{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:29:43Z","timestamp":1791430183895,"version":"4.3.3"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1007\/s00520-024-08835-2","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T06:02:07Z","timestamp":1728453727000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Low-dose methadone added to another opioid for cancer pain: a multicentre prospective study"],"prefix":"10.1007","volume":"32","author":[{"given":"Erwan","family":"Treillet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Perceau-Chambard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Economos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Chevalier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Picard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Frasca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Pouget","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Calvel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Tremellat-Faliere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Majerus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Antoine","family":"Quesnel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Chiquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Evin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Anne","family":"Seveque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Lebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Hardouin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Burnod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Renard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Bessodes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Giet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Serresse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"8835_CR1","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.jpainsymman.2015.12.340","volume":"51","author":"MHJ van den Beuken-van Everdingen","year":"2016","unstructured":"van den Beuken-van Everdingen MHJ, Hochstenbach LMJ, Joosten EAJ et al (2016) Update on prevalence of pain in patients with cancer: systematic review and meta-analysis. J Pain Symptom Manage 51:1070-1090.e9. https:\/\/doi.org\/10.1016\/j.jpainsymman.2015.12.340","journal-title":"J Pain Symptom Manage"},{"key":"8835_CR2","doi-asserted-by":"publisher","first-page":"S38","DOI":"10.1016\/S0885-3924(02)00411-6","volume":"24","author":"N Katz","year":"2002","unstructured":"Katz N (2002) The impact of pain management on quality of life. J Pain Symptom Manage 24:S38\u2013S47. https:\/\/doi.org\/10.1016\/S0885-3924(02)00411-6","journal-title":"J Pain Symptom Manage"},{"key":"8835_CR3","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3238\/arztebl.2018.0135","volume":"115","author":"M Schuster","year":"2018","unstructured":"Schuster M, Bayer O, Heid F, Laufenberg-Feldmann R (2018) Opioid rotation in cancer pain treatment. Dtsch Arzteblatt Int 115:135\u2013142. https:\/\/doi.org\/10.3238\/arztebl.2018.0135","journal-title":"Dtsch Arzteblatt Int"},{"key":"8835_CR4","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.2147\/JPR.S170269","volume":"11","author":"E Treillet","year":"2018","unstructured":"Treillet E, Laurent S, Hadjiat Y (2018) Practical management of opioid rotation and equianalgesia. J Pain Res 11:2587\u20132601. https:\/\/doi.org\/10.2147\/JPR.S170269","journal-title":"J Pain Res"},{"key":"8835_CR5","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s005200000180","volume":"9","author":"MP Davis","year":"2001","unstructured":"Davis MP, Walsh D (2001) Methadone for relief of cancer pain: a review of pharmacokinetics, pharmacodynamics, drug interactions and protocols of administration. Support Care Cancer 9:73\u201383. https:\/\/doi.org\/10.1007\/s005200000180","journal-title":"Support Care Cancer"},{"key":"8835_CR6","doi-asserted-by":"publisher","first-page":"CD003971","DOI":"10.1002\/14651858.CD003971.pub4","volume":"2","author":"AB Nicholson","year":"2017","unstructured":"Nicholson AB, Watson GR, Derry S, Wiffen PJ (2017) Methadone for cancer pain. Cochrane Database Syst Rev 2:CD003971. https:\/\/doi.org\/10.1002\/14651858.CD003971.pub4","journal-title":"Cochrane Database Syst Rev"},{"key":"8835_CR7","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.1089\/jpm.2021.0309","volume":"24","author":"E Treillet","year":"2021","unstructured":"Treillet E, Giet O, Picard S et al (2021) Methadone switching for cancer pain: a new classification of initiation protocols, based on a critical literature review. J Palliat Med 24:1884\u20131894. https:\/\/doi.org\/10.1089\/jpm.2021.0309","journal-title":"J Palliat Med"},{"key":"8835_CR8","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.jpainsymman.2016.05.022","volume":"52","author":"P Poulain","year":"2016","unstructured":"Poulain P, Berleur M-P, Lefki S et al (2016) Efficacy and safety of two methadone titration methods for the treatment of cancer-related pain: the EQUIMETH2 trial (methadone for cancer-related pain). J Pain Symptom Manage 52:626-636.e1. https:\/\/doi.org\/10.1016\/j.jpainsymman.2016.05.022","journal-title":"J Pain Symptom Manage"},{"key":"8835_CR9","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1080\/J354v19n04_05","volume":"19","author":"RA