{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:50:50Z","timestamp":1780505450625,"version":"3.54.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>This review aimed to evaluate the prevalence and characteristics of dysgeusia after hematopoietic cell transplantation (HCT).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A literature search (in PubMed, Embase.com and Web of Science) for clinical studies evaluating taste before and after HCT was performed up to June 22, 2023, in collaboration with a medical information specialist. After title and abstract review (N\u2009=\u2009807) followed by full-text review (N\u2009=\u200961), articles that met the inclusion criteria were summarized in a table and synthesized narratively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>11 articles were analyzed in this review. All studies had a prospective design and patient populations included children (N\u2009=\u20093) and adults (N\u2009=\u20098) undergoing allogeneic or autologous HCT. Taste was assessed objectively (N\u2009=\u20096) and\/or subjectively (N\u2009=\u20098) between baseline and 12 months after HCT. Before HCT, the self-reported (0\u201331%) and objective (2.4\u201310%) prevalence of dysgeusia was low. During the neutropenic phase, self-reported (20\u2013100%) and objective (21.4%) dysgeusia was highest. In the post-engraftment period, the self-reported (18%) and objective (0\u201333%) prevalence of dysgeusia decreased. Different taste qualities were assessed in six studies including salt, sour, bitter, sweet, and umami.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Some patients undergoing HCT experience dysgeusia prior to treatment. During the neutropenic phase, they had highest complaints, with recovery occurring in the post-engraftment period. All basic tastes, except bitter, were affected. Umami and salt were most affected during treatment. These findings have implications for patient management.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00520-024-08900-w","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T20:46:20Z","timestamp":1727297180000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Taste alterations after hematopoietic cell transplantation: a scoping review"],"prefix":"10.1007","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5098-5189","authenticated-orcid":false,"given":"Caroline G. R.","family":"Dequae","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1500-8390","authenticated-orcid":false,"given":"Judith E.","family":"Raber-Durlacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9264-9151","authenticated-orcid":false,"given":"Joel B.","family":"Epstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2075-7495","authenticated-orcid":false,"given":"Ralph","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1291-2798","authenticated-orcid":false,"given":"Alexa M. G. A.","family":"Laheij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,25]]},"reference":[{"key":"8900_CR1","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/s41409-023-01943-3","volume":"58","author":"JR Passweg","year":"2023","unstructured":"Passweg JR, Baldomero H, Ciceri F, Corbacioglu S, de la Camara R, Dolstra H et al (2023) Hematopoietic cell transplantation and cellular therapies in Europe 2021. The second year of the SARS-CoV-2 pandemic. A report from the EBMT activity survey. Bone Marrow Transplant 58:647\u2013658. https:\/\/doi.org\/10.1038\/s41409-023-01943-3","journal-title":"Bone Marrow Transplant"},{"key":"8900_CR2","doi-asserted-by":"publisher","first-page":"187","DOI":"10.3747\/co.26.5033","volume":"26","author":"A Bazinet","year":"2019","unstructured":"Bazinet A, Popradi G (2019) A general practitioner\u2019s guide to hematopoietic stem-cell transplantation. Curr Oncol 