{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T07:34:44Z","timestamp":1776497684300,"version":"3.51.2"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100019727","name":"Japan Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019727","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1007\/s00520-024-09128-4","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T18:48:19Z","timestamp":1735584499000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of radiotherapy-related late toxicities of skin and soft tissue in the neck on quality of life in head and neck cancer patients: a multi-institutional observational study in Japan"],"prefix":"10.1007","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8153-1836","authenticated-orcid":false,"given":"Takuya","family":"Higashino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Wakabayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadamoto","family":"Zenda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshichika","family":"Yasunaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Araki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Mukaigawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuro","family":"Onitsuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsumori","family":"Hamahata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keigo","family":"Narita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Arikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Takanari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Kadota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Yanagisawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Kimata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shimpei","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Sakuraba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichiro","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunobu","family":"Terao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuo","family":"Hyodo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiro","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotaro","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,30]]},"reference":[{"key":"9128_CR1","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.anl.2017.02.004","volume":"44","author":"KI Nibu","year":"2017","unstructured":"Nibu KI, Hayashi R, Asakage T, Ojiri H, Kimata Y, Kodaira T et al (2017) Japanese clinical practice guideline for head and neck cancer. Auris Nasus Larynx 44:375\u2013380. https:\/\/doi.org\/10.1016\/j.anl.2017.02.004","journal-title":"Auris Nasus Larynx"},{"key":"9128_CR2","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/s0360-3016(01)01690-x","volume":"51","author":"KK Ang","year":"2001","unstructured":"Ang KK, Trotti A, Brown BW, Garden AS, Foote RL, Morrison WH et al (2001) Randomized trial addressing risk features and time factors of surgery plus radiotherapy in advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys 51:571\u2013578. https:\/\/doi.org\/10.1016\/s0360-3016(01)01690-x","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"9128_CR3","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1053\/j.seminoncol.2019.07.002","volume":"46","author":"D Alterio","year":"2019","unstructured":"Alterio D, Marvaso G, Ferrari A, Volpe S, Orecchia R, Jereczek-Fossa BA (2019) Modern radiotherapy for head and neck cancer. Semin Oncol 46:233\u2013245. https:\/\/doi.org\/10.1053\/j.seminoncol.2019.07.002","journal-title":"Semin Oncol"},{"key":"9128_CR4","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1186\/s12885-018-4119-x","volume":"18","author":"C Narvaez","year":"2018","unstructured":"Narvaez C, Doemer C, Idel C, Setter C, Olbrich D, Ujmajuridze Z et al (2018) Radiotherapy related skin toxicity (RAREST-01): Mepitel\u00ae film versus standard care in patients with locally advanced head-and-neck cancer. BMC Cancer 18:197. https:\/\/doi.org\/10.1186\/s12885-018-4119-x","journal-title":"BMC Cancer"},{"key":"9128_CR5","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/s0360-3016(02)03819-1","volume":"55","author":"F Denis","year":"2003","unstructured":"Denis F, Garaud P, Bardet E, Alfonsi M, Sire C, Germain T et al (2003) Late toxicity results of the GORTEC 94\u201301 randomized