{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T21:46:54Z","timestamp":1791668814121,"version":"4.3.4"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005378","name":"Hacettepe University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005378","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this in vitro study was to evaluate the effect of radiotherapy on the surface microhardness and roughness of different bioactive restorative materials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      A total of 60-disc specimens (5\u00a0mm\u2009\u00d7\u20092\u00a0mm) were performed in four groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915 each) from Equia Forte HT, Cention N, Activa Bioactive Restorative, and Beautifil II. Following the polishing procedure (600, 1000, 1200 grit silicon carbide papers), all specimens were irradiated at 2\u00a0Gy per fraction, five times a week for a total dose of 70\u00a0Gy in 30 fractions over 7\u00a0weeks. Before and after the irradiation, the specimens were analyzed regarding the surface roughness and microhardness. Surface morphology was also analyzed by scanning electron microscopy. Kruskal\u2013Wallis test, Wilcoxon test, and paired sample\n                      <jats:italic>t<\/jats:italic>\n                      -test were used for statistical analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant differences were found after radiation with increased mean roughness of both Cention N (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and Beautifil II (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) groups. In terms of microhardness, only the Beautifil II group showed significant differences with decreased values after radiation. There were statistically significant differences among the groups\u2019 roughness and microhardness data before and after radiotherapy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The effect of radiotherapy might differ according to the type of the restorative material. Although results may differ for other tested materials, giomer tends to exhibit worse behaviour in terms of both surface roughness and microhardness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical relevance<\/jats:title>\n                    <jats:p>In patients undergoing head and neck radiotherapy, it should be taken into consideration that the treatment process may also have negative effects on the surface properties of anti-caries restorative materials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00520-024-08476-5","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T08:01:55Z","timestamp":1713427315000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of radiotherapy on the surface roughness and microhardness of contemporary bioactive restorative materials"],"prefix":"10.1007","volume":"32","author":[{"given":"Cansu","family":"Atalay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Ruya","family":"Yazici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"key":"8476_CR1","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1007\/s00066-006-1508-x","volume":"182","author":"B Al-Nawas","year":"2006","unstructured":"Al-Nawas B, Al-Nawas K, Kunkel M, Grotz KA (2006) Quantifying radioxerostomia: salivary flow rate, examiner\u2019s score, and quality of life questionnaire. Strahlenther Onkol 182:336\u2013341. https:\/\/doi.org\/10.1007\/s00066-006-1508-x","journal-title":"Strahlenther Onkol"},{"key":"8476_CR2","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1054\/bjom.2000.0468","volume":"38","author":"MJ Shaw","year":"2000","unstructured":"Shaw MJ, Kumar ND, Duggal M, Fiske J, Lewis DA, Kinsella T, Nisbet T (2000) Oral management of patients following oncology treatment: literature review. Br J Oral Maxillofac Surg 38:519\u2013524. https:\/\/doi.org\/10.1054\/bjom.2000.0468","journal-title":"Br J Oral Maxillofac Surg"},{"key":"8476_CR3","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1177\/0022034516639276","volume":"28","author":"NP Innes","year":"2016","unstructured":"Innes NP, Frencken JE, Bjorndal L, Maltz M, Manton DJ, Ricketts D, Van Landuyt K, Banerjee A, Campus G, Domejean S, Fontana M, Leal S, Lo E, Machiulskiene V, Schulte A, Splieth C, Zandona A, Schwendicke F (2016) Managing carious lesions: consensus recommendations on terminology. Adv Dent Res 28:49\u201357. https:\/\/doi.org\/10.1177\/0022034516639276","journal-title":"Adv Dent Res"},{"issue":"Suppl 