{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T09:23:49Z","timestamp":1792488229884,"version":"4.5.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T00:00:00Z","timestamp":1737158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T00:00:00Z","timestamp":1737158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["308178\/2018-1"],"award-info":[{"award-number":["308178\/2018-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1007\/s00520-024-09120-y","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T22:10:08Z","timestamp":1737151808000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of photobiomodulation and bethanechol chloride treatment on salivary composition and flow rate in head and neck cancer patients undergoing radiotherapy: longitudinal interventional experimental clinical study"],"prefix":"10.1007","volume":"33","author":[{"given":"Nat\u00e1lia","family":"Schepanski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna Melo","family":"da Silva Liebl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reila Taina","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floriatan Santos","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarice D. B.","family":"Amaral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel C.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Rita A.","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurindo Moacir","family":"Sassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa Rodrigues","family":"de Araujo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,18]]},"reference":[{"key":"9120_CR1","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1002\/ijc.33588","volume":"149","author":"J Ferlay","year":"2021","unstructured":"Ferlay J, Colombet M, Soerjomataram I, Parkin DM, Pi\u00f1eros M, Znaor A et al (2021) Cancer statistics for the year 2020: an overview. Int J Cancer 149:778\u201389. https:\/\/doi.org\/10.1002\/ijc.33588","journal-title":"Int J Cancer"},{"key":"9120_CR2","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.ijrobp.2023.03.047","volume":"118","author":"V Mercadante","year":"2024","unstructured":"Mercadante V, Al HA, McCaul J, Nutting C, Harrington K, Carnell D et al (2024) Salivary electrostimulation in the treatment of radiation therapy\u2013induced xerostomia (LEONIDAS-2): a multicenter, randomized, double-masked, sham-controlled, phase 3 trial. Int J Radiat Oncol Biol Phys 118:142\u201353. https:\/\/doi.org\/10.1016\/j.ijrobp.2023.03.047","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"9120_CR3","first-page":"18","volume":"2","author":"A Simoes","year":"2009","unstructured":"Simoes A, Campos L, Freitas PM, Eduardo CP, Nicolau J (2009) Laser as a therapy for oral complications induced by chemotherapy and radiotherapy. J Bras Laser 2:18\u201323","journal-title":"J Bras Laser"},{"key":"9120_CR4","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1089\/pho.2014.3741","volume":"32","author":"J Saleh","year":"2014","unstructured":"Saleh J, Figueiredo MAZ, Cherubini K, Braga-Filho A, Salum FG (2014) Effect of low-level laser therapy on radiotherapy-induced hyposalivation and xerostomia: a pilot study. Photomed Laser Surg 32:546\u201352. https:\/\/doi.org\/10.1089\/pho.2014.3741","journal-title":"Photomed Laser Surg"},{"key":"9120_CR5","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.oraloncology.2016.12.031","volume":"66","author":"V Mercadante","year":"2017","unstructured":"Mercadante V, Al Hamad A, Lodi G, Porter S, Fedele S (2017) Interventions for the management of radiotherapy-induced xerostomia and hyposalivation: a systematic review and meta-analysis. Oral Oncol 66:64\u201374. https:\/\/doi.org\/10.1016\/j.oraloncology.2016.12.031","journal-title":"Oral