{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:55:28Z","timestamp":1780451728668,"version":"3.54.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1007\/s00520-022-07384-w","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T16:04:39Z","timestamp":1665072279000},"page":"9659-9665","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Sarcopenia is an independent risk factor for depression in patients with advanced lung cancer"],"prefix":"10.1007","volume":"30","author":[{"given":"Dinglong","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaru","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiya","family":"Men","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingwei","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,6]]},"reference":[{"key":"7384_CR1","first-page":"e13086","volume":"28","author":"Brandenbarg Daan","year":"2019","unstructured":"Daan Brandenbarg, Maass Saskia WMC, Geerse Olaf P et al (2019) A systematic review on the prevalence of symptoms of depression, anxiety and distress in long-term cancer survivors: implications for primary care. Eur J Cancer Care (Engl) 28:e13086","journal-title":"Eur J Cancer Care (Engl)"},{"issue":"9","key":"7384_CR2","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1080\/08870446.2010.542815","volume":"26","author":"M Manning","year":"2011","unstructured":"Manning M, Bettencourt BA (2011) Depression and medication adherence among breast cancer survivors: bridging the gap with the theory of planned behaviour. Psychol Health 26(9):1173\u20131187","journal-title":"Psychol Health"},{"issue":"4","key":"7384_CR3","doi-asserted-by":"publisher","first-page":"101511","DOI":"10.1016\/j.clinre.2020.07.016","volume":"45","author":"L Zhou","year":"2021","unstructured":"Zhou L, Sun H (2021) The longitudinal changes of anxiety and depression, their related risk factors and prognostic value in colorectal cancer survivors: a 36-month follow-up study. Clin Res Hepatol Gastroenterol 45(4):101511","journal-title":"Clin Res Hepatol Gastroenterol"},{"issue":"7","key":"7384_CR4","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1176\/appi.ajp.2018.17111194","volume":"175","author":"FB Schuch","year":"2018","unstructured":"Schuch FB, Vancampfort D, Firth J et al (2018) Physical activity and incident depression: a meta-analysis of prospective cohort studies. Am J Psychiatry 175(7):631\u2013648","journal-title":"Am J Psychiatry"},{"key":"7384_CR5","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","volume":"12","author":"K Fearon","year":"2011","unstructured":"Fearon K, Strasser F, Anker SD et al (2011) Definition and classification of cancer cachexia: an international consensus. Lancet Oncol 12:489\u2013495","journal-title":"Lancet Oncol"},{"issue":"11\u201312","key":"7384_CR6","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1016\/j.nut.2016.04.003","volume":"32","author":"Y Hamaguchi","year":"2016","unstructured":"Hamaguchi Y, Kaido T, Okumura S, Kobayashi A et al (2016) Proposal for new diagnostic criteria for low skeletal muscle mass based on computed tomography imaging in Asian adults. Nutrition 32(11\u201312):1200\u20135","journal-title":"Nutrition"},{"issue":"1","key":"7384_CR7","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/s12877-022-02795-0","volume":"22","author":"XM Zhang","year":"2022","unstructured":"Zhang XM, Zhang ZB, Chen W, Wu X (2022) The association between handgrip strength and depression in cancer survivors: a cross-sectional study. Bmc Geriatr 22(1):111","journal-title":"Bmc Geriatr"},{"issue":"7","key":"7384_CR8","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/s41574-019-0174-x","volume":"15","author":"BK Pedersen","year":"2019","unstructured":"Pedersen BK (2019) Physical activity and muscle-brain crosstalk. Nat Rev Endocrinol 15(7):383\u2013392","journal-title":"Nat Rev Endocrinol"},{"issue":"11","key":"7384_CR9","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1017\/S0033291709992285","volume":"40","author":"M Pinquart","year":"2010","unstructured":"Pinquart M, Duberstein PR (2010) Depression and cancer mortality: a meta-analysis. Psychol Med 40(11):1797\u20131810","journal-title":"Psychol Med"},{"issue":"2","key":"7384_CR10","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.jad.2013.04.028","volume":"150","author":"M Zimmerman","year":"2013","unstructured":"Zimmerman M, Martinez JH, Young D et al (2013) Severity classification on the Hamilton