{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T01:15:41Z","timestamp":1779930941925,"version":"3.53.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Medizinische Hochschule Brandenburg CAMPUS GmbH"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>Due to disease- or therapy-associated immunosuppression, oncological patients suffer from significantly higher morbidity and mortality due to infections transmitted by respiratory pathogens such as <jats:italic>Streptococcus pneumoniae<\/jats:italic> and influenza virus. Although the German Standing Committee on Vaccination (STIKO) provides specific recommendations for vaccination against these pathogens, there is no data on vaccination rates in this high-risk population.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Data from the interventional <jats:italic>EVO study<\/jats:italic> were analyzed to provide information on vaccination rates against <jats:italic>Streptococcus pneumoniae<\/jats:italic> and influenza virus in oncological patients. Numbers presented in this publication summarize baseline and follow-up data of the control group; thus, data were not influenced by the intervention.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Data of 370 patients were analyzed; 20.5% of patients were treated for hematological malignancies and 79.5% for solid cancer. 28.1% of patients had received vaccination against influenza and 32.2% against <jats:italic>Streptococcus pneumoniae<\/jats:italic>; for the latter only 7.3% according recommendations. While vaccination rates where even lower for patients with thoracic carcinoma (influenza 26.7% and <jats:italic>Streptococcus pneumoniae<\/jats:italic> 6.0% according to STIKO recommendations), rates in patients with multiple myeloma were remarkably higher (39.0% and 14.6%).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Despite strong recommendations to vaccinate and the clear clinical need to prevent infections in the vulnerable group of oncological patients, only the minority was vaccinated against <jats:italic>Streptococcus pneumoniae<\/jats:italic> or influenza, underlining the urgent need for better vaccination strategies in this high-risk population.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00520-024-09023-y","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T14:27:37Z","timestamp":1732199257000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Streptococcus pneumoniae and influenza vaccination rates in oncological patients\u00a0\u2014\u00a0data from Germany"],"prefix":"10.1007","volume":"32","author":[{"given":"Emma","family":"Niederstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Journey","family":"Underwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maike","family":"de Wit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Reinwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Schwarzlose-Schwarck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Dammermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Markus","family":"Deckert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Til Ram\u00f3n","family":"Kiderlen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,21]]},"reference":[{"issue":"3","key":"9023_CR1","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.ijantimicag.2007.06.014","volume":"31","author":"G Maschmeyer","year":"2008","unstructured":"Maschmeyer G, Haas A (2008) The epidemiology and treatment of infections in cancer patients. Int J Antimicrob Agents 31(3):193\u2013197","journal-title":"Int J Antimicrob Agents"},{"issue":"3","key":"9023_CR2","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.medmal.2019.11.006","volume":"50","author":"A Monier","year":"2020","unstructured":"Monier A, Puyade M, Hernanz MPG, Bouchaert P, Leleu X, Tourani JM et al (2020) Observational study of vaccination in cancer patients: how can vaccine coverage be improved? Med Mal Infect 50(3):263\u2013268","journal-title":"Med Mal Infect"},{"issue":"9","key":"9023_CR3","doi-asserted-by":"publisher","first-page":"2677","DOI":"10.1007\/s00520-017-3675-y","volume":"25","author":"A