{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T18:12:30Z","timestamp":1788977550451,"version":"build-2803163510"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1007\/s00520-025-09191-5","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T23:57:57Z","timestamp":1738108677000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Oral microbiota in head and neck cancer patients during radiotherapy: a systematic review"],"prefix":"10.1007","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6673-2313","authenticated-orcid":false,"given":"Deise","family":"Kwiatkowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3366-2177","authenticated-orcid":false,"given":"Lauren Frenzel","family":"Schuch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7949-6971","authenticated-orcid":false,"given":"Nat\u00e1lia Mincato","family":"Klaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8662-5965","authenticated-orcid":false,"given":"Manoela Domingues","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2204-1634","authenticated-orcid":false,"given":"Juliana Balbinot","family":"Hilgert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5477-2768","authenticated-orcid":false,"given":"Lina Naomi","family":"Hashizume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"9191_CR1","doi-asserted-by":"publisher","unstructured":"Gharzai LA, Mierzwa ML, Peipert JD, Kirtane K, Casper K, Yadav P, Rothrock N, Cella D, Shaunfield S (2023) Monitoring Adverse Effects of Radiation Therapy in Patients With Head and Neck Cancer: The FACT-HN-RAD Patient-Reported Outcome Measure.\u00a0JAMA otolaryngology-- head & neck surgery\u00a0149(10): 884\u2013890. https:\/\/doi.org\/10.1001\/jamaoto.2023.2177","DOI":"10.1001\/jamaoto.2023.2177"},{"issue":"12","key":"9191_CR2","doi-asserted-by":"publisher","first-page":"2918","DOI":"10.1002\/cam4.1221","volume":"6","author":"HY Sroussi","year":"2017","unstructured":"Sroussi HY, Epstein JB, Bensadoun RJ, Saunders DP, Lalla RV, Migliorati CA, Heaivilin N, Zumsteg ZS (2017) Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease, and osteoradionecrosis. Cancer Med 6(12):2918\u20132931. https:\/\/doi.org\/10.1002\/cam4.1221","journal-title":"Cancer Med"},{"issue":"3","key":"9191_CR3","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/s41432-020-0119-1","volume":"21","author":"S Ara\u00fajo Andrade","year":"2020","unstructured":"Ara\u00fajo Andrade S (2020) Is there evidence that radiotherapy for head and neck cancer influences the incidence of dental caries? Evid Based Dent 21(3):116\u2013117. https:\/\/doi.org\/10.1038\/s41432-020-0119-1","journal-title":"Evid Based Dent"},{"issue":"10","key":"9191_CR4","doi-asserted-by":"publisher","first-page":"3594","DOI":"10.1002\/hed.25880","volume":"41","author":"M Baudelet","year":"2019","unstructured":"Baudelet M, Van den Steen L, Tomassen P, Bonte K, Deron P, Huvenne W, Rottey S, De Neve W, Sundahl N, Van Nuffelen G, Duprez F (2019) Very late xerostomia, dysphagia, and neck fibrosis after head and neck radiotherapy. Head Neck 41(10):3594\u20133603. https:\/\/doi.org\/10.1002\/hed.25880","journal-title":"Head Neck"},{"issue":"5","key":"9191_CR5","doi-asserted-by":"publisher","first-page":"425","DOI":"10.3290\/j.ohpd.a41364","volume":"16","author":"A Arrifin","year":"2018","unstructured":"Arrifin A, Heidari E, Burke M, Fenlon MR, Banerjee A (2018) The Effect of Radiotherapy for Treatment of Head and Neck Cancer on Oral Flora and Saliva. Oral Health Prev Dent 16(5):425\u2013429. https:\/\/doi.org\/10.3290\/j.ohpd.a41364","journal-title":"Oral Health Prev Dent"},{"issue":"4","key":"9191_CR6","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1177\/00220345750540040801","volume":"54","author":"LR