{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:47:43Z","timestamp":1787168863425,"version":"build-2736575974"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the Scientific Research Projects Unit of Istanbul University-Cerrahpa\u015fa","award":["TSA-2023-37257"],"award-info":[{"award-number":["TSA-2023-37257"]}]},{"name":"the Scientific Research Projects Unit of Istanbul University-Cerrahpa\u015fa","award":["TSA-2023-37257"],"award-info":[{"award-number":["TSA-2023-37257"]}]},{"name":"the Scientific Research Projects Unit of Istanbul University-Cerrahpa\u015fa","award":["TSA-2023-37257"],"award-info":[{"award-number":["TSA-2023-37257"]}]},{"name":"the Scientific Research Projects Unit of Istanbul University-Cerrahpa\u015fa","award":["TSA-2023-37257"],"award-info":[{"award-number":["TSA-2023-37257"]}]},{"name":"the Scientific Research Projects Unit of Istanbul University-Cerrahpa\u015fa","award":["TSA-2023-37257"],"award-info":[{"award-number":["TSA-2023-37257"]}]},{"name":"Okan University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to compare the effects of manual lymphatic drainage and bandaging (MLDB) combined with calf muscle exercise training (CMT) and\/or inspiratory muscle training (IMT) on edema, muscle strength, functional capacity, functionality, and quality of life (QoL) in patients with secondary lower limb lymphedema (LLL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A total of 76 patients (mean age: 47.06 \u00b1\u200916.16 years; 84.2% female) with LLL were included in the study and randomized into four groups: MLDB alone (Group 1), MLDB +\u2009CMT (Group 2), MLDB +\u2009IMT (Group 3), and MLDB +\u2009CMT +\u2009IMT (Group 4). The training programs were administered for 30 min per day, five days per week, over three weeks. Edema was assessed using circumference measurements (CM) and tissue dielectric constant (TDC). Muscle strength was evaluated using maximum inspiratory\/expiratory pressure (MIP\/MEP) and a dynamometer. Functional capacity was assessed with the 6-Minute Walk Test (6MWT), functionality with the Lower Extremity Functional Scale (LEFS), and QoL with the Lymphedema Quality of Life Scale (LYMQOL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the intra-group analyses, all assessments improved in all groups, except for MIP, MEP, and gastrocnemius muscle strength in Group 1 and MIP in Group 2 (p &lt;\u20090.05). In the inter-group analyses, Group 3 showed the largest effect sizes (ES) for reductions in TDC (ES: 2.34) and improvements in LYMQOL (ES: 1.74), MEP (ES: 1.46), and LEFS (ES: 1.44) (p &lt;\u20090.001 for all). Group 4 had the largest ES for increases in MIP (ES: 1.42, p\u2009&lt; 0.001). Group 2 showed the largest ES for improvements in gastrocnemius muscle strength (ES: 1.41, p\u2009&lt; 0.001). However, there were no significant differences among the groups in CM or 6MWT results (p &gt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Compared to enhancing leg muscle strength, improving respiratory muscle function in addition to MLDB had a greater impact on reducing edema and enhancing functionality and QoL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration Number<\/jats:title>\n                    <jats:p>NCT05609526.\u00a0Registration Date:\u00a014.11.2022.