26:187\u2013191. https:\/\/doi.org\/10.3747\/co.26.5033","journal-title":"Curr Oncol"},{"key":"8900_CR3","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.hemonc.2017.05.009","volume":"10","author":"NS Majhail","year":"2017","unstructured":"Majhail NS (2017) Long-term complications after hematopoietic cell transplantation. Hematol Oncol Stem Cell Ther 10:220\u2013227. https:\/\/doi.org\/10.1016\/j.hemonc.2017.05.009","journal-title":"Hematol Oncol Stem Cell Ther"},{"key":"8900_CR4","doi-asserted-by":"publisher","first-page":"219","DOI":"10.3816\/SCT.2004.n.014","volume":"1","author":"JE Raber-Durlacher","year":"2004","unstructured":"Raber-Durlacher JE, Barasch A, Peterson DE, Lalla RV, Schubert MM, Fibbe WE (2004) Oral complications and management considerations in patients treated with high-dose chemotherapy. Support Cancer Ther 1:219\u2013229. https:\/\/doi.org\/10.3816\/SCT.2004.n.014","journal-title":"Support Cancer Ther"},{"key":"8900_CR5","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s00520-014-2378-x","volume":"23","author":"S Elad","year":"2015","unstructured":"Elad S, Raber-Durlacher JE, Brennan MT, Saunders DP, Mank AP, Zadik Y et al (2015) Basic oral care for hematology-oncology patients and hematopoietic stem cell transplantation recipients: a position paper from the joint task force of the Multinational Association of Supportive Care in Cancer\/International Society of Oral Oncology (MASCC\/ISOO) and the European Society for Blood and Marrow Transplantation (EBMT). Support Care Cancer 23:223\u2013236. https:\/\/doi.org\/10.1007\/s00520-014-2378-x","journal-title":"Support Care Cancer"},{"key":"8900_CR6","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1007\/s00520-016-3083-8","volume":"24","author":"JB Epstein","year":"2016","unstructured":"Epstein JB, Smutzer G, Doty RL (2016) Understanding the impact of taste changes in oncology care. Support Care Cancer 24:1917\u20131931. https:\/\/doi.org\/10.1007\/s00520-016-3083-8","journal-title":"Support Care Cancer"},{"key":"8900_CR7","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1097\/SPC.0000000000000346","volume":"12","author":"S van Oort","year":"2018","unstructured":"van Oort S, Kramer E, de Groot JW, Visser O (2018) Taste alterations and cancer treatment. Curr Opin Support Palliat Care 12:162\u2013167. https:\/\/doi.org\/10.1097\/SPC.0000000000000346","journal-title":"Curr Opin Support Palliat Care"},{"key":"8900_CR8","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.bbmt.2017.10.022","volume":"24","author":"M Scordo","year":"2018","unstructured":"Scordo M, Shah GL, Peled JU, Preston EV, Buchan ML, Epstein JB et al (2018) Unlocking the complex flavors of dysgeusia after hematopoietic cell transplantation. Biol Blood Marrow Transplant 24:425\u2013432. https:\/\/doi.org\/10.1016\/j.bbmt.2017.10.022","journal-title":"Biol Blood Marrow Transplant"},{"key":"8900_CR9","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.oraloncology.2009.11.008","volume":"46","author":"JB Epstein","year":"2010","unstructured":"Epstein JB, Barasch A (2010) Taste disorders in cancer patients: pathogenesis, and approach to assessment and management. Oral Oncol 46:77\u201381. https:\/\/doi.org\/10.1016\/j.oraloncology.2009.11.008","journal-title":"Oral Oncol"},{"key":"8900_CR10","doi-asserted-by":"publisher","unstructured":"Ponticelli E, Clari M, Frigerio S, De Clemente A, Bergese I, Scavino E et al (2017) Dysgeusia and health-related quality of life of cancer patients receiving chemotherapy: a cross-sectional study. Eur J Cancer Care (Engl) 26. https:\/\/doi.org\/10.1111\/ecc.12633","DOI":"10.1111\/ecc.12633"},{"key":"8900_CR11","first-page":"58","volume":"7","author":"JH Hong","year":"2009","unstructured":"Hong JH, Omur-Ozbek P, Stanek BT, Dietrich AM, Duncan SE, Lee YW et al (2009) Taste