Brown","year":"1975","unstructured":"Brown LR, Dreizen S, Handler S, Johnston DA (1975) Effect of radiation-induced xerostomia on human oral microflora. J Dent Res 54(4):740\u2013750. https:\/\/doi.org\/10.1177\/00220345750540040801","journal-title":"J Dent Res"},{"issue":"1","key":"9191_CR7","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.radonc.2018.04.023","volume":"129","author":"J Hou","year":"2018","unstructured":"Hou J, Zheng H, Li P, Liu H, Zhou H, Yang X (2018) Distinct shifts in the oral microbiota are associated with the progression and aggravation of mucositis during radiotherapy. Radiother Oncol 129(1):44\u201351. https:\/\/doi.org\/10.1016\/j.radonc.2018.04.023","journal-title":"Radiother Oncol"},{"issue":"2","key":"9191_CR8","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/0030-4220(91)90461-k","volume":"71","author":"JB Epstein","year":"1991","unstructured":"Epstein JB, McBride BC, Stevenson-Moore P, Merilees H, Spinelli J (1991) The efficacy of chlorhexidine gel in reduction of Streptococcus mutans and Lactobacillus species in patients treated with radiation therapy. Oral Surg Oral Med Oral Pathol 71(2):172\u2013178. https:\/\/doi.org\/10.1016\/0030-4220(91)90461-k","journal-title":"Oral Surg Oral Med Oral Pathol"},{"issue":"4","key":"9191_CR9","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1159\/000070868","volume":"37","author":"HC Tong","year":"2003","unstructured":"Tong HC, Gao XJ, Dong XZ (2003) Non-mutans streptococci in patients receiving radiotherapy in the head and neck area. Caries Res 37(4):261\u2013266. https:\/\/doi.org\/10.1159\/000070868","journal-title":"Caries Res"},{"issue":"6","key":"9191_CR10","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1159\/000088184","volume":"39","author":"L Meng","year":"2005","unstructured":"Meng L, Liu J, Peng B, Fan M, Nie M, Chen Z, Gan Y, Bian Z (2005) The persistence of Streptococcus mutans in nasopharyngeal carcinoma patients after radiotherapy. Caries Res 39(6):484\u2013489. https:\/\/doi.org\/10.1159\/000088184","journal-title":"Caries Res"},{"key":"9191_CR11","doi-asserted-by":"publisher","unstructured":"Meca LB, Souza FR, Tanimoto HM, Castro AL, Gaetti-Jardim J\u00fanior E (2009) Influence of preventive dental treatment on mutans streptococci counts in patients undergoing head and neck radiotherapy. J Appl Oral Sci 17 Suppl(spe):5\u201312. https:\/\/doi.org\/10.1590\/s1678-77572009000700003","DOI":"10.1590\/s1678-77572009000700003"},{"issue":"28","key":"9191_CR12","first-page":"156","volume":"12","author":"M Shrestha","year":"2014","unstructured":"Shrestha M, Boaz K, Srikant N, Shakya A (2014) An assessment of candidal colonization and species differentiation in head and neck cancer patients receiving radiation. J Nepal Health Res Counc 12(28):156\u2013161","journal-title":"J Nepal Health Res Counc"},{"issue":"3","key":"9191_CR13","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s00520-005-0895-3","volume":"14","author":"B Al-Nawas","year":"2006","unstructured":"Al-Nawas B, Gr\u00f6tz KA (2006) Prospective study of the long term change of the oral flora after radiation therapy. Support Care Cancer 14(3):291\u2013296. https:\/\/doi.org\/10.1007\/s00520-005-0895-3","journal-title":"Support Care Cancer"},{"key":"9191_CR14","doi-asserted-by":"publisher","first-page":"S61","DOI":"10.4103\/ijmpo.ijmpo_247_17","volume":"40","author":"V Fotedar","year":"2019","unstructured":"Fotedar V, Ganju S, Fotedar S, Thakur P, Sharma A, Bhardwaj V (2019) Oral microflora among oral cancer patients undergoing radiotherapy in regional cancer center, Indira Gandhi