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00520-025-09436-3","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T09:51:23Z","timestamp":1744365083000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The effect of muscles in the treatment of lower limb lymphedema: respiratory muscles or leg muscles?"],"prefix":"10.1007","volume":"33","author":[{"given":"Ahmet","family":"Akgul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lknur","family":"Mazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamze","family":"Aydin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mumine","family":"Yavuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130pek","family":"Yeldan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,11]]},"reference":[{"key":"9436_CR1","unstructured":"F\u00f6ldi M, F\u00f6ldi E, Str\u00f6\u00dfenreuther R, Kubik S (2012) F\u00f6ldi's textbook of lymphology: for physicians and lymphedema therapists: Elsevier Health Sciences"},{"issue":"22","key":"9436_CR2","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.1056\/NEJMc1201684","volume":"366","author":"AK Greene","year":"2012","unstructured":"Greene AK, Grant FD, Slavin SA (2012) Lower-extremity lymphedema and elevated body-mass index. N Engl J Med 366(22):2136\u20132137","journal-title":"N Engl J Med"},{"issue":"10","key":"9436_CR3","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/j.jacc.2008.06.005","volume":"52","author":"SG Rockson","year":"2008","unstructured":"Rockson SG (2008) Diagnosis and management of lymphatic vascular disease. J Am Coll Cardiol 52(10):799\u2013806. https:\/\/doi.org\/10.1016\/j.jacc.2008.06.005","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"9436_CR4","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.jaad.2008.04.013","volume":"59","author":"K Kerchner","year":"2008","unstructured":"Kerchner K, Fleischer A, Yosipovitch G (2008) Lower extremity lymphedema update: pathophysiology, diagnosis, and treatment guidelines. J Am Acad Dermatol 59(2):324\u2013331. https:\/\/doi.org\/10.1016\/j.jaad.2008.04.013","journal-title":"J Am Acad Dermatol"},{"issue":"1\u20132","key":"9436_CR5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/s0169-409x(01)00150-8","volume":"50","author":"MA Swartz","year":"2001","unstructured":"Swartz MA (2001) The physiology of the lymphatic system. Adv Drug Deliv Rev 50(1\u20132):3\u201320. https:\/\/doi.org\/10.1016\/s0169-409x(01)00150-8","journal-title":"Adv Drug Deliv Rev"},{"issue":"3","key":"9436_CR6","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.ygyno.2012.03.017","volume":"125","author":"SF Liao","year":"2012","unstructured":"Liao SF, Li SH, Huang HY (2012) The efficacy of complex decongestive physiotherapy (CDP) and predictive factors of response to CDP in lower limb lymphedema (LLL) after pelvic cancer treatment. Gynecol Oncol 125(3):712\u2013715. https:\/\/doi.org\/10.1016\/j.ygyno.2012.03.017","journal-title":"Gynecol Oncol"},{"issue":"4","key":"9436_CR7","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1097\/01.sap.0000257149.42922.7e","volume":"59","author":"AG Warren","year":"2007","unstructured":"Warren AG, Brorson H, Borud LJ, Slavin SA (2007) Lymphedema: a comprehensive review. Ann Plast Surg 59(4):464\u2013472. https:\/\/doi.org\/10.1097\/01.sap.0000257149.42922.7e","journal-title":"Ann Plast Surg"},{"issue":"6","key":"9436_CR8","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1046\/j.1524-4741.2000.99072.x","volume":"6","author":"ED Paskett","year":"2000","unstructured":"Paskett ED, Stark N (2000) Lymphedema: Knowledge, Treatment, and Impact Among Breast Cancer Survivors. Breast J 6(6):373\u2013378. https:\/\/doi.org\/10.1046\/j.1524-4741.2000.99072.x","journal-title":"Breast J"},{"issue":"5","key":"9436_CR9","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1111\/j.1365-2354.2007.00877.x","volume":"17","author":"SJ Kim","year":"2008","unstructured":"Kim SJ, Park YD (2008) Effects of complex decongestive physiotherapy on the oedema and the quality of life of lower unilateral lymphoedema following treatment for gynecological cancer. Eur J Cancer Care 17(5):463\u2013468. https:\/\/doi.org\/10.1111\/j.1365-2354.2007.00877.x","journal-title":"Eur J Cancer