Oncol"},{"key":"9120_CR6","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.ijrobp.2007.04.021","volume":"69","author":"AP Jellema","year":"2007","unstructured":"Jellema AP, Slotman BJ, Doornaert P, Leemans CR, Langendijk JA (2007) Impact of radiation-induced xerostomia on quality of life after primary radiotherapy among patients with head and neck cancer. Int J Radiat Oncol Biol Phys 69:751\u201360. https:\/\/doi.org\/10.1016\/j.ijrobp.2007.04.021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"9120_CR7","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.ijpharm.2018.02.004","volume":"541","author":"OS Malallah","year":"2018","unstructured":"Malallah OS, Garcia CMA, Proctor GB, Forbes B, Royall PG (2018) Buccal drug delivery technologies for patient-centred treatment of radiation-induced xerostomia (dry mouth). Int J Pharm 541:157\u201366. https:\/\/doi.org\/10.1016\/j.ijpharm.2018.02.004","journal-title":"Int J Pharm"},{"key":"9120_CR8","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1007\/s00784-011-0612-1","volume":"16","author":"J Karbach","year":"2012","unstructured":"Karbach J, Walter C, Al-Nawas B (2012) Evaluation of saliva flow rates, Candida colonization and susceptibility of Candida strains after head and neck radiation. Clin Oral Investig 16:1305\u201312. https:\/\/doi.org\/10.1007\/s00784-011-0612-1","journal-title":"Clin Oral Investig"},{"key":"9120_CR9","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.radonc.2015.04.021","volume":"116","author":"JM Borras","year":"2015","unstructured":"Borras JM, Barton M, Grau C, Corral J, Verhoeven R, Lemmens V et al (2015) The impact of cancer incidence and stage on optimal utilization of radiotherapy: Methodology of a population based analysis by the ESTRO-HERO project. Radiother Oncol 116:45\u201350. https:\/\/doi.org\/10.1016\/j.radonc.2015.04.021","journal-title":"Radiother Oncol"},{"key":"9120_CR10","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.clindermatol.2017.06.010","volume":"35","author":"JW Millsop","year":"2017","unstructured":"Millsop JW, Wang EA, Fazel N (2017) Etiology, evaluation, and management of xerostomia. Clin Dermatol 35:468\u201376. https:\/\/doi.org\/10.1016\/j.clindermatol.2017.06.010","journal-title":"Clin Dermatol"},{"key":"9120_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/7802334","volume":"2022","author":"Y Li","year":"2022","unstructured":"Li Y, Li X, Pang R, Yang G, Tian M, Zhao T et al (2022) Diagnosis, prevention, and treatment of radiotherapy-induced xerostomia: a review. J Oncol 2022:1\u201315. https:\/\/doi.org\/10.1155\/2022\/7802334","journal-title":"J Oncol"},{"key":"9120_CR12","doi-asserted-by":"publisher","first-page":"126743","DOI":"10.1016\/j.jtemb.2021.126743","volume":"66","author":"LK Rosa","year":"2021","unstructured":"Rosa LK, Costa FS, Hauagge CM, Mobile RZ, de Lima AAS, Amaral CDB et al (2021) Oral health, organic and inorganic saliva composition of men with Schizophrenia: case-control study. J Trace Elem Med Biol 66:126743. https:\/\/doi.org\/10.1016\/j.jtemb.2021.126743","journal-title":"J Trace Elem Med Biol"},{"key":"9120_CR13","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1067\/mpr.2001.113778","volume":"85","author":"SP Humphrey","year":"2001","unstructured":"Humphrey SP, Williamson RT (2001) A review of saliva: Normal composition, flow, and function. J Prosthet Dent 85:162\u20139. https:\/\/doi.org\/10.1067\/mpr.2001.113778","journal-title":"J Prosthet Dent"},{"key":"9120_CR14","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1039\/C7AN01571B","volume":"143","author":"K Ngamchuea","year":"2018","unstructured":"Ngamchuea K, Chaisiwamongkhol K, Batchelor-McAuley