Medical College, Shimla. Indian J Med Paediatr Oncol 40:S61\u2013S64. https:\/\/doi.org\/10.4103\/ijmpo.ijmpo_247_17","journal-title":"Indian J Med Paediatr Oncol"},{"issue":"6","key":"9191_CR15","doi-asserted-by":"publisher","first-page":"2683","DOI":"10.1007\/s00520-019-05084-6","volume":"28","author":"A Vesty","year":"2020","unstructured":"Vesty A, Gear K, Biswas K, Mackenzie BW, Taylor MW, Douglas RG (2020) Oral microbial influences on oral mucositis during radiotherapy treatment of head and neck cancer. Support Care Cancer 28(6):2683\u20132691. https:\/\/doi.org\/10.1007\/s00520-019-05084-6","journal-title":"Support Care Cancer"},{"issue":"2","key":"9191_CR16","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/j.1601-0825.2011.01851.x","volume":"18","author":"MF Zarco","year":"2012","unstructured":"Zarco MF, Vess TJ, Ginsburg GS (2012) The oral microbiome in health and disease and the potential impact on personalized dental medicine. Oral Dis 18(2):109\u2013120. https:\/\/doi.org\/10.1111\/j.1601-0825.2011.01851.x","journal-title":"Oral Dis"},{"key":"9191_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2021.105906","volume":"88","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. Int J Surg 88:105906. https:\/\/doi.org\/10.1016\/j.ijsu.2021.105906","journal-title":"Int J Surg"},{"key":"9191_CR18","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/j.envint.2018.07.015","volume":"121","author":"RL Morgan","year":"2018","unstructured":"Morgan RL, Whaley P, Thayer KA, Sch\u00fcnemann HJ (2018) Identifying the PECO: A framework for formulating good questions to explore the association of environmental and other exposures with health outcomes. Environ Int 121:1027\u20131031. https:\/\/doi.org\/10.1016\/j.envint.2018.07.015","journal-title":"Environ Int"},{"key":"9191_CR19","unstructured":"National Institutes of Health (2021). Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. Updated July, 2021. Accessed January 10, 2022. Available from: https:\/\/www.nhlbi.nih.gov\/health-topics\/study-quality-assessment-tools"},{"key":"9191_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2020.104876","volume":"119","author":"G Eidt","year":"2020","unstructured":"Eidt G, Waltermann EDM, Hilgert JB, Arthur RA (2020) Candida and dental caries in children, adolescents and adults: A systematic review and meta-analysis. Arch Oral Biol 119:104876. https:\/\/doi.org\/10.1016\/j.archoralbio.2020.104876","journal-title":"Arch Oral Biol"},{"issue":"6","key":"9191_CR21","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/0030-4220(87)90171-x","volume":"64","author":"KM Rossie","year":"1987","unstructured":"Rossie KM, Taylor J, Beck FM, Hodgson SE, Blozis GG (1987) Influence of radiation therapy on oral Candida albicans colonization: a quantitative assessment. Oral Surg Oral Med Oral Pathol 64(6):698\u2013701. https:\/\/doi.org\/10.1016\/0030-4220(87)90171-x","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"9191_CR22","doi-asserted-by":"publisher","unstructured":"Gr\u00f6tz KA, Genitsariotis S, Vehling D, Al-Nawas B (2003) Long-term oral Candida colonization, mucositis and salivary function after head and neck radiotherapy. Support Care Cancer 11(11):717\u2013721.