{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:17:52Z","timestamp":1787242672676,"version":"build-2736575974"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T00:00:00Z","timestamp":1701734400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T00:00:00Z","timestamp":1701734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University of Innsbruck and Medical University of Innsbruck"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The standard therapy for lymphedema of any origin is complex physical decongestive therapy (CDT). It comprises manual lymph drainage (MLD), compression therapy (CT), exercise therapy (ET), skincare, and patient education. Additionally, intermittent pneumatic compression (IPC) can be applied. However, the contribution of MLD to decongestion is repeatedly questioned.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>This study re-analyzes a previous study during a 3-week decongestion period, comparing two different types of compression bandaging at the weekend. Sixty-one patients with unilateral breast cancer\u2013related lymphedema were included. The patients received the same therapy (CDT\u2009+\u2009IPC) except for the different weekend compression bandaging. MLD was performed twice a day on weekdays. The volume of the affected arm was measured on days 1, 5, 8, 12, 15, 19, and 22. For the analysis, the data of both study groups were pooled.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the week, the patients showed a significant volume reduction (\u2212\u2009155.23\u00a0mL (week 1),\u2009\u2212\u2009101.02\u00a0mL (week 2),\u2009\u2212\u200961.69\u00a0mL (week 3), respectively;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 each) with a high effect size. On the weekends without MLD, they showed a slight, but also significant increase (12.08\u00a0mL (weekend 1), 8.36\u00a0mL (weekend 2), 4.33\u00a0mL (weekend 3), respectively;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 each) with a medium effect size.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We showed a strong effect of MLD on volume reduction. Differences from other studies are the larger study population and the more intensive application of MLD. If applied intensively, MLD is strongly decongestive during a 3-week decongestion therapy for breast cancer\u2013related lymphedema.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00520-023-08210-7","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T01:01:31Z","timestamp":1701738091000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effectiveness of manual lymphatic drainage in intensive phase I therapy of breast cancer\u2013related lymphedema\u2014a retrospective analysis"],"prefix":"10.1007","volume":"32","author":[{"given":"Renato G.","family":"Kasseroller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6739-1198","authenticated-orcid":false,"given":"Erich","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,5]]},"reference":[{"issue":"1","key":"8210_CR1","first-page":"3","volume":"53","author":"International Society of Lymphology","year":"2020","unstructured":"International Society of Lymphology (2020) The diagnosis and treatment of peripheral lymphedema: 2020 Consensus Document of the International Society of Lymphology. 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