C, Compton RG (2018) Chemical analysis in saliva and the search for salivary biomarkers \u2013 a tutorial review. Analyst 143:81\u201399. https:\/\/doi.org\/10.1039\/C7AN01571B","journal-title":"Analyst"},{"key":"9120_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/6572381","volume":"2018","author":"E Kubala","year":"2018","unstructured":"Kubala E, Strzelecka P, Grzegocka M, Lietz-Kijak D, Gronwald H, Skomro P et al (2018) A review of selected studies that determine the physical and chemical properties of saliva in the field of dental treatment. Biomed Res Int 2018:1\u201313. https:\/\/doi.org\/10.1155\/2018\/6572381","journal-title":"Biomed Res Int"},{"key":"9120_CR16","doi-asserted-by":"publisher","unstructured":"Saavedra J, Novo D, Mesko M, Uchoa Vasconcellos AC, da Duarte Silva K, Rojas Zu\u00f1iga G, et al. (2022) Comparison of salivary electrolytes profile in oral potentially malignant disorders and oral squamous cell carcinoma. Asian Pacific J Cancer Prev 23:1031\u20139. https:\/\/doi.org\/10.31557\/APJCP.2022.23.3.1031","DOI":"10.31557\/APJCP.2022.23.3.1031"},{"key":"9120_CR17","doi-asserted-by":"publisher","first-page":"146","DOI":"10.4103\/0973-1482.137973","volume":"11","author":"S Shetty","year":"2015","unstructured":"Shetty S, Babu S, Kumari S, Shetty P, Hegde S, Karikal A (2015) Status of trace elements in saliva of oral precancer and oral cancer patients. J Cancer Res Ther 11:146. https:\/\/doi.org\/10.4103\/0973-1482.137973","journal-title":"J Cancer Res Ther"},{"key":"9120_CR18","doi-asserted-by":"publisher","first-page":"e76","DOI":"10.4317\/medoral.21395","volume":"22","author":"C Cotomacio","year":"2017","unstructured":"Cotomacio C, Campos L, Sim\u00f5es A, Jaguar G, Crosato EM, Alves F (2017) Influence of bethanechol on salivary parameters in irradiated patients. Med Oral Patol Oral Cir Bucal 22:e76\u201383. https:\/\/doi.org\/10.4317\/medoral.21395","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"9120_CR19","doi-asserted-by":"publisher","first-page":"105783","DOI":"10.1016\/j.oraloncology.2022.105783","volume":"127","author":"A Lin","year":"2022","unstructured":"Lin A, Helgeson ES, Treister NS, Schmidt BL, Patton LL, Elting LS et al (2022) The impact of head and neck radiotherapy on salivary flow and quality of life: results of the ORARAD study. Oral Oncol 127:105783. https:\/\/doi.org\/10.1016\/j.oraloncology.2022.105783","journal-title":"Oral Oncol"},{"key":"9120_CR20","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.oraloncology.2006.01.013","volume":"43","author":"BC Jham","year":"2007","unstructured":"Jham BC, Teixeira IV, Aboud CG, Carvalho AL, de Coelho MM, da Freire ARS (2007) A randomized phase III prospective trial of bethanechol to prevent radiotherapy-induced salivary gland damage in patients with head and neck cancer. Oral Oncol 43:137\u201342. https:\/\/doi.org\/10.1016\/j.oraloncology.2006.01.013","journal-title":"Oral Oncol"},{"key":"9120_CR21","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.radonc.2015.03.017","volume":"115","author":"GC Jaguar","year":"2015","unstructured":"Jaguar GC, Lima ENP, Kowalski LP, Pellizzon AC, Carvalho AL, Boccaletti KW et al (2015) Double-blind randomized prospective trial of bethanechol in the prevention of radiation-induced salivary gland dysfunction in head and neck cancer patients. Radiother Oncol 115:253\u20136. https:\/\/doi.org\/10.1016\/j.radonc.2015.03.017","journal-title":"Radiother Oncol"},{"key":"9120_CR22","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1080\/14764172.2017.1376097","volume":"20","author":"WA Gonz\u00e1lez-Arriagada","year":"2018","unstructured":"Gonz\u00e1lez-Arriagada WA, Ramos LMA, Andrade MAC, Lopes MA (2018) Efficacy