\u00a0https:\/\/doi.org\/10.1007\/s00520-003-0506-0\u00a0","DOI":"10.1007\/s00520-003-0506-0"},{"issue":"8","key":"9191_CR23","doi-asserted-by":"publisher","first-page":"929","DOI":"10.5005\/jp-journals-10024-2359","volume":"19","author":"S Kapoor","year":"2018","unstructured":"Kapoor S, Daveshwar SR, Sheth K, Daveshwar MR, Batra R, Agrawal V (2018) Effect of Radiotherapy on Cariogenic Organism Streptococcus sobrinus in Saliva in Head and Neck Cancer: A Clinical Study. J Contemp Dent Pract 19(8):929\u2013932","journal-title":"J Contemp Dent Pract"},{"issue":"2","key":"9191_CR24","doi-asserted-by":"publisher","first-page":"91","DOI":"10.4103\/ijabmr.IJABMR_151_19","volume":"10","author":"SR Daveshwar","year":"2020","unstructured":"Daveshwar SR, Kapoor SV, Daveshwar MR (2020) Quantitative Polymerase Chain Reaction Analysis of Cariogenic Streptococcus mutans in Saliva of Oral and Laryngeal Cancer Patients Undergoing Radiotherapy: A Clinical Study. Int J Appl Basic Med Res 10(2):91\u201396. https:\/\/doi.org\/10.4103\/ijabmr.IJABMR_151_19","journal-title":"Int J Appl Basic Med Res"},{"key":"9191_CR25","doi-asserted-by":"publisher","unstructured":"Anjali K, Manzoor M, Suryavanshi MV, Rudrapathy P, Rekha PD, Das R, Hameed A, Arun AB (2023) Dysbiosis of the oral microbiota composition is associated with oral squamous cell carcinoma and the impact of radiotherapy: a pilot study. FEMS Microbiol Lett 17;370:fnad111. https:\/\/doi.org\/10.1093\/femsle\/fnad111","DOI":"10.1093\/femsle\/fnad111"},{"issue":"1","key":"9191_CR26","doi-asserted-by":"publisher","first-page":"31","DOI":"10.4103\/0973-029X.92970","volume":"16","author":"H Suryawanshi","year":"2012","unstructured":"Suryawanshi H, Ganvir SM, Hazarey VK, Wanjare VS (2012) Oropharyngeal candidosis relative frequency in radiotherapy patient for head and neck cancer. J Oral Maxillofac Pathol 16(1):31\u201337. https:\/\/doi.org\/10.4103\/0973-029X.92970","journal-title":"J Oral Maxillofac Pathol"},{"issue":"3","key":"9191_CR27","first-page":"207","volume":"60","author":"P Kurnatowski","year":"2014","unstructured":"Kurnatowski P, Moqbil S, Kaczmarczyk D (2014) Signs, symptoms and the prevalence of fungi detected from the oral cavity and pharynx of radiotherapy subjects with head and neck tumors, and their susceptibility to chemotherapeutics. Ann Parasitol 60(3):207\u2013213","journal-title":"Ann Parasitol"},{"key":"9191_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2019.104480","volume":"106","author":"VJ M\u00fcller","year":"2019","unstructured":"M\u00fcller VJ, Belibasakis GN, Bosshard PP, Wiedemeier DB, Bichsel D, R\u00fccker M, Stadlinger B (2019) Change of saliva composition with radiotherapy. Arch Oral Biol 106:104480. https:\/\/doi.org\/10.1016\/j.archoralbio.2019.104480","journal-title":"Arch Oral Biol"},{"key":"9191_CR29","doi-asserted-by":"publisher","unstructured":"Putta P, Natarajan K, Beeraka SS, Manne RK, Sarath PV (2021) Prevalence of different fungal species in Saliva and Swab samples of patients undergoing Radiotherapy for Oral Cancer. J Pure Appl Microbiol 15(3):1180\u20131186. https:\/\/doi.org\/10.22207\/JPAM.15.3.07","DOI":"10.22207\/JPAM.15.3.07"},{"issue":"Suppl 1","key":"9191_CR30","doi-asserted-by":"publisher","first-page":"S109","DOI":"10.4103\/jpbs.JPBS_38_20","volume":"12","author":"AHH Priya","year":"2020","unstructured":"Priya AHH, Rajmohan AK, HP, Akash Raj S, Archana S, Venkatanarasu B, (2020) Evaluation of Alteration in Oral Microbial Flora Pre- and Postradiation Therapy in Patients with Head and Neck Cancer. J Pharm Bioallied Sci 12(Suppl 1):S109\u2013S113. https:\/\/doi.org\/10.4103\/jpbs.JPBS_38_20","journal-title":"J Pharm Bioallied Sci"},{"issue":"5","key":"9191_CR31","first-page":"605","volume":"23","author":"YY Zhang","year":"2014","unstructured":"Zhang YY, Li AQ, Wang NN, Liu LN, Cui JL (2014) Oral candida species distribution in patients receiving radiotherapy for head and neck cancer. Shanghai Kou Qiang Yi Xue 23(5):605\u2013608","journal-title":"Shanghai Kou Qiang Yi Xue"},{"issue":"6","key":"9191_CR32","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1590\/S1676-24442007000600004","volume":"43","author":"PRF