Alkan","year":"2017","unstructured":"Alkan A, Karc\u0131 E, Ya\u015far A, Tuncay G, K\u00f6ksoy EB, \u00dcr\u00fcn M et al (2017) Vaccination in oncology practice and predictors. Support Care Cancer 25(9):2677\u20132682","journal-title":"Support Care Cancer"},{"issue":"8","key":"9023_CR4","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.medmal.2019.09.004","volume":"49","author":"M Glavier","year":"2019","unstructured":"Glavier M, Puyade M, Roblot F, Rammaert B (2019) Vaccination of cancer patients treated with chemotherapy: a survey among general practitioners. Med Mal Infect 49(8):586\u2013592","journal-title":"Med Mal Infect"},{"issue":"1","key":"9023_CR5","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1177\/03008916231191547","volume":"110","author":"A Lasagna","year":"2024","unstructured":"Lasagna A, Brunello A, Silvestris N, Pedrazzoli P, Di Maio M, Cinieri S (2024) Italian oncologists and vaccinations against infectious diseases: results of a survey of the Italian Association of Medical Oncology. Tumori 110(1):60\u201368","journal-title":"Tumori"},{"issue":"26","key":"9023_CR6","first-page":"466","volume":"119","author":"TR Kiderlen","year":"2022","unstructured":"Kiderlen TR, Trostdorf K, Delmastro N, Salomon A, Scholz CW, Sp\u00e4th-Schwalbe E et al (2022) Raising immunization rates among cancer patients. Dtsch Arztebl Int 119(26):466\u2013467","journal-title":"Dtsch Arztebl Int"},{"key":"9023_CR7","unstructured":"Rieck T, Steffen A, Schmid-K\u00fcpke N, Feig M, Wichmann O, Siedler A (2020) Impfquoten bei Erwachsenen in Deutschland \u2013 Aktuelles aus der KV-Impfsurveillance und der Onlinebefragung von Krankenhauspersonal. OKaPII. (47):3\u201326"},{"issue":"12","key":"9023_CR8","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.1017\/S0950268810000919","volume":"138","author":"A Wong","year":"2010","unstructured":"Wong A, Marrie TJ, Garg S, Kellner JD, Tyrrell GJ (2010) Increased risk of invasive pneumococcal disease in haematological and solid-organ malignancies. Epidemiol Infect 138(12):1804\u20131810","journal-title":"Epidemiol Infect"},{"issue":"6","key":"9023_CR9","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.jinf.2012.08.015","volume":"65","author":"C Garcia-Vidal","year":"2012","unstructured":"Garcia-Vidal C, Ardanuy C, Gudiol C, Cuervo G, Calatayud L, Bodro M et al (2012) Clinical and microbiological epidemiology of Streptococcus pneumoniae bacteremia in cancer patients. J Infect 65(6):521\u2013527","journal-title":"J Infect"},{"key":"9023_CR10","unstructured":"RKI (2018) Mitteilung der St\u00e4ndigen Impfkommission (STIKO) beim RKI: Wissenschaftliche Begr\u00fcndung zur Empfehlung einer Impfung mit dem Herpes zoster-subunit-Totimpfstoff. Available from: https:\/\/www.rki.de\/DE\/Content\/Infekt\/EpidBull\/Archiv\/2018\/Ausgaben\/50_18.pdf?__blob=publicationFile. Accessed 08 Aug 2020"},{"key":"9023_CR11","first-page":"385","volume":"37","author":"RKI","year":"2016","unstructured":"RKI (2016) Mitteilung der St\u00e4ndigen Impfkommission: Wissenschaftliche Begr\u00fcndung f\u00fcr die Aktualisierung der Empfehlungen zur Indikationsimpfung gegen Pneumokokken f\u00fcr Risikogruppen. Epid Bull 37:385\u2013406","journal-title":"Epid Bull"},{"issue":"52","key":"9023_CR12","doi-asserted-by":"publisher","first-page":"7443","DOI":"10.1016\/j.vaccine.2012.10.025","volume":"30","author":"BY Lee","year":"2012","unstructured":"Lee BY, Bartsch SM, Willig AM (2012) The economic value of a quadrivalent versus trivalent influenza vaccine. Vaccine 30(52):7443\u20137446","journal-title":"Vaccine"},{"key":"9023_CR13","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.ijid.2020.02.040","volume":"93","author":"P Buchy","year":"2020","unstructured":"Buchy P, Badur S (2020) Who and when to vaccinate against influenza. Int J Infect Dis 93:375\u2013387","journal-title":"Int J Infect Dis"},{"key":"9023_CR14","first-page":"3","volume":"39","author":"J Schlaberg","year":"2023","unstructured":"Schlaberg