{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T02:23:20Z","timestamp":1785378200103,"version":"3.55.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1007\/s00520-025-09168-4","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T22:04:34Z","timestamp":1737151474000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Low-risk febrile neutropenia: does combined chemotherapy\/immune checkpoint inhibitor necessitate a change in approach?"],"prefix":"10.1007","volume":"33","author":[{"given":"Jamie M. J.","family":"Weaver","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bence","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Cooksley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,17]]},"reference":[{"issue":"3","key":"9168_CR1","doi-asserted-by":"publisher","first-page":"148","DOI":"10.52964\/AMJA.0720","volume":"17","author":"DS Lasserson","year":"2018","unstructured":"Lasserson DS, Harris C, Elias T, Bowen J et al (2018) What is the evidence base for ambulatory care for acute medical illness? Acute Med 17(3):148\u2013153","journal-title":"Acute Med"},{"issue":"380","key":"9168_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/bmj.p1","volume":"3","author":"T Cooksley","year":"2023","unstructured":"Cooksley T, Clarke S, Dean J et al (2023) NHS crisis: rebuilding the NHS needs urgent action. BMJ 3(380):1","journal-title":"BMJ"},{"key":"9168_CR3","unstructured":"Kelen G, Wolfe R, D\u2019Onofrio G et al (2021) Emergency department crowding: The Canary in the healthcare system. NEJM Catalyst"},{"issue":"11","key":"9168_CR4","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1001\/jamainternmed.2016.5974","volume":"176","author":"J Conley","year":"2016","unstructured":"Conley J, O\u2019Brien CW, Leff BA et al (2016) Alternative strategies to inpatient hospitalization for inpatient conditions: a systematic review. JAMA Intern Med 176(11):1693\u20131702","journal-title":"JAMA Intern Med"},{"issue":"380","key":"9168_CR5","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1136\/bmj.p343","volume":"17","author":"D Lasserson","year":"2023","unstructured":"Lasserson D, Cooksley T (2023) Virtual wards: urgent care policy must follow the evidence. BMJ 17(380):343","journal-title":"BMJ"},{"issue":"5","key":"9168_CR6","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1007\/s00520-015-3006-0","volume":"24","author":"C Font","year":"2016","unstructured":"Font C, Fernandez-Avil\u00e9s F, Calderon C et al (2016) Home management of acute medical complications in cancer patients. Support Care Cancer 24(5):2129\u20132137","journal-title":"Support Care Cancer"},{"issue":"1","key":"9168_CR7","doi-asserted-by":"publisher","first-page":"e13436","DOI":"10.1111\/ijcp.13436","volume":"74","author":"T Cooksley","year":"2020","unstructured":"Cooksley T, Marshall W, Ahn S et al (2020) Ambulatory emergency oncology: a key tenet for future emergency oncology care. Int J Clin Pract 74(1):e13436","journal-title":"Int J Clin Pract"},{"issue":"4","key":"9168_CR8","doi-asserted-by":"publisher","first-page":"266","DOI":"10.52964\/AMJA.0876","volume":"20","author":"S Gallier","year":"2021","unstructured":"Gallier S, Atkin C, Reddy-Kolanu V et al (2021) Applying a COVID Virtual Ward model, assessing patient outcomes and staff workload. Acute Med 20(4):266\u2013275","journal-title":"Acute Med"},{"issue":"3","key":"9168_CR9","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1080\/17512433.2021.1884067","volume":"14","author":"BL Rapoport","year":"2021","unstructured":"Rapoport BL, Cooksley T, Johnson DB et al (2021) Treatment of infections in cancer patients: an update from the neutropenia, infection and myelosuppression study group of the Multinational Association for Supportive Care in Cancer (MASCC). Expert Rev Clin Pharmacol 14(3):295\u2013313","journal-title":"Expert Rev Clin Pharmacol"},{"issue":"4","key":"9168_CR10","doi-asserted-by":"publisher","first-page":"178","DOI":"10.52964\/AMJA.0529","volume":"14","author":"T Cooksley","year":"2015","unstructured":"Cooksley T, Holland M, Klastersky J (2015) Ambulatory outpatient management of patients with low risk febrile neutropaenia. Acute Med 14(4):178\u2013181","journal-title":"Acute Med"},{"key":"9168_CR11","first-page":"199","volume":"6","author":"M Carstensen","year":"2008","unstructured":"Carstensen M, Sorensen J (2008) Outpatient management of febrile neutropenia: time to revise present treatment strategy. J Support Oncol 6:199\u2013208","journal-title":"J Support Oncol"},{"key":"9168_CR12","doi-asserted-by":"publisher","first-page":"2358","DOI":"10.1093\/annonc\/mdq745","volume":"22","author":"O Teuffel","year":"2011","unstructured":"Teuffel O, Ethier M, Alibhal S et al (2011) Outpatient management of cancer patients with febrile neutropenia: a systematic review and meta-analysis. Ann Oncol 22:2358\u20132365","journal-title":"Ann Oncol"},{"issue":"22","key":"9168_CR13","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1056\/NEJMoa1801005","volume":"378","author":"L Gandhi","year":"2018","unstructured":"Gandhi L, Rodr\u00edguez-Abreu D, Gadgeel S et al (2018) Pembrolizumab plus chemotherapy in metastatic non-small-cell lung cancer. N Engl J Med 378(22):2078\u20132092","journal-title":"N Engl J Med"},{"issue":"17","key":"9168_CR14","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1200\/JCO.23.01601","volume":"42","author":"YY