Bonan","year":"2007","unstructured":"Bonan PRF, Pires FR, Lopes MA, Hip\u00f3lito OD Jr (2007) Candida colonization and species in patients submitted to head and neck radiotherapy. J Bras Patol Med Lab 43(6):407\u2013412. https:\/\/doi.org\/10.1590\/S1676-24442007000600004","journal-title":"J Bras Patol Med Lab"},{"issue":"6","key":"9191_CR33","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1034\/j.1600-0714.2002.310603.x","volume":"31","author":"T Vuotila","year":"2002","unstructured":"Vuotila T, Ylikontiola L, Sorsa T, Luoto H, Hanemaaijer R, Salo T, Tj\u00e4derhane L (2002) The relationship between MMPs and pH in whole saliva of radiated head and neck cancer patients. J Oral Pathol Med 31(6):329\u2013338. https:\/\/doi.org\/10.1034\/j.1600-0714.2002.310603.x","journal-title":"J Oral Pathol Med"},{"issue":"1","key":"9191_CR34","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/ijos.2013.15","volume":"5","author":"YJ Hu","year":"2013","unstructured":"Hu YJ, Wang Q, Jiang YT, Ma R, Xia WW, Tang ZS, Liu Z, Liang JP, Huang ZW (2013) Characterization of oral bacterial diversity of irradiated patients by high-throughput sequencing. Int J Oral Sci 5(1):21\u201325. https:\/\/doi.org\/10.1038\/ijos.2013.15","journal-title":"Int J Oral Sci"},{"issue":"2","key":"9191_CR35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056343","volume":"8","author":"YJ Hu","year":"2013","unstructured":"Hu YJ, Shao ZY, Wang Q, Jiang YT, Ma R, Tang ZS, Liu Z, Liang JP, Huang ZW (2013) Exploring the dynamic core microbiome of plaque microbiota during head-and-neck radiotherapy using pyrosequencing. PLoS ONE 8(2):e56343. https:\/\/doi.org\/10.1371\/journal.pone.0056343","journal-title":"PLoS ONE"},{"issue":"3","key":"9191_CR36","doi-asserted-by":"publisher","first-page":"78","DOI":"10.5681\/joddd.2009.020","volume":"3","author":"A Azizi","year":"2009","unstructured":"Azizi A, Rezaei M (2009) Prevalence of Candida species in the oral cavity of patients undergoing head and neck radiotherapy. J Dent Res Dent Clin Dent Prospects 3(3):78\u201381. https:\/\/doi.org\/10.5681\/joddd.2009.020","journal-title":"J Dent Res Dent Clin Dent Prospects"},{"issue":"5","key":"9191_CR37","first-page":"585","volume":"59","author":"K Muthu","year":"2004","unstructured":"Muthu K, Raman R, Gopalakrishnan G (2004) Oropharyngeal flora changes in patients with head and neck malignancy post radiotherapy. Med J Malaysia 59(5):585\u2013590","journal-title":"Med J Malaysia"},{"issue":"3","key":"9191_CR38","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1590\/S1517-838220110003000024","volume":"42","author":"EJ Gaetti-Jardim","year":"2011","unstructured":"Gaetti-Jardim EJ, Ciesielski FI, de Sousa FR, Nwaokorie F, Schweitzer CM, Avila-Campos MJ (2011) Occurrence of yeasts, pseudomonads and enteric bacteria in the oral cavity of patients undergoing head and neck radiotherapy. Braz J Microbiol 42(3):1047\u20131055. https:\/\/doi.org\/10.1590\/S1517-838220110003000024","journal-title":"Braz J Microbiol"},{"issue":"1","key":"9191_CR39","doi-asserted-by":"publisher","first-page":"122","DOI":"10.4103\/jomfp.JOMFP_304_18","volume":"23","author":"PN Deo","year":"2019","unstructured":"Deo PN, Deshmukh R (2019) Oral microbiome: Unveiling the fundamentals. J Oral Maxillofac Pathol 23(1):122\u2013128. https:\/\/doi.org\/10.4103\/jomfp.JOMFP_304_18","journal-title":"J Oral Maxillofac Pathol"},{"issue":"11","key":"9191_CR40","doi-asserted-by":"publisher","first-page":"5721","DOI":"10.1128\/JCM.43.11.5721-5732.2005","volume":"43","author":"JA Aas","year":"2005","unstructured":"Aas JA, Paster