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The sessions were separated by a seven-day washout period. The trial was carried out in a hospital setting from September to November 2018.<\/jats:p>\n            <jats:p>The acceptability and safety of the intervention were assessed. The safety was evaluated as adverse events and immediate and 24-h changes in self-reported symptoms (pain, heaviness, and tension). Additionally, recruitment, completion rate, and post-exercise changes in LLL were assessed by circumferential measurements of the legs, dual energy X-ray absorptiometry (DXA), and bioimpedance spectroscopy (BIS), respectively.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Twenty-one out of 35 (60%) eligible patients were included, and 19 (90%) patients completed both exercise sessions. Acceptability was high, and there were no adverse events. There was no clinically relevant difference between performing exercise with and without compression in self-reported symptoms or in limb volume. Small statistically significant differences in soft tissue mass (164.2\u00a0g corresponding to 1.4%) and extracellular fluid (L-Dex range\u2009&lt;\u20095 units) were observed with and without compression, respectively, both favoring exercise with compression.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>HIIT on a stationary bike was acceptable for patients with LLL and seemed safe regardless of the use of compression garments.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Trial registration<\/jats:title>\n            <jats:p>Clinicaltrials.gov registration (NCT03653819).<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00520-025-09458-x","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T21:54:28Z","timestamp":1744840468000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exercise and cancer-related lymphedema in the lower limbs\u2014a randomized cross-over trial on high-intensity interval training (HIIT) with and without compression garments"],"prefix":"10.1007","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8164-1421","authenticated-orcid":false,"given":"Merete Celano","family":"Wittenkamp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8456-5364","authenticated-orcid":false,"given":"Carsten Bogh","family":"Juhl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3457-6249","authenticated-orcid":false,"given":"Bo","family":"Zerahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1993-3102","authenticated-orcid":false,"given":"Anders","family":"Vinther","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"key":"9458_CR1","volume-title":"International consensus","author":"Best practice for the management of lymphoedema","year":"2006","unstructured":"Best practice for the management of lymphoedema (2006) International consensus. 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