Depression Rating Scale. J Affect Disord 150(2):384\u20138","journal-title":"J Affect Disord"},{"issue":"1","key":"7384_CR11","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1152\/jappl.1998.85.1.115","volume":"85","author":"N Mitsiopoulos","year":"1985","unstructured":"Mitsiopoulos N, Baumgartner RN, Heymsfield SB, Lyons W, Gallagher D, Ross R (1985) Cadaver validation of skeletal muscle measurement by magnetic resonance imaging and computerized tomography. J Appl Physiol (1985) 85(1):115\u201322","journal-title":"J Appl Physiol (1985)"},{"issue":"1","key":"7384_CR12","first-page":"22","volume":"12","author":"SL Budui","year":"2015","unstructured":"Budui SL, Rossi AP, Zamboni M (2015) The pathogenetic bases of sarcopenia. Clin Cases Miner Bone Metab 12(1):22\u20136","journal-title":"Clin Cases Miner Bone Metab"},{"key":"7384_CR13","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3389\/fpsyt.2016.00036","volume":"7","author":"M Hallgren","year":"2016","unstructured":"Hallgren M, Herring MP, Owen N et al (2016) Exercise, Physical activity, and sedentary behavior in the treatment of depression: broadening the scientific perspectives and clinical opportunities. Front Psychiatry 7:36","journal-title":"Front Psychiatry"},{"issue":"2","key":"7384_CR14","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1002\/cphy.c110025","volume":"2","author":"FW Booth","year":"2012","unstructured":"Booth FW, Roberts CK, Laye MJ (2012) Lack of exercise is a major cause of chronic diseases. Compr Physiol 2(2):1143\u20131211","journal-title":"Compr Physiol"},{"issue":"6","key":"7384_CR15","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1176\/appi.ajp.160.6.1147","volume":"160","author":"MG Cole","year":"2003","unstructured":"Cole MG, Dendukuri N (2003) Risk factors for depression among elderly community subjects: a systematic review and meta-analysis. Am J Psychiatry 160(6):1147\u20131156","journal-title":"Am J Psychiatry"},{"issue":"9475","key":"7384_CR16","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1016\/S0140-6736(05)66665-2","volume":"365","author":"GS Alexopoulos","year":"2005","unstructured":"Alexopoulos GS (2005) Depression in the elderly. Lancet 365(9475):1961\u201370","journal-title":"Lancet"},{"issue":"6","key":"7384_CR17","doi-asserted-by":"publisher","first-page":"pyw001","DOI":"10.1093\/ijnp\/pyw001","volume":"19","author":"MM Hughes","year":"2016","unstructured":"Hughes MM, Connor TJ, Harkin A (2016) Stress-related immune markers in depression implications for treatment. Int J Neuropsychopharmacol 19(6):pyw001","journal-title":"Int J Neuropsychopharmacol"},{"issue":"4","key":"7384_CR18","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1093\/ageing\/afv013","volume":"44","author":"N Fukumori","year":"2015","unstructured":"Fukumori N, Yamamoto Y, Takegami M, Yamazaki S et al (2015) Association between hand-grip strength and depressive symptoms: locomotive syndrome and health outcomes in Aizu Cohort Study (LOHAS). Age Ageing 44(4):592\u20138","journal-title":"Age Ageing"},{"issue":"3","key":"7384_CR19","doi-asserted-by":"publisher","first-page":"201","DOI":"10.14735\/amko2019201","volume":"32","author":"L Sv\u011btl\u00e1kov\u00e1","year":"2019","unstructured":"Sv\u011btl\u00e1kov\u00e1 L, Sl\u00e1ma O, Sv\u011btl\u00e1k M et al (2019) Prevalence of anxiety and depression and their impact on the quality of life of cancer patients treated with palliative antineoplasic therapy - results of the PALINT trial. Klin Onkol 32(3):201\u2013207","journal-title":"Klin Onkol"},{"issue":"5","key":"7384_CR20","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1097\/PSY.0000000000000942","volume":"83","author":"J Walker","year":"2021","unstructured":"Walker J, Mulick A, Magill N, Symeonides S et al (2021) Major depression and survival in people with cancer. Psychosom Med 83(5):410\u2013416","journal-title":"Psychosom Med"},{"key":"7384_CR21","doi-asserted-by":"publisher","first-page":"110218","DOI":"10.1016\/j.jpsychores.2020.110218","volume":"138","author":"J Walker","year":"2020","unstructured":"Walker J, Magill N, Mulick A et al (2020) Different independent associations of depression and anxiety with survival in patients with cancer. J Psychosom Res 138:110218","journal-title":"J Psychosom Res"},{"issue":"45","key":"7384_CR22","doi-asserted-by":"publisher","first-page":"e0897","DOI":"10.1097\/MD.0000000000000897","volume":"94","author":"MF