BJ, Stokes LN, Olsen I, Dewhirst FE (2005) Defining the normal bacterial flora of the oral cavity. J Clin Microbiol 43(11):5721\u20135732. https:\/\/doi.org\/10.1128\/JCM.43.11.5721-5732.2005","journal-title":"J Clin Microbiol"},{"issue":"6","key":"9191_CR41","doi-asserted-by":"publisher","first-page":"R42","DOI":"10.1186\/gb-2012-13-6-r42","volume":"13","author":"N Segata","year":"2012","unstructured":"Segata N, Haake SK, Mannon P, Lemon KP, Waldron L, Gevers D, Huttenhower C, Izard J (2012) Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples. Genome Biol 13(6):R42. https:\/\/doi.org\/10.1186\/gb-2012-13-6-r42","journal-title":"Genome Biol"},{"issue":"7","key":"9191_CR42","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1177\/0022034513488119","volume":"92","author":"A Sim\u00f3n-Soro","year":"2013","unstructured":"Sim\u00f3n-Soro A, Tom\u00e1s I, Cabrera-Rubio R, Catalan MD, Nyvad B, Mira A (2013) Microbial geography of the oral cavity. J Dent Res 92(7):616\u2013621. https:\/\/doi.org\/10.1177\/0022034513488119","journal-title":"J Dent Res"},{"issue":"7","key":"9191_CR43","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1111\/odi.12686","volume":"23","author":"TM Richards","year":"2017","unstructured":"Richards TM, Hurley T, Grove L, Harrington KJ, Carpenter GH, Proctor GB, Nutting CM (2017) The effect of parotid gland-sparing intensity-modulated radiotherapy on salivary composition, flow rate and xerostomia measures. Oral Dis 23(7):990\u20131000. https:\/\/doi.org\/10.1111\/odi.12686","journal-title":"Oral Dis"},{"issue":"4","key":"9191_CR44","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1007\/s00784-015-1546-9","volume":"20","author":"D Bichsel","year":"2016","unstructured":"Bichsel D, Lanfranchi M, Attin T, Gr\u00e4tz KW, Stadlinger B (2016) Evaluation of oral prophylaxis during and after intensity-modulated radiotherapy due to head and neck cancer\u2014a retrospective study. Clin Oral Investig 20(4):721\u2013726. https:\/\/doi.org\/10.1007\/s00784-015-1546-9","journal-title":"Clin Oral Investig"},{"issue":"2","key":"9191_CR45","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1097\/00013542-199704000-00005","volume":"8","author":"MJ Wilson","year":"1997","unstructured":"Wilson MJ, Weightman AJ, Wade WG (1997) Applications of molecular ecology in the characterisation of uncultured microorganisms associated with human disease. Rev Med Microbiol 8(2):91\u2013101. https:\/\/doi.org\/10.1097\/00013542-199704000-00005","journal-title":"Rev Med Microbiol"},{"issue":"2","key":"9191_CR46","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1177\/014107680209500207","volume":"95","author":"W Wade","year":"2002","unstructured":"Wade W (2002) Unculturable bacteria\u2013the uncharacterized organisms that cause oral infections. J R Soc Med 95(2):81\u201383. https:\/\/doi.org\/10.1177\/014107680209500207","journal-title":"J R Soc Med"},{"issue":"2","key":"9191_CR47","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/s1079-2104(97)90061-5","volume":"84","author":"V Ramirez-Amador","year":"1997","unstructured":"Ramirez-Amador V, Silverman S Jr, Mayer P, Tyler M, Quivey J (1997) Candidal colonization and oral candidiasis in patients undergoing oral and pharyngeal radiation therapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 84(2):149\u2013153. https:\/\/doi.org\/10.1016\/s1079-2104(97)90061-5","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"3","key":"9191_CR48","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.tripleo.2006.02.005","volume":"103","author":"BC Jham","year":"2007","unstructured":"Jham BC, Fran\u00e7a EC, Oliveira RR, Santos VR, Kowalski LP, da Silva Freire