of low-level laser therapy as an auxiliary tool for management of acute side effects of head and neck radiotherapy. J Cosmet Laser Ther 20:117\u201322. https:\/\/doi.org\/10.1080\/14764172.2017.1376097","journal-title":"J Cosmet Laser Ther"},{"key":"9120_CR23","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1089\/pho.2017.4325","volume":"36","author":"BL Brzak","year":"2018","unstructured":"Brzak BL, Cigi\u0107 L, Bari\u010devi\u0107 M, Sabol I, Mravak-Stipeti\u0107 M, Risovi\u0107 D (2018) Different protocols of photobiomodulation therapy of hyposalivation. Photomed Laser Surg 36:78\u201382. https:\/\/doi.org\/10.1089\/pho.2017.4325","journal-title":"Photomed Laser Surg"},{"key":"9120_CR24","doi-asserted-by":"publisher","first-page":"103115","DOI":"10.1016\/j.critrevonc.2020.103115","volume":"156","author":"GC Louzeiro","year":"2020","unstructured":"Louzeiro GC, da Teixeira DS, Cherubini K, Figueiredo MAZ, Salum FG, de Figueiredo MAZ et al (2020) Does laser photobiomodulation prevent hyposalivation in patients undergoing head and neck radiotherapy? A systematic review and meta-analysis of controlled trials. Crit Rev Oncol Hematol 156:103115. https:\/\/doi.org\/10.1016\/j.critrevonc.2020.103115","journal-title":"Crit Rev Oncol Hematol"},{"key":"9120_CR25","doi-asserted-by":"publisher","first-page":"2825","DOI":"10.1200\/JCO.21.01208","volume":"39","author":"V Mercadante","year":"2021","unstructured":"Mercadante V, Jensen SB, Smith DK, Bohlke K, Bauman J, Brennan MT et al (2021) Salivary gland hypofunction and\/or xerostomia induced by nonsurgical cancer therapies: ISOO\/MASCC\/ASCO guideline. J Clin Oncol 39:2825\u201343. https:\/\/doi.org\/10.1200\/JCO.21.01208","journal-title":"J Clin Oncol"},{"key":"9120_CR26","doi-asserted-by":"publisher","unstructured":"Schepanski N, Costa FS, Machado EFM, Pacheco MN, Amaral CDB, Machado RC et al (2023) Evaluation of photobiomodulation therapy (PBMT) on salivary flow and composition in head and neck cancer patients undergoing radiation therapy. Oral Surg Oral Med Oral Pathol Oral Radiol\u00a0137(3):253\u2013263. https:\/\/doi.org\/10.1016\/j.oooo.2023.11.007","DOI":"10.1016\/j.oooo.2023.11.007"},{"key":"9120_CR27","doi-asserted-by":"publisher","first-page":"459","DOI":"10.4103\/jomfp.JOMFP_72_16","volume":"21","author":"M Kavitha","year":"2017","unstructured":"Kavitha M, Mubeen K, Vijayalakshmi K (2017) A study on evaluation of efficacy of bethanechol in the management of chemoradiation-induced xerostomia in oral cancer patients. J Oral Maxillofac Pathol 21:459\u201360. https:\/\/doi.org\/10.4103\/jomfp.JOMFP_72_16","journal-title":"J Oral Maxillofac Pathol"},{"key":"9120_CR28","doi-asserted-by":"publisher","unstructured":"Palma LF, Gonnelli FAS, Marcucci M, Dias RS, Giordani AJ, Segreto RA et al (2017) Impact of low-level laser therapy on hyposalivation, salivary pH, and quality of life in head and neck cancer patients post-radiotherapy. Lasers Med Sci 32:827\u2013832. https:\/\/doi.org\/10.1007\/s10103-017-2180-3","DOI":"10.1007\/s10103-017-2180-3"},{"key":"9120_CR29","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1590\/S0036-36341997000500006.","volume":"39","author":"JA Banderas-Tarabay","year":"1997","unstructured":"Banderas-Tarabay JA, Gonz\u00e1lez-Begn\u00e9 M, S\u00e1nchez-Gardu\u00f1o M, Mill\u00e1n-Cort\u00e9z E, L\u00f3pez-Rodr\u00edguez A, Vilchis-Vel\u00e1zquez A. (1997) Flujo y concentracion de proteinas en saliva total humana. Salud Publica Mex 39:433\u201341. https:\/\/doi.org\/10.1590\/S0036-36341997000500006","journal-title":"Salud Publica Mex"},{"key":"9120_CR30","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/S0360-3016(01)01512-7.","volume":"50","author":"A Eisbruch","year":"2001","unstructured":"Eisbruch A, Kim HM, Terrell JE, Marsh LH, Dawson LA, Ship JA (2001) Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer. Int J Radiat Oncol Biol Phys 50:695\u2013704. https:\/\/doi.org\/10.1016\/S0360-3016(01)01512-7","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"9120_CR31","unstructured":"INMETRO (2020) Orienta\u00e7\u00e3o sobre valida\u00e7\u00e3o de M\u00e9todos Anal\u00edticos. 