Care"},{"issue":"3","key":"9436_CR10","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1590\/1809-2950\/15476523032016","volume":"23","author":"HPS Soares","year":"2016","unstructured":"Soares HPS, Rocha A, Aguiar-Santos AM, Santos BS, Melo CML, Andrade MA (2016) Complex decongestant therapy with use of alternative material to reduce and control lymphedema in patients with endemic area of filariasis: a clinical trial. Fisioter Pesqui 23(3):268\u2013277. https:\/\/doi.org\/10.1590\/1809-2950\/15476523032016","journal-title":"Fisioter Pesqui"},{"issue":"8","key":"9436_CR11","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.1007\/s00520-017-3671-2","volume":"25","author":"T Fukushima","year":"2017","unstructured":"Fukushima T, Tsuji T, Sano Y, Miyata C, Kamisako M, Hohri H et al (2017) Immediate effects of active exercise with compression therapy on lower-limb lymphedema. Support Care Cancer 25(8):2603\u20132610. https:\/\/doi.org\/10.1007\/s00520-017-3671-2","journal-title":"Support Care Cancer"},{"issue":"6","key":"9436_CR12","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/j.jaad.2017.03.021","volume":"77","author":"AA Grada","year":"2017","unstructured":"Grada AA, Phillips TJ (2017) Lymphedema: Diagnostic workup and management. J Am Acad Dermatol 77(6):995\u20131006. https:\/\/doi.org\/10.1016\/j.jaad.2017.03.021","journal-title":"J Am Acad Dermatol"},{"key":"9436_CR13","first-page":"58","volume":"33","author":"MA Dery","year":"2000","unstructured":"Dery MA, Yonuschot G, Winterson BJ (2000) The effects of manually applied intermittent pulsation pressure to rat ventral thorax on lymph transport. Lymphology 33:58\u201361","journal-title":"Lymphology"},{"issue":"5","key":"9436_CR14","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1016\/j.jvsv.2022.04.012","volume":"10","author":"G Aydin","year":"2022","unstructured":"Aydin G, Yeldan I, Akgul A, Ipek G (2022) Effects of inspiratory muscle training versus calf muscle training on quality of life, pain, venous function and activity in patients with chronic venous insufficiency. J Vasc Surg Venous Lymphat Disord 10(5):1137\u20131146. https:\/\/doi.org\/10.1016\/j.jvsv.2022.04.012","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"issue":"8","key":"9436_CR15","doi-asserted-by":"publisher","first-page":"3593","DOI":"10.1007\/s00520-020-05521-x","volume":"28","author":"T Hasenoehrl","year":"2020","unstructured":"Hasenoehrl T, Palma S, Ramazanova D et al (2020) Resistance exercise and breast cancer-related lymphedema-a systematic review update and meta-analysis. Support Care Cancer 28(8):3593\u20133603. https:\/\/doi.org\/10.1007\/s00520-020-05521-x","journal-title":"Support Care Cancer"},{"key":"9436_CR16","doi-asserted-by":"publisher","unstructured":"Soriano-Maldonado A, Carrera-Ruiz \u00c1, D\u00edez-Fern\u00e1ndez DM, et al (2018) Effects of a 12-week resistance and aerobic exercise program on muscular strength and quality of life in breast cancer survivors: Study protocol for the EFICAN randomized controlled trial [published correction appears in Medicine (Baltimore) 98(49):e18419. https:\/\/doi.org\/10.1097\/MD.0000000000018419].","DOI":"10.1097\/MD.0000000000018419"},{"key":"9436_CR17","doi-asserted-by":"publisher","first-page":"850564","DOI":"10.3389\/fonc.2022.850564","volume":"12","author":"K Ram\u00edrez-Parada","year":"2022","unstructured":"Ram\u00edrez-Parada K, Lopez-Garzon M, Sanchez-Rojel C et al (2022) Effect of Supervised Resistance Training on Arm Volume, Quality of Life and Physical Perfomance Among Women at High Risk for Breast Cancer-Related Lymphedema: A Study Protocol for a Randomized Controlled Trial (STRONG-B). Front Oncol 12:850564. https:\/\/doi.org\/10.3389\/fonc.2022.850564","journal-title":"Front