Lugo","year":"2005","unstructured":"Lugo RA, Satterfield KL, Kern SE (2005) Pharmacokinetics of methadone. J Pain Palliat Care Pharmacother 19:13\u201324","journal-title":"J Pain Palliat Care Pharmacother"},{"key":"8835_CR10","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1097\/01.jcp.0000246218.28186.5d","volume":"26","author":"B Skjervold","year":"2006","unstructured":"Skjervold B, Bathen J, Spigset O (2006) Methadone and the QT interval: relations to the serum concentrations of methadone and its enantiomers (R)-methadone and (S)-methadone. J Clin Psychopharmacol 26:687\u2013689. https:\/\/doi.org\/10.1097\/01.jcp.0000246218.28186.5d","journal-title":"J Clin Psychopharmacol"},{"key":"8835_CR11","doi-asserted-by":"publisher","first-page":"e730","DOI":"10.1136\/bmjspcare-2018-001695","volume":"12","author":"C Chalker","year":"2022","unstructured":"Chalker C, O\u2019Neill H, Cranfield F (2022) Efficacy of low-dose and\/or adjuvant methadone in palliative medicine. BMJ Support Palliat Care 12:e730\u2013e735. https:\/\/doi.org\/10.1136\/bmjspcare-2018-001695","journal-title":"BMJ Support Palliat Care"},{"key":"8835_CR12","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1089\/pmr.2020.0034","volume":"1","author":"S Chary","year":"2020","unstructured":"Chary S, Abdul-Razzak A, Galloway L (2020) Ultralow-dose adjunctive methadone with slow titration, considering long half-life, for outpatients with cancer-related pain. Palliat Med Rep 1:119\u2013123. https:\/\/doi.org\/10.1089\/pmr.2020.0034","journal-title":"Palliat Med Rep"},{"key":"8835_CR13","doi-asserted-by":"publisher","first-page":"e4","DOI":"10.1016\/j.jpainsymman.2011.06.005","volume":"42","author":"M McKenna","year":"2011","unstructured":"McKenna M, Nicholson AB (2011) Use of methadone as a coanalgesic. J Pain Symptom Manage 42:e4\u2013e6. https:\/\/doi.org\/10.1016\/j.jpainsymman.2011.06.005","journal-title":"J Pain Symptom Manage"},{"key":"8835_CR14","doi-asserted-by":"publisher","first-page":"e5","DOI":"10.1016\/j.jpainsymman.2011.12.270","volume":"43","author":"C Haughey","year":"2012","unstructured":"Haughey C, Watson M, White C (2012) Use of methadone as a coanalgesic: response to McKenna and Nicholson. J Pain Symptom Manage 43:e5\u2013e6. https:\/\/doi.org\/10.1016\/j.jpainsymman.2011.12.270","journal-title":"J Pain Symptom Manage"},{"key":"8835_CR15","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1089\/jpm.2015.0525","volume":"19","author":"F Courtemanche","year":"2016","unstructured":"Courtemanche F, Dao D, Gagn\u00e9 F et al (2016) Methadone as a coanalgesic for palliative care cancer patients. J Palliat Med 19:972\u2013978. https:\/\/doi.org\/10.1089\/jpm.2015.0525","journal-title":"J Palliat Med"},{"key":"8835_CR16","doi-asserted-by":"publisher","first-page":"679","DOI":"10.3390\/life12050679","volume":"12","author":"P F\u00fcrst","year":"2022","unstructured":"F\u00fcrst P (2022) The use of low-dose methadone as add-on to ongoing opioid treatment in palliative cancer care-an underrated treatment? Life Basel Switz 12:679. https:\/\/doi.org\/10.3390\/life12050679","journal-title":"Life Basel Switz"},{"key":"8835_CR17","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1089\/jpm.2012.0335","volume":"16","author":"E Wallace","year":"2013","unstructured":"Wallace E, Ridley J, Bryson J et al (2013) Addition of methadone to another opioid in the management of moderate to severe cancer pain: a case series. J Palliat Med 16:305\u2013309. https:\/\/doi.org\/10.1089\/jpm.2012.0335","journal-title":"J Palliat Med"},{"key":"8835_CR18","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1097\/AJP.0000000000000959","volume":"37","author":"FCN Duarte","year":"2021","unstructured":"Duarte FCN, Ferraro LHDC, Ferreira A, Sakata RK (2021) A randomized controlled trial evaluating the analgesic effect of the combination of methadone with morphine for cancer related pain. Clin J Pain 37:664\u2013668. https:\/\/doi.org\/10.1097\/AJP.0000000000000959","journal-title":"Clin J Pain"},{"key":"8835_CR19","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.pain.2004.09.012","volume":"113","author":"RH Dworkin","year":"2005","unstructured":"Dworkin RH, Turk DC, Farrar JT et al (2005) Core outcome measures for chronic pain clinical trials: IMMPACT recommendations. Pain 113:9\u201319. https:\/\/doi.org\/10.1016\/j.pain.2004.09.012","journal-title":"Pain"},{"key":"8835_CR20","unstructured":"Common Terminology Criteria for Adverse Events (CTCAE) | Protocol Development | CTEP. https:\/\/ctep.cancer.gov\/protocoldevelopment\/electronic_applications\/ctc.htm. Accessed 21 Feb 2024"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-024-08835-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-024-08835-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-024-08835-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T09:08:32Z","timestamp":1731488912000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-024-08835-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,9]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["8835"],"URL":"https:\/\/doi.org\/10.1007\/s00520-024-08835-2","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,9]]},"assertion":[{"value":"27 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"716"}}