trial comparing radiotherapy with concomitant radiochemotherapy for advanced-stage oropharynx carcinoma: comparison of LENT\/SOMA, RTOG\/EORTC, and NCI-CTC scoring systems. Int J Radiat Oncol Biol Phys 55:93\u201398. https:\/\/doi.org\/10.1016\/s0360-3016(02)03819-1","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"9128_CR6","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.oraloncology.2010.03.005","volume":"46","author":"SA Bhide","year":"2010","unstructured":"Bhide SA, Nutting CM (2010) Advances in radiotherapy for head and neck cancer. Oral Oncol 46:439\u2013441. https:\/\/doi.org\/10.1016\/j.oraloncology.2010.03.005","journal-title":"Oral Oncol"},{"key":"9128_CR7","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1016\/S1470-2045(23)00265-6","volume":"24","author":"C Nutting","year":"2023","unstructured":"Nutting C, Finneran L, Roe J, Sydenham MA, Beasley M, Bhide S et al (2023) Dysphagia-optimised intensity-modulated radiotherapy versus standard intensity-modulated radiotherapy in patients with head and neck cancer (DARS): a phase 3, multicentre, randomised, controlled trial. Lancet Oncol 24:868\u2013880. https:\/\/doi.org\/10.1016\/S1470-2045(23)00265-6","journal-title":"Lancet Oncol"},{"key":"9128_CR8","doi-asserted-by":"publisher","first-page":"9173729","DOI":"10.1155\/2019\/9173729","volume":"2019","author":"F De Felice","year":"2019","unstructured":"De Felice F, Tombolini V, Valentini V, de Vincentiis M, Mezi S, Brugnoletti O et al (2019) Advances in the management of HPV-related oropharyngeal cancer. J Oncol 2019:9173729. https:\/\/doi.org\/10.1155\/2019\/9173729","journal-title":"J Oncol"},{"key":"9128_CR9","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.oooo.2016.01.007","volume":"122","author":"F De Felice","year":"2016","unstructured":"De Felice F, Thomas C, Patel V, Connor S, Michaelidou A, Sproat C et al (2016) Osteoradionecrosis following treatment for head and neck cancer and the effect of radiotherapy dosimetry: the guy\u2019s and St Thomas\u2019 head and neck cancer unit experience. Oral Surg Oral Med Oral Pathol Oral Radiol 122:28\u201334. https:\/\/doi.org\/10.1016\/j.oooo.2016.01.007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"9128_CR10","doi-asserted-by":"publisher","first-page":"3691","DOI":"10.1002\/cncr.30803","volume":"123","author":"F Caparrotti","year":"2017","unstructured":"Caparrotti F, Huang SH, Lu L, Bratman SV, Ringash J, Bayley A et al (2017) Osteoradionecrosis of the mandible in patients with oropharyngeal carcinoma treated with intensity-modulated radiotherapy. Cancer 123:3691\u20133700. https:\/\/doi.org\/10.1002\/cncr.30803","journal-title":"Cancer"},{"key":"9128_CR11","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.semradonc.2006.11.008","volume":"17","author":"J Brush","year":"2007","unstructured":"Brush J, Lipnick SL, Phillips T, Sitko J, McDonald JT, McBride WH (2007) Molecular mechanisms of late normal tissue injury. Semin Radiat Oncol 17:121\u2013130. https:\/\/doi.org\/10.1016\/j.semradonc.2006.11.008","journal-title":"Semin Radiat Oncol"},{"key":"9128_CR12","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1097\/01.prs.0000256047.47909.71","volume":"119","author":"G Rigotti","year":"2007","unstructured":"Rigotti G, Marchi A, Galie M, Baroni G, Benati D, Krampera M et al (2007) Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cells. Plast Reconstr Surg 119:1409\u20131422. https:\/\/doi.org\/10.1097\/01.prs.0000256047.47909.71","journal-title":"Plast Reconstr Surg"},{"key":"9128_CR13","doi-asserted-by":"publisher","first-page":"S59","DOI":"10.1097\/sap.0000000000002098","volume":"83","author":"MR Borrelli","year":"2019","unstructured":"Borrelli MR, Shen AH, Lee GK, Momeni A, Longaker MT, Wan DC (2019) Radiation-induced skin fibrosis. Ann Plast Surg 83:S59\u2013S64. https:\/\/doi.org\/10.1097\/sap.0000000000002098","journal-title":"Ann Plast Surg"},{"key":"9128_CR14","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1097\/PRS.0000000000007705","volume":"147","author":"EM Kenny","year":"2021","unstructured":"Kenny EM, Egro FM, Ejaz A, Coleman SR, Greenberger JS, Rubin JP (2021) Fat grafting in radiation-induced soft-tissue injury: a narrative review of the clinical evidence and implications for