{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T10:49:41Z","timestamp":1746787781316},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1007\/s00520-023-07943-9","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T11:02:45Z","timestamp":1690542165000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of thyme honey oral gel for the prevention of adriamycin and cyclophosphamide chemotherapy-induced oral mucositis in patients with breast cancer"],"prefix":"10.1007","volume":"31","author":[{"given":"Elnaz","family":"Jahanbani Mazraeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanambar","family":"Sadighi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soheila","family":"Manifar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hooman","family":"Bakhshandeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Rajabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,7,28]]},"reference":[{"key":"7943_CR1","first-page":"2115","volume-title":"Applied therapeutics","author":"AH Seung","year":"2013","unstructured":"Seung AH (2013) Adverse effect of chemotherapy and targeted agents. In: Alldrege BK, Corelli RL, ErNsT ME et al (eds) Applied therapeutics, 10th edn. Wolters Kluwer Health, Philadelphia, pp 2115\u20132118","edition":"10"},{"key":"7943_CR2","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1200\/JCO.2013.53.2630","volume":"32","author":"JL Leenstra","year":"2014","unstructured":"Leenstra JL, Miller RC, Qin R et al (2014) Doxepin rinse versus placebo in the treatment of acute oral mucositis pain in patients receiving head and neck radiotherapy with or without chemotherapy: a phase \u0448, randomized, double-blind trial (NCCTG-N09C6 [Alliance]). J Clin Oncol 32:1571\u20131577","journal-title":"J Clin Oncol"},{"key":"7943_CR3","doi-asserted-by":"publisher","first-page":"4423","DOI":"10.1002\/cncr.33100","volume":"126","author":"E Sharon","year":"2020","unstructured":"Sharon E, Karis Kin Fong Cheng RN, Barasch A, Lalla RV et al (2020) MASCC\/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer 126:4423\u20134431","journal-title":"Cancer"},{"key":"7943_CR4","doi-asserted-by":"publisher","DOI":"10.4172\/2327-5146.1000132","author":"NG Vallianou","year":"2014","unstructured":"Vallianou NG, Gounari P, Skourtis A et al (2014) Honey and its anti-inflammatory, anti-bacterial and anti-oxidant properties. Gen Med. https:\/\/doi.org\/10.4172\/2327-5146.1000132","journal-title":"Gen Med"},{"key":"7943_CR5","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005083.pub4","author":"AB Jull","year":"2015","unstructured":"Jull AB, Rodgers A, Walker N (2015) Honey as a topical treatment for wounds. Cochrane Database Syst Rev. https:\/\/doi.org\/10.1002\/14651858.CD005083.pub4","journal-title":"Cochrane Database Syst Rev"},{"key":"7943_CR6","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.eujim.2013.01.003","volume":"5","author":"M Charalambous","year":"2013","unstructured":"Charalambous M, Raftopoulos V, Lambrinou E et al (2013) The effectiveness of honey for the management of radiotherapy-induced oral mucositis in head and neck cancer patients: a systematic review of clinical trials. Eur J Integr 5:217\u2013225","journal-title":"Eur J Integr"},{"key":"7943_CR7","doi-asserted-by":"publisher","first-page":"190","DOI":"10.4103\/0973-1075.105689","volume":"18","author":"S Jayachandran","year":"2012","unstructured":"Jayachandran S, Balaji N (2012) Evaluating the effectiveness of topical application of natural honey and benzydamine hydrochloride in the management of radiation mucositis. Indian J Palliat Care 18:190\u2013195","journal-title":"Indian J Palliat Care"},{"key":"7943_CR8","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1007\/s00520-013-2031-0","volume":"22","author":"P Hawley","year":"2014","unstructured":"Hawley P, Hovan A, McGahan CE et al (2014) A randomized placebo-controlled trial of manuka honey for radiation-induced oral mucositis. Support Care Cancer 22:751\u2013761","journal-title":"Support Care Cancer"},{"key":"7943_CR9","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1007\/s00405-014-3233-x","volume":"272","author":"F Hashemian","year":"2015","unstructured":"Hashemian F, Baghbanian N, Majd Z et al (2015) The effect of thyme honey nasal spray on chronic rhinosinusitis: a double-blind randomized controlled clinical