7o ed. Rio de Janeiro, Brasil: Instituto Nacional de Metrologia, Qualidade e Tecnologia"},{"key":"9120_CR32","doi-asserted-by":"publisher","unstructured":"AOAC (2023) Appendix F \u2013 Guidelines for Standard Method Performance Requirements. In: Latimer GW Jr (ed) Official Methods of Analysis of AOAC International, Rockville. Oxford University Press, New York. https:\/\/doi.org\/10.1093\/9780197610145.005.006","DOI":"10.1093\/9780197610145.005.006"},{"key":"9120_CR33","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1080\/10934521003595290.","volume":"45","author":"A Astel","year":"2010","unstructured":"Astel A, Nikolov M, Christov V, Simeonova P, Simeonov V (2010) Chemometric assessment of clinical data for diabetes mellitus 2 ype patients using self-organizing maps. J Environ Sci Heal Part A 45:560\u2013568. https:\/\/doi.org\/10.1080\/10934521003595290","journal-title":"J Environ Sci Heal Part A"},{"issue":"60","key":"9120_CR34","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.neucom.2014.02.061.","volume":"147","author":"T Vatanen","year":"2015","unstructured":"Vatanen T, Osmala M, Raiko T, Lagus K, Sysi-Aho M, Ore\u0161i\u010d M et al (2015) Self-organization and missing values in SOM and GTM. Neurocomputing 147:60\u201370. https:\/\/doi.org\/10.1016\/j.neucom.2014.02.061","journal-title":"Neurocomputing"},{"key":"9120_CR35","doi-asserted-by":"publisher","first-page":"111","DOI":"10.3233\/IDA-1999-3203.","volume":"3","author":"J Vesanto","year":"1999","unstructured":"Vesanto J (1999) SOM-based data visualization methods. Intell Data Anal 3:111\u2013126. https:\/\/doi.org\/10.3233\/IDA-1999-3203","journal-title":"Intell Data Anal"},{"key":"9120_CR36","unstructured":"Vatanen T (2012) Self-Organizing Map algorithm (SOM Toolbox 2.1)"},{"key":"9120_CR37","unstructured":"Vesanto J, Himberg J, Alhoniemi E, Parhankangas J (1999) Self-organizing map in Matlab: The SOM Toolbox. In: Matlab DSP\u00a0Conference 1999, Espoo, Finland, November 16-17, 1999, pp 35\u201340"},{"key":"9120_CR38","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1016\/S0140-6736(08)60728-X.","volume":"371","author":"A Argiris","year":"2021","unstructured":"Argiris A, Karamouzis M V, Raben D, Ferris RL (2008) Head and neck cancer. Lancet 371:1695\u2013709. https:\/\/doi.org\/10.1016\/S0140-6736(08)60728-X","journal-title":"Lancet"},{"key":"9120_CR39","doi-asserted-by":"publisher","first-page":"105451","DOI":"10.1016\/j.oraloncology.2021.105451.","volume":"121","author":"A Chamoli","year":"2021","unstructured":"Chamoli A, Gosavi AS, Shirwadkar UP, Wangdale K V, Behera SK, Kurrey NK et al (2021) Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics. Oral Oncol 121:105451. https:\/\/doi.org\/10.1016\/j.oraloncology.2021.105451","journal-title":"Oral Oncol"},{"key":"9120_CR40","doi-asserted-by":"publisher","unstructured":"Deasy JO, Moiseenko V, Marks L, Chao KSC, Nam J, Eisbruch A (2010) Radiotherapy dose-volume effects on salivary gland function. Int J Radiat Oncol Biol Phys 76:S58\u2013S63. https:\/\/doi.org\/10.1016\/j.ijrobp.2009.06.090","DOI":"10.1016\/j.ijrobp.2009.06.090"},{"key":"9120_CR41","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1111\/joor.12664.","volume":"45","author":"AML Pedersen","year":"2018","unstructured":"Pedersen