and odor abnormalities in cancer patients. J Support Oncol 7:58\u201365","journal-title":"J Support Oncol"},{"key":"8900_CR12","doi-asserted-by":"publisher","first-page":"199","DOI":"10.2165\/00002018-200831030-00002","volume":"31","author":"RL Doty","year":"2008","unstructured":"Doty RL, Shah M, Bromley SM (2008) Drug-induced taste disorders. Drug Safety 31:199\u2013215. https:\/\/doi.org\/10.2165\/00002018-200831030-00002","journal-title":"Drug Safety"},{"key":"8900_CR13","doi-asserted-by":"publisher","first-page":"378281","DOI":"10.1155\/2014\/378281","volume":"2014","author":"TM Haverman","year":"2014","unstructured":"Haverman TM, Raber-Durlacher JE, Rademacher WM, Vokurka S, Epstein JB, Huisman C et al (2014) Oral complications in hematopoietic stem cell recipients: the role of inflammation. Mediators Inflamm 2014:378281. https:\/\/doi.org\/10.1155\/2014\/378281","journal-title":"Mediators Inflamm"},{"key":"8900_CR14","first-page":"519","volume":"76","author":"MG Marinone","year":"1991","unstructured":"Marinone MG, Rizzoni D, Ferremi P, Rossi G, Izzi T, Brusotti C (1991) Late taste disorders in bone marrow transplantation: clinical evaluation with taste solutions in autologous and allogeneic bone marrow recipients. Haematologica 76:519\u2013522","journal-title":"Haematologica"},{"key":"8900_CR15","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1093\/annonc\/mdx018","volume":"28","author":"LE Spotten","year":"2017","unstructured":"Spotten LE, Corish CA, Lorton CM, Ui Dhuibhir PM, O\u2019Donoghue NC, O\u2019Connor B et al (2017) Subjective and objective taste and smell changes in cancer. Ann Oncol 28:969\u2013984. https:\/\/doi.org\/10.1093\/annonc\/mdx018","journal-title":"Ann Oncol"},{"key":"8900_CR16","doi-asserted-by":"publisher","first-page":"467","DOI":"10.7326\/M18-0850","volume":"169","author":"AC Tricco","year":"2018","unstructured":"Tricco AC, Lillie E, Zarin W, O\u2019Brien KK, Colquhoun H, Levac D et al (2018) PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med 169:467\u2013473. https:\/\/doi.org\/10.7326\/M18-0850","journal-title":"Ann Intern Med"},{"key":"8900_CR17","doi-asserted-by":"publisher","unstructured":"Otten R, de Vries R, Schoonmade L (2019) Amsterdam efficient deduplication (AED) method (Version 1). Zenodo. https:\/\/doi.org\/10.5281\/zenodo.3582928","DOI":"10.5281\/zenodo.3582928"},{"key":"8900_CR18","doi-asserted-by":"publisher","first-page":"240","DOI":"10.3163\/1536-5050.104.3.014","volume":"104","author":"WM Bramer","year":"2016","unstructured":"Bramer WM, Giustini D, de Jonge GB, Holland L, Bekhuis T (2016) De-duplication of database search results for systematic reviews in EndNote. J Med Libr Assoc 104:240\u2013243. https:\/\/doi.org\/10.3163\/1536-5050.104.3.014","journal-title":"J Med Libr Assoc"},{"key":"8900_CR19","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","volume":"5","author":"M Ouzzani","year":"2016","unstructured":"Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A (2016) Rayyan-a web and mobile app for systematic reviews. Syst Rev 5:210. https:\/\/doi.org\/10.1186\/s13643-016-0384-4","journal-title":"Syst Rev"},{"key":"8900_CR20","doi-asserted-by":"publisher","first-page":"3553","DOI":"10.1007\/s00520-018-4200-7","volume":"26","author":"R Abasaeed","year":"2018","unstructured":"Abasaeed R, Coldwell SE, Lloid ME, Soliman SH, Macris PC, Schubert MM (2018) Chemosensory changes and quality of life in patients undergoing hematopoietic stem cell transplantation. Support Care Cancer 26:3553\u20133561. https:\/\/doi.org\/10.1007\/s00520-018-4200-7","journal-title":"Support Care Cancer"},{"key":"8900_CR21","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1097\/NCC.0b013e31819b5c81","volume":"32","author":"I Andersson","year":"2009","unstructured":"Andersson I, Ahlberg