Zhang","year":"2015","unstructured":"Zhang MF, Wen YS, Liu WY, Peng LF et al (2015) Effectiveness of mindfulness-based therapy for reducing anxiety and depression in patients with cancer: a meta-analysis. Medicine (Baltimore) 94(45):e0897","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"7384_CR23","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3109\/09540261.2013.864259","volume":"26","author":"I Barrera","year":"2014","unstructured":"Barrera I, Spiegel D (2014) Review of psychotherapeutic interventions on depression in cancer patients and their impact on disease progression. Int Rev Psychiatry 26(1):31\u201343","journal-title":"Int Rev Psychiatry"},{"issue":"13","key":"7384_CR24","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/1471-244X-13-140","volume":"16","author":"ZG Laoutidis","year":"2013","unstructured":"Laoutidis ZG, Mathiak K (2013) Antidepressants in the treatment of depression\/depressive symptoms in cancer patients: a systematic review and meta-analysis. Bmc Psychiatry 16(13):140","journal-title":"Bmc Psychiatry"},{"issue":"4","key":"7384_CR25","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1093\/ageing\/afz046","volume":"48","author":"AJ Cruz-Jentoft","year":"2019","unstructured":"Cruz-Jentoft AJ, Bahat G, Bauer J et al (2019) Writing group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the extended group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 48(4):601\u2013618","journal-title":"Age Ageing"},{"issue":"1","key":"7384_CR26","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1634\/theoncologist.2017-0255","volume":"23","author":"RD Nipp","year":"2018","unstructured":"Nipp RD, Fuchs G, El-Jawahri A, Mario J et al (2018) Sarcopenia is associated with quality of life and depression in patients with advanced cancer. Oncologist 23(1):97\u2013104","journal-title":"Oncologist"},{"issue":"1","key":"7384_CR27","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1002\/jcsm.12908","volume":"13","author":"Z Li","year":"2022","unstructured":"Li Z, Tong X, Ma Y, Bao T, Yue J (2022) Prevalence of depression in patients with sarcopenia and correlation between the two diseases: systematic review and meta-analysis. J Cachexia Sarcopenia Muscle 13(1):128\u2013144","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"1","key":"7384_CR28","doi-asserted-by":"publisher","first-page":"37","DOI":"10.4082\/kjfm.2016.37.1.37","volume":"37","author":"CH Byeon","year":"2016","unstructured":"Byeon CH, Kang KY, Kang SH et al (2016) Sarcopenia is not associated with depression in Korean adults: results from the 2010\u20132011 Korean National Health and Nutrition Examination Survey. Korean J Fam Med 37(1):37\u201343","journal-title":"Korean J Fam Med"},{"key":"7384_CR29","doi-asserted-by":"crossref","unstructured":"Gao L, Gao YH (2021) Advances in the research on the relationship between sarcopenia and depression[J]. Journal of Internal Medicine Concepts & Practice 16(06):442\u2013446","DOI":"10.17507\/tpls.1104.14"},{"issue":"1","key":"7384_CR30","first-page":"37","volume":"3","author":"J Illman","year":"2005","unstructured":"Illman J, Corringham R, Robinson D Jr, Davis HM et al (2005) Are inflammatory cytokines the common link between cancer-associated cachexia and depression? J Support Oncol 3(1):37\u201350","journal-title":"J Support Oncol"},{"issue":"3","key":"7384_CR31","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1097\/MCO.0b013e328352694f","volume":"15","author":"KN Jeejeebhoy","year":"2012","unstructured":"Jeejeebhoy KN (2012) Malnutrition, fatigue, frailty, vulnerability, sarcopenia and cachexia: overlap of clinical features. Curr Opin Clin Nutr Metab Care 15(3):213\u2013219","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"23","key":"7384_CR32","doi-asserted-by":"publisher","first-page":"3886","DOI":"10.1200\/JCO.2007.15.9525","volume":"26","author":"SM Dy","year":"2008","unstructured":"Dy SM, Lorenz KA, Naeim A et al (2008) Evidence-based recommendations for cancer fatigue, anorexia, depression, and dyspnea. J Clin Oncol 26(23):3886\u201395","journal-title":"J Clin Oncol"},{"issue":"12","key":"7384_CR33","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1200\/JCO.2012.45.2722","volume":"31","author":"L Martin","year":"2013","unstructured":"Martin L, Birdsell L, Macdonald N, Reiman T et al (2013) Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index. J Clin Oncol 31(12):1539\u201347","journal-title":"J Clin