AML, S\u00f8rensen CE, Proctor GB, Carpenter GH, Ekstr\u00f6m J. (2018) Salivary secretion in health and disease. J Oral Rehabil 45:730\u2013746. https:\/\/doi.org\/10.1111\/joor.12664","journal-title":"J Oral Rehabil"},{"key":"9120_CR42","doi-asserted-by":"publisher","unstructured":"Cronshaw M, Parker S, Anagnostaki E, Mylona V, Lynch E, Grootveld M (2020) Photobiomodulation dose parameters in dentistry: a systematic review and meta-analysis. Dent J (Basel) 8(4):114. https:\/\/doi.org\/10.3390\/dj8040114","DOI":"10.3390\/dj8040114"},{"key":"9120_CR43","doi-asserted-by":"publisher","unstructured":"Robijns J, Nair RG, Lodewijckx J, Arany P, Barasch A, Bjordal JM et al (2022) Photobiomodulation therapy in management of cancer therapy-induced side effects: WALT position paper 2022. Front Oncol 12. https:\/\/doi.org\/10.3389\/fonc.2022.927685","DOI":"10.3389\/fonc.2022.927685"},{"key":"9120_CR44","doi-asserted-by":"publisher","unstructured":"Ribeiro LN, Lima MH, Carvalho AT, Albuquerque RF, Le\u00e3o JC, Silva IH (2021) Evaluation of the salivary function of patients in treatment with radiotherapy for head and neck cancer submitted to photobiomodulation. Med Oral Patol Oral y Cir Bucal 26:e14\u2013e20. https:\/\/doi.org\/10.4317\/medoral.23912","DOI":"10.4317\/medoral.23912"},{"key":"9120_CR45","doi-asserted-by":"publisher","unstructured":"Uwitonze AM, Ojeh N, Murererehe J, Atfi A, Razzaque MS (2020) Zinc adequacy is essential for the maintenance of optimal oral health. Nutrients 12:949. https:\/\/doi.org\/10.3390\/nu12040949","DOI":"10.3390\/nu12040949"},{"key":"9120_CR46","doi-asserted-by":"publisher","unstructured":"Assis ALEM, Archanjo AB, Maranh\u00e3o RC, Mendes SO, de Souza RP, de Cicco R et al (2021) Chlorine, chromium, proteins of oxidative stress and DNA repair pathways are related to prognosis in oral cancer. Sci Rep 11:22314. https:\/\/doi.org\/10.1038\/s41598-021-01753-x","DOI":"10.1038\/s41598-021-01753-x"},{"key":"9120_CR47","doi-asserted-by":"publisher","unstructured":"Archanjo AB, Assis ALEM de, Oliveira MM de, Mendes SO, Bor\u00e7oi AR, Maia L de L et al (2020) Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival. Sci Rep 10:10382. https:\/\/doi.org\/10.1038\/s41598-020-67270-5","DOI":"10.1038\/s41598-020-67270-5"},{"key":"9120_CR48","doi-asserted-by":"publisher","first-page":"109715","DOI":"10.1016\/j.radonc.2023.109715.","volume":"186","author":"D Nakamura","year":"2023","unstructured":"Nakamura D, Pinto H, Elchin C, Berard L, Alves F, Antunes L et al (2023) Efficacy of bethanechol chloride in the treatment of radiation-induced xerostomia in patients with head and neck cancer: a systematic review and meta-analysis. Radiother Oncol 186:109715. https:\/\/doi.org\/10.1016\/j.radonc.2023.109715","journal-title":"Radiother Oncol"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-024-09120-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-024-09120-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-024-09120-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:42:21Z","timestamp":1739493741000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-024-09120-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,18]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["9120"],"URL":"https:\/\/doi.org\/10.1007\/s00520-024-09120-y","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4650778\/v1","asserted-by":"object"}]},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,18]]},"assertion":[{"value":"27 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Human Research Ethics Committee of Hospital Erasto Gaertner (No. 4-931-012). Informed consent for study participation was obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"113"}}