{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T22:23:59Z","timestamp":1755037439938},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1007\/s00520-023-07816-1","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T07:02:35Z","timestamp":1684738955000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genetic variability of oxidative stress and DNA repair genes associated with pre-treatment cancer-related fatigue in women with breast cancer"],"prefix":"10.1007","volume":"31","author":[{"given":"Tara","family":"Davis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa","family":"Koleck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Conway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Bender","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvette","family":"Conley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,5,22]]},"reference":[{"key":"7816_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21708","volume":"72","author":"RL Siegel","year":"2022","unstructured":"Siegel RL, Miller KD, Fuchs HE, Jemal A (2022) Cancer statistics, 2022. CA Cancer J Clin 72:7\u201333. https:\/\/doi.org\/10.3322\/caac.21708","journal-title":"CA Cancer J Clin"},{"key":"7816_CR2","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.jpainsymman.2008.04.018","volume":"37","author":"J-E Esther Kim","year":"2009","unstructured":"Esther Kim J-E, Dodd MJ, Aouizerat BE et al (2009) A review of the prevalence and impact of multiple symptoms in oncology patients. J Pain Symptom Manage 37:715\u2013736. https:\/\/doi.org\/10.1016\/j.jpainsymman.2008.04.018","journal-title":"J Pain Symptom Manage"},{"key":"7816_CR3","doi-asserted-by":"publisher","first-page":"e13051","DOI":"10.1111\/ecc.13051","volume":"28","author":"ME Schmidt","year":"2019","unstructured":"Schmidt ME, Scherer S, Wiskemann J, Steindorf K (2019) Return to work after breast cancer: The role of treatment-related side effects and potential impact on quality of life. Eur J Cancer Care (Engl) 28:e13051. https:\/\/doi.org\/10.1111\/ecc.13051","journal-title":"Eur J Cancer Care (Engl)"},{"key":"7816_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cpr.2018.05.004","volume":"63","author":"HJG Abrahams","year":"2018","unstructured":"Abrahams HJG, Gielissen MFM, Verhagen CAHHVM, Knoop H (2018) The relationship of fatigue in breast cancer survivors with quality of life and factors to address in psychological interventions: A systematic review. Clin Psychol Rev 63:1\u201311. https:\/\/doi.org\/10.1016\/j.cpr.2018.05.004","journal-title":"Clin Psychol Rev"},{"key":"7816_CR5","doi-asserted-by":"publisher","first-page":"904","DOI":"10.6004\/jnccn.2010.0067","volume":"8","author":"AM Berger","year":"2010","unstructured":"Berger AM, Abernethy AP, Atkinson A et al (2010) Cancer-related fatigue. J Natl Compr Canc Netw 8:904\u2013931. https:\/\/doi.org\/10.6004\/jnccn.2010.0067","journal-title":"J Natl Compr Canc Netw"},{"key":"7816_CR6","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1002\/pon.3907","volume":"25","author":"MM Goedendorp","year":"2016","unstructured":"Goedendorp MM, Jacobsen PB, Andrykowski MA (2016) Fatigue screening in breast cancer patients: identifying likely cases of cancer-related fatigue. Psychooncology 25:275\u2013281. https:\/\/doi.org\/10.1002\/pon.3907","journal-title":"Psychooncology"},{"issue":"Suppl 1","key":"7816_CR7","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1634\/theoncologist.12-S1-4","volume":"12","author":"M Hofman","year":"2007","unstructured":"Hofman M, Ryan JL, Figueroa-Moseley CD et al (2007) Cancer-related fatigue: the scale of the problem. Oncologist 12(Suppl 1):4\u201310. https:\/\/doi.org\/10.1634\/theoncologist.12-S1-4","journal-title":"Oncologist"},{"key":"7816_CR8","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/s0885-3924(99)00082-2","volume":"18","author":"PB