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We aimed to investigate prevalence of facial pain, its effect on health-related quality of life (HRQL) and trismus-related symptoms in a HNC cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009194) were prospectively followed post completion of radiotherapy (RT). Outcome measures included facial pain, HRQL, trismus-specific symptoms, and maximal interincisal opening (MIO).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Facial pain was reported by 50% at baseline. Corresponding figures for 3-, 12-, and 60\u00a0months post-RT were 70%, 54% and 41%. Moderate to severe pain was reported in 29\u201344% of patients reporting pain during the study period. Patients reporting pain scored significantly worse on more HRQL variables and trismus symptoms, as well as had significantly smaller MIO at all follow-up time points.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Facial pain was common in HNC patients pre- and post-RT and remained prevalent up to 5\u00a0years after completion of RT. Reductions in MIO were associated with more facial pain. Pain was also associated with worse HRQL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00520-023-08162-y","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T02:01:48Z","timestamp":1700013708000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Facial pain, health-related quality of life and trismus-related symptoms up to 5\u00a0years post-radiotherapy for head and neck cancer"],"prefix":"10.1007","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1450-589X","authenticated-orcid":false,"given":"Susan","family":"Aghajanzadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Therese","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Tuomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"My","family":"Engstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Finizia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,15]]},"reference":[{"key":"8162_CR1","unstructured":"Olle Bergman LJ, Micke Jaresand, Sara Nilsson (2018) Cancerfondsrapporten, available at https:\/\/staticfiles.cancerfonden.se\/Cancerfondsrapporten2018_webb_(2)_1521607903.pdf"},{"issue":"3","key":"8162_CR2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL et al (2021) Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. 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