trial. Eur Arch Otorhinolaryngol 272:1429\u20131439","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"7943_CR10","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1590\/S0100-879X2007000300010","volume":"40","author":"MA Botelho","year":"2007","unstructured":"Botelho MA, Nogueira NA, Bastos GM et al (2007) Antimicrobial activity of the essential oil from Lippia sidoides, carvacrol and thymol against oral pathogens. Braz J Med Biol Res 40:349\u2013356","journal-title":"Braz J Med Biol Res"},{"key":"7943_CR11","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1099\/jmm.0.008052-0","volume":"58","author":"N Guo","year":"2009","unstructured":"Guo N, Liu J, Wu X et al (2009) Antifungal activity of thymol against clinical isolates of fluconazole-sensitive and -resistant Candida albicans. J Med Microbiol 58:1074\u20131079","journal-title":"J Med Microbiol"},{"key":"7943_CR12","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1002\/j.0022-0337.2002.66.8.tb03559.x","volume":"66","author":"HV Worthington","year":"2002","unstructured":"Worthington HV, Clarkson JE (2002) Prevention of oral mucositis and oral candidiasis for patients with cancer treated with chemotherapy: Cochrane systematic review. J Dent Educ 66:903\u2013911","journal-title":"J Dent Educ"},{"key":"7943_CR13","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-015-0947-2","author":"RD De Castro","year":"2015","unstructured":"De Castro RD, de Souza TM, Bezerra LM et al (2015) Antifungal activity and mode of action of thymol and its synergism with nystatin against Candida species involved with infections in the oral cavity: an in vitro study. BMC Complement Altern Med. https:\/\/doi.org\/10.1186\/s12906-015-0947-2","journal-title":"BMC Complement Altern Med"},{"key":"7943_CR14","doi-asserted-by":"publisher","first-page":"391","DOI":"10.15171\/apb.2016.051","volume":"6","author":"A Aslani","year":"2016","unstructured":"Aslani A, Zolfaghari B, Davoodvandi F et al (2016) Design, formulation and evaluation of an oral gel Punica Grantum flower extract for the treatment of recurrent aphthous stomatitis. Adv Pharm Bull 6:391\u2013398","journal-title":"Adv Pharm Bull"},{"key":"7943_CR15","first-page":"109","volume":"3","author":"S Songkro","year":"2009","unstructured":"Songkro S, Rajatasereekul N, Cheewasrirungrueng N (2009) In vitro studies of mucoadhesiveness and release of nicotinamide oral gels prepared from bioadhesive polymers. Int J Pharmacol Pharm Sci 3:109\u2013116","journal-title":"Int J Pharmacol Pharm Sci"},{"key":"7943_CR16","first-page":"10","volume":"34","author":"GI Erowele","year":"2009","unstructured":"Erowele GI, Ndefo UA (2009) Oral mucositis: update on prevention and management. US Pharm 34:10\u201314","journal-title":"US Pharm"},{"key":"7943_CR17","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1038\/sj.bjc.6601231","volume":"89","author":"SP Blagden","year":"2003","unstructured":"Blagden SP, Charman SC, Sharples LD et al (2003) Performance status score: do patients and their oncologists agree? Br J Cancer 89:1022\u20131027","journal-title":"Br J Cancer"},{"key":"7943_CR18","first-page":"10","volume":"34","author":"GI Erowele","year":"2009","unstructured":"Erowele GI, Ndefo UA (2009) Oral mucositis: update on prevention and management strategies. US Pharm 34:10\u201314","journal-title":"US Pharm"},{"key":"7943_CR19","first-page":"59","volume":"74","author":"JA Kushner","year":"2008","unstructured":"Kushner JA, Lawrence HP, Shavol I et al (2008) Development and validation of a Patient-Reported Oral Mucositis Symptom (PROMS) scale. J Can Dent Assoc 74:59\u201359i","journal-title":"J Can Dent Assoc"},{"key":"7943_CR20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091733","author":"AM Gussgard","year":"2014","unstructured":"Gussgard AM, Hope AJ, Jokstad A et al (2014) Assessment of cancer therapy-induced oral mucositis using a patient-reported oral mucositis experience questionnaire. Plos One. https:\/\/doi.org\/10.1371\/journal.pone.0091733","journal-title":"Plos One"},{"key":"7943_CR21","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/sj.bmt.1705250","volume":"37","author":"PJ Stiff","year":"2006","unstructured":"Stiff PJ, Erder H, Bensinger WI et al (2006) Reliability and validity of a patient self-administered daily questionnaire to assess impact of oral