J, Vygen-Bonnet S, Falman A, Wilhelm J, Hummers E, von Kries R et al (2023) Aktualisierung der Empfehlungen der STIKO zur Standardimpfung von Personen \u2265 60 Jahre sowie zur Indikationsimpfung von Risikogruppen gegen Pneumokokken und die dazugeh\u00f6rige wissenschaftliche Begr\u00fcndung. Epidemiologisches Bull 39:3\u201344","journal-title":"Epidemiologisches Bull"},{"issue":"3","key":"9023_CR15","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1093\/cid\/cit816","volume":"58","author":"LG Rubin","year":"2014","unstructured":"Rubin LG, Levin MJ, Ljungman P, Davies EG, Avery R, Tomblyn M et al (2014) 2013 IDSA clinical practice guideline for vaccination of the immunocompromised host. Clin Infect Dis 58(3):309\u2013318","journal-title":"Clin Infect Dis"},{"issue":"9","key":"9023_CR16","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.3109\/0284186X.2014.914243","volume":"53","author":"A Berglund","year":"2014","unstructured":"Berglund A, Will\u00e9n L, Gr\u00f6deberg L, Skattum L, Hagberg H, Pauksens K (2014) The response to vaccination against influenza A(H1N1) 2009, seasonal influenza and Streptococcus pneumoniae in adult outpatients with ongoing treatment for cancer with and without rituximab. Acta Oncol 53(9):1212\u20131220","journal-title":"Acta Oncol"},{"key":"9023_CR17","unstructured":"Michaelis K, Scholz S, Buda S, Garbe E, Harder T, Ledig T et al (2020) Beschluss und Wissenschaftliche Begr\u00fcndung der St\u00e4ndigen Impfkommission (STIKO) f\u00fcr die Aktualisierung der Influenza-Impfempfehlung f\u00fcr Personen im Alter von \u2265 60 Jahren. Epid Bull 1:3\u201325"},{"issue":"5","key":"9023_CR18","doi-asserted-by":"publisher","first-page":"552","DOI":"10.7326\/0003-4819-87-5-552","volume":"87","author":"DW Ortbals","year":"1977","unstructured":"Ortbals DW, Liebhaber H, Presant CA, Van Amburg AL 3rd, Lee JY (1977) Influenza immunization of adult patients with malignant diseases. Ann Intern Med 87(5):552\u20137","journal-title":"Ann Intern Med"},{"key":"9023_CR19","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1186\/s12879-016-1648-2","volume":"16","author":"E Backhaus","year":"2016","unstructured":"Backhaus E, Berg S, Andersson R, Ockborn G, Malmstr\u00f6m P, Dahl M et al (2016) Epidemiology of invasive pneumococcal infections: manifestations, incidence and case fatality rate correlated to age, gender and risk factors. BMC Infect Dis 16:367","journal-title":"BMC Infect Dis"},{"issue":"1","key":"9023_CR20","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/apt.15057","volume":"49","author":"J Sitte","year":"2019","unstructured":"Sitte J, Frentiu E, Baumann C, Rousseau H, May T, Bronowicki JP et al (2019) Vaccination for influenza and pneumococcus in patients with gastrointestinal cancer or inflammatory bowel disease: a prospective cohort study of methods for improving coverage. Aliment Pharmacol Ther 49(1):84\u201390","journal-title":"Aliment Pharmacol Ther"},{"issue":"6","key":"9023_CR21","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1002\/pbc.22135","volume":"53","author":"E Zengin","year":"2009","unstructured":"Zengin E, Sarper N (2009) Humoral immunity to diphtheria, tetanus, measles, and hemophilus influenzae type b in children with acute lymphoblastic leukemia and response to re-vaccination. Pediatr Blood Cancer 53(6):967\u2013972","journal-title":"Pediatr Blood Cancer"},{"issue":"6","key":"9023_CR22","doi-asserted-by":"publisher","first-page":"e13725","DOI":"10.1111\/ecc.13725","volume":"31","author":"TR Kiderlen","year":"2022","unstructured":"Kiderlen TR, Trostdorf K, Delmastro N, Salomon A, Scholz CW, Spath-Schwalbe E et al (2022) Controlled non-randomised before-after study evaluating the impact of a focused recommendation card on vaccination rates of oncological patients-The Easy Vaccination in Oncology (EVO) strategy. Eur J Cancer Care (Engl) 31(6):e13725","journal-title":"Eur J Cancer Care (Engl)"},{"issue":"1","key":"9023_CR23","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1186\/s12887-021-02888-6","volume":"21","author":"BW