{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T08:27:36Z","timestamp":1765268856634},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s00520-022-07443-2","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T12:03:31Z","timestamp":1668081811000},"page":"10255-10262","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinicians\u2019 experience with topical benzydamine and morphine for the management of oral mucositis: adverse effects and barriers"],"prefix":"10.1007","volume":"30","author":[{"given":"Ariel","family":"Blanchard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noam","family":"Yarom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Levi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karis Kin Fong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Bossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yehuda","family":"Zadik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Elad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Atask force of the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer\/International Society of Oral Oncology (MASCC\/ISOO)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,11,10]]},"reference":[{"key":"7443_CR1","unstructured":"Lalla RV, Brennan MT, Gordon SM, Sonis ST, Rosenthal DI, Keefe DM (2019) Oral mucositis due to high-dose chemotherapy and\/or head and neck radiation therapy. J Natl Cancer Inst Monogr 53:17\u201324"},{"key":"7443_CR2","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3322\/caac.21704","volume":"72","author":"S Elad","year":"2022","unstructured":"Elad S, Yarom N, Zadik Y, Kuten-Shorrer M, Sonis ST (2022) The broadening scope of oral mucositis and oral ulcerative mucosal toxicities of anticancer therapies. CA Cancer J Clin 72:57\u201377","journal-title":"CA Cancer J Clin"},{"key":"7443_CR3","doi-asserted-by":"publisher","first-page":"3949","DOI":"10.1007\/s00520-019-04848-4","volume":"27","author":"CHL Hong","year":"2019","unstructured":"Hong CHL, Gueiros LA, Fulton JS, Cheng KKF, Kandwal A, Galiti D, Fall-Dickson JM, Johansen J, Ameringer S, Kataoka T, Weikel D, Eilers J, Ranna V, Vaddi A, Lalla RV, Bossi P, Elad S (2019) Systematic review of basic oral care for the management of oral mucositis in cancer patients and clinical practice guidelines. Support Care Cancer 27:3949\u20133967","journal-title":"Support Care Cancer"},{"key":"7443_CR4","unstructured":"Palifermin (marketed as Kepivance). In: Editor (ed)^(eds) Book Palifermin (marketed as Kepivance), City"},{"key":"7443_CR5","doi-asserted-by":"publisher","first-page":"4423","DOI":"10.1002\/cncr.33100","volume":"126","author":"S Elad","year":"2020","unstructured":"Elad S, Cheng KKF, Lalla RV, Yarom N, Hong C, Logan RM, Bowen J, Gibson R, Saunders DP, Zadik Y, Ariyawardana A, Correa ME, Ranna V, Bossi P (2020) MASCC\/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer 126:4423\u20134431","journal-title":"Cancer"},{"key":"7443_CR6","doi-asserted-by":"publisher","first-page":"3985","DOI":"10.1007\/s00520-019-04888-w","volume":"27","author":"A Ariyawardana","year":"2019","unstructured":"Ariyawardana A, Cheng KKF, Kandwal A, Tilly V, Al-Azri AR, Galiti D, Chiang K, Vaddi A, Ranna V, Nicolatou-Galitis O, Lalla RV, Bossi P, Elad S (2019) Systematic review of anti-inflammatory agents for the management of oral mucositis in cancer patients and clinical practice guidelines. Support Care Cancer 27:3985\u20133995","journal-title":"Support Care Cancer"},{"key":"7443_CR7","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1007\/s00520-019-05181-6","volume":"28","author":"DP Saunders","year":"2020","unstructured":"Saunders DP, Rouleau T, Cheng K, Yarom N, Kandwal A, Joy J, BektasKayhan K, van de Wetering M, Brito-Dellan N, Kataoka T, Chiang K, Ranna V, Vaddi A, Epstein J, Lalla RV, Bossi P, Elad S (2020) Systematic review of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the management of oral mucositis in cancer patients and clinical practice guidelines. Support Care Cancer 28:2473\u20132484","journal-title":"Support Care Cancer"},{"key":"7443_CR8","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0304-3959(03)00227-6","volume":"105","author":"LC Cerchietti","year":"2003","unstructured":"Cerchietti LC, Navigante AH, K\u00f6rte MW, Cohen AM, Quiroga PN, Villaamil EC, Bonomi MR, Roth BM (2003) Potential utility of the peripheral analgesic properties of morphine in stomatitis-related pain: a pilot study. Pain 105:265\u2013273","journal-title":"Pain"},{"key":"7443_CR9","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1007\/s00520-017-3904-4","volume":"26","author":"I Chitapanarux","year":"2018","unstructured":"Chitapanarux I, Tungkasamit T, Petsuksiri J, Kannarunimit D, Katanyoo K, Chakkabat C, Setakornnukul J, Wongsrita S, Jirawatwarakul N, Lertbusayanukul C, Sripan P, Traisathit P (2018) Randomized control trial of benzydamine HCl versus sodium bicarbonate for prophylaxis of concurrent chemoradiation-induced oral mucositis. Support Care Cancer 26:879\u2013886","journal-title":"Support Care Cancer"},{"key":"7443_CR10","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1016\/S0149-2918(01)80123-5","volume":"23","author":"D Pass\u00e0li","year":"2001","unstructured":"Pass\u00e0li D, Volont\u00e9 M, Pass\u00e0li GC, Damiani V, Bellussi L (2001) Efficacy and safety of ketoprofen lysine salt mouthwash versus benzydamine hydrochloride mouthwash in acute pharyngeal inflammation: a randomized, single-blind study. Clin Ther 23:1508\u20131518","journal-title":"Clin Ther"},{"key":"7443_CR11","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/j.1600-0536.2010.01707.x","volume":"63","author":"MM Canelas","year":"2010","unstructured":"Canelas