mucositis (OM) on pain and daily functioning in patients undergoing autologous hematopoietic stem cell transplantation (HSCT). Bone Marrow Transplant 37:393\u2013401","journal-title":"Bone Marrow Transplant"},{"key":"7943_CR22","doi-asserted-by":"publisher","first-page":"5186","DOI":"10.1200\/JCO.2005.02.8340","volume":"24","author":"PJ Stiff","year":"2006","unstructured":"Stiff PJ, Emmanouilides C, Bensinger WI et al (2006) Palifermin reduces patient-reported mouth and throat soreness and improves patient functioning in the hematopoietic stem-cell transplantation setting. J Clin Oncol 24:5186\u20135193","journal-title":"J Clin Oncol"},{"key":"7943_CR23","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1200\/JCO.2007.13.6028","volume":"26","author":"N Blijlevens","year":"2008","unstructured":"Blijlevens N, Schwenkglenks M, Bacon P et al (2008) Prospective oral mucositis audit: oral mucositis in patients receiving high-dose melphalan or BEAM conditioning chemotherapy\u2014European Blood and Marrow Transplantation Mucositis Advisory Group. J Clin Oncol 26:1519\u20131525","journal-title":"J Clin Oncol"},{"key":"7943_CR24","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1038\/sj.bmt.1702863","volume":"2","author":"P Stiff","year":"2001","unstructured":"Stiff P (2001) Mucositis associated with stem cell transplantation: current status and innovative approaches to management. Bone Marrow Transplant 2:S3\u2013S11","journal-title":"Bone Marrow Transplant"},{"key":"7943_CR25","doi-asserted-by":"publisher","first-page":"3956","DOI":"10.1200\/JCO.2002.05.046","volume":"20","author":"S El-Sayed","year":"2002","unstructured":"El-Sayed S, Nabid A, Shelley W et al (2002) Prophylaxis of radiation-associated mucositis in conventionally treated patients with head and neck cancer: a double-blind, phase \u0448, randomized, controlled trial evaluating the clinical efficacy of an antimicrobial lozenge using a validated mucositis scoring system. J Clin Oncol 20:3956\u20133963","journal-title":"J Clin Oncol"},{"key":"7943_CR26","doi-asserted-by":"publisher","first-page":"290","DOI":"10.3322\/canjclin.51.5.290","volume":"51","author":"WJ K\u04e7stler","year":"2001","unstructured":"K\u04e7stler WJ, Hejna M, Wenzel C et al (2001) Oral mucositis complicating chemotherapy and\/or radiotherapy: options for prevention and treatment. CA Cancer J Clin 51:290\u2013315","journal-title":"CA Cancer J Clin"},{"key":"7943_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00134","author":"B Murtaza","year":"2017","unstructured":"Murtaza B, Hichami A, Khan AS et al (2017) Alteration in taste perception in cancer: causes and strategies of treatment. Front Physiol. https:\/\/doi.org\/10.3389\/fphys.2017.00134","journal-title":"Front Physiol"},{"key":"7943_CR28","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1593\/neo.04169","volume":"6","author":"MU Naidu","year":"2004","unstructured":"Naidu MU, Ramana GV, Rani PU et al (2004) Chemotherapy-induced and\/or radiation therapy-induced oral mucositis\u2014complicating the treatment of cancer. Neoplasia 6:423\u2013431","journal-title":"Neoplasia"},{"key":"7943_CR29","unstructured":"Adriamycin\u00ae data sheet: https:\/\/www.medsafe.govt.nz\/profs\/datasheet\/a\/adriamycininj.pdf. Accessed 15 May 2022"},{"key":"7943_CR30","unstructured":"Cyclophosphamide-FDA: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2013\/012141s090,012142s112lbl.pdf. Accessed 15 May 2022"},{"key":"7943_CR31","unstructured":"Nicholas HG, Holford (2012) Pharmacokinetics and pharmacodynamics: rationale dosing and the time course of drug action in Bertram. In: Katzung\u00a0G (ed) Basic and clinical pharmacology, 12th edn. McGrawHill Professional, New York, pp 42\u201345"},{"key":"7943_CR32","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1007\/s00520-011-1158-0","volume":"20","author":"MC Janelsins","year":"2012","unstructured":"Janelsins MC, Mustian KM, Palesh OG et al (2012) Differential expression of cytokines in breast cancer patients receiving different chemotherapies: implications for cognitive impairment research. Support Care Cancer 20:831\u2013839","journal-title":"Support Care Cancer"},{"key":"7943_CR33","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1093\/annonc\/mdv206","volume":"26","author":"YT Cheung","year":"2015","unstructured":"Cheung