Jacobsen","year":"1999","unstructured":"Jacobsen PB, Hann DM, Azzarello LM et al (1999) Fatigue in women receiving adjuvant chemotherapy for breast cancer: characteristics, course, and correlates. J Pain Symptom Manage 18:233\u2013242. https:\/\/doi.org\/10.1016\/s0885-3924(99)00082-2","journal-title":"J Pain Symptom Manage"},{"key":"7816_CR9","doi-asserted-by":"publisher","first-page":"4560","DOI":"10.1111\/jocn.15047","volume":"28","author":"H Li","year":"2019","unstructured":"Li H, Sereika SM, Marsland AL et al (2019) Impact of chemotherapy on symptoms and symptom clusters in postmenopausal women with breast cancer prior to aromatase inhibitor therapy. J Clin Nurs 28:4560\u20134571. https:\/\/doi.org\/10.1111\/jocn.15047","journal-title":"J Clin Nurs"},{"key":"7816_CR10","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1002\/cncr.31827","volume":"125","author":"JE Bower","year":"2019","unstructured":"Bower JE, Asher A, Garet D et al (2019) Testing a biobehavioral model of fatigue before adjuvant therapy in women with breast cancer. Cancer 125:633\u2013641. https:\/\/doi.org\/10.1002\/cncr.31827","journal-title":"Cancer"},{"key":"7816_CR11","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.1007\/s00520-014-2204-5","volume":"22","author":"S Ancoli-Israel","year":"2014","unstructured":"Ancoli-Israel S, Liu L, Rissling M et al (2014) Sleep, fatigue, depression, and circadian activity rhythms in women with breast cancer before and after treatment: a 1-year longitudinal study. Support Care Cancer 22:2535\u20132545. https:\/\/doi.org\/10.1007\/s00520-014-2204-5","journal-title":"Support Care Cancer"},{"key":"7816_CR12","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s12885-021-09072-0","volume":"22","author":"A Hajj","year":"2022","unstructured":"Hajj A, Chamoun R, Salameh P et al (2022) Fatigue in breast cancer patients on chemotherapy: a cross-sectional study exploring clinical, biological, and genetic factors. BMC Cancer 22:16. https:\/\/doi.org\/10.1186\/s12885-021-09072-0","journal-title":"BMC Cancer"},{"key":"7816_CR13","first-page":"106","volume":"12","author":"FM Tabrizi","year":"2017","unstructured":"Tabrizi FM, Alizadeh S (2017) Cancer related fatigue in breast cancer survivors: in correlation to demographic factors. Maedica (Buchar) 12:106\u2013111","journal-title":"Maedica (Buchar)"},{"key":"7816_CR14","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s00520-012-1515-7","volume":"21","author":"AL Cheville","year":"2013","unstructured":"Cheville AL, Shen T, Chang M, Basford JR (2013) Appropriateness of the treatment of fatigued patients with stage IV cancer. Support Care Cancer 21:229\u2013233. https:\/\/doi.org\/10.1007\/s00520-012-1515-7","journal-title":"Support Care Cancer"},{"key":"7816_CR15","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1186\/s12905-020-01106-2","volume":"20","author":"HL S\u00f8rensen","year":"2020","unstructured":"S\u00f8rensen HL, Schj\u00f8lberg TK, Sm\u00e5stuen MC, Utne I (2020) Social support in early-stage breast cancer patients with fatigue. BMC Womens Health 20:243. https:\/\/doi.org\/10.1186\/s12905-020-01106-2","journal-title":"BMC Womens Health"},{"issue":"Suppl","key":"7816_CR16","doi-asserted-by":"publisher","first-page":"S48","DOI":"10.1016\/j.bbi.2012.06.011","volume":"30","author":"JE Bower","year":"2013","unstructured":"Bower JE, Lamkin DM (2013) Inflammation and cancer-related fatigue: mechanisms, contributing factors, and treatment implications. Brain Behav Immun 30(Suppl):S48-57. https:\/\/doi.org\/10.1016\/j.bbi.2012.06.011","journal-title":"Brain Behav Immun"},{"key":"7816_CR17","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1007\/s00520-015-2763-0","volume":"23","author":"LN