Oncol"},{"issue":"1","key":"9436_CR18","doi-asserted-by":"publisher","first-page":"100333","DOI":"10.1016\/j.apjon.2023.100333","volume":"11","author":"J Zhang","year":"2023","unstructured":"Zhang J, Zhou C, Ma Q, Zhang Y, Zhang X (2023) Preventing lower limb lymphedema after pelvic lymphadenectomy with progressive resistance exercise training: A randomized controlled trial. Asia Pac J Oncol Nurs 11(1):100333. https:\/\/doi.org\/10.1016\/j.apjon.2023.100333","journal-title":"Asia Pac J Oncol Nurs"},{"issue":"7","key":"9436_CR19","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.apmr.2010.03.021","volume":"91","author":"E Katz","year":"2010","unstructured":"Katz E, Dugan NL, Cohn JC, Chu C, Smith RG, Schmitz KH (2010) Weight lifting in patients with lower-extremity lymphedema secondary to cancer: a pilot and feasibility study. Arch Phys Med Rehabil 91(7):1070\u20131076. https:\/\/doi.org\/10.1016\/j.apmr.2010.03.021","journal-title":"Arch Phys Med Rehabil"},{"issue":"3","key":"9436_CR20","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1111\/1467-8721.ep10768783","volume":"1","author":"J Cohen","year":"1992","unstructured":"Cohen J (1992) Statistical power analysis. Curr Dir Psychol Sci 1(3):98\u2013101","journal-title":"Curr Dir Psychol Sci"},{"key":"9436_CR21","unstructured":"Urbaniak GC, Plous S (2008) Research randomizer. Available at: https:\/\/www.randomizer.org\/"},{"key":"9436_CR22","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1088\/0967-3334\/25\/2\/004","volume":"25","author":"J Nuutinen","year":"2004","unstructured":"Nuutinen J, Ik\u00e4heimo R, Lahtinen T (2004) Validation of a new dielectric device to assess changes of tissue water in skin and subcutaneous fat. Physiol Meas 25:447\u2013454","journal-title":"Physiol Meas"},{"key":"9436_CR23","doi-asserted-by":"crossref","unstructured":"American Thoracic Society; European Respiratory Society (2002) ATS\/ERS statement on respiratory muscle testing. Am J Respir Crit Care Med 166:518-624","DOI":"10.1164\/rccm.166.4.518"},{"key":"9436_CR24","unstructured":"Hislop HJ, Montgomery J (2002) Daniels and Worthingham\u2019s muscle testing: techniques of manual examination. 7th ed. WB Saunders"},{"key":"9436_CR25","doi-asserted-by":"crossref","unstructured":"ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories (2002) ATS statement: guidelines for the six-minute walk test. Am J Respit Crit Care Med 166:111-7. 30","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"9436_CR26","first-page":"371","volume":"79","author":"JM Binkley","year":"1999","unstructured":"Binkley JM, Stratford PW, Lott SA, Riddle DL (1999) The lower extremity functional scale (LEFS): scale development, measurement properties, and clinical application. North American Orthopaedic Rehabilitation Research Network. Phys Ther 79:371\u2013383","journal-title":"Phys Ther"},{"key":"9436_CR27","doi-asserted-by":"publisher","first-page":"S22","DOI":"10.12968\/bjcn.2008.13.Sup5.31193","volume":"13","author":"V Keeley","year":"2008","unstructured":"Keeley V (2008) Quality of life assessment tools in chronic oedema. Br J Community Nurs 13:S22\u2013S27","journal-title":"Br J Community Nurs"},{"key":"9436_CR28","volume-title":"Textbook of Dr","author":"G Wittlinger","year":"2004","unstructured":"Wittlinger G, Wittlinger H (2004) Textbook of Dr. Thieme, Vodder\u2019s manual lymph drainage"},{"issue":"195","key":"9436_CR29","first-page":"21","volume":"60","author":"P Page","year":"2008","unstructured":"Page P, Windsor Ellenbecker T (2008) Strength band training, reviewed by Sutton M. Physiother Can 60(195):21","journal-title":"Physiother Can"},{"key":"9436_CR30","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1519\/SSC.0b013e318195ad32","volume":"31","author":"DT McMaster","year":"2009","unstructured":"McMaster