MM, Cardoso JC, Gon\u00e7alo M, Figueiredo A (2010) Photoallergic contact dermatitis from benzydamine presenting mainly as lip dermatitis. Contact Dermatitis 63:85\u201388","journal-title":"Contact Dermatitis"},{"key":"7443_CR12","doi-asserted-by":"publisher","first-page":"44","DOI":"10.4103\/2277-9175.151254","volume":"4","author":"M Sarvizadeh","year":"2015","unstructured":"Sarvizadeh M, Hemati S, Meidani M, Ashouri M, Roayaei M, Shahsanai A (2015) Morphine mouthwash for the management of oral mucositis in patients with head and neck cancer. Adv Biomed Res 4:44","journal-title":"Adv Biomed Res"},{"key":"7443_CR13","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1002\/1097-0142(20010815)92:4<875::AID-CNCR1396>3.0.CO;2-1","volume":"92","author":"JB Epstein","year":"2001","unstructured":"Epstein JB, Silverman S Jr, Paggiarino DA, Crockett S, Schubert MM, Senzer NN, Lockhart PB, Gallagher MJ, Peterson DE, Leveque FG (2001) Benzydamine HCl for prophylaxis of radiation-induced oral mucositis: results from a multicenter, randomized, double-blind, placebo-controlled clinical trial. Cancer 92:875\u2013885","journal-title":"Cancer"},{"key":"7443_CR14","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/0030-4220(86)90035-6","volume":"62","author":"JB Epstein","year":"1986","unstructured":"Epstein JB, Stevenson-Moore P (1986) Benzydamine hydrochloride in prevention and management of pain in oral mucositis associated with radiation therapy. Oral Surg Oral Med Oral Pathol 62:145\u2013148","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"7443_CR15","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1016\/0360-3016(89)90964-4","volume":"16","author":"JB Epstein","year":"1989","unstructured":"Epstein JB, Stevenson-Moore P, Jackson S, Mohamed JH, Spinelli JJ (1989) Prevention of oral mucositis in radiation therapy: a controlled study with benzydamine hydrochloride rinse. Int J Radiat Oncol Biol Phys 16:1571\u20131575","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"7443_CR16","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1111\/j.1365-2354.2008.00943.x","volume":"18","author":"A Kazemian","year":"2009","unstructured":"Kazemian A, Kamian S, Aghili M, Hashemi FA, Haddad P (2009) Benzydamine for prophylaxis of radiation-induced oral mucositis in head and neck cancers: a double-blind placebo-controlled randomized clinical trial. Eur J Cancer Care (Engl) 18:174\u2013178","journal-title":"Eur J Cancer Care (Engl)"},{"key":"7443_CR17","first-page":"115","volume":"9","author":"A Prada","year":"1987","unstructured":"Prada A, Chiesa F (1987) Effects of benzydamine on the oral mucositis during antineoplastic radiotherapy and\/or intra-arterial chemotherapy. Int J Tissue React 9:115\u2013119","journal-title":"Int J Tissue React"},{"key":"7443_CR18","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/ajco.12288","volume":"11","author":"KM Sheibani","year":"2015","unstructured":"Sheibani KM, Mafi AR, Moghaddam S, Taslimi F, Amiran A, Ameri A (2015) Efficacy of benzydamine oral rinse in prevention and management of radiation-induced oral mucositis: a double-blind placebo-controlled randomized clinical trial. Asia Pac J Clin Oncol 11:22\u201327","journal-title":"Asia Pac J Clin Oncol"},{"key":"7443_CR19","doi-asserted-by":"crossref","unstructured":"Yan CH, Hubbard CC, Lee TA, Sharp LK, Evans CT, Calip GS, Rowan SA, McGregor JC, Gellad WF, Suda KJ (2022) Impact of hydrocodone rescheduling on dental prescribing of opioids. JDR Clin Trans Res: 0:1\u201311","DOI":"10.1177\/23800844221102830"},{"key":"7443_CR20","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.bjoms.2012.10.004","volume":"51","author":"M Lawrence","year":"2013","unstructured":"Lawrence M, Aleid W, McKechnie A (2013) Access to dental services for head and neck cancer patients. Br J Oral Maxillofac Surg 51:404\u2013407","journal-title":"Br J Oral Maxillofac Surg"},{"key":"7443_CR21","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.drugalcdep.2017.05.023","volume":"178","author":"R Brown","year":"2017","unstructured":"Brown R, Riley MR, Ulrich L, Kraly EP, Jenkins P, Krupa NL, Gadomski A (2017) Impact of New York prescription drug monitoring program, I-STOP, on statewide overdose morbidity. Drug Alcohol Depend 178:348\u2013354","journal-title":"Drug Alcohol Depend"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-022-07443-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-022-07443-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-022-07443-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T13:30:29Z","timestamp":1669901429000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-022-07443-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,10]]},"references-count":21,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["7443"],"URL":"https:\/\/doi.org\/10.1007\/s00520-022-07443-2","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"type":"print","value":"0941-4355"},{"type":"electronic","value":"1433-7339"}],"subject":[],"published":{"date-parts":[[2022,11,10]]},"assertion":[{"value":"23 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Institute Review Board of the Faculty of Medicine, at the Hebrew University, Jerusalem, Israel (#25052021).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Participants were informed that consent was implied by accessing the survey, which was voluntary and anonymous and allowed participants to withdraw from the survey at any time.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All the participants were informed that their de-identified data may be published for scientific purposes.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}