Janjigian","year":"2024","unstructured":"Janjigian YY, Ajani JA, Moehler M et al (2024) First-line nivolumab plus chemotherapy for advanced gastric, gastroesophageal junction, and esophageal adenocarcinoma: 3-year follow-up of the phase III CheckMate 649 trial. J Clin Oncol 42(17):2012\u20132020","journal-title":"J Clin Oncol"},{"key":"9168_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s44201-021-00001-2","volume":"1","author":"KH Todd","year":"2022","unstructured":"Todd KH (2022) Emergency cancer care: inaugural editorial. Emerg Cancer Care 1:1","journal-title":"Emerg Cancer Care"},{"issue":"1","key":"9168_CR16","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00520-016-3470-1","volume":"25","author":"T Cooksley","year":"2017","unstructured":"Cooksley T, Rice T (2017) Emergency oncology: development, current position and future direction in the US and UK. Support Care Cancer 25(1):3\u20137","journal-title":"Support Care Cancer"},{"issue":"3","key":"9168_CR17","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.jemermed.2019.09.032","volume":"58","author":"W Marshall","year":"2020","unstructured":"Marshall W, Campbell G, Knight T et al (2020) Emergency ambulatory management of low-risk febrile neutropenia: multinational association for supportive care in cancer fits-real-world experience from a UK cancer center. J Emerg Med 58(3):444\u2013448","journal-title":"J Emerg Med"},{"issue":"3","key":"9168_CR18","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1007\/s00520-017-3921-3","volume":"26","author":"BW Teh","year":"2018","unstructured":"Teh BW, Brown C, Joyce T et al (2018) Safety and cost benefit of an ambulatory program for patients with low-risk neutropenic fever at an Australian centre. Support Care Cancer 26(3):997\u20131003","journal-title":"Support Care Cancer"},{"issue":"9","key":"9168_CR19","doi-asserted-by":"publisher","first-page":"2937","DOI":"10.1007\/s00520-018-4194-1","volume":"26","author":"T Cooksley","year":"2018","unstructured":"Cooksley T, Campbell G, Al-Sayed T et al (2018) A novel approach to improving ambulatory outpatient management of low risk febrile neutropenia: an Enhanced Supportive Care (ESC) Clinic. Support Care Cancer 26(9):2937\u20132940","journal-title":"Support Care Cancer"},{"issue":"1","key":"9168_CR20","doi-asserted-by":"publisher","first-page":"13","DOI":"10.52964\/AMJA.0742","volume":"18","author":"C Brunner","year":"2019","unstructured":"Brunner C, Botten J, Wennike N et al (2019) Early supported discharge for patients with febrile neutropenia: experience from a large district hospital in the UK. Acute Med 18(1):13\u201318","journal-title":"Acute Med"},{"issue":"1","key":"9168_CR21","doi-asserted-by":"publisher","first-page":"6","DOI":"10.52964\/AMJA.0740","volume":"18","author":"E Marshall","year":"2019","unstructured":"Marshall E (2019) Ambulatory management in low risk neutropenic sepsis - a plea for integrated acute cancer care. Acute Med 18(1):6\u20137","journal-title":"Acute Med"},{"issue":"3","key":"9168_CR22","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1056\/NEJMoa2202809","volume":"387","author":"J Cortes","year":"2022","unstructured":"Cortes J, Rugo HS, Cescon DW, Im SA et al (2022) KEYNOTE-355 investigators. Pembrolizumab plus chemotherapy in advanced triple-negative breast cancer. N Engl J Med 387(3):217\u2013226","journal-title":"N Engl J Med"},{"issue":"6","key":"9168_CR23","doi-asserted-by":"publisher","first-page":"501","DOI":"10.7861\/clinmedicine.12-6-501","volume":"12","author":"M Jones","year":"2012","unstructured":"Jones M (2012) NEWSDIG: The national early warning score development and implementation group. Clin Med 12(6):501\u2013503","journal-title":"Clin Med"},{"issue":"5","key":"9168_CR24","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1111\/cea.14134","volume":"52","author":"S Hammond","year":"2022","unstructured":"Hammond S, Olsson-Brown A, Grice S, Naisbitt DJ (2022) Does immune checkpoint inhibitor therapy increase the frequency of adverse reactions to concomitant medications? Clin Exp Allergy 52(5):600\u2013603","journal-title":"Clin Exp Allergy"},{"issue":"6","key":"9168_CR25","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/j.jgo.2019.12.016","volume":"11","author":"I Ortland","year":"2020","unstructured":"Ortland I, Mendel Ott M, Kowar M et al (2020) Comparing the performance of the CARG and the CRASH score for predicting toxicity in older patients with cancer. J Geriatr Oncol 11(6):997\u20131005. https:\/\/doi.org\/10.1016\/j.jgo.2019.12.016","journal-title":"J Geriatr Oncol"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-025-09168-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-025-09168-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-025-09168-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T05:42:33Z","timestamp":1739511753000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-025-09168-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,17]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["9168"],"URL":"https:\/\/doi.org\/10.1007\/s00520-025-09168-4","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,17]]},"assertion":[{"value":"23 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This is an observational study with no ethical approval required. Local institutional board number: 3180.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"112"}}