1","key":"8476_CR4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/j.1834-7819.2010.01291.x","volume":"56","author":"JF McCabe","year":"2011","unstructured":"McCabe JF, Yan Z, Al Naimi OT, Mahmoud G, Rolland SL (2011) Smart materials in dentistry. Aust Dent J 56(Suppl 1):3\u201310. https:\/\/doi.org\/10.1111\/j.1834-7819.2010.01291.x","journal-title":"Aust Dent J"},{"key":"8476_CR5","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1080\/000163502753740179","volume":"60","author":"JW van Dijken","year":"2002","unstructured":"van Dijken JW (2002) Three-year performance of a calcium-, fluoride-, and hydroxyl-ions-releasing resin composite. Acta Odontol Scand 60:155\u2013159. https:\/\/doi.org\/10.1080\/000163502753740179","journal-title":"Acta Odontol Scand"},{"key":"8476_CR6","first-page":"73","volume":"4","author":"LC Pereira","year":"2002","unstructured":"Pereira LC, Nunes MC, Dibb RG, Powers JM, Roulet JF, Navarro MF (2002) Mechanical properties and bond strength of glass-ionomer cements. J Adhes Dent 4:73\u201380","journal-title":"J Adhes Dent"},{"key":"8476_CR7","doi-asserted-by":"publisher","first-page":"155","DOI":"10.2341\/16-095-L","volume":"42","author":"F Schwendicke","year":"2017","unstructured":"Schwendicke F, Kniess J, Paris S, Blunck U (2017) Margin integrity and secondary caries of lined or non-lined composite and glass hybrid restorations after selective excavation in vitro. Oper Dent 42:155\u2013164. https:\/\/doi.org\/10.2341\/16-095-L","journal-title":"Oper Dent"},{"key":"8476_CR8","unstructured":"GC. EQUIA Forte: GC (2015) [Available from:. https:\/\/cdn.gceurope.com\/v1\/PID\/equiaforte\/leaflet\/LFL_EQUIA_Forte_en.pdf. Accessed Acces Date"},{"key":"8476_CR9","doi-asserted-by":"publisher","unstructured":"Ilie N (2020) Erratum: Ilie, N. Comparative effect of self- or dual-curing on polymerization kinetics and mechanical properties in a novel, dental-resin-based composite with alkaline filler. running title: resin-composites with alkaline fillers. Materials 2018, 11, 108. Materials (Basel) 13. https:\/\/doi.org\/10.3390\/ma13235547","DOI":"10.3390\/ma13235547"},{"key":"8476_CR10","doi-asserted-by":"publisher","first-page":"296","DOI":"10.4103\/JCD.JCD_74_19","volume":"22","author":"N Gupta","year":"2019","unstructured":"Gupta N, Jaiswal S, Nikhil V, Gupta S, Jha P, Bansal P (2019) Comparison of fluoride ion release and alkalizing potential of a new bulk-fill alkasite. J Conserv Dent 22:296\u2013299. https:\/\/doi.org\/10.4103\/JCD.JCD_74_19","journal-title":"J Conserv Dent"},{"key":"8476_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2020.103474","volume":"102","author":"C Ruengrungsom","year":"2020","unstructured":"Ruengrungsom C, Burrow MF, Parashos P, Palamara JEA (2020) Evaluation of F, Ca, and P release and microhardness of eleven ion-leaching restorative materials and the recharge efficacy using a new Ca\/P containing fluoride varnish. J Dent 102:103474. https:\/\/doi.org\/10.1016\/j.jdent.2020.103474","journal-title":"J Dent"},{"key":"8476_CR12","doi-asserted-by":"publisher","first-page":"4437","DOI":"10.1007\/s00784-022-04407-y","volume":"26","author":"T Theerarath","year":"2022","unstructured":"Theerarath T, Sriarj W (2022) An alkasite restorative material effectively remineralized artificial interproximal enamel caries in vitro. Clin Oral Investig 26:4437\u20134445. https:\/\/doi.org\/10.1007\/s00784-022-04407-y","journal-title":"Clin Oral Investig"},{"key":"8476_CR13","doi-asserted-by":"publisher","first-page":"293","DOI":"10.4012\/dmj.2017-161","volume":"37","author":"S Garoushi","year":"2018","unstructured":"Garoushi S, Vallittu PK, Lassila L (2018) Characterization of fluoride releasing restorative dental materials. Dent Mater J 37:293\u2013300. https:\/\/doi.org\/10.4012\/dmj.2017-161","journal-title":"Dent Mater J"},{"key":"8476_CR14","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.dental.2017.01.011","volume":"33","author":"G Schmalz","year":"2017","unstructured":"Schmalz G, Galler KM (2017) Biocompatibility of biomaterials - lessons learned and considerations for the design of novel materials. Dent Mater 33:382\u2013393. https:\/\/doi.org\/10.1016\/j.dental.2017.01.011","journal-title":"Dent Mater"},{"key":"8476_CR15","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.dental.2017.07.014","volume":"33","author":"CC Madrid Troconis","year":"2017","unstructured":"Madrid Troconis CC, Santos-Silva AR, Brandao