YT, Ng T, Shwe M et al (2015) Association of proinflammatory cytokines and chemotherapy-associated cognitive impairment in breast cancer patients: a multi-centered, prospective, cohort study. Ann Oncol 26:1446\u20131451","journal-title":"Ann Oncol"},{"key":"7943_CR34","doi-asserted-by":"publisher","DOI":"10.1186\/1748717X-5-16","author":"A Meirovitz","year":"2010","unstructured":"Meirovitz A, Kuten M, Billan S et al (2010) Cytokines levels, severity of acute mucositis and the need of PEG tube installation during chemo-radiation for head and neck cancer\u2014a prospective pilot study. Radiant Oncol. https:\/\/doi.org\/10.1186\/1748717X-5-16","journal-title":"Radiant Oncol"},{"key":"7943_CR35","doi-asserted-by":"publisher","first-page":"268","DOI":"10.4103\/0973-1075.164892","volume":"21","author":"S Samdariya","year":"2015","unstructured":"Samdariya S, Lewis S, Kauser H et al (2015) A randomized controlled trial evaluating the role of honey in reducing pain due to radiation induced mucositis in head and neck cancer patients. Indian J Palliat Care 21:268\u2013273","journal-title":"Indian J Palliat Care"},{"key":"7943_CR36","first-page":"103","volume":"27","author":"H Mohamed","year":"2015","unstructured":"Mohamed H, Salma MA, Al Lenjawi B et al (2015) The efficacy and safety of natural honey on the healing of foot ulcers: a case series. Wounds 27:103\u2013114","journal-title":"Wounds"},{"key":"7943_CR37","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.bjoms.2011.03.005","volume":"50","author":"J Bardy","year":"2012","unstructured":"Bardy J, Molassiotis A, Ryder WD et al (2012) A double-blind, placebo-controlled, randomized trial of active manuka honey and standard oral care for radiation-induced oral mucositis. Br J Oral Maxillofac Surg 50:221\u2013226","journal-title":"Br J Oral Maxillofac Surg"},{"key":"7943_CR38","doi-asserted-by":"publisher","first-page":"317","DOI":"10.4103\/IJPC.IJPC_146_16","volume":"23","author":"A Amanat","year":"2017","unstructured":"Amanat A, Ahmed A, Kazmi A et al (2017) The effect of honey on radiation-induced oral mucositis in head and neck cancer patients. Indian J Palliat Care 23:317\u2013320","journal-title":"Indian J Palliat Care"},{"key":"7943_CR39","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1002\/hed.24431","volume":"36","author":"JL Co","year":"2016","unstructured":"Co JL, Mejia MB, Que JC et al (2016) Effectiveness of honey on radiation-induced oral mucositis, time to mucositis, weight loss, and treatment interruptions among patients with head and neck malignancies: a meta-analysis and systematic review of literature. Head Neck 36:1119\u20131128","journal-title":"Head Neck"},{"key":"7943_CR40","doi-asserted-by":"publisher","first-page":"163","DOI":"10.12788\/jcso.0041","volume":"12","author":"CJ Paoli","year":"2014","unstructured":"Paoli CJ, Bach BA, Quach D et al (2014) Performance status of real-world oncology patients before and after first course of chemotherapy. J Community Support Oncol 12:163\u2013170","journal-title":"J Community Support Oncol"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-023-07943-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-023-07943-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-023-07943-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T08:16:25Z","timestamp":1691741785000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-023-07943-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,28]]},"references-count":40,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["7943"],"URL":"https:\/\/doi.org\/10.1007\/s00520-023-07943-9","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,28]]},"assertion":[{"value":"17 April 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Approval was obtained from the ethics committee of Medical Researches of Pharmaceutical Sciences Branch of Islamic Azad University, Tehran, Iran.\u2014Reference number 5936, on August 17, 2014. The procedures used in this study adhere to the tenets of the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"The authors would declare that there is no conflict of interest in any context associated with this manuscript. The data presented here are not presented as oral or written in any scientific arena.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}}],"article-number":"497"}}