K, Stockelberg D, Brune M, Persson LO (2009) Health-related quality of life in patients undergoing allogeneic stem cell transplantation after reduced intensity conditioning versus myeloablative conditioning. Cancer Nurs 32:325\u2013334. https:\/\/doi.org\/10.1097\/NCC.0b013e31819b5c81","journal-title":"Cancer Nurs"},{"key":"8900_CR22","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1177\/0148607182006004287","volume":"6","author":"K Barale","year":"1982","unstructured":"Barale K, Aker SN, Martinsen CS (1982) Primary taste thresholds in children with leukemia undergoing marrow transplantation. JPEN J Parenter Enteral Nutr 6:287\u2013290. https:\/\/doi.org\/10.1177\/0148607182006004287","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"8900_CR23","doi-asserted-by":"publisher","first-page":"3019","DOI":"10.1007\/s00520-012-1559-8","volume":"20","author":"J Cohen","year":"2012","unstructured":"Cohen J, Laing DG, Wilkes FJ (2012) Taste and smell function in pediatric blood and marrow transplant patients. Support Care Cancer 20:3019\u20133023. https:\/\/doi.org\/10.1007\/s00520-012-1559-8","journal-title":"Support Care Cancer"},{"key":"8900_CR24","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1007\/s00520-019-04922-x","volume":"28","author":"MH Ferreira","year":"2020","unstructured":"Ferreira MH, Mello Bezinelli L, de Paula EF, Lopes RM, Pereira AZ, Hamerschlack N et al (2020) Association of oral toxicity and taste changes during hematopoietic stem cell transplantation: a preliminary study. Support Care Cancer 28:1277\u20131287. https:\/\/doi.org\/10.1007\/s00520-019-04922-x","journal-title":"Support Care Cancer"},{"key":"8900_CR25","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1097\/00002820-200401000-00007","volume":"27","author":"J Larsen","year":"2004","unstructured":"Larsen J, Nordstr\u00f6m G, Ljungman P, Gardulf A (2004) Symptom occurrence, symptom intensity, and symptom distress in patients undergoing high-dose chemotherapy with stem-cell transplantation. Cancer Nurs 27:55\u201364. https:\/\/doi.org\/10.1097\/00002820-200401000-00007","journal-title":"Cancer Nurs"},{"key":"8900_CR26","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1111\/petr.12535","volume":"19","author":"A Majorana","year":"2015","unstructured":"Majorana A, Amadori F, Bardellini E, Campus G, Conti G, Strohmenger L et al (2015) Taste dysfunction in patients undergoing hematopoietic stem cell transplantation: clinical evaluation in children. Pediatr Transplant 19:571\u2013575. https:\/\/doi.org\/10.1111\/petr.12535","journal-title":"Pediatr Transplant"},{"key":"8900_CR27","doi-asserted-by":"publisher","unstructured":"Patel SS, Hong S, Rybicki L, Farlow S, Dabney J, Kalaycio M et al (2023) A pilot trial of patient-reported outcomes for acute graft-versus-host-disease. Transplant Cell Ther 29:465.e1-.e7. https:\/\/doi.org\/10.1016\/j.jtct.2023.03.030","DOI":"10.1016\/j.jtct.2023.03.030"},{"key":"8900_CR28","doi-asserted-by":"publisher","first-page":"3850","DOI":"10.1002\/cncr.34444","volume":"128","author":"M Scordo","year":"2022","unstructured":"Scordo M, Shah GL, Adintori PA, Knezevic A, Devlin SM, Buchan ML et al (2022) A prospective study of dysgeusia and related symptoms in patients with multiple myeloma after autologous hematopoietic cell transplantation. Cancer 128:3850\u20133859. https:\/\/doi.org\/10.1002\/cncr.34444","journal-title":"Cancer"},{"key":"8900_CR29","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1111\/j.1600-0609.2004.00346.x","volume":"74","author":"CA Uyl-de Groot","year":"2005","unstructured":"Uyl-de Groot CA, Buijt I, Gloudemans IJ, Ossenkoppele GJ, Berg HP, Huijgens PC (2005) Health related quality of life in patients with multiple myeloma undergoing a double transplantation. Eur J Haematol 