no differences were found between CUP and non-CUP controls on the EORTC and PROMIS measures, of those that \u2018received written information about your cancer\u2026\u2019 and asked \u2018\u2026how useful was it?\u2019 fewer CUP patients reported finding the information useful 40% vs 61%, and more were likely to not have received written information at all 59% vs 32%; (<jats:italic>p<\/jats:italic>\u2009=\u20090.002). Additionally, of those that found information about their cancer online, fewer patients with CUP reported finding it useful 32% vs 48% control patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.005).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>CUP patients have unmet medical communication\/information needs and greater uncertainty in illness but do not differ in health-related quality of life domains compared to patients with advanced cancer of a known primary.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00520-022-07228-7","type":"journal-article","created":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T03:27:42Z","timestamp":1657337262000},"page":"8217-8229","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Uncertainty and the unmet informational needs of patients with cancer of unknown primary (CUP): a cross-sectional multi-site study"],"prefix":"10.1007","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1408-3615","authenticated-orcid":false,"given":"Lisa","family":"Guccione","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4066-3637","authenticated-orcid":false,"given":"Krista","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6826-6014","authenticated-orcid":false,"given":"Linda","family":"Mileshkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4522-1184","authenticated-orcid":false,"given":"Richard","family":"Tothill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9089-7525","authenticated-orcid":false,"given":"David","family":"Bowtell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1306-9686","authenticated-orcid":false,"given":"Stephen","family":"Quinn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0057-4744","authenticated-orcid":false,"given":"Anna","family":"DeFazio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1741-996X","authenticated-orcid":false,"given":"Chris S.","family":"Karapetis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4006-0289","authenticated-orcid":false,"given":"Nicholas","family":"Wilcken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2770-9445","authenticated-orcid":false,"given":"Madhu","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7677-3339","authenticated-orcid":false,"given":"Christopher","family":"Steer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Warren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6936-0942","authenticated-orcid":false,"given":"Ian M.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3374-6242","authenticated-orcid":false,"given":"Narayan","family":"Karanth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Bryant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9495-9543","authenticated-orcid":false,"given":"Penelope","family":"Schofield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,9]]},"reference":[{"key":"7228_CR1","unstructured":"Australian Institute of Health and Welfare, Cancer in Australia 2019. 2019, Australian Institute of Health and Welfare Canberra."},{"issue":"3","key":"7228_CR2","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1634\/theoncologist.2-3-142","volume":"2","author":"E Briasoulis","year":"1997","unstructured":"Briasoulis E, Pavlidis N (1997) Cancer of unknown primary origin. 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