AR (2007) Candida oral colonization and infection in Brazilian patients undergoing head and neck radiotherapy: A pilot study. Oral Surgery, Oral Med Oral Pathol Oral Radiol Endodontology 103(3):355\u2013358. https:\/\/doi.org\/10.1016\/j.tripleo.2006.02.005","journal-title":"Oral Surgery, Oral Med Oral Pathol Oral Radiol Endodontology"},{"issue":"4","key":"9191_CR49","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1111\/idh.12348","volume":"16","author":"A Almst\u00e5hl","year":"2018","unstructured":"Almst\u00e5hl A, Finizia C, Carl\u00e9n A, Fagerberg-Mohlin B, Alstad T (2018) Mucosal microflora in head and neck cancer patients. Int J Dent Hyg 16(4):459\u2013466. https:\/\/doi.org\/10.1111\/idh.12348","journal-title":"Int J Dent Hyg"},{"issue":"1","key":"9191_CR50","doi-asserted-by":"publisher","first-page":"39","DOI":"10.4103\/ijc.IJC_155_17","volume":"54","author":"S Raj","year":"2017","unstructured":"Raj S, Sharma D, Mate P, Capoor MR, Bhowmik KT (2017) A study of changes in the oral fungal flora of patients on radiotherapy for head and neck malignancies and their correlation with funguria and fungemia. Indian J Cancer 54(1):39\u201342. https:\/\/doi.org\/10.4103\/ijc.IJC_155_17","journal-title":"Indian J Cancer"},{"issue":"2","key":"9191_CR51","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/BF00436507","volume":"112","author":"CR Paula","year":"1990","unstructured":"Paula CR, Sampaio MC, Birman EG, Siqueira AM (1990) Oral yeasts in patients with cancer of the mouth, before and during radiotherapy. Mycopathologia 112(2):119\u2013124. https:\/\/doi.org\/10.1007\/BF00436507","journal-title":"Mycopathologia"},{"issue":"1","key":"9191_CR52","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jnci.2017.01.006","volume":"29","author":"GK Singh","year":"2017","unstructured":"Singh GK, Capoor MR, Nair D, Bhowmik KT (2017) Spectrum of fungal infection in head and neck cancer patients on chemoradiotherapy. J Egypt Natl Canc Inst 29(1):33\u201337. https:\/\/doi.org\/10.1016\/j.jnci.2017.01.006","journal-title":"J Egypt Natl Canc Inst"},{"key":"9191_CR53","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.ctro.2019.10.006","volume":"20","author":"H Saito","year":"2019","unstructured":"Saito H, Shodo R, Yamazaki K, Katsura K, Ueki Y, Nakano T, Oshikane T, Yamana N, Tanabe S, Utsunomiya S, Ohta A, Abe E, Kaidu M, Sasamoto R, Aoyama H (2019) The association between oral candidiasis and severity of chemoradiotherapy-induced dysphagia in head and neck cancer patients: A retrospective cohort study. Clin Transl Radiat Oncol 20:13\u201318. https:\/\/doi.org\/10.1016\/j.ctro.2019.10.006","journal-title":"Clin Transl Radiat Oncol"},{"issue":"44","key":"9191_CR54","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000013073","volume":"97","author":"Y Kawashita","year":"2018","unstructured":"Kawashita Y, Funahara M, Yoshimatsu M, Nakao N, Soutome S, Saito T, Umeda M (2018) A retrospective study of factors associated with the development of oral candidiasis in patients receiving radiotherapy for head and neck cancer: Is topical steroid therapy a risk factor for oral candidiasis? Medicine (Baltimore) 97(44):e13073. https:\/\/doi.org\/10.1097\/MD.0000000000013073","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"9191_CR55","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s12903-018-0595-2","volume":"18","author":"JA Banas","year":"2018","unstructured":"Banas JA, Drake DR (2018) Are the mutans streptococci still considered relevant to understanding the microbial etiology of dental caries? BMC Oral Health 18(1):129. https:\/\/doi.org\/10.1186\/s12903-018-0595-2","journal-title":"BMC Oral