74:136\u2013143. https:\/\/doi.org\/10.1111\/j.1600-0609.2004.00346.x","journal-title":"Eur J Haematol"},{"key":"8900_CR30","doi-asserted-by":"publisher","first-page":"e642","DOI":"10.4317\/medoral.24647","volume":"26","author":"A Wysocka-S\u0142owik","year":"2021","unstructured":"Wysocka-S\u0142owik A, Gil L, \u015alebioda Z, Dorocka-Bobkowska B (2021) Oral complaints in patients with acute myeloid leukemia treated with allogeneic hematopoietic stem cell transplantation. Med Oral Patol Oral Cir Bucal 26:e642\u2013e650. https:\/\/doi.org\/10.4317\/medoral.24647","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"8900_CR31","doi-asserted-by":"publisher","unstructured":"Schubert MM, Correa ME (2008) Oral graft-versus-host disease. Dent Clin North Am 52:79\u2013109, viii-ix. https:\/\/doi.org\/10.1016\/j.cden.2007.10.004","DOI":"10.1016\/j.cden.2007.10.004"},{"key":"8900_CR32","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1007\/s00277-017-3087-6","volume":"96","author":"T Sato","year":"2017","unstructured":"Sato T, Konuma T, Miwa Y, Sugihara N, Tsuru Y, Narita H et al (2017) A cross-sectional study on late taste disorders in survivors of allogeneic hematopoietic cell transplantation. Ann Hematol 96:1841\u20131847. https:\/\/doi.org\/10.1007\/s00277-017-3087-6","journal-title":"Ann Hematol"},{"key":"8900_CR33","doi-asserted-by":"publisher","first-page":"e19","DOI":"10.1016\/j.oraloncology.2008.04.001","volume":"45","author":"H Yamashita","year":"2009","unstructured":"Yamashita H, Nakagawa K, Hosoi Y, Kurokawa A, Fukuda Y, Matsumoto I et al (2009) Umami taste dysfunction in patients receiving radiotherapy for head and neck cancer. Oral Oncol 45:e19-23. https:\/\/doi.org\/10.1016\/j.oraloncology.2008.04.001","journal-title":"Oral Oncol"},{"key":"8900_CR34","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.anl.2004.05.002","volume":"31","author":"HB Shi","year":"2004","unstructured":"Shi HB, Masuda M, Umezaki T, Kuratomi Y, Kumamoto Y, Yamamoto T et al (2004) Irradiation impairment of umami taste in patients with head and neck cancer. Auris Nasus Larynx 31:401\u2013406. https:\/\/doi.org\/10.1016\/j.anl.2004.05.002","journal-title":"Auris Nasus Larynx"},{"key":"8900_CR35","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1177\/01945998211018386","volume":"166","author":"SS Jang","year":"2022","unstructured":"Jang SS, Choi JS, Kim JH, Kim N, Ference EH (2022) Discordance between subjective and objective measures of smell and taste in US adults. Otolaryngol Head Neck Surg 166:572\u2013579. https:\/\/doi.org\/10.1177\/01945998211018386","journal-title":"Otolaryngol Head Neck Surg"},{"key":"8900_CR36","doi-asserted-by":"publisher","unstructured":"van den Brink M, I IJ, Tissing WJE, Havermans RC (2021) Taste dysfunction in children-a clinical perspective and review of assessment methods. Chem Senses 46.https:\/\/doi.org\/10.1093\/chemse\/bjab035","DOI":"10.1093\/chemse\/bjab035"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-024-08900-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-024-08900-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-024-08900-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T04:24:17Z","timestamp":1729311857000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-024-08900-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,25]]},"references-count":36,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["8900"],"URL":"https:\/\/doi.org\/10.1007\/s00520-024-08900-w","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,25]]},"assertion":[{"value":"28 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no relevant competing interests related to the content of this article, except that one of the co-authors (JE) also serves as an editor for this journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"687"}}