TB, Lopes MA, de Goes MF (2017) Impact of head and neck radiotherapy on the mechanical behavior of composite resins and adhesive systems: a systematic review. Dent Mater 33:1229\u20131243. https:\/\/doi.org\/10.1016\/j.dental.2017.07.014","journal-title":"Dent Mater"},{"key":"8476_CR16","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s10856-021-06543-5","volume":"32","author":"DMG de Amorim","year":"2021","unstructured":"de Amorim DMG, Verissimo AH, Ribeiro AKC, de Assuncao ESRO, de Assuncao IV, Caldas M, Borges BCD (2021) Effects of ionizing radiation on surface properties of current restorative dental materials. J Mater Sci Mater Med 32:69. https:\/\/doi.org\/10.1007\/s10856-021-06543-5","journal-title":"J Mater Sci Mater Med"},{"key":"8476_CR17","doi-asserted-by":"publisher","first-page":"408","DOI":"10.4103\/ijdr.IJDR_72_17","volume":"30","author":"RBW El","year":"2019","unstructured":"Lima RBWE, De Vasconcelos LC, Pontual ML, Meireles SS, Andrade AKM, Duarte RM (2019) Effect of ionizing radiation on the properties of restorative materials. Indian J Dent Res 30:408\u2013413. https:\/\/doi.org\/10.4103\/ijdr.IJDR_72_17","journal-title":"Indian J Dent Res"},{"key":"8476_CR18","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2020.vol34.0005","volume":"34","author":"M Ugurlu","year":"2020","unstructured":"Ugurlu M, Ozkan EE, Ozseven A (2020) The effect of ionizing radiation on properties of fluoride-releasing restorative materials. Braz Oral Res 34:e005. https:\/\/doi.org\/10.1590\/1807-3107bor-2020.vol34.0005","journal-title":"Braz Oral Res"},{"key":"8476_CR19","first-page":"44","volume":"24","author":"VRSJP Novais","year":"2015","unstructured":"Novais VRSJP, Rodrigues RB, Roscoe MG, Vald\u00edvia ADCM, Soares CJ (2015) Effect of irradiation on the mechanical behavior of restorative materials. Rev Odontol Bras Cent 24:44\u201348","journal-title":"Rev Odontol Bras Cent"},{"key":"8476_CR20","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1055\/s-0040-1708619","volume":"6","author":"MN Hegde","year":"2016","unstructured":"Hegde MN, Hegde ND, Kumari SN, Sanjeev G (2016) Effect of ionising radiation on micro hardness property of restorative materials. J Health Allied Sci 6:57\u201361","journal-title":"J Health Allied Sci"},{"key":"8476_CR21","doi-asserted-by":"publisher","unstructured":"Turjanski S, Par M, Bergman L, Soce M, Grego T, Klaric Sever E (2023) Influence of ionizing radiation on fluoride-releasing dental restorative materials. Polymers (Basel) 15. https:\/\/doi.org\/10.3390\/polym15030632","DOI":"10.3390\/polym15030632"},{"key":"8476_CR22","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.dental.2017.10.006","volume":"34","author":"SBN Brandeburski","year":"2018","unstructured":"Brandeburski SBN, Della Bona A (2018) Effect of ionizing radiation on properties of restorative materials. Dent Mater 34:221\u2013227. https:\/\/doi.org\/10.1016\/j.dental.2017.10.006","journal-title":"Dent Mater"},{"key":"8476_CR23","first-page":"e168","volume":"59","author":"FL Viero","year":"2011","unstructured":"Viero FL, Boscolo FN, Demarco FF, Faot F (2011) Effect of radiotherapy on the hardness and surface roughness of two composite resins. Gen Dent 59:e168\u2013e172","journal-title":"Gen Dent"},{"key":"8476_CR24","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1002\/(sici)1097-4636(19981205)42:3<465::aid-jbm17>3.0.co;2-f","volume":"42","author":"JL Ferracane","year":"1998","unstructured":"Ferracane JL, Berge HX, Condon JR (1998) In vitro aging of dental composites in water\u2013effect of degree of conversion, filler volume, and filler\/matrix coupling. J Biomed Mater Res 42:465\u2013472. https:\/\/doi.org\/10.1002\/(sici)1097-4636(19981205)42:3<465::aid-jbm17>3.0.co;2-f","journal-title":"J Biomed Mater Res"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-024-08476-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-024-08476-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-024-08476-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T05:14:11Z","timestamp":1715577251000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-024-08476-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,18]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["8476"],"URL":"https:\/\/doi.org\/10.1007\/s00520-024-08476-5","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,18]]},"assertion":[{"value":"22 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"295"}}