future studies. Plast Reconstr Surg 147:819\u2013838. https:\/\/doi.org\/10.1097\/PRS.0000000000007705","journal-title":"Plast Reconstr Surg"},{"key":"9128_CR15","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1089\/wound.2022.0103","volume":"13","author":"CE Berry","year":"2024","unstructured":"Berry CE, Abbas DB, Lintel HA, Churukian AA, Griffin M, Guo JL et al (2024) Adipose-derived stromal cell-based therapies for radiation-induced fibrosis. Adv Wound Care 13:235\u2013252. https:\/\/doi.org\/10.1089\/wound.2022.0103","journal-title":"Adv Wound Care"},{"key":"9128_CR16","doi-asserted-by":"publisher","first-page":"127","DOI":"10.15430\/jcp.2016.21.3.127","volume":"21","author":"H Yoon","year":"2016","unstructured":"Yoon H, Sohn M, Jung M (2016) Media use and the cancer communication strategies of cancer survivors. J Cancer Prev 21:127\u2013134. https:\/\/doi.org\/10.15430\/jcp.2016.21.3.127","journal-title":"J Cancer Prev"},{"key":"9128_CR17","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.maturitas.2017.05.012","volume":"105","author":"N Mourouti","year":"2017","unstructured":"Mourouti N, Panagiotakos DB, Kotteas EA, Syrigos KN (2017) Optimizing diet and nutrition for cancer survivors: a review. Maturitas 105:33\u201336. https:\/\/doi.org\/10.1016\/j.maturitas.2017.05.012","journal-title":"Maturitas"},{"key":"9128_CR18","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1097\/cco.0000000000000376","volume":"29","author":"PV Viscuse","year":"2017","unstructured":"Viscuse PV, Price K, Millstine D, Bhagra A, Bauer B, Ruddy KJ (2017) Integrative medicine in cancer survivors. Curr Opin Oncol 29:235\u2013242. https:\/\/doi.org\/10.1097\/cco.0000000000000376","journal-title":"Curr Opin Oncol"},{"key":"9128_CR19","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s00405-007-0561-0","volume":"265","author":"E Babin","year":"2008","unstructured":"Babin E, Sigston E, Hitier M, Dehesdin D, Marie JP, Choussy O (2008) Quality of life in head and neck cancers patients: predictive factors, functional and psychosocial outcome. Eur Arch Otorhinolaryngol 265:265\u2013270. https:\/\/doi.org\/10.1007\/s00405-007-0561-0","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"9128_CR20","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.cps.2012.10.002","volume":"40","author":"S Malay","year":"2013","unstructured":"Malay S, Chung KC (2013) How to use outcomes questionnaires: pearls and pitfalls. Clin Plast Surg 40:261\u2013269. https:\/\/doi.org\/10.1016\/j.cps.2012.10.002","journal-title":"Clin Plast Surg"},{"key":"9128_CR21","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s12955-024-02312-4","volume":"22","author":"JM Bonsel","year":"2024","unstructured":"Bonsel JM, Itiola AJ, Huberts AS, Bonsel GJ, Penton H (2024) The use of patient-reported outcome measures to improve patient-related outcomes - a systematic review. Health Qual Life Outcomes 22:101. https:\/\/doi.org\/10.1186\/s12955-024-02312-4","journal-title":"Health Qual Life Outcomes"},{"key":"9128_CR22","doi-asserted-by":"publisher","first-page":"108S","DOI":"10.1097\/01.prs.0000234610.81672.e7","volume":"118","author":"SR Coleman","year":"2006","unstructured":"Coleman SR (2006) Structural fat grafting: more than a permanent filler. Plast Reconstr Surg 118:108S-120S. https:\/\/doi.org\/10.1097\/01.prs.0000234610.81672.e7","journal-title":"Plast Reconstr Surg"},{"key":"9128_CR23","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1097\/PRS.0b013e31819f2928","volume":"123","author":"B Phulpin","year":"2009","unstructured":"Phulpin B, Gangloff P, Tran N, Bravetti P, Merlin JL, Dolivet G (2009) Rehabilitation of irradiated head and neck tissues by autologous fat transplantation. Plast Reconstr Surg 123:1187\u20131197. https:\/\/doi.org\/10.1097\/PRS.0b013e31819f2928","journal-title":"Plast Reconstr Surg"},{"key":"9128_CR24","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1007\/s00455-010-9293-1","volume":"26","author":"V Navach","year":"2010","unstructured":"Navach V, Calabrese LS, Zurlo V, Alterio D, Funicelli L, Giugliano G (2010) Functional base of tongue fat injection in a patient with severe postradiation dysphagia. Dysphagia 