{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T17:23:05Z","timestamp":1763227385003},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Scalp cooling is an increasingly recognized non-pharmacologic approach to minimize chemotherapy-induced alopecia (CIA). Several commercially available machine-based and manual scalp cooling systems are available; however, literature reports of effectiveness are highly variable. The purpose of this study was to determine real-world tolerability and subjective effectiveness of a manual cold capping system in minimizing CIA across a variety of patient race and hair types. This study was a single-institution review of outcomes from manual cold capping.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We identified retrospective cohort of adult patients who presented to discuss cold capping between January 14, 2019, and March 31, 2022. Data collected from medical records included demographics, decision to pursue\/continue cold capping, diagnoses, chemotherapy regimens, hair characteristics (length, thickness, coarseness, type), and subjective perception of percentage of hair retained. Those with successful vs. unsuccessful cold capping (\u2265\u200950% vs.\u2009&lt;\u200950% of hair retained) were compared based on the patient-level factors of interest.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Findings<\/jats:title>\n                <jats:p>A total of 100 patients initiated cold capping during the study period, and 95% of them completed cold capping. The majority of patients who started cold capping completed it. The median-reported percentage of hair maintained was 75%, and 82\/89 (92.1% of patients) had favorable results, defined as\u2009\u2265\u200950% of hair retained. The only patient-level factor associated with favorable response was chemotherapy regimen, with fewer patients receiving doxorubicin-containing regimens having successful hair retention compared to other chemotherapy types (71.4% successful results vs. 95.7% for those receiving paclitaxel-containing regimens and 96.6% for those receiving docetaxel-containing regimens (<jats:italic>p<\/jats:italic>\u2009=\u20090.018). There was no difference in success based on patient race\/ethnicity or hair characteristics.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Interpretation<\/jats:title>\n                <jats:p>The overall effectiveness (92.1%) in this study is consistent to higher than many literature reports. One possible reason for the high success in our cohort is compliance with cold capping protocols, meaning applying the cap in the appropriate manner and wearing the cap for the prescribed durations, which may impact effectiveness.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00520-024-08393-7","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T02:09:39Z","timestamp":1710295779000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Retrospective evaluation of Penguin Cold Caps for chemotherapy-induced alopecia"],"prefix":"10.1007","volume":"32","author":[{"given":"Dale","family":"Weaver","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle L.","family":"Pershing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bethany","family":"Golden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Hammel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline Kefalas","family":"Russ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Cripe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,13]]},"reference":[{"issue":"2","key":"8393_CR1","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s00520-008-0475-4","volume":"17","author":"F Mols","year":"2009","unstructured":"Mols F, van den Hurk CJ, Vingerhoets AJ, Breed WP (2009) Scalp cooling to prevent chemotherapy-induced hair loss: practical and clinical considerations. 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The study was reviewed and approved by the OhioHealth Institutional Review Board (IRB1839459) with a waiver of informed consent. The study was reviewed and approved by the OhioHealth Institutional Review Board (IRB1839459) with a waiver of informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Evidence before this studyWe searched EBSCOhost using the terms \u201ccold capping OR cold cap AND penguin cold cap AND breast cancer\u201d between January 2013 and July 2023. The search ended with 23 results. Many of the articles reviewed a manual cold capping system versus a machine-based cold capping system or using a machine-based cold capping system. The results from the studies did show favorable outcomes with using a cold capping system to reduce chemotherapy-induced alopecia.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research in context"}},{"value":"Our institution reviewed multiple cold capping systems and ended up choosing Penguin Cold Caps. Some of the reasons are portability and flexibility than machine-based cold capping systems. The outcomes in our study were higher than the current literature.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Added value of this study"}},{"value":"We had a partnership with Over My Head boutique, which is one reason for the high success in our cohort. The patients had a higher compliance with cold capping protocols, meaning applying the cap in the appropriate manner and wearing the cap for the prescribed durations, which may impact effectiveness.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Implications of all the available evidence"}}],"article-number":"225"}}