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The aim of this pilot study was to estimate the feasibility of\u00a0therapeutic education and physical activity (TEPA)\u00a0by measuring the patients\u2019 adherence to this multidimensional intervention.\u00a0The secondary aim was to\u00a0estimate\u00a0the impact of TEPA on clinical outcomes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Patients with hematologic cancer participated in this\u00a0single-center, open-label,\u00a0randomized controlled trial. The control group (CG) received two educational group sessions on fatigue and physical activity. The experimental group (EG) received the two educational sessions plus six weekly individual sessions aimed at implementing a personalized physical exercise\u00a0program.\u00a0Follow-ups were at 1, 3,\u00a0and 7\u00a0months.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Forty-six\u00a0patients referred to chemotherapy were included, corresponding to 54% of recruitment rate. Adherence\u00a0reached 90% in the EG and 68% in the CG. Most patients (65% in EG and 64% in CG) attended a minimum of 80% of the planned sessions. Overall retention rate was 87% (85% in EG and 91% in CG). No adverse events were registered. No between-group\u00a0differences were detected in fatigue (FACIT-F), psychological distress (NCCN Distress Thermometer), QoL (EORTC QLQ-C30), or functional exercise\u00a0capacity (TUG test and 6MWT). Adherence to an active lifestyle, measured by a semi-structured interview, increased from 56.5 to 84% in\u00a0the EG at 7\u00a0months (<jats:italic>p<\/jats:italic>\u2009=\u20090.02), whereas it decreased slightly in the CG (from 47.8 to 42.9%).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Multidimensional rehabilitation interventions are feasible and safe in this population, and larger trials should focus on the efficacy of such approaches on clinically relevant outcomes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>ClinicalTrials.gov Identifier: NCT03403075.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00520-022-07530-4","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T09:03:37Z","timestamp":1671440617000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Therapeutic education and physical activity are feasible and safe in hematologic cancer patients referred to chemotherapy: results of a randomized controlled trial"],"prefix":"10.1007","volume":"31","author":[{"given":"Monia Allisen","family":"Accogli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Denti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4645-0336","authenticated-orcid":false,"given":"Stefania","family":"Costi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Fugazzaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,12,19]]},"reference":[{"key":"7530_CR1","unstructured":"Associazione Italiana Oncologia Medica (2020) I numeri del Cancro in Italia 2020 https:\/\/www.aiom.it\/wp-content\/uploads\/2020\/10\/2020_Numeri_Cancro-operatori_web.pdf. 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They have no conflict of interest. The GRADE Onlus Foundation had no role in the definition of the study design, in the collection, analysis, or interpretation of the data, in the writing of the report, or in the decision to submit the article for publication.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"61"}}