26:196\u2013199. https:\/\/doi.org\/10.1007\/s00455-010-9293-1","journal-title":"Dysphagia"},{"key":"9128_CR25","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.jcms.2016.10.019","volume":"45","author":"J Gutierrez Santamaria","year":"2017","unstructured":"Gutierrez Santamaria J, MasiaGridilla J, Pamias Romero J, Giralt Lopez-de-Sagredo J, BescosAtin MS (2017) Fat grafting is a feasible technique for the sequelae of head and neck cancer treatment. J Craniomaxillofac Surg 45:93\u201398. https:\/\/doi.org\/10.1016\/j.jcms.2016.10.019","journal-title":"J Craniomaxillofac Surg"},{"key":"9128_CR26","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1097\/PRS.0000000000004686","volume":"142","author":"RJ Karmali","year":"2018","unstructured":"Karmali RJ, Hanson SE, Nguyen AT, Skoracki RJ, Hanasono MM (2018) Outcomes following autologous fat grafting for oncologic head and neck reconstruction. Plast Reconstr Surg 142:771\u2013780. https:\/\/doi.org\/10.1097\/PRS.0000000000004686","journal-title":"Plast Reconstr Surg"},{"key":"9128_CR27","doi-asserted-by":"publisher","first-page":"3647","DOI":"10.1002\/hed.25888","volume":"41","author":"MF Griffin","year":"2019","unstructured":"Griffin MF, Drago J, Almadori A, Kalavrezos N, Butler PE (2019) Evaluation of the efficacy of lipotransfer to manage radiation-induced fibrosis and volume defects in head and neck oncology. Head Neck 41:3647\u20133655. https:\/\/doi.org\/10.1002\/hed.25888","journal-title":"Head Neck"},{"key":"9128_CR28","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1056\/NEJMoa0912217","volume":"363","author":"KK Ang","year":"2010","unstructured":"Ang KK, Harris J, Wheeler R, Weber R, Rosenthal DI, Nguyen-Tan PF et al (2010) Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 363:24\u201335. https:\/\/doi.org\/10.1056\/NEJMoa0912217","journal-title":"N Engl J Med"},{"key":"9128_CR29","doi-asserted-by":"publisher","first-page":"2940","DOI":"10.1200\/JCO.2013.53.5633","volume":"32","author":"KK Ang","year":"2014","unstructured":"Ang KK, Zhang Q, Rosenthal DI, Nguyen-Tan PF, Sherman EJ, Weber RS et al (2014) Randomized phase III trial of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III to IV head and neck carcinoma: RTOG 0522. J Clin Oncol 32:2940\u20132950. https:\/\/doi.org\/10.1200\/JCO.2013.53.5633","journal-title":"J Clin Oncol"},{"key":"9128_CR30","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/s0360-3016(01)02735-3","volume":"52","author":"S Hirota","year":"2002","unstructured":"Hirota S, Tsujino K, Oshitani T, Hishikawa Y, Takada Y, Kono M et al (2002) Subcutaneous fibrosis after whole neck irradiation. Int J Radiat Oncol Biol Phys 52:937\u2013943. https:\/\/doi.org\/10.1016\/s0360-3016(01)02735-3","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"9128_CR31","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1016\/j.ejca.2012.04.005","volume":"48","author":"WK So","year":"2012","unstructured":"So WK, Chan RJ, Chan DN, Hughes BG, Chair SY, Choi KC et al (2012) Quality-of-life among head and neck cancer survivors at one year after treatment\u2013a systematic review. Eur J Cancer 48:2391\u20132408. https:\/\/doi.org\/10.1016\/j.ejca.2012.04.005","journal-title":"Eur J Cancer"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-024-09128-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-024-09128-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-024-09128-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T19:56:08Z","timestamp":1737402968000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-024-09128-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,30]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["9128"],"URL":"https:\/\/doi.org\/10.1007\/s00520-024-09128-4","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,30]]},"assertion":[{"value":"16 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"In accordance with the Declaration of Helsinki, the study protocol was approved by the National Cancer Center Institutional Review Board (2022\u2013214) on October 24, 2022, prior to the first inclusion in National Cancer Center Hospital East on November 14, 2022, and subsequently approved by all participating institutions. Ethical approval was obtained from institutional ethics boards before patient recruitment.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"64"}}