Demissie","year":"2021","unstructured":"Demissie BW, Amele EA, Yitayew YA, Yalew ZM (2021) Acute lower respiratory tract infections and associated factors among under-five children visiting Wolaita Sodo University Teaching and Referral Hospital, Wolaita Sodo, Ethiopia. BMC Pediatr 21(1):413","journal-title":"BMC Pediatr"},{"issue":"1","key":"9023_CR24","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.vaccine.2007.10.053","volume":"26","author":"M Sinisalo","year":"2007","unstructured":"Sinisalo M, Vilpo J, Itala M, Vakevainen M, Taurio J, Aittoniemi J (2007) Antibody response to 7-valent conjugated pneumococcal vaccine in patients with chronic lymphocytic leukaemia. Vaccine 26(1):82\u201387","journal-title":"Vaccine"},{"issue":"37","key":"9023_CR25","doi-asserted-by":"publisher","first-page":"4047","DOI":"10.1016\/j.vaccine.2013.04.065","volume":"31","author":"YL Ho","year":"2013","unstructured":"Ho YL, Brand\u00e3o AP, de Cunto Brandileone MC, Lopes MH (2013) Immunogenicity and safety of pneumococcal conjugate polysaccharide and free polysaccharide vaccines alone or combined in HIV-infected adults in Brazil. Vaccine 31(37):4047\u20134053","journal-title":"Vaccine"},{"issue":"3","key":"9023_CR26","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1002\/cncr.21203","volume":"104","author":"CD Cooksley","year":"2005","unstructured":"Cooksley CD, Avritscher EB, Bekele BN, Rolston KV, Geraci JM, Elting LS (2005) Epidemiology and outcomes of serious influenza-related infections in the cancer population. Cancer 104(3):618\u2013628","journal-title":"Cancer"},{"issue":"8","key":"9023_CR27","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1093\/infdis\/jis487","volume":"206","author":"CR Beck","year":"2012","unstructured":"Beck CR, McKenzie BC, Hashim AB, Harris RC, University of Nottingham I, the ImmunoCompromised Study G et al (2012) Influenza vaccination for immunocompromised patients: systematic review and meta-analysis by etiology. J Infect Dis 206(8):1250\u20139","journal-title":"J Infect Dis"},{"issue":"6","key":"9023_CR28","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1200\/JCO.2003.06.008","volume":"21","author":"CC Earle","year":"2003","unstructured":"Earle CC (2003) Influenza vaccination in elderly patients with advanced colorectal cancer. J Clin Oncol 21(6):1161\u20131166","journal-title":"J Clin Oncol"},{"issue":"3","key":"9023_CR29","doi-asserted-by":"publisher","first-page":"e0120544","DOI":"10.1371\/journal.pone.0120544","volume":"10","author":"LS Rabello","year":"2015","unstructured":"Rabello LS, Silva JR, Azevedo LC, Souza I, Torres VB, Rosolem MM et al (2015) Clinical outcomes and microbiological characteristics of severe pneumonia in cancer patients: a prospective cohort study. PLoS One 10(3):e0120544","journal-title":"PLoS One"},{"issue":"31","key":"9023_CR30","doi-asserted-by":"publisher","first-page":"3703","DOI":"10.1016\/j.vaccine.2015.06.012","volume":"33","author":"P Loubet","year":"2015","unstructured":"Loubet P, Kerneis S, Groh M, Loulergue P, Blanche P, Verger P et al (2015) Attitude, knowledge and factors associated with influenza and pneumococcal vaccine uptake in a large cohort of patients with secondary immune deficiency. Vaccine 33(31):3703\u20133708","journal-title":"Vaccine"},{"issue":"7","key":"9023_CR31","doi-asserted-by":"publisher","first-page":"3657","DOI":"10.1007\/s00520-020-05883-2","volume":"29","author":"MJ Rensink","year":"2021","unstructured":"Rensink MJ, van Laarhoven HWM, Holleman F (2021) Cocoon vaccination for influenza in patients with a solid tumor: a retrospective study. Support Care Cancer 29(7):3657\u20133666","journal-title":"Support Care Cancer"},{"issue":"7","key":"9023_CR32","doi-asserted-by":"publisher","first-page":"ofab198","DOI":"10.1093\/ofid\/ofab198","volume":"8","author":"A Chang","year":"2021","unstructured":"Chang A, Ellingson MK, Flowers CR, Bednarczyk RA (2021) Influenza vaccination rates among patients with a history of cancer: analysis of the National