{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:23:36Z","timestamp":1772119416189,"version":"3.50.1"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003945","name":"Link\u00f6ping University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003945","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Few studies have focused on the late adverse events after oncologic treatment in pelvic cancer patients. Here, the treatment effect\/interventions were studied on late side effects as GI, sexual, and urinary symptoms in pelvic cancer patients who visited a highly specialized rehabilitation clinic in Link\u00f6ping.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective longitudinal cohort study included 90 patients who had at least one visit at the rehabilitation clinic for late adverse events at Link\u00f6ping University hospital between 2013 to 2019. The toxicity of the adverse events was analyzed by using the common terminology criteria for adverse events (CTCAE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      By comparing the toxicity of symptoms between visits 1 and 2, we showed that the GI symptoms decreased with 36.6% (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.013), the sexual symptoms with 18.3% (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001), and urinary symptoms with 15.5% (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004). Patients who received bile salt sequestrant had a significant improvement in grade of GI symptoms as diarrhea\/fecal incontinence at visit 2 compared to visit 1 where 91.3% were shown to have a treatment effect (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0034). The sexual symptoms (vaginal dryness\/pain) significantly improved due to local estrogens between visits 1 and 2 where 58.1% had a reduction of symptoms (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0026).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The late side effects as GI, sexual, and urinary symptoms was significantly reduced between visits 1 and 2 at the specialized rehabilitation center in Link\u00f6ping. Bile salt sequestrants and local estrogens are effective treatments for side effects as diarrhea and vaginal dryness\/pain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00520-023-07733-3","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T18:02:16Z","timestamp":1681408936000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Late adverse events in patients with pelvic cancer after oncologic treatment\u2014intervention and treatment effect"],"prefix":"10.1007","volume":"31","author":[{"given":"Sofia","family":"Iselius","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annica","family":"Knutsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasmus","family":"Mikiver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srinivas","family":"Uppugunduri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,4,13]]},"reference":[{"key":"7733_CR1","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.ejon.2009.02.007","volume":"13","author":"J Abayomi","year":"2009","unstructured":"Abayomi J, Kirwan J, Hackett A (2009) The prevalence of chronic radiation enteritis following radiotherapy for cervical or endometrial cancer and its impact on quality of life. 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The study protocol was approved by the regional ethical committee in Stockholm, Sweden (Reference number: 2021\u201305034).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All patients have signed a formal consent to participate in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"263"}}