Saligan","year":"2015","unstructured":"Saligan LN, Olson K, Filler K et al (2015) The biology of cancer-related fatigue: a review of the literature. Support Care Cancer 23:2461\u20132478. https:\/\/doi.org\/10.1007\/s00520-015-2763-0","journal-title":"Support Care Cancer"},{"key":"7816_CR18","doi-asserted-by":"publisher","first-page":"E122","DOI":"10.5888\/pcd14.170128","volume":"14","author":"M Swen","year":"2017","unstructured":"Swen M, Mann A, Paxton RJ, Dean LT (2017) Do Cancer-Related Fatigue and Physical Activity Vary by Age for Black Women With a History of Breast Cancer? Prev Chronic Dis 14:E122. https:\/\/doi.org\/10.5888\/pcd14.170128","journal-title":"Prev Chronic Dis"},{"key":"7816_CR19","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1080\/08870440802110831","volume":"24","author":"R Banthia","year":"2009","unstructured":"Banthia R, Malcarne VL, Ko CM et al (2009) Fatigued breast cancer survivors: the role of sleep quality, depressed mood, stage and age. Psychol Health 24:965\u2013980. https:\/\/doi.org\/10.1080\/08870440802110831","journal-title":"Psychol Health"},{"key":"7816_CR20","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1002\/cncr.31790","volume":"125","author":"JE Bower","year":"2019","unstructured":"Bower JE (2019) The role of neuro-immune interactions in cancer-related fatigue: Biobehavioral risk factors and mechanisms. Cancer 125:353\u2013364. https:\/\/doi.org\/10.1002\/cncr.31790","journal-title":"Cancer"},{"key":"7816_CR21","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/B978-0-12-803269-5.00002-4","volume-title":"Oxidative stress, inflammation, and disease Oxidative stress and biomaterials","author":"S Chatterjee","year":"2016","unstructured":"Chatterjee S (2016) Oxidative stress, inflammation, and disease Oxidative stress and biomaterials. Elsevier, pp 35\u201358"},{"key":"7816_CR22","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.ccell.2020.06.001","volume":"38","author":"JD Hayes","year":"2020","unstructured":"Hayes JD, Dinkova-Kostova AT, Tew KD (2020) Oxidative stress in cancer. Cancer Cell 38:167\u2013197. https:\/\/doi.org\/10.1016\/j.ccell.2020.06.001","journal-title":"Cancer Cell"},{"key":"7816_CR23","doi-asserted-by":"publisher","first-page":"2846819","DOI":"10.1155\/2018\/2846819","volume":"2018","author":"MFCJ Paz","year":"2018","unstructured":"Paz MFCJ, Sobral ALP, Picada JN et al (2018) Persistent Increased Frequency of Genomic Instability in Women Diagnosed with Breast Cancer: Before, during, and after Treatments. Oxid Med Cell Longev 2018:2846819. https:\/\/doi.org\/10.1155\/2018\/2846819","journal-title":"Oxid Med Cell Longev"},{"key":"7816_CR24","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1186\/s40064-016-2061-4","volume":"5","author":"TA Koleck","year":"2016","unstructured":"Koleck TA, Bender CM, Sereika SM et al (2016) Polymorphisms in DNA repair and oxidative stress genes associated with pre-treatment cognitive function in breast cancer survivors: an exploratory study. Springerplus 5:422. https:\/\/doi.org\/10.1186\/s40064-016-2061-4","journal-title":"Springerplus"},{"key":"7816_CR25","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1188\/18.ONF.308-326","volume":"45","author":"CM Bender","year":"2018","unstructured":"Bender CM, Merriman JD, Sereika SM et al (2018) Trajectories of cognitive function and associated phenotypic and genotypic factors in breast cancer. Oncol Nurs Forum 45:308\u2013326. https:\/\/doi.org\/10.1188\/18.ONF.308-326","journal-title":"Oncol Nurs Forum"},{"key":"7816_CR26","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1016\/j.freeradbiomed.2010.09.006","volume":"49","author":"S Reuter","year":"2010","unstructured":"Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB (2010) Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Biol Med 49:1603\u20131616. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2010.09.006","journal-title":"Free Radic Biol Med"},{"key":"7816_CR27","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1002\/cncr.29393","volume":"121","author":"CM Bender","year":"2015","unstructured":"Bender CM, Merriman JD, Gentry AL et al (2015) Patterns of change in cognitive function with anastrozole therapy. Cancer 121:2627\u20132636. https:\/\/doi.org\/10.1002\/cncr.29393","journal-title":"Cancer"},{"key":"7816_CR28","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1097\/00006199-200007000-00001","volume":"49","author":"PM Meek","year":"2000","unstructured":"Meek PM, Nail LM, Barsevick A et al (2000) Psychometric testing of fatigue instruments for use with cancer patients. Nurs Res 49:181\u2013190. https:\/\/doi.org\/10.1097\/00006199-200007000-00001","journal-title":"Nurs Res"},{"key":"7816_CR29","volume-title":"EdITS Manual for the Profile of Mood States","author":"D McNair","year":"1992","unstructured":"McNair D, Lorr M, Droppleman LF (1992) EdITS Manual for the Profile of Mood States. EdITS\/Educational and Industrial Testing Service, San Diego, CA"},{"key":"7816_CR30","first-page":"391","volume-title":"Advances in painresearch and therapy","author":"CS Cleeland","year":"1989","unstructured":"Cleeland CS (1989) Measurement of pain by subjective report. In: Chapman CR, Loeser JD (eds) Advances in painresearch and therapy. Raven Press, New York, pp 391\u2013403"},{"key":"7816_CR31","volume-title":"Beck Depression Inventory-II","author":"AT Beck","year":"1996","unstructured":"Beck AT (1996) Beck Depression Inventory-II. The Psychological Corporation, San Antonio"},{"key":"7816_CR32","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1126\/science.aab3389","volume":"350","author":"EH Blackburn","year":"2015","unstructured":"Blackburn EH, Epel ES, Lin J (2015) Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection. Science 350:1193\u20131198. https:\/\/doi.org\/10.1126\/science.aab3389","journal-title":"Science"},{"key":"7816_CR33","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/35094000","volume":"1","author":"EC Friedberg","year":"2001","unstructured":"Friedberg EC (2001) How nucleotide excision repair protects against cancer. Nat Rev Cancer 1:22\u201333. https:\/\/doi.org\/10.1038\/35094000","journal-title":"Nat Rev Cancer"},{"key":"7816_CR34","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/s1097-2765(00)80177-x","volume":"3","author":"F Tirode","year":"1999","unstructured":"Tirode F, Busso D, Coin F, Egly JM (1999) Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7. Mol Cell 3:87\u201395. https:\/\/doi.org\/10.1016\/s1097-2765(00)80177-x","journal-title":"Mol Cell"},{"key":"7816_CR35","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/j.jid.2020.11.012","volume":"141","author":"ERH Rizza","year":"2021","unstructured":"Rizza ERH, DiGiovanna JJ, Khan SG et al (2021) Xeroderma pigmentosum: A model for human premature aging. J Invest Dermatol 141:976\u2013984. https:\/\/doi.org\/10.1016\/j.jid.2020.11.012","journal-title":"J Invest Dermatol"},{"key":"7816_CR36","doi-asserted-by":"publisher","first-page":"e144","DOI":"10.3324\/haematol.2019.223370","volume":"105","author":"KA Oetjen","year":"2020","unstructured":"Oetjen KA, Levoska MA, Tamura D et al (2020) Predisposition to hematologic malignancies in patients with xeroderma pigmentosum. Haematologica 105:e144\u2013e146. https:\/\/doi.org\/10.3324\/haematol.2019.223370","journal-title":"Haematologica"},{"key":"7816_CR37","doi-asserted-by":"publisher","first-page":"13487","DOI":"10.1073\/pnas.1414135111","volume":"111","author":"JE Cleaver","year":"2014","unstructured":"Cleaver JE, Brennan-Minnella AM, Swanson RA et al (2014) Mitochondrial reactive oxygen species are scavenged