DT, Cronin J, McGuigan M (2009) Forms of variable resistance training. J Strength Cond Res 31:50\u201364","journal-title":"J Strength Cond Res"},{"issue":"7","key":"9436_CR31","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/j.rmr.2021.04.003","volume":"38","author":"M Beaumont","year":"2021","unstructured":"Beaumont M, Le Tallec F, Villiot-Danger E (2021) Inspiratory muscle training during pulmonary rehabilitation. Rev Mal Respir 38(7):754\u2013767. https:\/\/doi.org\/10.1016\/j.rmr.2021.04.003","journal-title":"Rev Mal Respir"},{"key":"9436_CR32","volume-title":"Statistical power analysis for the behavioral Sciences","author":"J Cohen","year":"1998","unstructured":"Cohen J (1998) Statistical power analysis for the behavioral Sciences. Psychology Press"},{"issue":"1","key":"9436_CR33","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.asjsur.2020.03.022)","volume":"44","author":"X Wu","year":"2021","unstructured":"Wu X, Liu Y, Zhu D, Wang F, Ji J, Yan H (2021) Early prevention of complex decongestive therapy and rehabilitation exercise for prevention of lower extremity lymphedema after operation of gynecologic cancer. Asian J Surg 44(1):111\u2013115. https:\/\/doi.org\/10.1016\/j.asjsur.2020.03.022)","journal-title":"Asian J Surg"},{"issue":"10","key":"9436_CR34","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1177\/02683555231194419","volume":"38","author":"G Aydin","year":"2023","unstructured":"Aydin G, Yeldan I, Akgul A (2023) The relationship between inspiratory muscle strength, venous refilling time, disease severity, and functional capacity in patients with chronic venous insufficiency. Phlebology 38(10):649\u2013656. https:\/\/doi.org\/10.1177\/02683555231194419","journal-title":"Phlebology"},{"issue":"2","key":"9436_CR35","doi-asserted-by":"crossref","first-page":"151","DOI":"10.32635\/2176-9745.RBC.2014v60n2.484","volume":"60","author":"APM Abreu","year":"2014","unstructured":"Abreu APM, Endres D, Costa AB, Cecagno SC, Martini RR, Leguisamo CP (2014) Respiratory muscle strength in patients in pre- and postoperative liver transplantation. Rev Bras Cancerol 60(2):151\u2013157","journal-title":"Rev Bras Cancerol"},{"issue":"4","key":"9436_CR36","doi-asserted-by":"publisher","first-page":"469","DOI":"10.15446\/revfacmed.v67n4.68950","volume":"67","author":"AM Espina Lopez","year":"2019","unstructured":"Espina Lopez AM, Daza-Arana JE, Pinzon-Sanabria LM, Perdomo-Quiroga Y, Ruiz-Jimenez JP (2019) Effects of muscle energy technique for quadratus lumborum on respiratory muscle strength in patients with breast cancer. Rev Fac Med 67(4):469\u2013475","journal-title":"Rev Fac Med"},{"issue":"2","key":"9436_CR37","doi-asserted-by":"publisher","first-page":"14","DOI":"10.5114\/pq.2023.112271","volume":"31","author":"E Kutlu","year":"2023","unstructured":"Kutlu E, Ergin G, Alptu\u011f B, Karadibak D (2023) The relationship between lymphedema, posture, respiratory functions, exercise capacity, and the quality of life after breast cancer treatment. Physiother Quart 31(2):14\u201320","journal-title":"Physiother Quart"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-025-09436-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-025-09436-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-025-09436-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:30:29Z","timestamp":1746837029000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-025-09436-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,11]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["9436"],"URL":"https:\/\/doi.org\/10.1007\/s00520-025-09436-3","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,11]]},"assertion":[{"value":"4 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"375"}}