Health Interview Survey. Open Forum Infect Dis 8(7):ofab198","journal-title":"Open Forum Infect Dis"},{"issue":"1","key":"9023_CR33","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1186\/s12889-015-1970-4","volume":"15","author":"B B\u00f6deker","year":"2015","unstructured":"B\u00f6deker B, Remschmidt C, Schmich P, Wichmann O (2015) Why are older adults and individuals with underlying chronic diseases in Germany not vaccinated against flu? A population-based study. BMC Public Health 15(1):618","journal-title":"BMC Public Health"},{"issue":"3","key":"9023_CR34","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1017\/S095026880200780X","volume":"129","author":"B Christenson","year":"2002","unstructured":"Christenson B, Lundbergh P (2002) Comparison between cohorts vaccinated and unvaccinated against influenza and pneumococcal infection. Epidemiol Infect 129(3):515\u2013524","journal-title":"Epidemiol Infect"},{"issue":"10","key":"9023_CR35","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1093\/cid\/ciu680","volume":"59","author":"HQ McLean","year":"2014","unstructured":"McLean HQ, Thompson MG, Sundaram ME, Meece JK, McClure DL, Friedrich TC et al (2014) Impact of repeated vaccination on vaccine effectiveness against influenza A(H3N2) and B during 8 seasons. Clin Infect Dis 59(10):1375\u20131385","journal-title":"Clin Infect Dis"},{"issue":"48","key":"9023_CR36","first-page":"845","volume":"107","author":"AM Reuss","year":"2010","unstructured":"Reuss AM, Walter D, Feig M, Kappelmayer L, Buchholz U, Eckmanns T et al (2010) Influenza vaccination coverage in the 2004\/05, 2005\/06, and 2006\/07 seasons: a secondary data analysis based on billing data of the German associations of statutory health insurance physicians. Dtsch Arztebl Int 107(48):845\u2013850","journal-title":"Dtsch Arztebl Int"},{"issue":"5","key":"9023_CR37","doi-asserted-by":"publisher","first-page":"e179","DOI":"10.1016\/j.amepre.2020.05.009","volume":"59","author":"BH Bardenheier","year":"2020","unstructured":"Bardenheier BH, Zullo AR, Jutkowitz E, Gravenstein S (2020) Characteristics of repeated influenza vaccination among older U.S. adults. Am J Prev Med 59(5):e179\u2013e88","journal-title":"Am J Prev Med"},{"key":"9023_CR38","unstructured":"RKI (2019) Empfehlungen der St\u00e4ndigen Impfkommission beim Robert Koch-Institut \u2013 2019\/2020. Epidemiologisches Bull 22(34):314\u201364"},{"key":"9023_CR39","doi-asserted-by":"crossref","unstructured":"Zintel S, Flock C, Arbogast AL, Forster A, von Wagner C, Sieverding M (2022) Gender differences in the intention to get vaccinated against COVID-19: a systematic review and meta-analysis.\u00a0J Public Health\u00a01\u201325","DOI":"10.2139\/ssrn.3803323"},{"issue":"10","key":"9023_CR40","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1055\/a-1155-6738","volume":"46","author":"CSL M\u00fcller","year":"2020","unstructured":"M\u00fcller CSL, Vogt T, Yordanova K (2020) Dermatologische Impfpraxis \u2013 Herausforderungen im klinischen Alltag. Aktuelle Dermatol 46(10):434\u2013448","journal-title":"Aktuelle Dermatol"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-024-09023-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-024-09023-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-024-09023-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T15:06:38Z","timestamp":1733756798000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-024-09023-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,21]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["9023"],"URL":"https:\/\/doi.org\/10.1007\/s00520-024-09023-y","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,21]]},"assertion":[{"value":"26 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Ethics Committee of Brandenburg Medical School as part of a broader study context (protocol code E-01\u201320190123, date of approval 10 April 2019).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all subjects involved in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"813"}}