by Cockayne syndrome B protein in human fibroblasts without nuclear DNA damage. Proc Natl Acad Sci USA 111:13487\u201313492. https:\/\/doi.org\/10.1073\/pnas.1414135111","journal-title":"Proc Natl Acad Sci USA"},{"key":"7816_CR38","doi-asserted-by":"publisher","first-page":"40414","DOI":"10.1074\/jbc.M112.421404","volume":"287","author":"KE Hill","year":"2012","unstructured":"Hill KE, Wu S, Motley AK et al (2012) Production of selenoprotein P (Sepp1) by hepatocytes is central to selenium homeostasis. J Biol Chem 287:40414\u201340424. https:\/\/doi.org\/10.1074\/jbc.M112.421404","journal-title":"J Biol Chem"},{"key":"7816_CR39","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1002\/pon.5028","volume":"28","author":"JM Gullett","year":"2019","unstructured":"Gullett JM, Cohen RA, Yang GS et al (2019) Relationship of fatigue with cognitive performance in women with early-stage breast cancer over 2 years. Psychooncology 28:997\u20131003. https:\/\/doi.org\/10.1002\/pon.5028","journal-title":"Psychooncology"},{"key":"7816_CR40","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.breast.2017.04.003","volume":"33","author":"LK Juvet","year":"2017","unstructured":"Juvet LK, Thune I, Elvsaas IK\u00d8 et al (2017) The effect of exercise on fatigue and physical functioning in breast cancer patients during and after treatment and at 6 months follow-up: A meta-analysis. Breast 33:166\u2013177. https:\/\/doi.org\/10.1016\/j.breast.2017.04.003","journal-title":"Breast"},{"key":"7816_CR41","doi-asserted-by":"publisher","unstructured":"Mishra SI, Scherer RW, Geigle PM, Berlanstein DR, Topaloglu O, Gotay CC, Snyder C (2012) Exercise interventions on health-related quality of life for cancer survivors.\u00a0Cochrane Database Syst Rev\u00a02012(8):CD007566. https:\/\/doi.org\/10.1002\/14651858.CD007566.pub2","DOI":"10.1002\/14651858.CD007566.pub2"},{"key":"7816_CR42","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.cmet.2019.03.013","volume":"30","author":"S Sato","year":"2019","unstructured":"Sato S, Basse AL, Sch\u00f6nke M et al (2019) Time of exercise specifies the impact on muscle metabolic pathways and systemic energy homeostasis. Cell Metab 30:92-110.e4. https:\/\/doi.org\/10.1016\/j.cmet.2019.03.013","journal-title":"Cell Metab"},{"key":"7816_CR43","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1097\/NNR.0000000000000598","volume":"71","author":"AS Kleckner","year":"2022","unstructured":"Kleckner AS, Kleckner IR, Culakova E et al (2022) Exploratory Analysis of Associations Between Whole Blood Mitochondrial Gene Expression and Cancer-Related Fatigue Among Breast Cancer Survivors. Nurs Res 71:411\u2013417. https:\/\/doi.org\/10.1097\/NNR.0000000000000598","journal-title":"Nurs Res"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-023-07816-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-023-07816-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-023-07816-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T09:08:54Z","timestamp":1686388134000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-023-07816-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,22]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["7816"],"URL":"https:\/\/doi.org\/10.1007\/s00520-023-07816-1","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,22]]},"assertion":[{"value":"29 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in this study, involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study was approved by the University of Pittsburgh Institutional Review Board. This study does not involve animal data or biological material.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors affirm that human research participants provided informed consent for publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"345"}}