Health"},{"issue":"4","key":"9191_CR56","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1159\/000259809","volume":"6","author":"H Llory","year":"1972","unstructured":"Llory H, Dammron A, Gioanni M, Frank RM (1972) Some population changes in oral anaerobic microorganisms, Streptococcus mutans and yeasts following irradiation of the salivry glands. Caries Res 6(4):298\u2013311. https:\/\/doi.org\/10.1159\/000259809","journal-title":"Caries Res"},{"key":"9191_CR57","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1159\/000072350","volume":"12","author":"KT Beer","year":"2002","unstructured":"Beer KT, Zehnder D, Lussi A, Greiner RH (2002) Saliva flow, pH, buffer capacity, and colonization by Streptococcus mutans during and after radical radiotherapy of head and neck tumours. Otorhinolaryngol Nova 12:137\u2013144. https:\/\/doi.org\/10.1159\/000072350","journal-title":"Otorhinolaryngol Nova"},{"issue":"3","key":"9191_CR58","doi-asserted-by":"publisher","first-page":"295","DOI":"10.4034\/1519.0501.2008.0083.0007","volume":"8","author":"JV Pereira","year":"2008","unstructured":"Pereira JV, Souza FEC, Alves PM, Ara\u00fajo CRF, Gomes DQC (2008) Evaluation of streptococcus mutans and salivary flow rate in head and neck cancer patients submitted to radiation therapy and chemotherapy. Pesqui Bras Odontopediatria Clin Integr 8(3):295\u2013299","journal-title":"Pesqui Bras Odontopediatria Clin Integr"},{"issue":"2","key":"9191_CR59","doi-asserted-by":"publisher","first-page":"75","DOI":"10.4068\/cmj.2013.49.2.75","volume":"49","author":"MS Kang","year":"2013","unstructured":"Kang MS, Oh JS, Jeong KY, Kim HJ, Lee JJ, Lee GS, Lim HJ, Lim HS (2013) Analysis of cariogenic bacteria in saliva of cancer patients. Chonnam Med J 49(2):75\u201380. https:\/\/doi.org\/10.4068\/cmj.2013.49.2.75","journal-title":"Chonnam Med J"},{"issue":"5","key":"9191_CR60","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1159\/000261473","volume":"26","author":"S Joyston-Bechal","year":"1992","unstructured":"Joyston-Bechal S, Hayes K, Davenport ES, Hardie JM (1992) Caries incidence, mutans streptococci and lactobacilli in irradiated patients during a 12-month preventive programme using chlorhexidine and fluoride. Caries Res 26(5):384\u2013390. https:\/\/doi.org\/10.1159\/000261473","journal-title":"Caries Res"},{"key":"9191_CR61","doi-asserted-by":"publisher","first-page":"1366153","DOI":"10.3389\/froh.2024.1366153","volume":"5","author":"MC van Dijk","year":"2024","unstructured":"van Dijk MC, Petersen JF, Raber-Durlacher JE, Epstein JB, Laheij AMGA (2024) Diversity and compositional differences in the oral microbiome of oral squamous cell carcinoma patients and healthy controls: a scoping review. Front Oral Health 5:1366153. https:\/\/doi.org\/10.3389\/froh.2024.1366153","journal-title":"Front Oral Health"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-025-09191-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-025-09191-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-025-09191-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:42:36Z","timestamp":1739493756000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-025-09191-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,29]]},"references-count":61,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["9191"],"URL":"https:\/\/doi.org\/10.1007\/s00520-025-09191-5","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,29]]},"assertion":[{"value":"21 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with human or animal subjects performed by any of the authors. Hence, no ethics approval was required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"127"}}