Oncol"},{"issue":"11","key":"7384_CR34","doi-asserted-by":"publisher","first-page":"3390","DOI":"10.1093\/rheumatology\/keaa141","volume":"59","author":"AM Rathbun","year":"2020","unstructured":"Rathbun AM, Shardell MD, Ryan AS, Hochberg MC et al (2020) Association between disease progression and depression onset in persons with radiographic knee osteoarthritis. Rheumatology Oxford 59(11):3390\u20133399","journal-title":"Rheumatology Oxford"},{"issue":"6","key":"7384_CR35","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1002\/jcsm.12468","volume":"10","author":"J Ubachs","year":"2019","unstructured":"Ubachs J, Ziemons J, Minis-Rutten IJG et al (2019) Sarcopenia and ovarian cancer survival: a systematic review and meta-analysis. J Cachexia Sarcopenia Muscle 10(6):1165\u20131174","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"1","key":"7384_CR36","doi-asserted-by":"publisher","first-page":"2447","DOI":"10.1038\/s41598-019-39120-6","volume":"9","author":"T Shiroyama","year":"2019","unstructured":"Shiroyama T, Nagatomo I, Koyama S et al (2019) Impact of sarcopenia in patients with advanced non-small cell lung cancer treated with PD-1 inhibitors: a preliminary retrospective study. Sci Rep 9(1):2447","journal-title":"Sci Rep"},{"key":"7384_CR37","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.jneuroim.2015.08.012","volume":"287","author":"CF Jehn","year":"2015","unstructured":"Jehn CF, Becker B, Flath B et al (2015) Neurocognitive function, brain-derived neurotrophic factor (BDNF) and IL-6 levels in cancer patients with depression. J Neuroimmunol 287:88\u201392","journal-title":"J Neuroimmunol"},{"key":"7384_CR38","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.bbr.2014.06.045","volume":"272","author":"A Lebena","year":"2014","unstructured":"Lebena A, Vegas O, Gomez-Lazaro E et al (2014) Melanoma tumors alter proinflammatory cytokine production and monoamine brain function, and induce depressive-like behavior in male mice. Behav Brain Res 272:83\u201392","journal-title":"Behav Brain Res"},{"key":"7384_CR39","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.psyneuen.2013.12.016","volume":"42","author":"S Hughes","year":"2014","unstructured":"Hughes S, Jaremka LM, Alfano CM et al (2014) Social support predicts inflammation, pain, and depressive symptoms: longitudinal relationships among breast cancer survivors. Psychoneuroendocrinology 42:38\u201344","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"7384_CR40","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/MCO.0b013e328340d849","volume":"14","author":"K Kurz","year":"2011","unstructured":"Kurz K, Schroecksnadel S, Weiss G, Fuchs D (2011) Association between increased tryptophan degradation and depression in cancer patients. Curr Opin Clin Nutr Metab Care 14(1):49\u201356","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"8","key":"7384_CR41","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1017\/S1461145709000091","volume":"12","author":"YC Wei","year":"2009","unstructured":"Wei YC, Zhou FL, He DL, Bai JR et al (2009) Oxidative stress in depressive patients with gastric adenocarcinoma. Int J Neuropsychopharmacol 12(8):1089\u20131096","journal-title":"Int J Neuropsychopharmacol"},{"key":"7384_CR42","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.ctrv.2016.11.004","volume":"52","author":"B Bortolato","year":"2017","unstructured":"Bortolato B, Hyphantis TN, Valpione S et al (2017) Depression in cancer: the many biobehavioral pathways driving tumor progression. Cancer Treat Rev 52:58\u201370","journal-title":"Cancer Treat Rev"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-022-07384-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-022-07384-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-022-07384-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T15:16:01Z","timestamp":1667661361000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-022-07384-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,6]]},"references-count":42,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["7384"],"URL":"https:\/\/doi.org\/10.1007\/s00520-022-07384-w","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,6]]},"assertion":[{"value":"8 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. The study was approved by a certified medical ethics committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from the participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}